简介:Theeffectandmechanismofcarmustine(BCNU)combinedwithall-transretinoicacid(ATRA)ontheapoptosisofhumanglioblastomaU251cellswereinvestigatedbymeansof3-(4,5-dimethylthiazol-2-yl)-2,5-diphe-nyltetrazoliumbromide(MTT)assay,flowcytometry,reversetranscription-polymerasechainreaction(RT-PCR)andWesternblotanalysis.TheresultsshowthatBCNUorATRAshowstime-anddose-dependentinhibitioneffectsonhumanglioblastomaU251cellsandthecombinationofBCNUwithATRAshowsansynergisticinhibitioneffectonhumanglioblastomaU251cells,andthecombinedBCNUandATRAcansignificantlyinhibittheproliferationofhumanglioblastomaU251cells,andinducetheapoptosisofthem,makingthecellsarrestinthestageofG1phase,thestageofSandG2phasesdecline,therateoftheapoptosisofhumanglioblastomaU251cellsincrease,thecorrespondingmRNAexpressionofcyclinEandcyclin-dependentkinase2(CDK2)downregulatedandthecorrespon-dingmRNAexpressionofp27kip1unregulated.Inaddition,thecombinedBCNUandATRAreducedtheproteinexpressionofnuclearfactorkappaB(NF-κB).Takentogether,theseresultssuggestthatthetreatmentofhumanglioblastomaU251cellswithacombinationapplicationofATRAandBCNUcanexertsynergisticeffect,thecourseofthiskindofcombinationchemotherapymaylikelybeassociatedwithmultiplemolecularmechanismsforapoptosis,furthermore,thecyclinEandp27kip1shouldbeconsideredasnoveltargetsforcontrollingthegrowthofglioblastomacells.
简介:ThespectrumoftheΣ(1193)excitedstates,Σ,withisospinI=1andstrangenessS=??1isoneofthemostimportantissuesinhadronicphysics.TheΣresonancesaremostlyproducedandstudiedinK-inducedreactions.ManyΣresonancesarenowcatalogedbytheParticleDataGroup[1].However,ourknowledgeoftheseresonancesisstillverypoor.Intheenergyregionbelow2GeV,onlyafewofthemarewellestablished,suchastheΣ(1385)ofspin-parityJP=3=2+,Σ(1670)ofJp=3=2??andΣ(1775)ofJp=5=2??.Theothersarenotwellestablishedandsomeofthemareevenoflargeuncertaintiesontheirexistence.Thus,thestudyoftheΣresonancewiththeavailableexperimentaldataisnecessary.
简介:SomecharacterizationsoftheconditionalexpectationoperatorsonLebesgue-BochnerspacesL_p(μ,X)aregiven,where1≤p<∞,p≠2.AlsoanexampleisgiventoshowthatthecharacterizationsoftheconditionalexpectationoperatorsonL_p(μ,X)aredifferentfromthatonL_p(μ)_zFinally,arepresentationoftheconstant-preservingcontractiveprojectiononspacesL_p(μ,X)isgotwhen0<p<1.
简介:<正>LetD={z∈:|z|<1}andφbeanormalfunctionon[0,1).Forp∈(0,1)suchafunctionφisusedtodefineaBergmanspaceA~p(φ)onDwithweightφ~p(|·|)/(1-|·|~2).Inthispaper,thedualspaceofA~p(φ)isgiven,fourcharacteristicsofCarlesonmeasureonA~p(φ)areobtained.Moreover,asanapplication,threesequenceinterpolationtheoremsinA~p(φ)arederived.
简介:Letp(z)=beapolynomialdegreenandletThenaccord-ingtoBernstein’sinequality||p’||
简介:Thepurposeofthepresentpaperistoevaluatetheerroroftheapproximationofthefunc-tionfL1[0,1]byKantorovich-BernsteinpolynomialsinLp-metric(0<p<1).
简介:InthispaperwestudytheconvergencenfaclassofmeansonHp(G)(0<p<1),themeanstaketheBochner-Rieszmeansin[1],thegeneralizedBochner-Rieszmeansin[2],andtheoperatorsTΦrin[3]asspecialcases.Weobtainweak-typeestimatesfortheassociatedmaximaloperatorsandthemaximalmeanboundednessforthemeans.
简介:Inthispaper,wegetW1,p(Rn)-boundednessfortangentialmaximalfunc-tionandnontangentialmaximalfunction,whichimprovesJ.Kinnunen,P.LindqvistandTananka’sresults.
简介:<正>WestudythesolvabilityoftheCauchyproblem(1.1)-(1.2)forthelargestpossibleclassofinitialvalues,forwhich(1.1)-(1.2)hasalocalsolution.Moreover,wealsostudythecriticalcaserelatedtotheinitialvalueu0,for1<p<∞.
简介:Inthispaperwewillshowthatifanapproximationprocess{Ln}n∈Nisshapepreservingrelativetotheconeofallk-timesdifferentiablefunctionswithnon-negativek-thderivativeon[0,1],andtheoperatorsLnareassumedtobeoffiniterankn,thentheorderofconvergenceofDkLnftoDkfcannotbebetterthann2evenforthefunctionsxk,xk+1,xk+2onanysubsetof[0,1]withpositivemeasure.Takingintoaccountthisfact,wewillbeabletofindsomeasymptoticestimatesoflinearrelativen-widthofsetsofdifferentiablefunctionsinthespaceLp[0,1],p∈N.
简介:Let(.theMuckenhouptclass).Inthispaper,theauthorintroducetheweightedHerz-typeHardyspaces(w2)andpresenttheiratomicdecomposition.Usingtheatomicdecomposition,theauthorfindouttheirdualspaces,establishtheboundednessonthesespacesofthepseudo-differentialoperatorsoforderzeroandshowthat,theclassofC(Rn)-functionswithcompactlysupport,isdenseinandthereisasubsequence,whichconvergesindistrbutionalsensetosomedistributionof,ofanyboundedsequenceinInaddition,theauthoralsosetuptheboundednessofsomenon-linearquantitiesincompensatedcompactness.
简介:InthispaperwestudythetheoreticalpropertiesofmultigridalgorithmfordiscretizationofthePoissonequationin2Dusingamortarelementmethodundertheassumptionthatthetriangulationsoneverysubdomainareuniform.WeprovetheconvergenceoftheW-cyclewithasufficientlylargenumberofsmoothingsteps.ThevariableV-cyclemultigridpreconditionerarealsoavailable.
简介:混乱理论教了我们很可能有非线性和随机的输入愿望的一个系统生产不规则的数据。如果随机的错误是不规则的数据,那么随机的错误过程将提起非线性(Kantz和Schreiber(1997))。Tsai(1986)与AR(1)错误在线性模型为自相关和heteroscedasticity介绍了合成测试。刘(2003)与DBL在非线性的模型为关联和heteroscedasticity介绍了合成测试(p,0,1)错误。因此,在回归模型的重要问题是bilinearity,关联和heteroscedasticity的察觉。在这篇文章,作者与DBL讨论非线性的模型的更一般的大小写(p,q,1)由20测试的随机的错误。为bilinearity,关联,和heteroscedasticity的测试的几统计在简单矩阵公式被获得,并且表示。有线性错误的回归模型的结果与双线性的错误被扩大到那些。模拟学习被执行调查测试统计的力量。这篇文章的所有结果扩大并且发展结果Tsai(1986),魏,等(1995),和刘,等(2003)。
简介:Fluorescencepropertiesofaseriesofstyrene/p-divinylbenzene(St/p-DVB)copolymerbeadswereinvestigatedbysteady-statefluorescencespectra.Inadditiontothefluorescenceofthephenylringexcimer,anewemissionbandatca395nmappearswhenp-DVBcontentinfeedishigherthan13%(wt).Theintensityofthisnewemissionwasfoundtochangewithp-DVBcontentandtodecreasewithswollenbeads.Theoriginofthisnewemissionisconsideredtobeamulti-ringexcimerformation.
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简介:Thespectrumofisospin3/2Δ++(1232)excitedstatesisoneofthemostimportantissuesinhadronicphysicsandisattractingmuchattentionbecauseitisthemostexperimentallyaccessiblesystemcomposedofthreeidenticalvalencequarks.However,ourknowledgeontheseresonancesmainlycomesfromoldNexperimentsandisstillverypoor[1].Intheenergyregionaroundorabove2.0GeV,therearestillmanytheoreticalpredictionsofmissingΔstateswhichhavesofarnotbeenobserved.Searchingforthesemissingstatesfromotherproductionprocessesisnecessary.ApossiblenewexcellentsourceforstudyingtheseΔresonancecomprisesthe+p!K+Σ+(1385)andpp!nK+Σ+(1385)reactions,whichhaveaspecialadvantage,i:e:,thereisnocontributionsfromisospin1/2nucleonresonancesduetotheisospinandchargeconservations.