简介：Ovariancanceristhesecondmostlethalgynecologicalcancerworldwideandwhilemostpatientsrespondtoinitialtherapy,theyoftenrelapsewithresistantdisease.Humanepidermalgrowthfactorreceptors(especiallyHER1/EGFRandHER2/ERBB2)areinvolvedindiseaseprogression;hence,strategiestoinhibittheiractioncouldproveadvantageousinovariancancerpatients,especiallyinpatientsresistanttofirstlinetherapy.Monoclonalantibodiesandtyrosinekinaseinhibitorsaretwoclassesofdrugsthatactonthesereceptors.Theyhavedemonstratedvaluableantitumoractivityinmultiplecancersandtheirpossibleuseinovariancancercontinuestobestudied.Inthisreview,wediscussthehumanepidermalgrowthfactorreceptorfamily;reviewemergingclinicalstudiesonmonoclonalantibodiesandtyrosinekinaseinhibitorstargetingthesereceptorsinovariancancerpatients;andproposefutureresearchpossibilitiesinthisarea.

简介：

简介：AIMTo学习discoidin象我一样domaincontaining蛋白质3的效果(EDIL3)在人的透镜的增长和上皮间充质的转变(EMT)上的弄空上皮的房间(LEC).METHODSRNA干扰被用来在vitro在人的LEC禁止EDIL3的表示。房间的形态学用一台转换显微镜被观察。房间增长用EdU工具包被估计。房间移植用Transwell房间被调查，LEC的EMT用共焦的显微镜并且西方的弄污被估计。转变生长因素(TGF)小径用数据显示出的西方的blotting.RESULTSThe被调查那个silencingEDIL3表达式改变了LEC形态学并且压制了LEC增长(P<0.05)并且移植(P<0.01)。而且，西方的弄污的结果证明那EDIL3弄空减少了光滑的肌肉肌动朊的表示(-SMA)(P<0.001)并且vimentin(P<0.01)，当增加时E-cadherin的表示(P<0.001)。EDIL3弄空能压制Smad2的phosphorylation(P<0.01)并且Smad3(P<0.01)并且exracellular信号的激活调整了kinase(英皇家空军之阶级最低之兵)(P<0.05).CONCLUSIONThe调查结果显示EDIL3可能经由TGF小径在LEC参予增长和EMT并且可以是为以后的囊opacification的处理的一个潜在的治疗学的目标。

简介：Notopterygiumincisum(QH)hasbeenusedforthetreatmentofrheumatoidarthritis(RA),andvolatileoilsmaybeitsmainlybioactiveconstituents.ThepresentstudywasdesignedtoanalyzethevolatilecompoundsinQHandtodeterminetheanti-arthriticcapacityofNotopterygiumvolatileoilsandthepotentialmechanismofaction.ThevolatilecompoundsanalysiswasconductedbyGC-MS.Theanti-arthriticcapacitytestofthevolatileoilswasconductedonadjuvant-inducedarthritis(AIA)rats.Theanti-inflammatorypropertywastestedinNOreleasemodelinRAW264.7cells.Endothelialcellswereusedtoevaluatetheanti-proliferativeandanti-tubeformativeeffects.70compoundswereanalyzedbyGC-MSinthevolatileoils.NotopterygiumvolatileoilsweakenedtheratAIAinadose-dependentmanner(2,4,and8gcrudedrug/kg).TheNOproductionbyRAW264.7wasdecreasedbymorethan50%inNotopterygiumvolatileoils(5,15,and45μg·mL-1)pretreatedgroups.NotopterygiumvolatileoilsalsoinhibitedEAhy926cellproliferationandfurtherdelayedEAhy926cellcapillarytubeformationinaconcentration-dependentmanner.Theanti-NOproductive,anti-proliferative,andanti-tubeformativeeffectsofNotopterygiumvolatileoilsstronglysuggestedthatthetherapeuticeffectofQHinAIAmightberelatedtothepotentanti-inflammatoryandanti-angiogeniccapacitiesofthevolatileoils.

简介：AerobicricetechnologyisstillnewinMalaysia,andinformationregardingMARDIAerob1(MA1),thefirstlocalaerobicricevariety,isstilllacking.Therefore,comparativestudieswerecarriedouttodeterminethephysiologicalperformanceofaerobicricevarietyMA1andlowlandricevarietyMR253underwaterstressgivenatthepanicleinitiation,floweringandripeningstages.Thisexperimentwasarrangedinarandomizedcompleteblockdesign.Stomatalconductance(gs),chlorophyllafluorescence(Fv/Fm),leafrelativewatercontent(leafRWC),andsoilmoisturecontent(SMC)aswellasyieldcomponentparameterssuchaspaniclenumber,grainyieldand100-grainweightweremeasured.ResultsrevealedthatgsandleafRWCforbothvarietiesdecreasedwithdepletionofSMC.ThecorrelationstudybetweenthephysiologicalparametersandSMCindicatedthatFv/Fmwasnotaffectedbywaterstress,regardlessofvarieties.Theyieldcomponents(paniclenumber,grainyieldand100-grainweight)forbothvarietiesgreatlydecreasedwhenwaterstresswasimposedatthepanicleinitiationstage.Thisstudyshowedthatthepanicleinitiationperiodwasthemostsensitivestagetowaterstressthatcontributedtoasubstantialreductioninyieldforbothvarieties.Undertheaerobiccondition(control),MR253producedhigherpaniclenumber,100-grainweightandyieldthanMA1.AlthoughMR253isbredforlowland,itiswelladaptedtoaerobiccondition.

简介：

简介：硼是不平常的物理特征从电子缺乏的、高度去除的共有原子价契约导出的周期表和展览上的碳的邻居。作为碳的最近的邻居，硼以类似于碳的许多方法，例如有采用sp2杂交的短共有原子价半径和灵活性。因此，硼能能够形成单层graphene的结构的类似物。尽管许多理论报纸报导了发现硼的二维的同素异形体，为如此的原子薄的硼nanostructures没有试验性的证据直到2016。最近，单个层的硼的成功的合成(叫作borophene)在Ag(111)上，底层打开硼nanostructures的时代。在这简短评论，我们将讨论以合成技术，描述和原子模型在borophene上被做了的进步。然而，borophene只在幼年期；更多的努力被期望在优秀样品的控制合成上在未来被作并且定制它的物理性质。

简介：这研究的目的是调查形态学，在锦鸡儿属植物arborescens的种子梗的光合的产品的传播线路打。在在flowering以后的各种各样的阶段并且用扫描电子显微镜学在种子成熟评估种子梗的角色。我们发现成熟种子梗主要由容器，sclerenchymatous房间和parenchymatous房间组成了。伸长的房间在在种子梗和种子之间的连接形成了一枚戒指，并且一大空被sclerenchymatous房间的二层在内部种子生产，它工作支撑种子生长。在戒指的中心的洞在当种子成熟，扩大的种子开发，和洞的一个早阶段期间被关上。为材料运输有二条线路，它从种子梗开始了：从种子上衣的到胚胎，和直接进入胚胎的另外一个。容器，充满种子梗，是为由种子的营养素的吸收的小径。容器浓密地在种子梗被包装，并且容器的房间墙的第二等的变厚被网络线变厚描绘，当在种子以内的容器的房间墙的第二等的变厚被螺丝钉线变厚描绘时。容器的词法特征对它的功能适应。

简介：Performanceenhancementisconsideredanessentialpartofsport.1However,intheworldofcompetitiveandhigh-performancesports,thereisincreasingevidenceofahighprevalenceofperformance-enhancingdrugabuse.2-4Theuseofdrugsthatis,bannedsubstances-hasbecomeaseriousproblemwithsignificantsocial,ethical,policy,andpersonalconsequences,5-7andconsequentlycompromisestheintegrityofsportsandsportsmanshipatalllevelsofcompetition,aswellasthehealthandwell-beingofindividualathletesandpublichealthingeneral.

简介：在最近的年里，几个研究组为对存在大楼的地震反应评价学习了分析方法的新一代。不过，许多重要开发仍然被需要以便定义更多的可靠、有效的评价过程。而且关于存在大楼，由于低知识水平，线性有弹性的分析是允许的唯一的分析方法，这应该被加亮。一样的代码(例如NTC2008，EC8)为地震需求的评估与行为因素把线性动态分析看作参考方法。这类分析基于一个线性橡皮的结构的模型题目到一个设计系列，由通过一个行为因素减少有弹性的光谱获得了。行为因素(在一些代码的减小因素或q因素)被用来减少从线性分析获得以便考虑非线性的结构的能力的有弹性的光谱纵标或力量。行为因素应该基于几个参数被定义，例如机械材料特征，结构的系统，不规则和设计过程影响地震非线性的能力。在实际应用程序，仍然有详细规则和为存在大楼足够的精确行为因素价值的明显的缺乏。在这个工作，造类型的主要存在RC-MRF的地震能力的一些调查被执行了。为了做地震力量的正确评估，要求，与力量协调的实际行为因素价值基于地震安全评价过程被建议了并且在意大利的地震代码与价值相比报导了，NTC08。

简介：Inthispaper,rankfactorizationsandfactorleftprimefactorizationsarestudied.Theauthorsprovethatanypolynomialmatrixwithfullrowrankhasfactorleftprimefactorizations.Andforaclassofpolynomialmatrices,theauthorsgiveanalgorithmtodecidewhethertheyhaverankfactorizationsorfactorleftprimefactorizationsandcomputethesefactorizationsiftheyexist.

简介：AIMTo评估剥去与在没有胶囊的support.METHODSDSAEK的严重地损坏的眼睛的透镜(IOL)培植与工匠虹爪IOL培植相结合的工匠缺少晶状体intraocular相结合的自动化endothelialkeratoplasty(DSAEK)的descemet的复杂并发症和结果在29只眼睛上被执行。所有眼睛由于从优先的intraocular手术和眼睛的损伤的复杂并发症具有反常结构。眼睛的复杂并发症观察了包括的接枝脱臼，高intraocular压力(IOP)，IOL脱臼，有斑点的浮肿和hyphema。最好改正的视觉尖酸(BCVA)，IOP和吝啬的中央endothelial房间密度(ECD)是有的recorded.RESULTSThirteen眼睛眼睛的损伤的历史，10只眼睛有前面的房间IOL，16只眼睛有优先的vitrectomy。虹在22种情况中是反常的。接枝脱臼发生在5(17.2%)29只眼睛。IOL脱臼发生在2只眼睛(6.9%)。高IOP在9只眼睛被发现并且与处理被控制。外科手术前的吝啬的BCVA是20/286。6mo手术后的吝啬的BCVA是20/42。平均中心ECD是在6mo的1965.3房间/公里2，并且施主房间损失的率是与工匠缺少晶状体IOL培植相结合的34.7%.CONCLUSIONDSAEK是为没有胶囊的支持，在aphakic眼睛解决endothelial和透镜混乱的一种其他的选择。然而，它应该与严重的虹缺点为眼睛小心地被执行。

简介：Tumor-targetingantibodieswereinitiallydefinedasagroupoftherapeuticmonoclonalantibodies(mAb)thatrecognizetumor-specificmembraneproteins,blockcellsignaling,andinducetumor-killingthroughFc-driveninnateimmuneresponses.However,inthepastdecade,ampleevidencehasshownthattumor-targetingmAb(TTmAb)eradicatestumorcellsviaactivationofcytotoxicTcells(CTLs).Inthisreview,wespecificallyfocusonhowTTmAbsinduceadaptiveanti-tumorimmunityanditspotentialincombinationtherapywithimmunecytokines,checkpointblockade,radiation,andenzymetargetedsmallmoleculedrugs.ExploringthemechanismsofthesepreclinicalstudiesandretrospectiveclinicaldatawillsignificantlybenefitthedevelopmentofhighlyefficientandspecificTTmAb-orientedanti-tumorremedies.

简介：

简介：

简介：RodrigoRatosays“SotheAmericaneconomyneedstheworld,andtheworldneedstheAmericaneconomy”?.Forthat,itispossibletonotethattheshorthistoryofUSpolicyintheMiddleEast,includingthesuccessionofpresidential“doctrines”,fromTrumanthroughtoBushII,confirmedWashington’sappreciationofthestrategicroleoftheEasternMediterraneanandtheoilrichstatesoftheMiddleEastinthebroadercontextofUSpolicygoals.Thisinterestisduetothefactthatthisregion(MiddleEast)hasalargeofoilreservesandhugeeconomicrecourses.Thisregionholdsabout66%oftheworldoilreserves,andthisoilreservewillmaketheregiondominateforalongertimeontheglobaloilmarketandinternationaloil-producingorganizations,suchasOPEC,socontrolonthisregionhasbecomeafocusofattentiontodecision-makersintheworld,andthereisnodoubtthattheUnitedStateswasthemostprominentwhotriedtocontroltheregion.ThepurposeofthecurrentresearchistoshedlightontheUnitedStates’economicpresenceintheMiddleEastregiontounderstandhowUnitedStates’presencehasdevelopedintheregionandwhatmotiveswerebehinditspresence.

简介：

简介：

简介：在这篇文章，为复杂顺序的几乎星形的mappings的锋利的生长定理第一被给。第二，沿着一个联合起来的方向的失真定理也作为生长定理的申请被建立。特别地，使用我们的结果罐头还原剂到一些著名结果。

简介：Intheanalysisofhowenvironmentalregulationaffectsthecomparativeadvantageoftrade,existingliteratureignoresindustry’sinherentheterogeneity,whichdrawsremarkablydifferentconclusions.Inviewofthis,thepaperanalyzedthemechanismofenvironmentalregulationontheexportqualityofdifferentindustriesfromtheperspectiveoffactorinputstructureheterogeneity.BasedonthepaneldataofChina’smanufacturingindustry,thepaperusedthesystemgeneralizedmethodofmomentsmethodtoexaminetheheterogeneityinfluenceofenvironmentalregulationonmanufacturingexportquality.Thestudyfoundthat,first,environmentalregulationaffectedtheexportqualityupgradeofthemanufacturingsectorthroughoffseteffectandcompensationeffect,andthedirectionoftheimpactwouldmainlydependontheindustry’sfactorinputstructure.Second,forindustrieswithlargerfixed-assetinvestment(FAI)ratiointhefactorinputstructure,thecurrentenvironmentalregulationpolicywasnotconducivetotheexportqualityupgradingoftheindustries.However,therewasasignificantU-shapeddynamicrelationshipbetweenthem.Asenvironmentalregulationsbecamestricter,whenregulatorystringencywentbeyondtheinflectionpoint,thepolicywouldpromotetheupgradingofexportquality.ButforindustrieswithsmallerproportionofFAI,environmentalregulationexertedafavorableimpactontheexportqualityupgrade,followingaJ-shapedmarginalgrowthcurve.Third,forindustrieswithdifferentfactorinputstructure,theirexportqualityhadbeeneffectivelyupgradedasexpectedbyfactorslikehumancapitalinvestment,independentR&D,technologyintroduction,andforeigndirectinvestment;butraisingpercapitacapitalstockandexpandingenterprisesizedidnotproducesignificantdirectimpactonexportqualityupgrade.Theseconclusionsremainedrobustafterusingdifferentmeasurementmethodsandreplacingwithothervariables.Therefore,thispapersuggeststhatgovernmentsshouldt