简介：Inpastterroristattacks,vehicleborneimprovisedexplosivedevices(VBIED)havebeentheprimarymannerofattackingbuildingsandinfrastructures.Preventingunauthorizedvehiclesfromapproachingaprotectedareawithanti-ramsystemswouldmaintainanestablishedstandoffdistanceagainstmovingandstationaryvehiclesandconsequentlyreduceblastanddebristhreats.Thisstrategyhasbeenconsideredthefirstlineofdefenceagainstterrorists.Severaltypesofanti-ramdeviceshavebeendevelopedinaccordancewithU.S.DepartmentofStateK-ratingcriteria,forexample,wedgebarriers,risingbeams,sliding/swinggates,anddroparms.However,thesedevicestypicallyneedadeepfoundationforinstallationandcan'tbeimplementedintomanylocationswhereadepthofexcavationislimitedinordertoprotectutilitylinesofbuildingsandinfrastructures.Thispaperpresentsarecentdevelopmentofaseriesofshallowfootinganti-rambollardsystems(SFABS)thatcansatisfyK-12ratingwithonlyfive-inchthickfooting.Ahigh-fidelityphysicsbasedfiniteelementtechniquewithavehiclecrashmodelisusedforpredictinganti-ramcapacityanddeterminingdesignparametersoftheSFABS.Full-scalevehiclecrashtestsofthedevelopedSFABSsystemshavebeencarriedouttovalidatethedesignandanalysis.

简介：Age-relatedhearingloss(AHL),orpresbycusis,isthemostcommonneurodegenerativedisorderandtopcommunicationdeficitoftheagedpopulation.GeneticpredispositionisoneofthemajorfactorsinthedevelopmentofAHL.Generally,AHLisassociatedwithanage-dependentlossofsensoryhaircells,spiralganglionneuronsandstriavasculariscellsintheinnerear.Althoughthemechanismsleadingtogenetichearinglossarenotcompletelyunderstood,caspase-familyproteasesfunctionasimportantsignalsintheinnerearpathology.ItisnowacceptedthatmousemodelsarethebesttoolstostudythemechanismofgenetichearinglossorAHL.Here,weprovideabriefreviewofrecentstudiesonhearingimprovementinmousemodelsofAHLbyanti-apoptotictreatment.

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简介：在我们进一步探索并且适用的这篇论文，我们的最近的反散开的流动改正了有限差别WENO策划让能量守恒定律与污染物质繁殖计算浅水方程的theSaint-Venant系统的高顺序，它被一个运输方程描述。动机是高度命令当在答案的光滑的区域为近似把高顺序作为精确性时，为能量守恒定律的反散开的WENO计划生产接触断绝的锋利的分辨率。到有污染物质的运输的浅水方程的Saint-Venant系统的theanti散开的高顺序WENO计划的应用程序完成高分辨率

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简介：Thisarticlebrieflyoutlineshowanti-terrorismstrugglesbecamelinkedandtheirrelationshipthereafterwithhumanrightsissuesininternationalpoliticallife.Withequalrelevanceandvaluetohumandevelopment,anti-terrorismeffortsandhumanrightsprotectionarethemselvesnotmutuallyexclusiveorcontradictory.Theirconflictineverydaylifehassometimesresultedfromthefactthattheyarebothmanipulatedintheserviceofcertainpoliticalends.What’smore,therehasneverbeenperfecthumanrightsprotectionintheworldsofar,whichoftenmakeshumanrightsproblemsaneasychargeagainstalmosteverygovernment.Noanti-terroristactivitiesineithertheUSorEuropehavebeenreallyconstrainedbytheideaofhumanrightsnomatterhowbeautifultheirrhetorichasbeen.Nowbothhumanrightsandanti-terrorismhavebeenmadeintoatoolofdiplomacyandinternationalpolitics.WiththewarinAfghanistanover,theUnitedStatesisenhancingitshumanrightsdiplomacytogetherwithitsanti-terrorismdiplomacy.Trulyefficient,comprehensiveinternationalcooperationonanti-terrorismisstillfaraway.

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简介：ObjectivesToinvestigatetheanti-apoptoticeffectsofmesenchymalstemcells(MSCs)onhypoxicinjuredcardiacmyocytesinvitro.MethodsMSCswereisolatedfrombonemarrowofSprague-Dawley(SD)rats,andcardiacmyocytesfromneonatalrats.Theratcardiacmyocyteswereco-culturedwithMSCsorMSC-conditionedmediainanoxia(95%N2+5%CO2)for72hours.CellapoptosiswasmeasuredbyHoechst33258staining.TheexpressionofBcl-2andBaxincardiacmyocyteswastestedbyWesternBlot.ResultsTheapoptoticratewas51.6%±2.4%whencardiacmyocyteswereculturedincontinuoushypoxiaandwassignificantlydecreasedwhencardiacmyocyteswerecoculturedwithMSCsorMSC-conditionedmedia(15.1%±5.4%and24.0%±4.2%respectively,P<0.001).ThedecreasedexpressionofBaxinthecardiacmyocyteswasgreatlyrelatedtothedecreasingofapoptosis,buttherewasnodifferenceinBcl-2expressionamongthesegroups.ConclusionsCo-culturedMSCsshowedsignificantanti-apoptoticeffectsoncardiacmyocytesincontinuoushypoxia.ThemechanismmaybetheinteractofcelltocellandparacrineofcytokineswhicheffectedtheexpressionofBaxinthecardiacmyocytes.

简介：为粒子形态学和对使流体化床的动力学的描述的球状和Zingg因素的比较被介绍。它被发现那Zingg因素Fz=LH/B2(在分别地，L，H和B是一个粒子的长度，宽度和高度的地方)很好描述粒子形态学的效果。试验性的结果证明非球形的粒子给以压力落下同样与球形的粒子相比优秀的使流体化的穷人，Umf，等等。与一样的卷等价物直径，非球形的粒子有更低的Umf和使流体化的系数。一些光滑的曲线在参数，Umf和Fz之间被获得了。使液化的质量能被使流体化评估系数，它在这份报纸被相关到Zingg因素和最小的使流体化速度。

简介：这份报纸建议调节叉回转仪(M-TFG)到decouple的micromachined的一个改进图案在更好并且到增加分辨率驾驶并且察觉到指示之间的生气谈话。由采用双褶层的春天暂停，开车模式和感觉模式是机械地decoupled。通过双褶层的春天暂停和开车梳子的地点的小心的布局设计，机械联合效果被从察觉孤立讨厌的刺激进一步减少。优秀因素调查证明那个高质量的因素能被使用这结构达到，它能引进精确分辨率。作为结果，这个图案有潜力为起始的水平应用程序完成低偏爱飘移和精确分辨率。

简介：ThepurposeofthispaperistoconstructanorthogonalArmletmulti-waveletswithmul-tiplicityranddilationfactora.Firstly,thedefinitionofArmletswithdilationfactoraisproposedinthispaper.BasedontheTwo-scaleSimilarTransform(TST),thenotionofthePara-unitaryA-scaleSimilarTransform(PAST)isintroduced,andwealsogivethetransformonthealltwo-scalematrixsymbolsofthemulti-waveletswithdilationa.ThenweshowthatthePASTandthetransformonthematrixsymbolsofthemulti-waveletskeeptheorthogonalityofthemulti-waveletssystem.Wediscusstheconditionthatmulti-waveletscorrespondingtothemulti-scalingfunctionsareallArmlets.AfterperformingthePASTandthetransformonthematrixsymbolsofthemulti-wavelets,themulti-scalingfunctioncanbebalancedandthecorrespondingmulti-waveletscanbeArmletsatthesametime.TheconstructionofArmletswithhighorderisalsodiscussed.Atlast,byagivenexample,wecanconcludethatthealgorithmisfeasibleandefficient.

简介：AbstractNon-alcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver disease worldwide. It refers to a range of liver conditions affecting people who drink little or no alcohol. NAFLD comprises non-alcoholic fatty liver and non-alcoholic steatohepatitis (NASH), the more aggressive form of NAFLD. NASH is featured by steatosis, lobular inflammation, hepatocyte injury, and various degrees of fibrosis. Although much progress has been made over the past decades, the pathogenic mechanism of NAFLD remains to be fully elucidated. Hepatocyte nuclear factor 4α (HNF4α) is a nuclear hormone receptor that is highly expressed in hepatocytes. Hepatic HNF4α expression is markedly reduced in NAFLD patients and mouse models of NASH. HNF4α has been shown to regulate bile acid, lipid, glucose, and drug metabolism. In this review, we summarize the recent advances in the understanding of the pathogenesis of NAFLD with a focus on the regulation of HNF4α and the role of hepatic HNF4α in NAFLD. Several lines of evidence have shown that hepatic HNF4α plays a key role in the initiation and progression of NAFLD. Recent data suggest that hepatic HNF4α may be a promising target for treatment of NAFLD.

简介：现在的调查被执行决定通过最佳索引因素(OIF)选择的特征是否能作为与一起考虑的所有特征相比象二不同的年的叠的图象一样在单个年的卫星图象上提供各种各样的范畴的改进分类精确性。进一步，以便决定是否在那里发生有特征的OIF价值的相应增加的不同范畴的分类精确性的增加从两个提取了单个年并且叠了图象，我们与特征的不同联合的OIF价值执行了在各种各样的范畴的制片人精确性(PA)之间的线性回归。调查证明那在那里发生在二不可渗透的范畴viz的PA的重要改进。中等布满建筑物、低密度布满建筑物从作为与所有乐队相比与最高的OIF值联系的乐队和主要部件和为两个的主要部件的分类坚定单个年和叠的图象分别地。回归分析为决定单个年并且叠了分别地意味着与OIF价值的相应增加的在信息内容的增加之间的直接关系的流行的图象的各种各样的范畴展出了在回归系数和OIF价值之间的积极趋势。研究证明特征提取了通过从单个年和叠的图象的OIF能够作为与一起分享的所有特征相比提供显著地改进的PA。

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简介：AbstractImportance:The use of factor VIII (FVIII) concentrates under pharmacokinetic (PK) guidance has become the main approach for treatment of hemophilia. However, limited PK research has been conducted in Chinese pediatric patients.Objective:To investigate the PK parameters of various FVIII concentrates in Chinese pediatric patients.Methods:Seventy-nine patients were enrolled (28 treated with Kogenate FS®, 23 treated with Advate®, and 28 treated with GreenMono™). All enrolled patients participated in single-dose PK analysis after at least a 3-day washout period. Blood samples were collected predose, as well as at 1 h, 9 h, 24 h, and 48 h after infusion; FVIII levels were measured using a one-stage clotting assay. von Willebrand Factor Antigen (VWF:Ag) levels and blood types were also determined. PK parameters were evaluated by WAPPS-Hemo.Results:Mean values of terminal elimination half-life time (t1/2) for the Kogenate FS®, Advate®, and GreenMono™ FVIII groups were 12.24 h, 10.18 h, and 9.62 h; median clearance values were 4.16, 6.23, and 5.11 mL·kg-1·h-1; and median in vivo recovery values were 1.97, 1.55, and 1.61 IU/dL per IU/kg. Longer t1/2, higher in vivo recovery, and lower clearance were observed in patients with higher VWF:Ag level who were treated with recombinant concentrates.Interpretation:Chinese pediatric patients with hemophilia had FVIII PK characteristics similar to those previously observed in non-Chinese children, including large variation among individuals. VWF:Ag level and FVIII brand were associated with differences in FVIII PK. Thus, PK-guided dosing should be used to optimize individualized therapy in Chinese children.

简介：在医药超声成像地里，由织物的速度不同类导致了以便获得高分辨率并且改正阶段错误，联合最小的变化beamforming的一个高分辨率的医药超声成像方法和一般连贯因素被介绍。首先，从元素的数据为集中被推迟；然后，多信道的数据被用于最小的变化beamforming；同时，数据从数组空格被转变到横梁空格计算一般连贯因素；最后，一般连贯因素习惯于重量最小的变化beamforming的结果。医药图象被成像系统得到。实验基于点目标和无回声的包囊目标被用来验证建议方法。结果证明在分辨率，对比和坚韧性的方面的建议方法比最小的变化beamforming和常规beamforming好。

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简介：Catalyticcombustionofpropane-airmixturewasinvestigated.Platinumcatalystsoveraflatstainlesssteelwithγ-aluminawashcoatwereemployed.Theemployedburnerhasthreecatalystssetparalleltothemixtureflow,spacedatanintervalof5,10and15mm.Bothexperimentandnumericalsimulationweremadeatinlettemperatureof553K,inletvelocityof3to7m/sandequivalenceratioof0.3to0.5.Inthenumericalsimulation,two-dimensional,steadystatemodelwasdevelopedtocalculatethetemperatureandspeciesconcentrationingas-phase.Inthismodel.chemicalreactiononthecatalystsurfaceandthatinthegasphasewereassumedtooccurinthree-steps.Thenumericalresultsshowgoodagreementwithexperimentalresults.Itwasfoundthatthepropertiesofthecatalyststronglyaffectthecatalystsurfacetemperature.Especially,thethermalconductivityofcatalysthasagreateffect,whiletheemissivityofcatalysthaslesseffect.

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