简介:XiJianyingisunfortunateandfortunateatthesametime.Nowinherlate60s,thewomaninShandongProvince,easternChina,hassufferedanunknownpaininherheadsinceyoung.Sheisfortunateinthatforthepast20years,apharmaceuticalcompanyinJinan,theprovincialcapital,hasdoneeverythingitcantorelieveherofthepain.Believeitornot,theDongfeng(meaningEastWind)PharmaceuticalFactoryhasbeenproducinga"miracle"medicinejustforonepatient,forXi,wholivesinamountainousvillageonthesuburbsofTai’anCity,intotaldisregardofthehugecostinvolvedandthelossthusincurred.
简介:Although,theessenceofotopointsremainsunknownatthemoment,manymedicalworkershavetermedthemtemporarilyas"auricularspecificstimulatingpoints".Theygiveanexplanationthatwhentheinternalorgansorthebodytrunkisoutoforder,tenderpoints,changesofthecutaneouselectricalresistance,appearance,colour,etc.mayoccuratsomesitesoftheauri-cle.Themedicalworkerscanusethesereactionsasareferenceformakingadiagnosisandstimulatethesesitestopreventandtreatdiseases.Thesereactionpointsarealsotheotopoint.Therefore,theotopointisalsocalledastenderpoint,orgoodconductionpoint,reactionpoint,stimulatingpointortreatmentpoint.
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简介:AnefficientandgoodDNAextractionprotocolshouldbesimple,affordableandyieldenoughDNAwithhighquality.Rice(OryzasativaL.)DNAextractionmethodsoftenuseseedlingsorleavesratherthanthegrainsandtendtobetime-consuming,involvemultiplesteps,andusehazardouschemicalsandexpensiveenzymes.RicegrainsofferseveralbenefitsoverseedlingsandleavesasasourceofDNAforgeneticanalysis.However,thesebenefitsareunderutilizedbecausethebulkofaricegrainismadeupofstarch.Itisparticularlyimportant,butdifficulttogetridofthestarchwhileextractingDNAfromricegrains.Thisco-precipitatedpolysaccharideisaknowninhibitorofDNApolymeraseactivityinpolymerasechainreaction(PCR).WedescribehereaverysimpleandhighlyaffordableChelex?-100basedDNAextractionmethodfromricegrains.Itdoesnotrequireanyhazardouschemicalsorenzymes.ThismethodreproduciblyextractsDNAwithgoodpurityindices(A260/A230andA260/A280values),butrequiresonlyafewsteps.
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简介:摘要76岁男性患者,反复腹泻1年余。既往行前纵隔肿瘤切除术,术后病理诊断AB型胸腺瘤。患者腹泻症状突出,结合各项检查结果诊断为Good综合征,合并肺部感染、霉菌性食管炎,病程迁延,严重营养不良。应用免疫球蛋白静脉滴注冲击治疗,并营养支持、抗感染治疗,好转出院。Good综合征是与胸腺瘤相关的成人免疫缺陷病,临床罕见,表现缺乏特异性,极易漏诊、误诊,预后不良风险极高,须加强随访。
简介:摘要Good综合征是一种原发性免疫缺陷合并胸腺瘤疾病,在1955年被首次发现。典型的特征是胸腺瘤,低丙种球蛋白血症,外周血低或缺少B细胞,CD4+T淋巴细胞减少,CD4+/CD8+T淋巴细胞比值倒置,T细胞有丝分裂原增殖反应减少。临床表现多样,约50%的患者以顽固性腹泻为主要症状。目前关于Good综合征患者出现腹泻的病因还未明确,可能与病原体感染、吸收不良综合征、自身免疫性因素等相关。本文报道了2例厦门大学附属第一医院收治的以腹泻为主要表现的Good综合征患者。2例患者均有胸腺瘤病史,反复肺部感染表现,肠镜检查均发现溃疡性病变,病理提示慢性炎症细胞浸润,肉芽组织形成,无浆细胞或仅可见少量浆细胞浸润。实验室检查表现为低丙种球蛋白血症、外周血T淋巴细胞计数减少、B淋巴细胞减少或缺失、CD4+/CD8+T淋巴细胞的比值倒置。目前主要的治疗措施包括手术切除胸腺瘤、静脉补充丙种球蛋白(IVIG)、针对不同病原体的抗感染处理等,但治疗的总体有效率不高,预后不良。
简介:Aconstructionmethodbasedonthep-planetodesignhigh-girthquasi-cycliclow-densityparity-check(QC-LDPC)codesisproposed.Firstlythegoodpointsineverylineofthep-planecanbeascertainedthroughfilteringthebadpoints,becausethedesignedparity-checkmatrixesusingthesepointshavetheshortcyclesinTannergraphofcodes.Thenoneofthebestpointsfromtheresidualgoodpointsofeverylineinthep-planewillbefound,respectively.Theoptimalpointisalsosingledoutaccordingtothebiterrorrate(BER)performanceoftheQC-LDPCcodesatlast.ExplicitnecessaryandsufficientconditionsfortheQC-LDPCcodestohavenoshortcyclesarepresentedwhichareinfavorofremovingthebadpointsinthep-plane.Sincepreventingtheshortcyclesalsopreventsthesmallstoppingsets,theproposedconstructionmethodalsoleadstoQC-LDPCcodeswithahigherstoppingdistance.