简介:摘要:(2022年版)义务教育语文课程标准背景下的统编版小学语文教材,更为注重学生的阅读积累。本文旨在探讨基于新课标视域下,小学语文教学中1+X链式整合教学理念的应用。首先从该教学理念的内涵入手,深入分析了此教学理念的理论根据,然后从建立学习任务群、教学评价一体化和多元化课堂探索三个方面提出了在语文教学中实现1+X链式整合教学理念的具体应用策略。最后,对该教学理念所带来的一系列好处进行了总结。
简介:摘要:随着教育改革的不断深入,初中语文阅读教学面临着新的挑战与机遇。传统的阅读教学模式已难以满足学生个性化与多样化的阅读需求,如何有效地拓宽学生的阅读视野,提升学生的阅读素养,成为当前初中语文教学亟待解决的问题。而“1+X”群文阅读教学作为一种新型的教学模式,以其灵活的组合方式和丰富的教学内容,为初中语文阅读教学提供了新的思路与方向。基于此,本文章对初中语文“1+X”群文阅读教学进行探讨,以供相关从业人员参考。
简介:摘要:在我国职业教育改革持续深入落实的时代背景下,高职院校面向各专业的人才培养工作打造了全新的模式,旨在培养具有高素质的职业技术人才。物联网是近年来快速发展的专业,其对学生的专业职业技术能力有着极高的要求。“1+X”证书制度,是把学历证书和职业技能等级证书结合起,是职教改革方案的一大亮点,也是一项重大创新。在高职院校物联网专业的教学中,采用“1+X”证书制度不仅可以提升本专业的教学质量,还可以输送高质量的职业技术人才。本文将依据相关研究成果及教学实践经验,从多个角度分析并探讨了高职院校物联网专业“1+X”证书制度的应用模式,以期能够提供经验参考。
简介:AbstractBackground:Macrophages play an important role in renal ischemia reperfusion injury, but the functional changes of macrophages under hypoxia/reoxygenation and the related mechanism are unclear and need to be further clarified.Methods:The effects of hypoxia/reoxygenation on functional characteristics of RAW264.7 macrophages were analyzed through the protein expression detection of pro-inflammatory factors TNF-α and CD80, anti-inflammatory factors ARG-1 and CD206. The functional implications of C-X3-C motif chemokine receptor 1(CX3CR1) down-regulation in hypoxic macrophages were explored using small interfering RNA technology. Significance was assessed by the parametric t-test or nonparametric Mann-Whitney test for two group comparisons, and a one-way ANOVA or the Kruskal-Wallis test for multiple group comparisons.Results:Hypoxia/reoxygenation significantly increased the protein expression of M1-related pro-inflammatory factors TNF-α, CD80 and chemokine C-X3-C motif chemokine ligand 1 (CX3CL1)/CX3CR1 and inhibited the protein expression of M2-related anti-inflammatory factors ARG-1 and CD206 in a time-dependent manner in RAW264.7 cells. However, the silencing of CX3CR1 in RAW264.7 cells using specific CX3CR1-siRNA, significantly attenuated the increase in protein expression of TNF-α (P < 0.05) and CD80 (P < 0.01) and the inhibition of ARG-1 (P < 0.01) and CD206 (P < 0.01) induced by hypoxia/reoxygenation. In addition, we also found that hypoxia/reoxygenation could significantly enhance the migration (2.2-fold, P < 0.01) and adhesion capacity (1.5-fold, P < 0.01) of RAW264.7 macrophages compared with the control group, and CX3CR1-siRNA had an inhibitory role (40% and 20% reduction, respectively). For elucidating the mechanism, we showed that the phosphorylation levels of ERK (P < 0.01) and the p65 subunit of NF-κB (P < 0.01) of the RAW264.7 cells in the hypoxic/reoxygenation group were significantly increased, which could be attenuated by down-regulation of CX3CR1 expression (P < 0.01, both). ERK inhibitors also significantly blocked the effects of hypoxic/reoxygenation on the protein expression of M1-related pro-inflammatory factors TNF-α, CD80 and M2-related anti-inflammatory factors ARG-1 and CD206. Moreover, we found that conditioned medium from polarized M1 macrophages induced by hypoxia/reoxygenation, notably increased the degree of apoptosis of hypoxia/reoxygenation-induced TCMK-1 cells, and promoted the protein expression of pro-apoptotic proteins bax (P < 0.01) and cleaved-caspase 3 (P < 0.01) and inhibited the expression of anti-apoptotic protein bcl-2 (P < 0.01), but silencing CX3CR1 in macrophages had a protective role. Finally, we also found that the secretion of soluble CX3CL1 in RAW264.7 macrophages under hypoxia/reoxygenation was significantly increased.Conclusions:The findings suggest that hypoxia/reoxygenation could promote M1 polarization, cell migration, and adhesion of macrophages, and that polarized macrophages induce further apoptosis of hypoxic renal tubular epithelial cells by regulating of CX3CL1/CX3CR1 signaling pathway.
简介:[摘要] 本文根据建筑业转型升级与可持续发展的需求,以工程实践能力提升为导向,引入BIM和虚拟仿真技术,推进高职院校《建筑工程项目管理》课程的混合式教学改革的重大意义;指出目前高职院校在课程教学内容、教学方式、教学组织、教学评价上存在的,并严重阻碍教学效果提升的主要问题;在提出本课程混合式教学改革的基本思路的基础上上,即以培养实践能力为目标,构建一体化教学模式;以职业岗位需求为导向,改革工程教学内容;以线上线下相结合为路径,创新教学组织形式;以校企协同育人为机制,强化教学实习环节,构建本课程混合式教学改革的主要内容。
简介:摘要:本文分析了丽水传统茶叶经营人才培养模式存在的问题,阐述了基于“1+X”证书制度下茶叶经营人才培养模式改革的必要性,提出基于“1+X”证书制度下茶叶经营人才培养模式的改革措施,以期为地方产业培养更多高素质高技能的应用型茶专业人才。
简介:【摘要】电子商务时代,数据对于公司运营有着至关重要的价值,对于数据分析人才的需求也愈发迫切。目前,很多学校对于电商行业数据分析人才的培养还存在一定的认识不足。“1+X证书制度”新形势下,高职学生如何培养数据分析思维并有效建立起数据分析能力,是本文探讨的重点内容。
简介:摘 要 本文在调研布线行业岗位工作和技能要求的基础上,按照“1+X证书”制度的要求,分析了《综合布线》课程的课程定位、技能培养标准,重点进行了课程教学改革研究,实现课程和技能证书的融合。