简介：研究被进行在C在碱新陈代谢的变化上调查高温的效果。升起我们在福雷斯特植物生态学的关键实验室的幼苗，东北林地大学，Heilongiang，中国。60-day-oldC。玫瑰我们有34片叶子的幼苗与30°C的温度在房间被孵化；为短期的热的40°C震惊实验；20°C，25°C；为长期的实验的35°C。vindoline的内容，catharanthine，vinblastine；在C的长春新碱。玫瑰我们离开；根在短术语(16h)在不同温度被检查；长期(116d)。结果在短期的热吃惊下面显示出那，vindoline的内容，catharanthine；在幼苗的叶子的vinblastine在40°C是更高的与比在30°C，但是在6h处理以后，vindoline的内容；在二温度下面的catharanthine来到了一样的水平。Catharanthine只在C被散布。升起我们根；它的内容被40%在40°C在二小时孵化以后增加，当在30°C孵化慢慢地增加了时；在6h到达了最高的价值。在长期的实验，monomeric碱catharanthine的集中；vindoline比在25°C在20°C是更高的；在35°C的条件下面有锋利的增加。当时为二聚的碱，越高，看了那温度，vinblastine内容的山峰价值越earlier出现。长春新碱有连续改进；达到了0.027mg·g[1]在在比处于另外的条件的那些高的35°C状况下面的第16白天。高温能在C支持不同的碱的累积，这被结束。升起我们；累积特征是高度与处理时间有关。

简介：UsingtheexampleofthePHELIXhigh-energyshortpulselaserwediscussthetechnicalpreconditionstoinvestigateionaccelerationwithsubmicrometerthicktargets.Weshowhowthetemporalcontrastofthissystemwasimprovedtopreventpre-ionizationofsuchtargetsonthenanosecondtimescale.Furthermoretheinfluenceoftypicalfluctuationsoruncertaintiesoftheon-targetintensityonionaccelerationexperimentsisdiscussed.Wereporthowtheseuncertaintieswerereducedbyimprovingtheassessmentandcontroloftheon-shotintensityandbyoptimizingthepositioningofthetargetintothefocalplane.Finallywereportonexperimentalresultsshowingmaximumprotonenergiesinexcessof85MeVforionaccelerationviathetargetnormalsheathaccelerationmechanismusingtargetthicknessesontheorderofonemicrometer.

简介：Inthispaperwestudytheexistenceoflimitcycleforcubicsystem（E）3,ofKolmogorovtypewithaconicalgebraictrajectoryF2（x,y）=ax2+2bxy+cy2+dx+ey+f=0Ithasbeenprovedinmyformerpapersthat（E）3doesn’thaveanylimitcycleonthewholeplaneIfb2-ac≠0,Nowweareinvestigatingthecasewhereb2-ac=0.Weprovethesufficientandnecessaryformula（2）or（13）witbwhich（E）3musthaveaparabolictrajectoryF2（x,y）=0.Thentherewillnotbeanylimitcycleonthefullplane.Onthebasisofthis,weconclude:ThecubicsystemofKolmogorovtypewithanon-degeneratedquadraticalgebraictrajectoryonthewholeplanehasnolimitcycle.

简介：InordertodiscussthecontentdistributionsandfluxesofheavymetalsinsuspendedmattersduringatidalcycleintheturbiditymaximumaroundtheChangjiang(Yangtze)Estuary,thecontentsofheavymetals(Zn,Pb,Cd,CoandNi)havebeenanalyzed.Duringatidalcycle,theaveragecontentsofheavymetalsareintheorderofZn>Ni>Pb>CoàCd.Theaveragecontentsinebbtidearegenerallyhigherthanthatinfloodtide.However,attheinshoreSta.11,influencedbythecontaminationfromthenearbywastetreatmentplant,theaveragecontentsofZnandNiinfloodtidearehigherthanthoseinebbtideandattheoffshoreSta.10,thecontentofCdinfloodtidehigherthanthatinebbtideduetomarine-derivedmaterials.Thefiveheavymetals,mainlyterrigenous,aretransportedtowardseast-northeast,andsettledownwithsuspendedmattersintheareabetweenSta.11andSta.10.Influencedbymarine-derivedmaterials,thefluxvalueofCddoesnotaltersignificantlywithobviouslychanginginfluxdirectiontowardsnorthwest.Thesourceofheavymetals,thesalinityofwaterandtheconcentrationofsuspendedmattersarethemainfactorscontrollingthecontentdistributionsofheavymetalsduringatidalcycle.Thereisapositivecorrelationbetweenthecontentsofheavymetals(Zn,Pb,CoandNi)andthesalinityofwater,whiletheoppositecorrelationbetweenthecontentsandtheconcentrationsofsuspendedmatters.Becauseofmarine-derivedmaterials,thecontentofCdisnotcorrelatedwiththeconcentrationofsuspendedmattersandthesalinityofwater.

简介：Thepreliminarydesignofamulti-barrelspelletinjectorwithcyclerefrigeratorasanadvancedplasma-fuellingtoolforHL-2Atokamakhasbeenproposed.Thedesignaimsatprecisetemperaturecontrol,easyoperation.withhighreliabilityandhighflexibility.GM-cyclerefrigeratorandpipe-gunStructurehavebeenemployedtoproduce25pelletsin25gunbarrelssimultaneouslyandthedesignaims.havebeenaccomplished.Primedesignprinciple,engineeringparameters,structureandlayoutofthecryostatcomponentsaswellascalculationofheatloadforthecryostatarepresented.

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简介：一些重要诊断特征为一模型物理背景在模型精力运输，变换，和周期被反映。诊断大气的精力周期是向理解并且改善数字模型的一个合适的方法。在这研究，混合时空域精力周期的明确的表达被计算，在大气的精力以内的静止、短暂的波浪的角色全球地区性的吸收和预言系统(葡萄)模型骑车被诊断并且与为2011年7月的NCEP分析数据相比。精力周期的带平均数的部件的贡献被调查解释数字模型的表演。

简介：InthepaperweuseanonsingularfunctionasanelementaryrecurringfunctiontogenerateaportiongraphG(f)onr-arydeBruijn-goodgraph,defineorderfunctiononG(f),constructassociatedstatematrixsets,mergecyclesbyinterchangingsuccessorsofassociatedstatestoformafulllengthcycle-theHamiltoncycleonr-arydeBruijn-goodgraph(ther-aryd(?)Bruijnsequence).

简介：基于镍的单个水晶superalloy与的低周期的疲劳(LCF)行为[001]取向在T0掳C的中间的温度和T0+的更高的温度被学习在10的经常的低紧张率下面的250掳C?3s?1在周围的空气。superalloy展出了依赖于温度并且使用紧张振幅的周期的紧张压缩不对称现象。破裂表面上的分析证明表面和表面下的扔micropores是主要裂缝开始地点。内部Ta富有的碳化物经常在所有标本被观察。骨折的二种不同类型被frac-togaphy建议。一种类型被模式描绘--我与一台用显微镜裂开在T0+的不平的表面250掳C。而在更低的温度T0C的另外的类型赞成了中的一个或几八面{111}飞机，与正常模式相对照--我生长模式典型地在低装载观察了频率(几Hz)。为二个裂开的模式的失败机制纬鈥?正在砍在T0+在矩阵和纬/纬鈥?接口在T0掳C和裂开的反对ned和矩阵猛抛250掳C。

简介：Inaccordancewithnonperturbativequantumscatteringtheory,weinvestigatephotoelectronangulardistributions(PADs)fromabove-thresholddetachment(ATD)ofnegativeionsirradiatedbycircularlypolarizedfew-cyclelaserfields.Electronsejectedonthepolarizationplanedemonstratedistinctanisotropiesinangulardistributionswhichdistinctlyvarywiththecarrier-envelope(CE)phase.Theanisotropyiscausedbyinterferencebetweentransitionchannels;italsodependsstronglyonlaserfrequency,pulseduration,andkineticenergyofphotoelectrons.Optimalemissionofphotoelectrons,whichvarieswithCEphase,makesitpossibletocontrolphotoelectronmotion.

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简介：Veryhighcyclefatigue(VHCF)propertiesofalowtemperaturetemperingbearingsteelGCr15withsmoothandhole-defectspecimensarestudiedbyemployingarotarybendingtestmachinewithfrequencyof52.5Hz.Bothsmoothandhole-defectspecimensbreakinVHCFregimewithsomedifferenceinfatiguecrackinitiation.Forsmoothspecimens,afinegranulararea(FGA)isobservednearthegrainboundaryinthefracturesurfaceofthespecimensbrokenafter10~7cycles.ButnoFGAisobservedinthehole-defectspecimensbrokeninVHCFregime,andtheVHCFcrackdoesnotinitiatefromthesmallholeatthesurfaceasitdoesatloworhighcyclefatigueregime.InternalstressisemployedtoexplaintheVHCFbehaviorofthesetwotypesofspecimens.Atlast,anadvanceddislocationmodelbasedonTanakaandMuramodelisproposedtoillustratetheinternalstressprocessandtopredictfatiguecrackinitiationlifewithFGAobservedinthefractureregion.

简介：MicroRNAs是否定地在post-transcriptional水平调制基因表示的短规章的RNA，并且深深地涉及癌症的几种类型的致病。调查特定的miRNAs和他们的目标基因是否参予喉的癌的分子的致病，oligonucleotidemicroarrays被用来与正常纸巾相比在喉的癌纸巾估计microRNAs和mRNAs的微分表示侧面。oncogenicmiRNA，microRNA-21(miR-21)，被发现是在喉的癌纸巾的upregulated。由特定的antisenseoligonucleotides的miR-21击倒而miR-21的overexpression提高了细胞的生长活动，由殖民地形成试金检测了，禁止了HEp-2细胞的增长潜力。miR-21抑制引起的房间数字减小由于G1-S阶段转变的控制的损失，而不是apoptosis的显著增加。随后，miR-21的新目标基因，BTG2，被发现是在喉的癌纸巾的downregulated。BTG2被知道充当一个平底锅房间周期管理者和肿瘤suppressor。这些调查结果显示miR-21的那异常表情可以由维持BTG2的底层贡献喉的癌的恶意的显型。oncogenicmiR-21和它的目标基因的鉴定，BTG2，为癌症诊断和治疗在喉的癌是潜在地珍贵的。

简介：Anovelandsimplefibergratingsensorbasedonhigh-duty-cyclesamplefiberBragggratingisproposedanddemonstratedexperimentally.Thistypeofsensorcanmeasurestrainandtemperaturesimultaneouslywithmeritsoflowcost,highsensitivityandimmunitytoelectro-magneticinterference.Thesensorhasanaccuracyof20μεand0.8℃overastrainrangeof500～1500μεandatemperaturerangeof5～36℃underexperimentalconditions.

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简介：NCAR社区陆地模型(CLM3)的一缺乏由于高建模的不现实的联盟者甚至在在一个北方的草地地点上的冬季的中间是模仿的雪的消失向下狂暴的流动。这被垂直的雪埋葬部分的不恰当的处理为短植被引起。为短植被的新雪埋葬部分明确的表达然后被建议并且验证了在situ观察使用。在CLM3的这修正大部分移开不现实的表面狂暴的流动，导致更合理的雪融化过程，并且改进雪水等价物(SWE)模拟。而且，全球离线的模拟证明理智、潜伏的建议明确的表达减少在雪期间象扎根的温度一样加热流动在短植被上融化季节主导的区域。相应地，SWE被提高，导致在一样的时期期间的导致snowmelt的流量的增加。而且，敏感测试显示这些改进在建议明确的表达对准确功能的形式或参数价值感觉迟钝。

简介：AbstractBackground:Obesity and insulin resistance (IR) are common features of polycystic ovary syndrome (PCOS). Metformin (MET) increases insulin sensitivity, but it is associated with unsatisfactory weight loss. The glucagon-like peptide-1 receptor agonist exenatide has been shown to reduce weight and IR in patients with diabetes. This study aimed to explore the therapeutic effects of exenatide once-weekly (QW) combined with MET on body weight, as well as metabolic and endocrinological parameters in overweight/obese women with PCOS.Methods:Fifty overweight/obese women with PCOS diagnosed via the Rotterdam criteria were randomized to one of two treatment groups: MET (500 mg three times a day [TID]) or combination treatment (COM) (MET 500 mg TID, exenatide 2 mg QW) for 12 weeks. The primary outcomes were anthropometric changes associated with obesity, and the secondary outcomes included changes in reproductive hormone levels, glucose and lipid metabolism, and C-reactive protein.Results:Forty (80%) patients completed the study. COM therapy was superior to MET monotherapy in reducing weight (P = 0.045), body mass index (BMI) (P = 0.041), and waist circumference (P = 0.023). Patients in the COM group on an average lost 3.8 ± 2.4 kg compared with 2.1 ± 3.0 kg in the MET group. In the COM group, BMI and waist circumference decreased by 1.4 ± 0.87 kg/m2 and 4.63 ± 4.42 cm compared with 0.77 ± 1.17 kg/m2 and 1.72 ± 3.07 cm in the MET group, respectively. Moreover, levels of fasting glucose, oral glucose tolerance test (OGTT) 2-h glucose, and OGTT 2-h insulin were significantly lower with COM therapy than with MET (P < 0.050). Mild and moderate gastrointestinal reactions were the most common adverse events in both groups.Conclusions:COM therapy was more effective than MET alone in reducing body weight, BMI, and waist circumference, and improving insulin sensitivity in overweight/obese women with PCOS, with acceptable short-term side effects.Trial registration:ClinicalTrials.gov, NCT04029272. https://clinicaltrials.gov/ct2/show/NCT04029272

简介：ThecreepbehaviorofAI2O3.SiO2fiberreinforcedZL109compositeshasbeeninvestigatedatfourtemperaturesrangingfrom553to623K.Theresultsshowhighstressexponentandhighapparentcreepactivationenergy.Agoodcorrelationbetweenthenormalizedcreeprateandnormalizedeffectivestressmeansthatthetruestressexponentofminimumcreepstrainrateofthecompositeisverycloseto5,andtheminimumcreepstrainrateismatrixlatticediffusioncontrolled.Thethresholdstressdecreaseswithincreasingtemperaturelinearlyanddisappearsatatemperaturecloseto623K.Itisassumedthatthelongrangeinternalbackstressesgeneratedincreepreducetheloadtransfertofibersandtheinteractionbetweendislocationsandstrengtheningprecipitatesdecreasesathightemperature.Atahightemperaturewherethelongrangeinternalbackstressesisveryclosetotheappliedstress,thethresholdstressdisappears.

简介：ADRNN(diagonalrecurrentneuralnetwork)anditsRPE(recurrentpredictionerror)learningalgorithmareproposedinthispaper.UsingofthesimplestructureofDRNNcanreducethecapacityofcalculation.TheprincipleofRPElearningalgorithmistoadjustweightsalongthedirectionofGauss-Newton.Meanwhile,itisunnecessarytocalculatethesecondlocalderivativeandtheinversematrixes,whoseunbiasednessisproved.Withapplicationtotheextremelyshorttimepredictionoflargeshippitch,satisfactoryresultsareobtained.Predictioneffectofthisalgorithmiscomparedwiththatofauto-regressionandperiodicaldiagrammethod,andcomparisonresultsshowthattheproposedalgorithmisfeasible.