简介: [摘要 ]目的 研究分析瑞格列奈治疗老年 2型糖尿病合并糖尿病肾病(Ⅲ期)的临床效果。方法 此次研究的对象是选取 2018年 7月~ 2019年 12月于我院就诊的年龄≥ 60岁的 2型糖尿病合并糖尿病肾病(Ⅲ期)患者 200例,将其临床资料进行回顾性分析,并随机分为两组,瑞格列奈组( A组, 100例)和门冬胰岛素 30R组( B组, 100例),疗程 3个月,以空腹血糖( FPG) <7.0 mmol/L,餐后 2 h血糖( 2 hPG) <10.0 mmol/L为治疗目标;将血糖 <3.9 mmol/L定义为低血糖事件。记录治疗前后两组 FPG、 2 hPG、糖化血红蛋白( HbA1c)、尿微量清蛋白、肌酐( Cr)水平,低血糖发生率及血生化指标的变化,比较两种方法在降糖效果及安全性方面的差异。结果 两组患者治疗 3个月后 FPG、 2 hPG及 HbA1c、 Cr水平均明显下降,与治疗前比较,差异有统计学意义( P<0.05); A组低血糖发生率明显低于 B组,差异有统计学意义( P<0.05)。结论 瑞格列奈治疗年龄≥ 60岁的 2型糖尿病合并糖尿病肾病(Ⅲ期)患者,能有效控制血糖,降低低血糖发生率,且对肾功能无影响。轻、中度肾功能损害的老年患者应用瑞格列奈是安全、有效的。 [关键词 ]瑞格列奈;糖尿病肾病;老年患者;临床效果 [Abstract] Objective To study and analyze the clinical effect of repaglinide in the treatment of elderly type 2 diabetes mellitus with diabetic nephropathy (stage III). Methods 200 patients with type 2 diabetes mellitus and diabetic nephropathy (stage III) aged ≥ 60 years who were treated in our hospital from July 2018 to December 2019 were selected for this study. The clinical data were analyzed retrospectively and randomly divided into two groups. The treatment period was 3 months, with fasting blood glucose (FPG) < 7.0 Mmol / L, 2 hours postprandial blood glucose (2 HPG) < 10.0 mmol / l was the treatment target; blood glucose < 3.9 mmol / l was defined as hypoglycemic event. The changes of FPG, 2hPG, HbA1c, urinary microalbumin, creatinine (CR), incidence of hypoglycemia and blood biochemical indexes were recorded before and after treatment, and the differences of hypoglycemic effect and safety between the two methods were compared. Results the levels of FPG, 2 HPG, HbA1c and Cr in the two groups were significantly lower than those before treatment (P < 0.05), and the incidence of hypoglycemia in group A was significantly lower than that in group B (P < 0.05). Conclusion regolide can effectively control blood glucose, reduce the incidence of hypoglycemia, and has no effect on renal function in patients with type 2 diabetes mellitus and diabetic nephropathy (stage III). It is safe and effective to use repaglinide in elderly patients with mild or moderate renal impairment.
简介: [摘要 ]目的 研究分析瑞格列奈治疗老年 2型糖尿病合并糖尿病肾病(Ⅲ期)的临床效果。方法 此次研究的对象是选取 2018年 7月~ 2019年 12月于我院就诊的年龄≥ 60岁的 2型糖尿病合并糖尿病肾病(Ⅲ期)患者 200例,将其临床资料进行回顾性分析,并随机分为两组,瑞格列奈组( A组, 100例)和门冬胰岛素 30R组( B组, 100例),疗程 3个月,以空腹血糖( FPG) <7.0 mmol/L,餐后 2 h血糖( 2 hPG) <10.0 mmol/L为治疗目标;将血糖 <3.9 mmol/L定义为低血糖事件。记录治疗前后两组 FPG、 2 hPG、糖化血红蛋白( HbA1c)、尿微量清蛋白、肌酐( Cr)水平,低血糖发生率及血生化指标的变化,比较两种方法在降糖效果及安全性方面的差异。结果 两组患者治疗 3个月后 FPG、 2 hPG及 HbA1c、 Cr水平均明显下降,与治疗前比较,差异有统计学意义( P<0.05); A组低血糖发生率明显低于 B组,差异有统计学意义( P<0.05)。结论 瑞格列奈治疗年龄≥ 60岁的 2型糖尿病合并糖尿病肾病(Ⅲ期)患者,能有效控制血糖,降低低血糖发生率,且对肾功能无影响。轻、中度肾功能损害的老年患者应用瑞格列奈是安全、有效的。 [关键词 ]瑞格列奈;糖尿病肾病;老年患者;临床效果 [Abstract] Objective To study and analyze the clinical effect of repaglinide in the treatment of elderly patients with type 2 diabetes mellitus complicated with diabetic nephropathy (stage III). Methods from July 2018 to December 2019, 200 patients with type 2 diabetes mellitus complicated with diabetic nephropathy (stage III) were selected and randomly divided into two groups: repaglinide group (group A, 100 cases) and insulin aspart 30R group (group B, 100 cases). The course of treatment was 3 months, with fasting blood glucose (FPG) < 7.0 The treatment target was 2 h postprandial blood glucose (2 HPG) < 10.0 mmol / L; the hypoglycemia event was defined as blood glucose < 3.9 mmol / L. The levels of FPG, 2 HPG, HbA1c, urinary microalbumin, creatinine (CR), incidence of hypoglycemia and changes of blood biochemical indexes were recorded before and after treatment. The hypoglycemic effect and safety of the two methods were compared. Results the levels of FPG, 2 HPG, HbA1c and Cr in the two groups were significantly decreased after 3 months of treatment (P < 0.05); the incidence of hypoglycemia in group A was significantly lower than that in group B (P < 0.05). Conclusion repaglinide can effectively control blood glucose, reduce the incidence of hypoglycemia, and has no effect on renal function in patients with type 2 diabetes mellitus complicated with diabetic nephropathy (stage III) over 60 years old. It is safe and effective to use repaglinide in elderly patients with mild or moderate renal impairment.
简介:【摘要】目的:研究糖尿病专科护理门诊在 2型糖尿病轻度认知障碍患者中的应用价值 。方法:选择在2018年 7 月至 2019年
简介:【摘要】 目的:分析评估在肥胖2型糖尿病合并糖尿病肾病患者析治疗中应用三仁汤治疗的临床效果。方法:随机筛选我医院接收的80例肥胖2型糖尿病肾病患者,将其通过随机数字表法分成观察与对照两组,组间人数有40例,对照组患者给予临床常规西药治疗方案,观察组患者在西药治疗基础上添加中药三仁汤,详细对比两组最终取得的治疗效果。结果:治疗后与对照组各指标结果比较发现,观察组患者的血脂、血糖和肾功能各项指标均得到良好改善,两组指标对比差值有统计学意义(P<0.05)。结论:对肥胖2型糖尿病肾病患者治疗中添加中药三仁汤,可有效提高临床治疗效果,及时改善患者的血脂水平,提升血糖控制效果,减轻肾功能损伤程度。