简介:目的:研究2型糖尿病患者糖尿病性视网膜病变(diabeticretinopathy,DR)与干眼的相关性。方法:选取2015-08/2017-02于我院眼科门诊就诊的干眼患者资料,其中2型糖尿病无DR患者50例100眼,合并非增殖性视网膜病变者(nonproliferativediabeticretinopathy,NPDR)50例100眼、合并增殖性视网膜病变者(proliferativediabeticretinopathy,PDR)50例100眼,非糖尿病的干眼患者50眼作为对照组。分别行眼表疾病指数(ocularsurfacediseaseindex,OSDI)问卷、泪液分泌试验(SchirmerItest,SIt)、泪膜破裂时间(break-uptime,BUT)和角膜荧光染色(fluoresceinstaining,FL)检查。比较三组糖尿病患者干眼的患病率及各组干眼程度的差异性。结果:2型糖尿病患者中无DR眼、合并NPDR眼、合并PDR眼的干眼患病率分别为:44%、51%、59%。无DR干眼患者与对照组干眼程度、OSDI、SIt、BUT、FL差异均无统计学意义(P>0.05)。NPDR干眼患者较无DR干眼患者干眼程度更严重,OSDI、SIt、BUT、FL差异均有统计学意义(P<0.05);PDR干眼患者较NPDR干眼患者干眼程度更严重,SIt、BUT、FL差异均有统计学意义(P<0.05),但OSDI评分低,与无DR干眼患者差异无统计学意义(P>0.05)。结论:2型糖尿病患者随着DR的发生与进展,干眼的患病率增加,干眼的严重程度也增加,但严重DR患者眼表不适症状可能减轻。
简介:目的:探讨眼眶IgG4相关疾病(IgG4-RD)的临床病理特点。方法:收集整理23例35眼眼眶IgG4-RD患者的临床病理资料,对其进行组织学和免疫组织化学观察,总结其临床和病理特点。结果:眼眶IgG4-RD患者23例35眼,其中男8例9眼,女15例26眼,年龄28-72(平均52.1)岁。19例30眼来源于泪腺,4例5眼来源于眶内其他部位。以泪腺区肿胀或眼球突出就诊。单侧11例,双侧12例。病程1mo-10a,平均27mo。1例1眼6mo后复发。大体:灰白色结节状肿物,泪腺表面有很薄的纤维膜包绕。组织学特点:泪腺腺泡、导管组织严重萎缩甚至消失,被大量密集的淋巴细胞、浆细胞及淋巴滤泡替代,伴有不同程度的纤维化。免疫组织化学染色:23例35眼IgG4阳性浆细胞均〉50个/HPF,IgG4/IgG阳性浆细胞比值〉40%。结论:眼眶IgG4-RD主要发生于泪腺组织,通过组织学特点和免疫组织化学IgG4的表达可明确诊断。IgG4-RD应早期筛查、预防和治疗。
简介:目的评价两种显微手术方法吻合泪小管断裂的效果。方法在手术显微镜下直接找出泪小管的断端,按手术方式不同分为两组,即麻醉导管单路插管吻合组(30眼)和硅胶管双路环行插管吻合组(37眼)。结果所有病例均在手术显微镜下直接找到鼻侧泪小管断端并且一次手术成功吻合泪小管,随访6月~31月(平均11.5月),麻醉导管单路插管术30眼,治愈24例,好转3眼,失败3眼,治愈率80%;硅胶管双路环行插管术37眼,治愈32眼,好转3眼,失败2眼,治愈率86.5%。结论应用显微外科技术可明显提高治疗泪小管断裂的临床效果;硅胶管双路环行置入法是理想的治疗泪小管断裂的方法。
简介:AIM:Toreporttheeffectivenessandsafetyofprimary23-Gauge(G)vitreoretinalsurgeryforrhegmatogenousretinaldetachment(RRD).·METHODS:Inthisretrospectivestudy,49eyesof49consecutivepatientswhounderwentprimary23-Gtransconjunctivalsuturelessvitrectomy(TSV)forRRDbetweenJanuary2007andJuly2009atourinstitutionwereevaluated.·RESULTS:Meanfollow-uptimewas8.9±7.7months(1-28months).Retinalreattachmentwasachievedwithasingleoperationin47(95.9%)of49eyes.Intwoeyes(4.1%),retinalredetachmentduetonewbreakswassuccessfullytreatedwithreoperationusingthe23-GTSVsystem.MeanlogMARvisualacuitywas2.01±0.47preoperativelyand1.3±0.5postoperatively(P<0.001,Pairedt-test).Meanpreoperativeintraocularpressure(IOP)was14.1±2.8mmHg.MeanpostoperativeIOPwas12.3±3.6mmHgat1day,13.1±2.1mmHgat1week,14.3±2.2mmHgat1month.Iatrogenicperipheralretinalbreakwasobservedin1eye(2.0%)intraoperatively.Nosutureswererequiredtoclosethescleralorconjunctivalopenings,andnoeyesrequiredconvertionofsurgeryto20-Gvitrectomy.·CONCLUSION:Primary23-GTSVsystemwasobservedtobeeffectiveandsafeinthetreatmentofRRD.
简介:目的探讨化脓性泪小管炎的诊断及治疗方法。方法回顾性分析2008年1月至2015年6月在我院收治的28例化脓性泪小管炎确诊患者。把他们分为4组。第1组单纯泪小管炎,冲洗泪道有液体进入鼻口腔。第2组泪小管炎合并泪小管阻塞。第3组泪小管炎合并慢性泪囊炎但不合并泪小管阻塞。第4组泪小管炎合并慢性泪囊炎及泪小管阻塞。所有组用聚维酮碘结膜囊冲洗及泪小管灌洗,同时泪小管中用妥布霉素冲洗并注入盐酸左氧氟沙星眼用凝胶,眼局部给予妥布霉素地塞米松滴眼液点眼,脓性分泌物减轻后第1组给予保守治疗;第2组给予泪小管切开术。第3组给予泪囊鼻腔吻合术。第4组给予泪囊鼻腔吻合+泪小管切开术,术后同术前保守治疗。结果所有组泪小管炎全部治愈。但第2及第4组各有1例泪小管阻塞。结论聚维酮碘结膜囊冲洗及泪小管灌洗,泪小管中用妥布霉素冲洗并注入盐酸左氧氟沙星眼用凝胶,眼局部给予妥布霉素地塞米松滴眼液点眼,或在此基础上合并泪小管切开和/或泪囊鼻腔吻合术,简单方便,疗效确切。
简介:目的探讨复方樟柳碱对视网膜挫伤的临床效果。方法将42例视网膜挫伤患者根据入院时间分为两组,06年初到08年底18例作为对照组,09年初至2011年10月24例为试验组。两组均使用ATP40mg+辅酶A100单位+肌苷200mg组成的能量合剂和250ml丹参注射液,试验组加用复方樟柳碱注射液2ml颞浅动脉旁注射,观察两组的疗效。结果试验组24例,16例治愈,6例好转,2例无效,治愈与好转率之和为91.67%。对照组18例,8例治愈,3例好转,7例无效,治愈与好转率之和为61.11%。两组治愈和好转之和比较,差异有显著意义(X^2=4.0332,P〈0.05)。结论复方樟柳碱对于视网膜挫伤效果明显。
简介:AIM:Todescribethecharacteristicsofmodulationtransferfunction(MTF)ofanteriorcornealsurface,andobtainthethenormalreferencerangeofMTFatdifferentspatialfrequenciesandopticalzonesoftheanteriorcornealsurfaceinmyopes.·METHODS:Fourhundredeyesfrom200patientswereexaminedunderSIRIUScornealtopographysystem.PhoenisanalysissoftwarewasappliedtosimulatetheMTFcurvesofanteriorcornealsurfaceatverticalandhorizontalmeridiansatthe3,4,5,6,7mmopticalzonesofcornea.TheMTFvaluesatspatialfrequenciesof5,10,15,20,25,30,35,40,45,50,55and60cycles/degree(c/d)wereselected.·RESULTS:TheMTFcurveofanteriorcornealsurfacedecreasedrapidlyfromlowtointermediatefrequency(0-15cpd)atvariousopticalzonesofcornea,thevaluedecreasedto0slowlyathigherfrequency(>15cpd).Withtheincreaseoftheopticalzonesofcornea,MTFcurvedecreasedgradually.3)Intherangeof3mm-6mmopticalzonesofthecornea,theMTFvaluesmeasuredathorizontalmeridianweregreaterthanthecorrespondingvaluesathorizontalmeridianofeachspatialfrequency,thedifferencewasstatisticallysignificant(P<0.05).At7mmopticalzonesofcornea,theMTFvaluesmeasuredathorizontalmeridianwerelessthanthecorrespondingvaluesatverticalmeridianat10-60spatialfrequencies(cpd),andthedifferencewasstatisticallysignificantin25,30,35,40,45,50cpd(P<0.05).·CONCLUSION:MTFcanbeusedtodescribetheimagingqualityofopticalsystemsatanteriorcornealsurfaceobjectivelyindetail.
简介:研究显示,趋化因子受体3(chemokinereceptor3,CCR3)在眼部主要分布于视网膜色素上皮细胞中,亦表达于脉络膜血管内皮细胞(CECs)中。CCR3的特异性高表达在湿性年龄相关性黄斑变性(age-relatedmaculardegeneration,AMD)中被发现,并被证明在湿性AMD患者脉络膜新生血管(choroidalneovascularization,CNV)的产生中具有重要作用。本文拟对CCR3的结构、功能、目前研究存在的问题及未来的研究方向做一综述。相信随着对CCR3研究的进一步深入,必将帮助我们寻找到一种湿性AMD诊断和治疗的新方法,同时也可能对其它CNV性疾病研究以及新的抗CNV药物提供重要参考。
简介:AIM:ToIntroduceanewspecializedvisualacuitychartforamblyopicchildrenaged3-5yearsoldanditsclinicalapplications.METHODS:ThenewvisualacuitychartandnotationsweredesignedbasedonWeber-Fechnerlaw.Theoptotypeswereredagainstawhitebackgroundandwerespeciallyshapedfourbasicgeometricsymbols:circle,square,triangle,andcross.Aregulargeometricprogressionoftheoptotypesizesanddistributionwasemployedtoarrangein14lines.Theprogressionrateoftheoptotypesizebetweentwolineswas1.2589andthetestingdistancewas3m.VisualacuityscorecouldberecordedaslogMARnotationordecimalnotation.Agestratifieddiagnosticcriteriaforamblyopiaestablishedbyconsensusstatementondiagnosisofamblyopia(2011)amongmembersoftheStrabismusandPediatricOphthalmologyGroup,OphthalmologySociety,ChineseMedicalAssociation(SPOGOSCMA)wereillustratedinthenewvisualacuitychart.RESULTS:Whenassessingvisualacuityinchildrenaged3-5yearsold,thisnewvisualacuitychartthatconsistsoffoursymmetricalshapes(triangle,square,cross,andcircle)overcameaninabilitytorecognizethelettersofthealphabetanddifficultiesindesignatingthedirectionofblackabstractsymbolssuchasthetumbling’E’orLandolt’C’,whichthesubjectswerepronetoloseinterestin.Thevisualacuityscoremayberecordedindifferentnotations:decimalacuityandlogMAR.Thesetwonotationscanbeeasilyconvertedeachotherintheneweyechart.Themeasurementsofthisnewchartnotonlyshowedasignificantcorrelationandagoodconsistencywiththeinternationalstandardlogarithmicvisualacuitychart(r=0.932,P<0.01),butalsoindicatedahightest-retestreliability(89%ofretestscoreswerewithin0.1logMARunitsoftheinitialtestscore).CONCLUSION:Theresultsofthisstudysupportthevalidityandreliabilityofdistancevisualacuitymeasurementsusingtheneweyechartinchildrenaged3to5yearsoverawiderangeofvisualacuities,andtheneweyechartisgreatforearl