简介:AIM:Toinvestigatethelifetimeriskofdevelopmentofesophagealadenocarcinomaand/orhigh-gradedysplasiainpatientsdiagnosedwithBarrett’sesophagus.METHODS:DatawereextractedfromtheUnitedKingdomNationalBarrett’sOesophagusRegistryondateofdiagnosis,patientageandgenderof7877patientsfromwhohadbeenregisteredfrom35UnitedKingdomcenters.LifeexpectancywasevaluatedfromUnitedKingdomNationalStatisticsdatabasedupongenderandageatyearatdiagnosis.Thesedatawerethenusedwithpublishedestimatesofannualadenocarcinomaandhigh-gradedysplasiaincidencesfrommetaanalysesandlargepopulation-basedstudiestoestimateoveralllifetimeriskofdevelopmentofthesestudyendpoints.RESULTS:ThemeanageatdiagnosisofBarrett’sesophaguswas61.6yearsinmalesand67.3yearsinfemales.Themeanlifeexpectancyatdiagnosiswas23.1yearsinmales,20.7yearsinfemalesand22.2yearsoverall.Usingdatafrompublishedmeta-analyses,thelifetimeriskofdevelopmentofadenocarcinomawasbetween1in8and1in14andthelifetimeriskofhigh-gradedysplasiaoradenocarcinomawas1in5to1in6.Usingdatafrom3largerecentpopulation-basedcohortstudiesthelifetimeriskofadenocarcinomawasbetween1in10and1in37andofthecombinedendpointofhigh-gradedysplasiaandadenocarcinomawasbetween1in8and1in20.AgeatBarrett’sesophagusdiagnosisisreducingandlifeexpectancyisincreasing,whichwillpartiallycounter-balancelowerannualcancerincidence.CONCLUSION:Thereisasignificantlifetimeriskofdevelopmentofhigh-gradedysplasiaandadenocarcinomainBarrett’sesophagus.
简介:Objective:Toobservetheclinicalefficacyofacupuncture-moxibustionintreatingAlzheimer’sdisease(AD).Methods:Forty-eighteligibleADpatientswereenrolledtoreceiveacupunctureplusherb-partitionedmoxibustion.Mini-mentalstateexamination(MMSE)wasadoptedforevaluationbeforeandafterintervention,andthetherapeuticefficacywasobserved.Results:Afterintervention,theMMSEscorechangedsignificantly(P<0.01),andthetotaleffectiveratewas83.3%.Conclusion:Acupuncture-moxibustioncansignificantlyimprovethecognitivefunctionofADpatients,beneficialtothegeneralpromotionofthequalityoflife.
简介:摘要目的探讨Richter's综合症的临床特点、发病机制、危险因素、治疗及预后,提高对其疾病本质的认识。方法报道1例Richter's综合症,分析其临床特点,实验室检查,治疗过程并复习文献。结果与结论患者以淋巴细胞增多及淋巴结肿大为首发表现,诊断为慢性淋巴细胞白血病后,在治疗过程中出现淋巴结、脾脏进行性肿大,经淋巴结活检证实转化为弥漫大B细胞淋巴瘤。虽经积极治疗,但诊断后仅存活6月。RS病人治疗困难,预后不佳。
简介:目的马尾藻类海草wightiiGreville是属于有大约200种类的Sargassaceae家庭的海洋的棕色的水藻。整个干燥植物粉末的ethanolic摘录包含了众多的phytoconstituents,包括flavonoids。学习在老鼠集中于马尾藻类海草wightii的anticancer活动。在二剂量的马尾藻类海草wightii(EESW)的ethanolic摘录铺平的方法被用来用DAL房间线在老鼠检验anticancer活动导致癌症。身体重量,可行、不能生存的肿瘤房间计数,吝啬的幸存时间,寿命的增加,和hematological参数为EESW的anticancer活动被观察。在老鼠的DAL房间的intraperitoneal接种显著地增加了的结果癌症房间计数。在在对待EESW的组癌症动物观察的癌症细胞数字的减少显示测试药在肿瘤细胞增长上有重要禁止的效果。有EESW的治疗也在肿瘤重量显示出重要减少,并且因此增加了对待DAL的老鼠的lifespan。另外,EESW管理显著地在对待DAL的老鼠恢复了hematological参数。现在的学习结果建议摘录提议的那个政府的结论提高了抗氧化剂潜力。因此,EESW拥有anticancer活动,这能从这研究被结束。
简介:ObjectiveToreportoutcomesofnonsurgicalandsurgicalmanagementofMenière’sdiseaseatBeijingTiantanHospital.MethodsPatientswithMenière’sdiseasewerecategorizedintogroupsbasedonhearingandqualityoflife.Individualizedmanagementwasprovided,includinglifestylemodification,drugtherapies,endolymphaticsacdecompressionandlabyrinthectomy.Treatmentoutcomeswereevaluatedduringupto24monthsfollowup.ResultsEightysevenpatientsunderwentlifestylemodificationanddrugtherapies.ThevertigocontrolrateofGradeAandBwas76.9%and83.8%respectively.Sixpatientsreceivedsurgicalmanagement,includingendolymphaticsacdecompression(n=5)andlabyrinthectomy(n=1).Forthesepatients,thevertigocontrolrateofGradeAandBwas80%and100%,respectively.ConcluIsionsManagementofMenière’sdiseasedependsonseveralfactors,i.e.severitiesofvertigoandhearingloss,qualityoflife,surgicalcontraindicationsandpatientsubjectivedesire.Thetreatmentisdrugtherapiesforthemajorityofpatients,aswellaslifestylemodification.Surgicalindicationsarerareandtheleastinvasiveproceduresshouldbeconsideredfirst.Theresultsofsurgeryaregenerallysatisfying.
简介:目的分析某院短期内神经外科多例患者手术部位感染(SSI)的可能原因。方法收集该院2013年2月1日-3月15日135例神经外科手术患者资料,采用病例对照研究,回顾性分析可能引起SSI的危险因素。结果135例手术患者,5例发生SSI,感染率为3.70%。病例对照研究显示,第5手术间使用情况和进行二次手术的比值比分别为4.07(95%CI:0.52~36.65)、18.00(95%CI:2.00~180.00)。各手术主刀医生施行手术患者SSI率与该科2012年平均SSI率2.54%(17/669)比较,差异均无统计学意义(均P〉0.05)。第5手术间环境卫生学检测,除麻醉机袖带的菌落总数超标外,其余采样部位单位面积菌落总数均符合国家要求;且麻醉机袖带采样培养的微生物为凝固酶阴性葡萄球菌,与感染患者致病微生物无关。结论进行二次手术是此次短期多例神经外科患者发生SSI的高危因素。
简介:Parkinson’sdisease(PD)isanage-relatedneurodegenerativedisordercharacterizedbytypicalmotorsignsandsymptomsthatareduetodopamine(DA)depletioninthebasalganglia.ThetreatmentofPDissymptomatic,andaimsatreplacingthelostDAinputusingeitherL-DOPAorDAagonists.ThecausesofPDareunknownin
简介:摘要目的对5种梅毒检测方法的临床应用效果进行评价分析,为今后的临床检验工作提供可靠的参考依据。方法采集梅毒患者血清标本60份,对其分别采取梅毒螺旋体血球凝集试验(TPHA)、甲苯胺红不加热血清试验(TRUST)、酶联免疫吸附试验(ELISA)、梅毒螺旋体明胶颗粒凝集试验(TPPA)、胶体金法进行检测,并对5种检测手段的检测结果进行对比分析。结果经对比发现,ELISA在梅毒血清检测中,灵敏度和特异性较其他四种手段发生显著升高(P<0.05);TRUST、TPHA法以及胶体金法的敏感性较低(P<0.05)。结论在梅毒血清检测中,ELISA法的灵敏度和特异性良好,可与TPPA发联合,作为梅毒筛查的首选检测手段,为临床诊治工作提供可靠的参考依据。