简介：维生素D3起来调整的蛋白质(VDUP1)1是涉及维持细胞的动态平衡的多功能的蛋白质。VDUP1被许多压力导致。相反地，VDUP1经常在各种各样的肿瘤纸巾和房间线被减少。VDUP1的在表示上通过房间周期拘捕禁止房间增长。VDUP1与thioredoxin(Trx)交往并且否定地调整表示和涉及氧化还原作用规定的Trx的抗氧化剂功能。VDUP1-/-鼠标比野类型的鼠标更产生carcinogenesis并且在包括自然漂亮房间的开发和函数建立免疫系统是有缺点的。而且，VDUP1-/-mice表演损害了Kreb调停周期的丰满的酸利用。在这评论，我们在多样的细胞的回答，特别地与增长的它的关系，apoptosis，区别，和象癌症那样的疾病和压力相关的疾病讨论了VDUP1的多功能的角色。

简介：Ahallmarkofallformsofneurodegenerativediseasesisimpairmentofneuronalfunctions,andinmanycasesneuronalcelldeath.Althoughtheetiologyofneurodegenerativediseasesmaybedistinct,differentdiseasesdisplayasimilarpathogenesis,forexampleabnormalimmunitywithinthecentralnervoussystem(CNS),activationofmacrophage/microgliaandtheinvolvementofproinflammatorycytokines.Recentstudiesshowthatneuronsinaneurodegenerativestateundergoahighlyregulatedprogrammedcelldeath,alsocalledapoptosis.TNF-relatedapoptosis-inducingligand(TRAIL),amemberoftheTNFfamily,hasbeenshowntobeinvolvedinapoptosisduringmanydiseases.Asonememberofadeathligandfamily,TRAILwasoriginallythoughttotargetonlytumorcellsandwasnotpresentinCNS.However,recentdatashowedthatTRAILwasunregulatedinHIV-1-infectedandimmune-activatedmacrophages,amajordiseaseinducingcellduringHIV-1-associateddementia(HAD).TRAILisalsoinducedonneuronbyβ-amyloidprotein,animportantpathogenforAlzheimer'sdisease.Inthisreview,wesummarizethepossiblecommonaspectsthatTRAILinvolvedthoseneurodegenerativediseases,TRAILinducedapoptosissignalingintheCNScells,andspecificroleofTRAILinindividualdiseases.Cellular&MolecularImmunology.2005;2(2):113-122.

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简介：AbstractInnate lymphoid cells (ILCs) are a group of lymphocytes without diversified antigen receptors encoded by gene rearrangement on T and B cells. ILCs, which are tissue-resident innate immune cells, expressed particularly in the mucosa or the barrier surface, contribute to the formation of lymphoid organs, the maintenance of tissue homeostasis, and the regulation of antimicrobial defenses. It has been recently reported that ILCs were enriched at the maternal-fetal interface. During a successful pregnancy, the maternal immune system must tolerate a fetus as an allograft. With the new defined of ILCs, a number of studies have shown that three types of ILCs are involved in embryonic development and pregnancy maintenance as well as the occurrence and development of pregnancy-related complications. This article reviews the types and roles of ILCs in normal pregnancy and pregnancy-related diseases.

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简介：Dr.YINMingisskilledatthepediatricdiseasesandwinsthetrustfromherpatientsandtheirfamilies.Ilearnedalotfromtheclinicalpracticewithherandnowtheexperienceisasfollows.

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简介：AbstractBackground:The association of milk intake with cardiovascular disease (CVD) and cause-specific mortality remained controversial and evidence among the Chinese population was limited. We aimed to study the relationship between milk intake and CVDs among general Chinese adults.Methods:A total of 104,957 participants received questionnaire survey. Results of physical examination such as anthropometric measurements and biochemical tests during 2007 to 2008, demographic data and their information on milk intake were collected through standardized questionnaires. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) of CVD incidence, cause-specific mortality and all-cause mortality related to milk intake. Restricted cubic splines (RCSs) were applied to examine dose-response associations.Results:Among the 91,757 participants with a median follow-up period of 5.8 years, we documented 3877 CVD cases and 4091 all-cause deaths. Compared with participants who never consumed milk, the multivariate-adjusted HRs (95% CIs) of CVD incidence for 1 to 150 g/day, 151 to 299 g/day, and ≥300 g/day were 0.94 (0.86-1.03) (P > 0.05), 0.77 (0.66-0.89) (P < 0.05), and 0.59 (0.40-0.89) (P < 0.05), respectively; each 100 g increase of daily milk intake was associated with 11% lower risk of CVD incidence (HR, 0.89; 95% CI: 0.85-0.94; P < 0.001), and 11% lower risk of CVD mortality (HR, 0.89; 95% CI: 0.82-0.97; P = 0.008) after adjustment for age, sex, residential area, geographic region, education level, family history of CVD, smoking, alcohol drinking, physical activity level, body mass index, and healthy diet status (ideal or not). RCS analyses also showed a linear dose-response relationship with CVD (P for overall significance of the curve <0.001; P for non-linearity = 0.979; P for linearity <0.001) and stroke (P for overall significance of the curve = 0.010; P for non-linearity = 0.998; P for linearity = 0.002) incidence, and CVD mortality (P for overall significance of the curve = 0.045; P for non-linearity = 0.768; P for linearity = 0.014) within the current range of daily milk intake.Conclusions:Daily milk intake was associated with lower risk of CVD incidence and mortality in a linear inverse relationship. The findings provide new evidence for dietary recommendations in CVD prevention among Chinese adults and people with similar dietary pattern in other countries.

简介：AIMTo评估安全和27计量器(27G)的功效侧面为有跟随27GPPV的各种各样的vitreoretinal疾病的61只眼睛(58个病人)的临床的结果是的各种各样的vitreoretinaldiseases.METHODSThe的治疗的同等planavitrectomy(PPV)回顾地，reviewed.RESULTSSurgical指示包括了rhegmatogenous网膜的分开(n=24)，完整厚度的有斑点的洞(n=12)，糖尿病的retinopathy(n=11)，玻璃的出血(n=6)，Eales疾病(n=4)，病理学近视相关玻璃吝啬的后续是166.4牵敧祲刮卅?協桔???????????????挠灡?潬潴祭?????????????????????????浥瑡硯汹湩攭獯湩?€浩畭潮汦潵敲'諟Ｉ????????吗?????????????？？

简介：通过ubiquitin-proteasome系统的蛋白质降级是细胞内部的蛋白质的non-lysosomal解朊作用的主要小径。它在象房间周期的规定那样的许多基本细胞的过程起重要作用有免疫力、煽动性的回答的前进，分割，开发和区别，apoptosis，房间trafficking，和调整。这个系统的中央元素是到指向的蛋白质的ubiquitin的连接，它是然后由26Sproteasome认出了的共有原子价，腺苷triphosphate依赖的、多催化的朊酶。损坏，氧化，否则象控制许多批评细胞的函数的规章的蛋白质一样的错误褶层蛋白质在这降级进程的目标之中。这个系统的错误导致细胞的动态平衡的dysregulation和多重疾病的发展。在这评论，我们在煽动性、自体免疫的疾病的开发描述了基本生物化学和ubiquitin-proteasome系统，和它的复杂角色的分子的生物学。另外，与ubiquitin-proteasome系统有关的治疗和潜在的治疗学的目标也被讨论。细胞与分子的免疫学。2006；3(4):255-261。

简介：<正>Immunologicaltolerancetoselfisessentialformaintainingtheintegrityoftheorgansystems,anditsbreakdownmayleadtothedevelopmentofautoimmunediseases.Tolerancetoselfismaintainedthroughseveralmechanisms,whichincludenegativeselection,functionalinactivation(anergy)andsuppressionofautoreactivelymphocytes.However,onlynegativeselectionpermanentlyremovesautoreactivecellsthroughapoptosis.WhileithaslongbeenknownthatnegativeselectionrequiresaTcellreceptor(TCR)signal,itisunclearwhetheradeathligandsignalisalsoinvolved.TRAIL,thetumornecrosisfactor(TNF)-relatedapoptosis-inducingligand,isanewlydescribedmemberoftheTNFfamily.Unlikeotherdeathligandsof

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简介：Inthepresentpaper,theauthorgivessomecommentsonacupuncturetreatmentofdiseasesfrom1)selectingacupointsbasedonseasonalconditions;2)performingreinforcingorreducingneedlingmanipulationsinaccordancewiththewaxingandwanningofthemoon;3)conductingacupuncturetreatmentinaccordancewiththetimeandthestateofdisease;and4)performingacupuncturetreatmentbasedontheprosperityordeclineofthemeridian-qi,whicharedescribedinmedicalbookTheYellowEmperor'sInternalClassic.

简介：InordertoobserveseveralantibodiestoliverantigensinChinesepatientswithdifferentfiverdiseasesandtodiscussthecharacteristicsoftheautoantibodiesinautoimmuneliverdiseases,from1412patients,detectedbyindirectimmumofluoreseence(IIF)initially,230patientswithabnormalALTwerechosenanddividedinto5groups:①autoimmunediseasesgroup,42cases:18withautoimmtmehepatitis(AIH),21withprimarybiliarycirrhosis(PBC),3withprimarysclerosingcholangitis(PSC).②HAVgroup,23cases;③HBVgroup,70cases;④HCVgroup,35casesand⑤NonA-Egroup,60cases.First,ANA,AMA,SMA,liver-kidneymicrosomalantibody(LKM)andsoonweretestedby1/F.Then,LKM-1,fivercytosofic-1(LC-1),solubleliverantigen/fiverpancreas(SLA/LP)andsubtypeofAMA(M2)aswellasANAprofilesuchasSS-A,SS-BanddsDNAweretestedbyWesternblotandimmtmoblotstripsassay,respectively.Theresultswerethatamong1412cases,thosediagnosedasAIH,PBCandPSCaccotmtedfor12.7‰,14.9‰and2.1‰,respectively,ofthesamplesbeingtested.2/230withLKM-1and2/230withSLA/LPwereseeninindividualsinfectedwithAIHandHCV,respectively.AllpatientswithPBCshowedAMAandM2antibodies.NospecificANApatternwasseeninAIHby1/Fbutanti-actinwasonlyfoundinpatientswithAIH.InNonA-Egroup,fourcaseswerepositiveofAMAandM2;threehadhightiterofSMAandother4hadSS-A,SS-BordsDNAantibodies,etc.Itwasconcludedthatthedetectionofanti-fiverantigens,ANAprofileandAMAsubtypeswerehelpfulforthediagnosisofautoimmunefiverdiseasesandoverlapsyndromes.InpatientswithNonA-Ehepatitis,thediagnosisofPBCorAIHshouldbetakenintoconsideration.

简介：Gutmicrobiotaareinvolvedinthedevelopmentorpreventionofvariousdiseasessuchastype2diabetes,fattyliver,andmalignancysuchascolorectalcancer,breastcancerandhepatocellularcarcinoma.Alzheimer’sdisease,osteoporosis,sarcopenia,atheroscleroticstrokeandcardiovasculardiseasearemajordiseasesassociatedwithdecreasedactivitiesofdailyliving(ADL),especiallyinelderlypeople.Recentanalyseshaverevealedtheimportanceofgutmicrobiotainthecontrolofthesediseases.Thecompositionordiversityofthesemicrobiotaisdifferentbetweenpatientswiththeseconditionsandhealthycontrols,andadministrationofprobioticsorprebioticshasbeenshowneffectiveinthetreatmentofthesediseases.Gutmicrobiotamayaffectdistantorgansthroughmechanismsthatincluderegulatingtheabsorptionofnutrientsand/ortheproductionofmicrobialmetabolites,regulatingandinteractingwiththesystemicimmunesystem,andtranslocatingbacteria/bacterialproductsthroughdisruptedmucosalbarriers.Thus,thegutmicrobiotamaybeimportantregulatorsinthedevelopmentofdiseasesthataffectADL.Althoughadequateexerciseandproperdietareimportantforpreventingthesediseases,theircombinationwithinterventionsthatmanipulatethecompositionand/ordiversityofgutmicrobiotacouldbeapromisingstrategyformaintaininghealthconditionandpreservingADL.ThisreviewthussummarizescurrentunderstandingoftheroleofgutmicrobiotainthedevelopmentorpreventionofdiseasescloselyassociatedwiththemaintenanceofADL.

简介：Tworecentstudieshavediscoveredasurprisinglinkbetweenthreeseeminglydifferentclinicaldiseases:onethatdestroysbonemarrow,anotherthatpreventssundamagefrombeingrepaired,andathirdwhichcauseschildrentoshowsignsofagingextremelyearly.Ithasbeenfoundthatallthreediseasesarecausedbymutationsinthesamegene.Mutationscomeinanumberofdifferentflavors,

简介：ToinvestigatethesignificanceoftheSARS-associatedcoronavirus(SARS-CoV)antibody,detectedbyELISAandindirectimmunofluorescenceassays(IFA)fortheSARS-CoVVeroE6celllysates,innon-SARSsubjects,114serumsamplesfromhealthycontrolsand104serumspecimensfromautoimmunediseasepatientswerecollected.TheresultsofELISAshowedthatamong114serafromhealthycontrols,4(3.5%)werepositiveofSARS-CoV-IgGantibodyand114(100%)wereallnegativeofSARS-CoV-IgMantibody;thespecificityofSARS-CoV-IgGantibodyforSARSpatientswas96.5%,butthespecificityofbothSARS-CoV-IgGand-IgMantibodiesforSARSpatientswas100%.In58caseswithSLE,positiveratesofSARS-CoV-IgGand-IgMantibodieswere32.8%(19/58)and8.6%(5/58),respectively,inwhich11cases(19%)werepositiveofbothSARS-CoV-IgGand-IgMantibodies;in10caseswithSS,positiverateofbothSARS-CoV-IgGand-IgMantibodieswas10%(1/10);in16caseswithMCTD,positiverateofSARS-CoV-IgGwas37.5%(6/16),positiverateofbothSARS-CoV-IgGand-IgMantibodieswas6.3%(1/16);in20caseswithRA,onecasewaspositive(5%)ofSARS-CoV-IgG.However,ofallsampleswithpositiveSARS-CoV-IgGand-IgMantibodiesforautoimmunediseasesandhealthycontrols,SARS-CoVRNAandantibodieswereallnegativebyRT-PCRandIFA.AllserafornegativeorpositiveELISAresultswerealsonegativeorpositiveresultsusingELISAwithVeroE6cellslysates.ThesestudiesshowedthatSARS-CoVVeroE6celllysatesfortheELISAtodetectSARS-CoVantibodiescouldleadtothefalse-positivereactionsorcross-reactionsofSARS-CoVantibodiesinnon-SARSdiseasesandhealthycontrols,andthefalse-positivereactionsorcross-reactionswererelatedtoVeroE6celllysatesandautoantibodiesinnon-SARSpopulation.

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