简介:摘要:目的 减少膈下游离气体误诊为胃肠道穿孔。方法 回顾分析一例腹部平片提示膈下游离气体患者误诊为胃穿孔的临床病例。结果 腹腔镜探查术中发现子宫穿孔,术后入重症医学科进一步观察治疗。三天后患者病情稳定,转妇产科治疗。
简介:摘要:通过分析该儿童疑似新型冠状病毒肺炎患儿的临床资料,给患儿早期使用喜炎平、干扰素治疗,体温迅速下降,但病程中呼吸道症状反复,根据其临床表现与检查结果增加阿奇霉素治疗,在隔离治疗6天后患儿病情好转回家继续隔离服药治疗,疗程13天,门诊随访预后良好。结果:因目前尚无抗新型冠状病毒的特效药物,治疗中以对症治疗为主,早期抗病毒治疗,根据病情变化随时调整隔离治疗方案,能迅速有效地控制病情发展,阻止并发症的发生,缩短病程。
简介:摘要67岁女性患者,发现右后胸部肿块6月余。肺增强CT检查示右侧第9/10后肋间隙水平胸壁内见卵圆形、结节状密度灶,边界清,大小约1.8 cm×2.2 cm,可见浅分叶,增强后见明显不均匀强化。2019年7月在全麻下行右侧胸壁肿块切除术+胸壁修补术,病理诊断为SMARCA4缺失的胸部肉瘤。术后随访2个月,肿瘤未见复发和远处转移,患者至上海市肿瘤医院进一步治疗。SMARCA4缺失的胸部肿瘤侵袭性强,易发生远处转移,确诊需依赖组织病理学、免疫组织化学或SMARCA2基因检测。其治疗原则首选根治性手术,术后辅助放、化疗等综合治疗。
简介:AbstractBackground:Degree of mucosal recovery is an important indicator for evaluating the therapeutic effects of drugs in treatment of inflammatory bowel disease (IBD). Increasing evidences has proved that tight junction (TJ) barrier dysfunction is one of the pathological mechanisms of IBD. The aim of this study was to observe whether enhancement of TJ can decrease colitis recurrence.Methods:Eighty C57BL/6 mice were randomly divided into four groups including normal group, colitis group, sulfasalazine (SASP) treated group, and traditional Chinese drug salvianolic acid B (Sal B) treated group. Colitis was established in mice by free drinking water containing dextran sulfate sodium, after treatments by SASP and Sal B, recombinant human interleukin-1β (IL-1β) was injected intraperitoneally to induce colitis recurrence.Results:Compared with sham control, cell apoptosis in colitis group was increased from 100.85 ± 3.46% to 162.89 ± 11.45% (P = 0.0038), and TJ dysfunction marker myosin light chain kinase (MLCK) was also significantly increased from 99.70 ± 9.29% to 296.23 ± 30.78% (P = 0.0025). The increased cell apoptosis was reversed by both SASP (125.99 ± 8.45% vs. 162.89 ± 11.45%, P = 0.0059) and Sal B (104.27 ± 6.09% vs. 162.89 ± 11.45%, P = 0.0044). High MLCK expression in colitis group was reversed by Sal B (182.44 ± 89.42% vs. 296.23 ± 30.78%, P = 0.0028) but not influenced by SASP (285.23 ± 41.04% vs. 296.23 ± 30.78%, P > 0.05). The recurrence rate induced by recombinant human IL-1β in Sal B-treated group was significantly lower than that in SASP-treated group.Conclusions:These results suggested a link between intestinal mucosal barrier dysfunction, especially TJ barrier dysfunction, and colitis recurrence. The TJ barrier dysfunction in remission stage of colitis increased the colitis recurrence. This study might provide potential treatment strategies for IBD recurrence.