简介:摘要目的通过检测血管内皮生长因子(VEGF)及环氧合酶-2(COX-2)在肝癌大鼠中表达的变化探讨益气四虫汤对肝癌大鼠的干预作用。方法40只雄性SD大鼠,随机分为空白组、模型组、益气四虫汤组、益气四虫汤防治组(简称“防治组”),每组1O只。除空白组外。其余3组大鼠均以含0.05%2-AAF的饲料喂养12周,防治组在诱癌的同时灌服益气四虫汤。益气四虫汤组于诱癌第4周开始给药,剂量均为1.5g.kg-1.d-1(以含生药计算)。12周末观察瘤体积及瘤重量的变化,并采用免疫组织化学方法检测各组大鼠标本中VEGF及COX-2的表达。结果模型组VEGF及COX-2的表达明显高于空白组(P<0.01);益气四虫汤组、防治组VEGF及COX-2的表达明显低于模型组(P<0.01);防治组优于益气四虫汤组。结论VEGF及COX-2在肝癌大鼠中表达增强,益气四虫汤能降低肝癌大鼠VEGF及COX-2的表达,早期应用效果更好。
简介:采用纳米Ti02-K2Cr207协同体系光催化氧化,分光光度法测定染料浓度.通过正交实验设计,研究pH值、TiO2用量、K2Cr2O,初始浓度、反应温度、紫外光照时间等因素对染料消解的影响.实验结果表明,各因素的影响程度从大到小依次为pH值〉K2Cr2O7浓度〉rriO:用量〉反应温度〉紫外光照时间;最佳消解条件为pH=1.0,TiO2用量为1.0g·L-1,K2Cr207初始浓度为10mmol·L-1,反应温度为90℃,紫外光照时间为12min.
简介:Diabetesisaleadingchronicdiseaseofchildhoodandadolescence.Inadditiontothewell-knownauto-immune,insulin-dependentdiabetesmellitus(type1diabetes(T1D)),thepasttwodecadeshavewitnessedtheemergenceoftype2diabetes(T2D)inchildrenandadolescents,whichpreviouslywasonlyseeninmiddle-agedorolderadults.Oneofthekeycomponentsofdiabetesmanagementisphysicalactivity(PA).ThebeneficialeffectsofincreasedPAanddecreasedsedentarybehaviorareextremelyimportantinyouthwithdiabetesbecauseofthemarkedlyincreasedlong-termriskofcardiovasculardiseaseinthispopulationcomparedtopersonswithoutdiabetes.Thisreviewaimstocomprehensivelysummarizetheepidemiologic,observationalresearchpublishedandlistedinPubMedbetween1970and2012onPAandsedentarybehaviors,aswellasphysicalfitnessinchildrenandadolescentswithTIDandT2D.Additionally,wedescribebrieflythestateofknowledgeonperceivedbarriersofPAinpersonswithdiabetes,withafocusonhypoglycemia.Finally,weprovideanoverviewoftheepidemiologicalliteraturepertainingtohealthbenefitsofincreasedPAinyouthwithTIDandT2Dandbrieflydiscussthetopicofexercise-relatedhypoglycemia.