简介：组织缺氧可诱导的factor-1α；(HIF-1α；)在调整angiogenesis起一个重要作用，它为肿瘤生长和转移是必要的。HIF1A的基因变化(编码HIF-1α；)被显示了影响一个个人的危险性到许多人的肿瘤；然而，在在HIF1A单个核苷酸的多型性(SNP)和风险正在冲突的前列腺癌症(PCa)之间的协会上证实。我们genotyped在用TaqMan方法的HIF1A(rs11549465，rs11549467和rs2057482)的三潜在地功能的多型性并且在662 的盒子控制研究与PCa风险估计了他们的协会；在一张中国汉人口的PCa病人和716控制。与rs11549467GG遗传型相比，变体遗传型GA+；AA有显著地增加的PCa风险(调整机会比率(或)=1.70；95%；信心间隔(CI)=1.06-2.72)，特别地在更老的病人之中(OR=2.01；95%；CI=1.05-3.86)，吸烟者(OR=2.06；95%；CI=1.07-3.99)，从未喝酒者(OR=2.16；95%；CI=1.20-3.86)并且没有癌症的家庭历史的病人(OR=1.71；95%；CI=1.02-2.89)。而且，有rs11549467变体遗传型的病人与一个更高级的格利森分数被联系(OR=2.14；95%；CI=1.22-3.75)。没有改变的PCa风险与rs11549465和rs2057482多型性被联系。然而，rs2057482和rs11549467的联合变体遗传型与增加的PCa风险被联系(OR=2.10；95%；在带三的题目或更多的风险等位基因之中的CI=1.23-3.57)。这些结果建议HIF1A多型性可以在中国汉人口影响PCa危险性和前进。

简介：无

简介：TheaimofthispaperistoestablishanextensionofqualitativeandquantitativeuncertaintyprinciplesfortheFouriertransformconnectedwiththesphericalmeanoperator.

简介：现在的纸的主要目标是调查象包括关系那样的很多个有用性质，失真界限，系数估计，隶属结果，Fekete-Szeg吗？为分析功能的一个新子类的问题和某其它，它借助于线性操作员这里被定义。这里介绍，那些在更早的工作获得了的结果的相关连接也被指出。

简介：LetH2=（-△）2+V2betheSchrodingertypeoperator,whereVsatisfiesreverseHolderinequality.Inthispaper,weestablishtheLPboundednessforV2H2-1,H2-1V2,VH2-1/2andH2-1/2V,andthatoftheircommutators.WealsoprovethatH2-1V2,H2-1/2VareboundedfromBMOLtoBMOL.

简介：Inthispaper,anewcompletelyintegrablesystemrelatedtothecomplexspectralproblem—φ_(xx)+(i/4)uφ_x+(i/4)(uφ)_x+(1/4)vφ=iλφ_xandtheconstrainedBowsoftheBoussinesqequationsaregenerated.AccordingtotheviewpointofHamiltonianmechanics,theEuler-LagrangeequationsandtheLegendretransformations,areasonableJacobi-Ostrogradskycoordinatesystemisobtained.Moreover,bymeansoftheconstrainedconditionsbetweenthepotentialu,vandtheeigenfunctionφ,theinvolutiverepresentationsofthesolutionsfortheBoussinesqequationhierarchyaregiven.

简介：TheJidongareaislocatedonthenorthmarginoftheNorthChinacraton.ItisanucleuscomposedoftheoldestrocksinChina.PrecambrianmetamorphicrockswithvariousPhanerozoicgranitoidsinvadedarewidespread.Golddepositsherehaveclosespatialrelationstogranitoids.Somedepositsoccurwithinthemandothersintheouterzoneofthecontactbeltoftheintrusion,extendingthousandsofmetres.Therehavebeencontroversialviewsinregardtotherelationsofthedepositstotheintrusionsalthoughtraditionaltechniqueshavebeenusedtodatetheintrusions.Inordertosolvesuchaproblem,theSHRIMPtechniquewasadoptedtodatetheU-PbagesofzirconcollectedfromtheYueryaintrusionwhichhoststhelarge-sizedYueryaAudepositandQingshankouintrusion2kmawayfromtheJinchangyu(larger-sized)Audeposit.Analysisshowsthattheagesof175±1Maand174±3MaforYueryaintrusionandtheageof199±2MaforQingshankougraniteindicatetheEarlyYanshanianstageoftheMeso-

简介：TyphoonslandinginthecentralandnorthofFujianProvinceoftenseriouslyimpactZhejiangProvince.MuchattentionhasbeengiventoexceptionallytorrentialrainintheSouth/NorthYandangmountainousregionsinthesoutheastofZhejiangProvinceassociatedwithtyphoon-landing.TyphoonHaitang(2005)isatypicalcaseofsuchacategory,whichlandedinHuangqiTownofLianjiangCountyinFujianProvince,andmeanwhilegreatlyimpactedSoutheastZhejiang.AnumericalsimulationhasbeenperformedwiththePSU/NCARnon-hydrostaticmodelMM5V3tostudythetorrentialrainassociatedwithTyphoonHaitang.ThecomparisonofsimulatedandobservedrainfallsshowsthattheMM5V3wasabletowellsimulatenotonlytheintensitybutalsothelocationsofsevereheavyrainofTyphoonHaitang,especiallythelocationsofthesouth/northheavyraincenterareasintheSouth/NorthYandangmountainousregions.Meanwhile,thediagnosticanalysishasbeenalsocarriedoutforbetterunderstandingofthesevereheavyrainmechanismbyusingthemodeloutputdataofhighresolution.Thediagnosticanalysisindicatesthatthewestwardtiltoftheaxisofvorticityfromlowerlayertoupperlayeroverthesouthheavyraincenterareaandthecoupledstructureofconvergenceinthelowerlayeranddivergenceintheupperleveloverthenorthheavyraincenterarea,werebothpropitioustostrongerupwardmotioninthelayersbetweenthemidandupperatmosphere,andthesecondarycirculationinducedbytheverticalshearoftheambientwindsfurtherstrengthenedtheupwardmotionintheheavyrainareas.AfterHaitangpassedthroughTaiwanIslandintotheTaiwanStrait,thewatervaporeastofTaiwanIslandwascontinuouslytransferredbytyphooncirculationtowardsSouthWenzhou,leadingtothetorrentialrainfallintheSouthYandangmountainousregionsouthofWenzhou.Subsequently,Haitangmovednorthwards,thewatervaporbelteastofTaiwanIslandslowlyadvancednorthwards,theprecipitationrateobviouslyenhancedintheNorth

简介：CrustaldeformationinthenorthernpartofNorthChinaassociatedwithZhangbeiearthquakeisanalyzedusingGPSdatacollectedduring1992,1996and1999,precisere-levelingdatacol-lectedduring1992,1998and2000,andINSARresult(September22,1997-May6,1998).Theresultsindicate:①Theverticaldeformationisnotremarkablesince1992.TheverticalcrustaldeformationinthecentralandnorthernpartofNorthChinainrecent10yearsisofin-heritance.Thescopeofthesignificantdeformationis15km×15kmwithamagnitudeof250mmwhentheeventoccurred.②ThehorizontaldeformationisnotremarkableinanyunitofNorthChina.③Beforeandaftertheevent(1992-1996and1996-1999),thereiskinematicchangeofhorizontalmotionbetweendifferentunits.TheactivitymodealongYinshantectoniczonechangedfromrelativestaticstatetoleft-lateralstrikeslip;ThedominantextensionalmovementalongShanziriftzonechangedtoright-lateralstrikeslip;Yanshantectoniczonechangedfromleft-lateralstrike-slipwithextensiontoleft-lateralstrikeslip;Yanshan-Hebeitransitionalzoneformedbeforetheeventdisappearedaftertheevent.④Thescaleofthedeformationiscloselyrelatedtothephysicalpropertyofmediaandgeologicalstructureenvironment.Furtheranalys-isindicatesthat①ZhangbeiearthquakedoesnotmeanthattheearthquakeactivitybeginstobestrengthenedinNorthChina;②Thecrustalmovementisnormalatpresent;③Nextstron-gerearthquakeinNorthChianmightbelocatedinYanshantectoniczone,especiallyatitsbothends,andShanxitectoniczone.

简介：Objective:IL-22-producingCD4+Thelpercells(Th22cells)havebeenidentifiedasmajorinducersoftissueinflammationandimmuneresponses.Currently,nopreviousstudyexploredtheroleofTh22cellsinthepathogenesisofhepatocellularcarcinoma(HCC).ThestudyaimedtodeterminethebiologicalfunctionofTh22cellsanditseffectorIL-22inHCCpatients.Methods:Forty-fiveHCCpatientsand19healthycontrolswererecruitedandtheirperipheralbloodwascollected.ThefreshHCCtissues,adjacentHCCtissuesandtennormallivertissueswerealsocollected.FlowcytometryanalysiswasusedtodeterminethefrequenciesofcirculatingTh22cellsandTh17cells.SerumIL-22levelsweretestedbyenzyme-linkedimmunosorbentassay(ELISA).Immunohistochemicalstainingandreal-timepolymerasechainreaction(PCR)wereusedtodetectIL-22proteinandmRNAintissuesspecimens,respectively.Results:CirculatingTh22cells,Th17cellsandserumIL-22levelsweresignificantlyelevatedinHCCpatientscomparedwiththoseofhealthycontrols(P<0.001).Th22cellswereshowedtobepositivelycorrelatedwithIL-22inHCCpatients(P<0.05),butnotinhealthycontrols.NosignificantdifferenceswerefoundinHCCpatientswithHBeAgpositivityornegativityintermofTh22cellsandserumIL-22levels.TheexpressionofIL-22proteinandmRNAwashighestinHCCtissues,followedbyadjacentHCCtissuesandnormallivertissues.Furthermore,Th22cells,serumIL-22levelsandIL-22mRNAwereelevatedatstageIII-IVcomparedwithstageI-IIofHCC(P<0.05).Conclusions:ElevationofcirculatingTh22cellsandIL-22maybeimplicatedinthepathogenesisofHCC,andpotentiallybecellulartargetsfortherapeuticintervention.

简介：AbstractIntroduction:Pterygium inversum unguis (PIU) refers to a disorder that distal portion of the nail bed adheres to ventral surface of the nail plate, leading to the absence of the distal groove. This is not a common condition in existing literature, thus its pathogenesis has not been elucidated. The occurrence can be congenital, idiopathic, or secondary. Here we present a case of PIU associated with systemic lupus erythematosus (SLE).Case presentation:A 33-year-old woman presented with distal nail bed of the bilateral fingers (excluding the thumbs) adheres to the ventral surface of the nail plate, associated with a malar rash, photosensitivity, and arthritis, whose further laboratory examinations confirmed immunologic disorders. All these clinical characteristics and laboratory results point to the diagnosis of PIU secondary to SLE. Treatment of SLE and topical application of tretinoin 0.025% were performed and resulted in the improvement of most discomforts but PIU. There has no aggravation or alleviation of the PIU during a year of follow-up.Discussion:Acquired form of PIU is reportedly associated with connective tissue diseases or other conditions, which may be caused by abnormal distal circulation or exposure to certain chemical stimuli. Some therapies may be available, while the most effective strategy is to treat potential disorder. Clinicians should be vigilant to find out the underlying causes of PIU, so as to obtain better therapeutic efficacy.Conclusion:We observed a rare disorder of PIU associated with SLE. Hence when identifying a patient of PIU, comprehensive evaluations and long-term follow-up are imperative to to detect the development of connective tissus diseases, such as SLE.

简介：BackgroundIncreasedserumleveloflipoprotein(a)(Lp(a))isassociatedwithatherosclerosis.WhetherincreasedLp(a)levelisindependentlyassociatedwiththeseverityofcoronaryarterydisease(CAD)isunclear.MethodsSubjectswereenrolledandreceivedcoronaryangiographytoassessthenumberofstenosedcoronaryartery.ThesubjectswithCADweredividedintonon-significant(<50%stenosis),singleandmultivesselstenosis(≥50%stenosis)groups.Parametersofinterestatbaselinewerecollected.StatisticalanalyseswereperformedtoevaluatetherelationshipbetweenLp(a)levelandCADseverity.ResultsTotally745populationswereenrolledanddiagnosedasCAD(n=605)orwithoutCAD(n=140)onthebasisofangiographyexamination.AscomparedtothesubjectswithoutCAD,serumlevelsofLp(a)andCRP,andthepercentagesofsubjectswithsmokingordiabetesweresignificantlyhigherinsubjectswithCAD.Incontrast,serumlevelsofHDL-CandApo-AweresignificantlylowerinsubjectswithCADascomparedtosubjectswithoutCAD.Incomparisonofsubjectswithnon-significantstenosis(serumLp(a)level,170.0±19.7mg/dL),serumLp(a)levelwassignificantlyhigherinsubjectswithsingle(245.5±22.3mg/dL)ormultiplevesselstenoses(265.8±14.0mg/dL).Withmultivariateregressionanalyses,afteradjustedforage,gender,smoking,familyhistoryandhypertension,therewasstillsignificantassociationbetweenserumLp(a)levelandthenumberofcoronaryarterystenosis.Afteradditionaladjustmentfordiabetes,HbA1c,totalcholesterol,LDL-C,Apo-A,uricacidandCRP,Lp(a)remainedstronglyassociatedwithCADseverity.ConclusionSerumLp(a)levelwassignificantlyassociatedwiththeseverityofcoronaryarterystenosis,whichmayaddthevalueoncardiovascularriskevaluation.

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简介：除了在1-slim，解决方案Ut(x)为所有起始的值在牛肉熏香肠空格与一个向量领域联系了的作者构造设置了并且获得向量领域与低整齐是未必围住的一个斜伴随的操作符和非线性的部分的和的1-quasi-sure流动性质，也就是单一的可辨性。而且，在答案导致的牛肉熏香肠空间的转变下面的能力的等价被获得。

简介：

简介：Inthispaper,anotionofnegativesidep-mixing(p-mixing)whichcanberegardedasasymptoticnegativeassociationisdefined,andsomeRosenthaltypeinequalitiesforp-mix-ingrandomfieldsareestablished.Thecompleteconvergenceandalmostsuresummabilityontheconvergencerateswithrespecttothestronglawoflargenumbersarealsodiscussedforp--mixingrandomfields.Theresultsobtainedextendthosefornegativelyassociatedsequencesandp'-mixingrandomfields.

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简介：钾和磷酸盐被酸水解作用过程在低温度提取分解联系的磷和钾矿石的一种新类型。影响溶解率的主要因素被调查，例如磨上好，硫磺的酸的数量和氟化物盐，反应时间和温度，等等。同时，可溶的钾和磷酸盐的形成上的各种各样的因素的效果也被讨论。反应产品和残余被X光检查衍射(XRD)决定，扫描电子显微镜(SEM)分析和其它工具。结果证明分别地，钾和磷的溶解率在95.64wt%lessthan的一种谷物尺寸的条件下面是70wt%和93.7wt%0.074公里，9.78gg-1硫磺的酸，0.5gg-1铵氟化物，160桴???瑳畲瑣牵獥椠?慭湩慴湩摥映牯戠瑯??愠摮吠?湩楣敤瑮瀠汯牡穩瑡潩?愠摮映牯愠杮敬?景椠据摩吗？？

简介：DearEditor,IamDr.SorayaMediero,fromDepartmentofOphthalmologyofLaPazUniversityHospital,Madrid,Spain.IwritetopresentacasereportofkeratoconusassociatedwithWilliams-Beurensyndrome(WBS).Toourknowledge,thisisthefourthreportofkeratoconusassociatedwithWBSandthe

简介：Hildebrandclassifiedallsemi-homogeneousconesinR~3andcomputedtheircorrespondingcompletehyperbolicaffinespheres.WecomputeisothermalparametrizationsforHildebrand’snewexamples.Aftergivingtheiraffinemetricsandaffinecubicforms,weconstructthewholeassociatedfamilyforeachofHildebrand’sexamples.ThegenericmemberoftheseaffinespheresisgivenbyWeierstrassP,ζandσfunctions.IngeneralanyregularconvexconeinR~3hasanaturalassociatedS~1-familyofsuchcones,whichdeservesfurtherstudies.