简介:摘要:本论文通过临床追踪研究,对慢性盆腌炎的治疗和预后进行了深入研究和探讨。选取了一组进行常规治疗的病例,另一组直接接受妇科微创治疗。比较了两种不同治疗方法对患者疾病恢复和预后的影响,发现妇科微创治疗对慢性盆腔炎的治疗效果更佳,具有更快的恢复速度,较好的预后和较低的复发率。论文进一步探讨了妇产科微创治疗相比传统治疗方法在患者恢复、预后和生活质量提升等方面的优势,为临床治疗提供了更好的参照。同时,鉴于微创治疗方法的高效性和低副作用,建议尽早推广至更广泛的治疗领域,为慢性盆腔炎的预防、治疗以及患者的生活质量提高提供更加科学的依据。
简介:摘要:目的:随着生活方式的改变,慢性病如高血压、糖尿病、心血管疾病等日益增多,严重威胁人们的健康。医院体检项目中慢性病风险因素分析的主要目的在于识别并评估个体患慢性病的风险,为早期预防、诊断和治疗提供科学依据,从而降低慢性病的发病率和死亡率。方法:我们采用了多种方法对慢性病风险因素进行分析。首先,通过问卷调查收集受检者的基本信息,包括年龄、性别、家族史、生活习惯等。其次,进行体格检查,测量身高、体重、腰围等指标,计算体质指数以评估肥胖程度。再者,利用生化检测手段检查血糖、血脂、血压等生理指标。最后,结合所有收集到的数据,运用统计学方法分析各因素与慢性病风险之间的关联性。结果:经过综合分析,我们发现年龄、家族史、不良生活习惯(如吸烟、过量饮酒、缺乏运动)、肥胖以及高血压、高血糖、高血脂等生理指标异常是慢性病的主要风险因素。其中,高龄、有家族史、肥胖以及三高(高血压、高血糖、高血脂)人群患慢性病的风险显著增加。结论:通过医院体检项目中的慢性病风险因素分析,我们能够有效地识别出高危人群,为他们提供个性化的健康指导和干预措施。这不仅有助于降低个体患慢性病的风险,还能提高整个社会的健康水平。因此,建议将慢性病风险因素分析作为医院体检的常规项目,并加强相关健康教育和宣传工作,以提高公众的慢性病防控意识。
简介:TheaimofthisstudyistoinvestigatecyclinE,pl6inkdaandki67aspossiblediagnosticbiomarkersforcervicalpreneoplasiausingcervicalexfoliated-cellspecimens,andevaluatethesignificanceforscreeningpatientsathighriskofdevelopingcervicalcarcinoma.TheexpressionofcyclinE,pl6inkdaandki67wasexaminatedin78cervicalexfoliatedepithelialspecimensdiagnosedasatypicalsquamouscellsofundeterminedsignificance(ASCUS)(12cases),cervicalintraepithelialneoplasia(CIN)oftype1(17cases),CIN2_3(38cases)andinvasivecarcinoma(11cases)usingimmunohistochemicalanalysis,andsimultaneously,theDNAstatusofhumanpapillomavims(HPY)type16/18wasdetectedbypolymerasechainreaction(PCR)usingtypespecificprimers,cyclinE,pl6inkdaandki67werealloverexpressedinCINsandinvasivecarcinoma,comparedwithlittleexpressioninASCUS(P<0.005).OverexpressionofcyclinEwasobservedinCIN1(94.1%,X^2=21.16,P<0.01),andp16inkdaandki67wereoverexpressedininvasivecarcinoma(100%and90.9%respectively).Thedegreeofpl6inkdaandki67expressioncorrelatedwellwiththatofepitheliallesions(P<0.005).HPV16/18infectionwasassessedinC1Nsandinvasivecarcinomasamples,andrevealedasignificantrelationshipwiththedegreeofcervicalepitheliallession.Theexpressionlevelofpl6inkdaandki67seemedmorecloselyassociatedwithHPVI6infectionthanthatofcyclinE(rs=1.0vsrs=0.4).Only1caseinCINIanddcasesinCIN2-3ofHPV18positivesamplesweredetected.Thereforenostatisticalsignificancewasfoundbystatisticalanalysis.OverexpressionofcyclinE,pl6inkdaandki67inCINsandinvasivecarcinomacellsdemonstratesthepotentialuseofcyclinE,pl6inkdaandki67asdiagnosticbiomarkersforHPV-relatedcervicalneoplasticlesions.Inaddition,thistechniquecanbeusedforscreeningpatientsathighriskofdevelopingcervicalcarcinoma.
简介:ThegenomeoftheenterohemorrhagicEscherichiacoliO157:H7EDL933contains177“O”-islands(OIs).TostudytheirpotentialcontributiontotheO157-specificpathogenicity,wesurveyedthedistributionof22OIsbyPCRandDNAhybridizationin17isolatesofShigatoxinproducing(Stx-positive)E.coliO157:H7,andcomparedwiththeirdistributionin21isolatesofStx-negativeE.coliO157and21isolatesofnon-O157entericpathogens.Fourteenof22OIswerepresentinnon-O157entericpathogensanalyzed.Eightof22OIswerefoundonlyinthe17Shigatoxin-(Stx)positiveE.coliO157:H7isolates,buttheywereabsentfromthe21Stx-negativeE.coliO157:NMandO157Hundisolatestested.Amongthe8OIs,onlyOI43orOI48wereexclusivelydetectedinStx-positiveE.coliO157:H7,absentfromneitherofStx-negativeE.coliO157andnon-O157entericpathogens,suchasSalmonella,ShigeUa,Citrobacter,Vibriocholera,enteropathogen-icE.coli(EPEC),enteroadherentE.coli(EAEC),enteroinvasiveE.coli(E1EC)andenterotoxingenicE.coli(ETEC).TheOI43andOI48are83kbinsizeandidenticalinDNAsequences,whichencodegenesforurease,telluriteresistanceandadherence.ByanalyzingtheirjunctiongeneswithPCRandDNAhybridization,wefoundthat21ChineseisolateshaveOI48only.However,for7Japanesepatientisolates,4haveOI43and3haveOI48;forAmericanisolates,2havebothofO143andOI48,2haveOI48only.ThesedataconfirmedthehighlyplasticityofthepathogenicE.coligenome.TheuniquepresenceofOI43/OI48inStx-positiveE.coli0157:H7denotesitscriticalroleinthepathogenicityspecifictothispathogen.