简介：Glioblastoma(GBM)isatypeoftumorthatishighlylethaldespitemaximaltherapy.Standardtherapeuticapproachesprovidemodestimprovementinprogression-freeandoverallsurvival,necessitatingtheinvestigationofnoveltherapies.Oncologictherapyhasrecentlyexperiencedarapidevolutiontoward'targetedtherapy',withdrugsdirectedagainstspecifictargetswhichplayessentialrolesintheproliferation,survival,andinvasivenessofGBMcells,includingnumerousmoleculesinvolvedinsignaltransductionpathways.Inhibitorsofthesemoleculeshavealreadyenteredorareundergoingclinicaltrials.However,significantchallengesintheirdevelopmentremainbecauseseveralpreclinicalandclinicalstudiespresentconflictingresults.Inthisarticle,wewillprovideanup-to-datereviewofthecurrenttargetedtherapiesinGBM.

简介：Differentapproachesfortreatinglungcancerhavebeendevelopedovertime,includingchemotherapy,radiotherapyandtargetedtherapiesagainstactivatingmutations.Lately,betterunderstandingoftheroleoftheimmunologicalsystemintumorcontrolhasopenedmultipledoorstoimplementdifferentstrategiestoenhanceimmuneresponseagainstcancercells.Itisknownthattumorcellseludeimmuneresponsebyseveralmechanisms.Thedevelopmentofmonoclonalantibodiesagainstthecheckpointinhibitorprogrammedcelldeathprotein1(PD-1)anditsligand(PD-L1),onTcells,hasledtohighactivityincancerpatientswithlonglastingresponses.Nivolumab,anantiPD-1inhibitor,hasbeenrecentlyapprovedforthetreatmentofsquamouscelllungcancerpatients,giventhesurvivaladvantagedemonstratedinaphaseIIItrial.Pembrolizumab,anotherantiPD-1antibody,hasreceivedFDAbreakthroughtherapydesignationfortreatmentofnon-smallcelllungcancer(NSCLC),supportedbydatafromaphaseItrial.ClinicaltrialswithantiPD-1/PD-L1antibodiesinNSCLChavedemonstratedverygoodtolerabilityandactivity,withresponseratesaround20%andamediandurationofresponseof18months.

简介：AIM:ToevaluatetheefficacyandsafetyofN-butyl-2-cyanoacrylateintreatingacutebleedingofgastricvaricesinchildren.METHODS:Theretrospectivestudyincluded21childrenwith47episodesofactivegastricvaricealbleedingwhoweretreatedbyendoscopicinjectionofN-butyl-2-cyanoacrylateatAsanMedicalCenterChildren’sHospitalbetweenAugust2004andDecember2011.Toreducetheriskofembolism,eachinjectionconsistedof0.1-0.5mLof0.5mLN-butyl-2-cyanoacrylatedilutedwith0.5or0.8mLLipiodol.Theprimaryoutcomewasincidenceofhemostasisaftervaricealobliterationandthesecondaryoutcomewascomplicationoftheprocedure.RESULTS:The21patientsexperienced47episodesofactivegastricvaricealbleeding,includingrebleeding,forwhichtheyreceivedatotalof52cyanoacrylateinjections.Following42bleedingepisodes,hemostasiswasachievedafteroneinjectionandfollowingfivebleedingepisodesitwasachievedaftertwoinjections.Themeanvolumeofeachsinglealiquotofcyanoacrylateinjectedwas0.3±0.1mL(range:0.1-0.5mL).Injectionachievedhemostasisin45of47(95.7%)episodesofacutegastricvaricealbleeding.Elevenpatients(52.4%)developedrebleedingevents,withthemeandurationofhemostasisbeing11.1±11.6mo(range:1.0-39.2mo).Notreatment-relatedcomplicationssuchasdistalembolismwerenotedwiththeexceptionofabdominalpaininonepatient(4.8%).Amongfourmortalities,onepatientdiedofvaricealrebleeding.CONCLUSION:Endoscopicvaricealobliterationusingasmallvolumeofaliquotswithrepeatedcyanoacrylateinjectionwasaneffectiveandsafeoptionforthetreatmentofgastricvaricesinchildren.

简介：StandardTherapyforHeartFailureUntilnowtheprincipalfocusofheartfailuretherapyhasbeenonthesympatheticnervoussystemandtherenin-angiotensinsystem.Betablockadecounterstheunwantedeffectsofcatecholaminesonthemyocardiumaswellasmoderatelyreducingafterload.Sinceangiotensinisavasoconstrictorandhassometoxiceffectonthemyocardium,bothcontributingtoheartfailure,inhibitionoftherenin–angiotensinsystemhasbeenlogicaltherapyforheartfailure.However,useofangiotensinconvertingenzyme(ACE)inhibitorsmayincreasebradykininlevels,whichareresponsibleforthecoughthatmaybeassociatedwiththeiruseaswellasangioedemathatmayresultfromthesamemedications.

简介：王朝的更迭不过是一种权力的褪去和另外一种权力的崛起。他们并不想参与到任何一种权力之中。他们历经世事,早已从先辈的妄想中冷静下来,如今,唯有那平静的生活能扣动他们的心弦。十三、鸭嘴龙记德里克王朝灭亡的消息传入禽龙米娜的耳朵里,那时候,她正悠闲地躺在地上,倾听夜晚的声音。她只说了一句:瞧,我们早知道死亡要来了!便继续闭上了眼睛。米娜上方的天是那种从未见过的美丽:在天际等待的最后一抹

简介：Triple-negativebreastcancer(TNBC)isdiagnosedmorefrequentlyinyoungerandpremenopausalwomenandishighlyprevalentinAfricanAmericanwomen.TNBCisatermderivedfromtumorsthatarecharacterizedbytheabsenceofER,PgR,andHER2.SopatientswithTNBCdonotbenefitfromhormonalortrastuzumab-basedtherapies.TNBCsarebiologicallyaggressive,althoughsomereportssuggestthattheyrespondtochemotherapybetterthanothertypesofbreastcancer,prognosisremainspoor.Thisisdueto:shorteneddisease-freeintervalintheadjuvantandneoadjuvantsettingandamoreaggressivecourseinthemetastaticsetting.

简介：Wearecurrentlyfacedwithanagingpopulation,whichisrapidlygrowingworldwide.Twothirdsofcanceroccursintheover65-yearagegroup.Societalconceptionsfromthepasthavecreatedageiststereotypes;oldageisassociatedwithfrailtyandtheelderlyareperceivedtobedestinedfordeteriorationandlossofindependence.Cancerwithintheelderlyisalsosubjecttothesestereotypes,withelderlycancerpatientsconsideredbysomenotaslikelytorecoverasyoungerpatientswithcancer.Wesummariseandreviewthecurrentconcernsregardingelderlymanagementandtreatmentsutilisedforthemanagementofoncologicaldiseaseintheelderly,anddiscusstheimpactofunder-treatmentwithinthispopulation.

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简介：干洗腿用双手紧抱一侧大腿，稍用力从大腿向下按摩，一直到足踝，然后再从踝部按摩至大腿根，用同样的方法按摩男一条腿，重复10～20遍，可使关节灵活、腿肌与步行能力增强，预防下肢静脉曲张、水肿及肌肉萎缩等。

简介：无主之地有人在城市花园的旁边种上了几十株棉花这是一件多么新奇的事从夏天到秋天，我看到棉花开花、结桃但一直不知道是什么人、出于什么目的种下的

简介：Bell’spalsyisacommonlyseencranialnervediseaseandcanresultincompromisedfacialappearanceandfunctions.Itsetiology,prognosisandtreatmentarestillbeingdebated.Thispaperisareviewofrecentdevelopmentintheunderstandingofetiology,diagnosisandnon-surgicaltreatmentofBell’spalsy.

简介：AIM:Toreviewpublishedclinicalstudiesexaminingtheeffectofnatamycininthetreatmentoffungalkeratitis.METHODS:WeselectedthepublicationsinCENTRAL,MEDLINE,EMBASE,CNKI,andCBM.Thisstudysystematicallyreviewedpublishedrandomizedcontrolledtrials(RCTs)thatcomparednatamycintootherantifungalagents,andconductedfeasibleMeta-analysisofefficacyresultsusingRevman5.2software.RESULTS:WeincludedseventrialswhichweremainlycarriedoutindevelopingcountriesofAsia,withfivetrialsconductedinIndia,oneeachinChinaandBangladesh.Atotalof804participantswererandomizedtofollowingcomparisons:2%econazoleversus5%natamycinshowedlittledifferenceintheeffectsoftreatmentoffungalkeratitis[RR=0.99,95%confidenceinterval(CI),0.8to1.21];chlorhexidinegluconateversus5%natamycinindicatedthattheresultsonhealingoftheulcerat21dwaslessconclusive(RR=0.77,95%CI,0.55to1.08;I2=0%);1%voriconazoleversus5%natamycinsuggestedthatnatamycintreatmentappearedtobesignificantlybetteroutcomesthanvoriconazole(regressioncoefficient=-0.18logMAR;95%CI,-0.30to-0.05;P=0.006),especiallyinFusariumcases(regressioncoefficient=-0.41logMAR;95%CI,-0.61to-0.20;P<0.001);natamycinversusfluconazoleshowedasignificantdifferenceincurerate(χ2=5.048,P<0.05)andnatamycingroupwasmoreeffectivethanfluconazoleinaverageperiodoftherapy(t=7.94,P<0.01).CONCLUSION:Natamycinwasapreferablechoiceinthetreatmentoffungalkeratitis,especiallyintheearlyperiodofFusariumcases.

简介：Polyethylenimine-polyL-lysinePEI-PLL共聚物经由PEI开始的L离氨酸N-carboxyanhydrideLysZ-NCA的戒指洞聚合被综合。有siRNA的PEI-PLL的complexation被粒子尺寸和希腊语的第六个字母潜力大小学习。流动cytometric分析和共焦的成像显示出它的优秀细胞内部的trafficking能力。PEI-PLL在vitro比商业PEI-25k显示了更高的基因silencing效率和更低的cytotoxicity。在antitumor学习，PEI-PLL进一步与siVEGF被相结合并且显然为CT26肿瘤模型的处理显示出肿瘤抑制效果。因此，PEI-PLL是在vivo的进一步的antitumor处理的一个有希望的siRNA搬运人候选人。

简介：Objective:Toreportasurgicalmethodforthetreatmentofpre-auricularfistulatolowerpost-operativerecurrencerate.Methods:Clinicaldataof187patientswithpre-auricularfistulawhounderwentenblocresectionattheAffiliatedHospitalofLuzhouMedicalCollegefromAugust2006toNovember2012wereretrospectivelyreviewed.FactorsthatmightaffecttheprognosisfollowingEnblocfistularesectionborderedbythesuperficialtemporalisfascia,helixperichondriumandauriculocephalicsulcuswereinvestigated.Results:Ofthe187patients,181achievedprimaryhealingand6endedupwithdelayedhealing.Duringthefollow-upperiod(onetosevenyears),therewere4casesofrecurrence(2.1%).Conclusions:Cleardemarcationofsurgicalresectioncanfacilitateeasyandthoroughresectionofpreauricularfistulaandleadtolowrecurrencerate.Propertimingandcarefulsearchforpotentialfistulabranchesarethetwocrucialfactorsaffectingprognosis.

简介：重点词汇1.papern.纸;纸张paper表示"纸;纸张"时,是不可数名词。apieceofpaper一张纸拓展(1)paper可作定语,如:papermoney纸币。(2)paper意为"试卷;论文"时,是可数名词。Pleasehandoutthepapers.请分发试卷。2.pollutev.污染Diditpollutetheenvironment?它对环境有污染吗?拓展(1)pollutionn.污染;污染物air/noisepollution空气/噪音污染

简介：下棋盘数在一棵大树下，大伙儿都在乘凉，花斑虎和威威猫也在树下下象棋。小鹿斑比、花娜、邦邦三个也走了过来，围着看他们下棋。

简介：我是一个小学生，一个武功盖世的小学生，一个深藏不露的小学生。十年前的一天，有一个自称杨过的老头给了我一本武功秘籍。从此，我去山洞里潜心修炼。10年后，终于修练了一身绝世武功，出洞后才发现只不过过了10小时。我的大侠生涯开始了!

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简介：饮酒过量会伤身，甚至可能导致猝死。但在不同情况下．猝死的原因各有差异，预防方式也有所不同。一般来说，常见的原因有以下7种。

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