简介:【摘要】目的:对冠心病心力衰竭患者实施益气通脉汤+酚妥拉明联合治疗,并观察该用药方案对其心室重构的影响和作用。方法:回顾性分析我院76例冠心病心力衰竭患者的临床资料,以治疗方式的不同将其划分为两组,对照组(n=38例,行常规西医治疗)和研究组(n=38,在常规西医治疗的基础上加用益气通脉汤与酚妥拉明)。密切观察2组患者在应用不同治疗方式前后的心功能相关指标的变化情况。结果:治疗后两组的心功能相关指标均明显改善,且研究组的IVST、LVEDD皆低于对照组,LVEF高于对照组,差异存在可比性(P<0.05)。结论:冠心病心力衰竭患者经益气通脉汤联合酚妥拉明治疗可取得确切效果,既能恢复患者的心功能,又可以改善心室重构,值得继续推广和使用。
简介: 摘要:目的 探讨联合应用培哚普利和坎地沙坦治疗慢性充血性心力衰竭 (CHF)的疗效及对心室重构的影响。方法将 160例 CHF患者随机分为对照组、培哚普利组、坎地沙坦组和联合治疗组,每组 40例,共治疗 16周。对照组采用常规治疗;培哚普利组在常规治疗基础上加用培哚普利治疗;坎地沙坦组在常规治疗基础上加用坎地沙坦治疗;联合治疗组在常规治疗基础上加用培哚普利、坎地沙坦治疗。治疗中,观察评价各组患者左心功能和左心室形态[左室射血分数( LVEF)、左室收缩末期内径 (LVESD)、左室后壁厚度 (LVPWT)、左室舒张末期内径 (LVEDD)、室间隔厚度 (IVST)]、心肌重塑相关细胞因子[白介素 6( IL6)、基质金属蛋白酶( MMP) 3、 MMP 9]以及药物治疗安全性。结果联合治疗组总有效率为 100.0%高于培哚普利组( 90.0%)、坎地沙坦组( 87.5%)、对照组( 65.0%),差异有统计学意义( P< 0.05)。与对照组比较,其他 3组 LVESD、 LVEDD、 IVST、 LVPWT与 IL6、 MMP3、 MMP9均显著下降, LVEF显著升高,差异有统计学意义( P< 0.05),且联合治疗组各上述指标均优于培哚普利组和坎地沙坦组( P< 0.05)。 4组治疗安全性差异无统计学意义( P> 0.05)。结论培哚普利与坎地沙坦均能够改善患者心功能的改善,抑制心室重塑 ,且两者联合治疗疗效更好。 关键词:慢性心力衰竭;培哚普利;坎地沙坦;心室重塑 ABSTRACT: Objective To investigate the efficacy of perindopril and candesartan in the treatment of chronic congestive heart failure (CHF) and its effect on ventricular remodeling. Methods 160 patients with CHF were randomly divided into control group, perindopril group, candesartan group and combined treatment group, 40 cases in each group for 16 weeks. The control group was treated with routine treatment; the perindopril group was treated with perindopril on the basis of routine treatment; the Candesartan group was treated with candesartan on the basis of routine treatment; the combined treatment group was treated with perindopril and candesartan on the basis of routine treatment. During the treatment, left ventricular function and left ventricular morphology [left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), left ventricular end diastolic diameter (LVEDD), interventricular septal thickness (IVST)], cytokines related to myocardial remodeling [interleukin 6 (IL6), matrix metalloproteinase (MMP) were observed and evaluated. (MMP) 3, MMP 9 and drug safety. Results The total effective rate of combined treatment group was 100.0% higher than that of perindopril group (90.0%), candesartan group (87.5%) and control group (65.0%). The difference was statistically significant (P < 0.05). Compared with the control group, LVESD, LVEDD, IVST, LVPWT, IL6, MMP3 and MMP9 in the other three groups decreased significantly, and LVEF increased significantly (P < 0.05), and the above indexes in the combined treatment group were better than those in perindopril group and candesartan group (P < 0.05). There was no significant difference in treatment safety between the four groups (P > 0.05). Conclusion Both perindopril and candesartan can improve cardiac function and inhibit ventricular remodeling, and the combined treatment of perindopril and candesartan is more effective.
简介:摘要实战化救护技能模拟训练是以作战任务为牵引,实战环境为背景,以提高战场救护能力为根本而进行贴近实战的训练。针对日常训练中护理人员缺乏实战经验,通过构建战场急救、转运后送到野战医疗所等实战化训练场景,使受训人员救护技能模拟训练更贴近实战,从而在战时的恶劣条件与环境下确保救护质量。
简介:摘要:本文探讨了为什么需要为医学实践提供理论基础,该理论应包含的内容以及应如何教授它。同时还为教师何实习医生提供了临床学习的观点及方法。
简介:摘要目的对腹部罕见疑难病例超声诊断的思考。方法将本院2017年1月-2017年10月收治的急性胰腺炎患者64例作为本身研究的的对象,其中对照组(n=32)按照传统方式检测,参照组(n=32)进行腹部超声检查,对两组检测出的胰腺肿大、形态改变、实质改变和腹腔积液等数据进行对比,并和剖腹后的病理切片检测结果进行比较。结果对急性胰腺炎进行腹部超声检测后,实验组胰腺肿大的准确率并没有显著性差异,但在胰腺体形态改变、实质改变和腹腔积液方面的检测准确率方面有着显著性差异。结论腹部超声检测技术在实际临床医学检测急性胰腺炎的诊断上有着良好的诊断价值,是值得在临床医学中进行推广和使用的。