简介:AIM:Toexaminethemechanismofthedevelopmentofpseudoexfoliation(PSX)syndromeviabothcytokineformationandendothelialvasorelaxingandgrowthfactorsthatwillprovideusnewtherapeuticinsightsforthetreatment.METHODS:Thisisacrosssectionalstudyincludedtwogroups;Group1:controlpatientswithnuclearcataract(n=20,aged51-80years).Group2:PSXpatientswithnuclearcataract(n=18,aged50-90years).Patientswithotherophthalmicproblemsandsystemicdiseaseswereexcluded.Vascularendothelialgrowthfactor(VEGF),interleukin-6(IL-6)andinterleukin-1β(IL-1β)andnitrotyrosinelevelsweredeterminedthroughserumsamplesbyEnzyme-linkedimmunosorbentassay(ELISA)method.Nitrite-nitratelevelsweremeasuredwithphotometricendpointdetermination.RESULTS:Therewerenosignificantdifferencesbetweenthegroupsintermsofage,VEGF,IL-1β,nitrite-nitrateandnitrotyrosine.ThesignificantresultswerethemeanIL-6levelsthatwerehigherinPSXgroup2(37.68±29.52pg/mL)comparedtothatincontrolgroup1(15.32±10.08pg/mL)(P<0.001).CONCLUSION:SeveralinteractingandextendingbiochemicalpathwaysmayleadtothepromotionofVEGFandIL-6expressions.IL-6whichistheonlyalteredmarkerinourstudymayindirectlycauseanincreaseofvascularpermeabilityandneovascularization.WesuggestinflammationasafactorthatcanbeinvolvedinetiopathogenesisofPSX.
简介:目的分析老年人视力损害的眼病病因及心理影响。方法收集眼科门诊60岁以上老人850例,分三组:60-69岁,70-79岁,≥80岁。检查视力、眼科仪器检查、评估心理状况,对数据进行统计分析。结果各视力级别的总比例:≥5.0(5.46%),较好视力4.5-4.9(60.62%),低视力4.0-4.4(24.34%),盲〈4.0(9.58%)。在年龄组间随年龄增高,较好视力的比例下降(66.45%,57.11%,38.23%),低视力(25.33%,35.54%,47.27%)和盲(5.12%,7.24%,14.50%)的比率升高,差异有统计学意义(P〈0.05)。随视力级别下降,心理状况水平优的人数比例而降低(90.13%,82.31%,34.24%,2.10%),状况水平差的比例而升高(1.73%,5.46%,45.35%,85.44%),差异有统计学意义(P〈0.05)。低视力和盲的主要眼病构成比:白内障52.33%,屈光不正20.11%,老年性黄斑变性14.32%,糖尿病视网膜病变7.02%,眼底静脉阻塞3.10%。结论老年人视力损害眼病前五位是白内障,屈光不正,老年性黄斑变性,糖尿病视网膜病变,眼底静脉阻塞。老年人低视力和盲的比例高,视力损害者不良心理状况比例高,视力损害对老年人心理状况的影响值得重视。
简介:目的调查视网膜母细胞瘤(retinoblastoma,RB)患儿家长的心理健康状况。方法采用国际通用的焦虑自评量表和抑郁自评量表对121名患儿家长进行问卷调查,以国内常模作为对照。采用SAS8.0统计软件对数据进行t检验和方差分析。结果RB患儿家长的焦虑标准分(53.80±10.42)和抑郁标准分(58.90±10.89)均高于国内常模(P均〈0.0001)。双眼RB患儿家长的焦虑标准分(58.19±10.57)和抑郁标准分(62.46±11.84)明显高于单眼RB组(焦虑和抑郁值分别为51.73±9.77,57.22±10.09,P值分别为0.0083,0.0423)。患儿所处的治疗阶段不同,家长文化程度不同,家庭经济状况不同,家长的焦虑和抑郁程度也不同。结论RB患儿家长的焦虑、抑郁水平明显高于国内正常人群,提示对RB患儿家长进行心理疏导的必要性。
简介:AIM:Toinvestigatetheantifibroticeffectofthefreeze-driedbilayeredfibrin-bindingamnioticmembraneasadrugdeliverysystemonglaucomasurgeryinrabbitmodel.Theaimofthisstudywastoprepareanovellocaldeliverysystemforthesustainedandcontrollablereleaseof5-Fu.METHODS:Twenty-fourJapanesewhiterabbitswererandomizedintothreegroups:theexperimentalgroup(oculartrabeculectomyincombinationwith5-Fuloadedfreeze-driedbilayeredfibrin-bindingamnioticmembranetransplantation),thecontrolgroup(oculartrabeculectomyincombinationwith5-Fu)andtheblankgroup(singletrabeculectomy).HEstaining,massionstainingandimmunohistochemistryforα-SMAwereperformedondays7,14,21and30followingsurgery.Theconcentrationof5-Fuinrabbitaqueoushumorwasexaminedbyhighperformanceliquidchromatography(HPLC)3daysafterthesurgery.RESULTS:Statisticaldifferenceswerenotedinintraocularpressureamonggroupsonday7,14,21and30followingsurgery.Histologyfurtherdemonstratedthattrabeculectomyincombinationwithfreeze-driedbilayeredfibrin-bindingamnioticmembraneyieldedwellwoundhealingandnoscarformationandwasbeneficialforlongtermeffect.CONCLUSION:HPLCshowedagoodslow-releaseeffectwithfreeze-driedbilayeredfibrin-bindingamnioticmembrane.
简介:目的:探讨低视力患者的心理健康状况及受到的社会支持。方法:从解放军总医院第一附属医院、同仁医院、中医眼科医院采用方便取样的方式抽取105例低视力患者进行调查。采用一般情况调查表、症状自评量表(SCL-90)、社会支持评定量表(SSRS)施测。结果:(1)低视力患者与社会常模进行比较,两者的SCL-90九个因子(除人际关系外)平均得分均存有显著性差异(P〈0.01或P〈0.05)。(2)不同年龄组被试在人际关系、焦虑、敌对、偏执、精神病五个因子上得分存在显著性差异(P〈0.05)。(3)SCL-90量表与社会支持量表的相关性研究表明社会支持总分与主观支持得分呈负相关,与客观支持与社会支持度上呈部分负相关。结论:低视力患者存在心理健康问题、主观上感受到的社会支持少,应注重低视力患者的心理护理。