简介:摘要:相较国外发达国家,我国在儿童职业启蒙教育方面起步较晚,对6-12岁农村儿童进行“铁色文化”职业启蒙问卷调查,并对结果进行分析,进而提出在社会、家庭、学校三方面的努力方向。
简介:【摘要】目的:对6S护理模式在临床上的应用进行数据化地分析。方法:研究开展时间为2021年1月至2021年8月,采样对象为该时间段内进入我院进行非传染病以及重大疾病的、需要护理的患者。采集样本60例,为了便于数据的分析与收集将选中的60例样本患者利用奇偶表法,分成数目相等的两组,n=30;一组为研究组,一组为对照组。针对研究组进行本次差异性实验中的6S管理模式进行护理;对照组按照惯例进行常规模式进行护理。对本次研究对象的住院患者的护理基础项目评分以及患者满意程度的评分进行比对。结果:经过数据比对后,观察得知进行差异性护理后研究组患者的各项目打分都要相较于对照组患者的评分高(P
简介:AbstractBackground:Ubiquitin-conjugating enzyme E2C (UBE2C) has been shown to be associated with the occurrence of various cancers and involved in many tumorigenic processes. This study aimed to investigate the specific molecular mechanism through which UBE2C affects breast cancer (BC) proliferation.Methods:BC-related datasets were screened according to filter criteria in the Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA) database. Then differentially expressed genes (DEGs) were identified using Venn diagram analysis. By using DEGs, we conducted the following analyses including Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), protein-protein interaction (PPI), and survival analysis, and then validated the function of the hub gene UBE2C using quantitative reverse transcription-polymerase chain reaction (RT-qPCR), cell counting kit-8 (CCK-8) assay, transwell assay, and Western blot assay.Results:In total, 151 DEGs were identified from the GEO and TCGA databases. The results of GO analysis demonstrated that the DEGs were significantly enriched with mitotic nuclear division, lipid droplet, and organic acid-binding. KEGG analysis showed that the peroxisome proliferators-activated receptor (PPAR) signaling pathway, regulation of lipolysis in adipocytes, and proximal tubule bicarbonate reclamation were significantly enriched in the signal transduction pathway category. The top three hub genes that resulted from the PPI network were FOXM1, UBE2C, and CDKN3. The results of survival analysis showed a close relationship between UBE2C and BC. The results of CCK-8 and transwell assays suggested that the proliferation and invasion of UBE2C knockdown cells were significantly inhibited (P < 0.050). The results of Western blot assay showed that the level of phosphorylated phosphatase and tensin homology deleted on chromosome 10 (p-PTEN) was obviously increased (P < 0.050), whereas the levels of phosphorylated protein kinase B (p-AKT), phosphorylated mammalian target of rapamycin (p-mTOR), and hypoxia-inducible factor-1 alpha (HIF-1α) were dramatically decreased (P < 0.050) in the UBE2C knockdown cell.Conclusion:UBE2C can promote BC proliferation by activating the AKT/mTOR signaling pathway.
简介:摘要目的探讨"4C"延续护理模式对产妇产褥期的生活质量与母乳喂养自我效能的影响。方法采用便利抽样法,选择2019年2—12月某三级医院产科住院的136名产妇为研究对象。按照随机数字表随机分为对照组和干预组,每组68名。对照组采用常规护理方法,干预组在对照组的基础上应用"4C"延续护理模式进行干预。采用简明健康调查量表、母乳喂养自信心量表比较两组产妇干预前后的生活质量与母乳喂养自我效能。本研究共发放问卷136份,回收有效问卷126份,有效回收率为92.65%。结果干预组产妇干预后的简明健康调查量表、母乳喂养自信心量表评分均高于对照组,差异有统计学意义(P<0.05)。结论"4C"延续护理模式能提高产妇产褥期的生活质量,提高其母乳喂养自我效能。
简介:[摘要]音乐现在成了人们生活中不可或缺的一部分,是人类思想的寄托与载体。音乐是有目的的,是有内涵的,其中隐含了作者的生活体验,思想情怀。一款好的PC音乐播放器不仅要能够提供好的音乐播放效果,更应该能够为用户提供方便。针对目前PC环境下的音乐播放器功能比较单一,只能实现简单的音乐播放、循环播放、随机播放等简单功能。而人们有时候更多的时候去听一首歌,喜欢的是那些深入人内心的歌词,有时候人们还想在听觉享受的同时,是不是也有视觉上的享受。本系统将研究人们越来越广泛的需求来设计一款功能较全面的多媒体播放器,实现歌曲,歌词与MV的同步播放,还可以通过歌词来切换播放进度。