简介:Asearlyas2000yearsago,ancientChinesemedicalrecordshaddescribedtherelationshipbetweendiseasesandappearanceindetail.Moreover,modernmedicinehasalsoconstantlystudiedtherelationshipbetweenfacialfeaturesandhealthinevolutionaryterms.Itiswellknownthatmanyhereditarydiseasesinvolvecertainabnormalfacialfeaturesandgenemutations.Thetumorisalsoconsideredasgeneticdisordertosomeextent,sowhatistherelationshipbetweencancergeneticsandcongenitaldevelopmentoffacialfeatures?Here,wereviewedsomecluestotheappearance-gene-tumorrelation,whichmightbecomethetargetsintheearlypreventionorgenetherapyofcancerinthefuture.Thissummaryprovidedusanewstrategyforthecancergeneticscreeningandanewresearchdirectionforgeneticdiagnosisofthepotentialdisease.
简介:Studiesontherelationshipbetweencorporaterealestate(CRE)andeconomiccyclesareverythin,especiallyfromdevelopingcountries,suchasSouthAfrica.More,inpractice,mostfirmshardlydedicateenoughresourcestoCREdivisions.Thisleadstothatmanagementnotfullymaximisesthewealthofshareholders.Thisstudyusesmulti-linearregressiontotesthowGDP,interestrate,andtotalcorporatecostsreacttochangesinCRE.ThesampleismadeupofbluechipfirmslistedontheJohannesburgStockExchange(JSE).Theresultsrevealmixedbagsolutions-forcertainfirms;GDP,interestrate,andcorporatecostsarestatisticallysignificantandviceversa.More,thisanalysiscanbereplicatedtoothersimilarindustriesandindicesaroundtheworld.
简介:Objective:Toinvestigatetherelationshipbetweengenemutationandpathologicaltypeoflungcancer,inspectandverifytheconsistencybetweenhomologousgenesmutationinvariouspathologictype.Methods:CombinedwiththeCOSMICandUniProtdatabase,weobtainedthereportedoverallbig-samplemutationdataoflungcancerandtheproteinsequencesofthetop20mutatedgenes,respectively.Analyzethedataandclustertheproteinsequencesandthendeducethehomologousgene.Ultimately,analyzethemutationsofdifferentpathologicaltypesofhomologousgenes.Results:TP53(32.32%)hasthehighestmutationrateinlungcancer,followedbyEGFR(29.12%).Thecopynumbervariability(CNV)ofgenes:KRAS,LRP1B,CDKN2A,KMT2C,FAT1,PIK3CA,RB1,ERBB4,GRIN2AandKDRbetweeneachpathologicaltypeisstaticallysignificant(P<0.05).ThegenedifferentialexpressionratebetweenadenocarcinomaandsquamouscarcinomaofgeneTP53,KRAS,LRP1B,CDKN2A,STK11,FAT4,KMT2D,NFE2L2,KEAP1,PIK3CA,RB1,ERBB4,SMARCA4andKDRarestatisticallysignificant(P<0.05).ThesimilarityoftheproteinsequenceofEGFRandERBB4canreach93%,andFAT4andFAT1are81%.Forsmallcellcarcinoma,there’snodifferenceinCNVbetweenthetwogroupsofhomologousgenes,andnodifferencebetweenFAT4andFAT1inadenocarcinoma.Conclusion:TheCNVandgeneexpressionoflungcancer-associatedgenesarerelevanttopathologictypes.GFRandERBB4arehomologous,FAT4andFAT1arealsoamongthetop20mutationgenes.Additionally,there’snodifferenceinCNVbetweenthetwogroupsofsmallcellcarcinoma,whichisthesamebetweenFAT4andFAT1inadenocarcinoma.
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简介:Relationshipsbetweendiameteratbreastheight(dbh)versusstanddensity,andtreeheightversusdbh(heightcurve)wereexploredwiththeaimtofindiftherewerefunctionallinksbetweencorrespondentparametersoftherelationships,exponentsandinterceptsoftheirpowerfunctions.Ageometricmodelofaforeststandusingaconicapproximationsuggestedthatthereshouldbeinterrelationsbetweencorrespondentexponentsandinterceptsoftherelationships.Itisequivalenttoatypeof‘relationshipbetweenrelationships’thatmightexistinaforeststandundergoingself-thinning,andmeansthatparametersofonerelationshipmaybepredictedfromparametersofanother.Thepredictionsofthemodelweretestedwithdataonforeststandstructurefrompublisheddatabasesthatinvolvedanumberoftreesspeciesandsitequalitylevels.Itwasfoundthatthecorrespondentexponentsandinterceptsmaybedirectlyrecalculatedfromoneanotherforthesimplestcasewhenthetotalstemsurfaceareawasindependentofstanddensity.Forcaseswheretotalstemsurfaceareachangeswiththedropofdensity,itispossibletodevelopageneralizationofthemodelinwhichtheinterrelationshipsbetweencorrespondentparameters(exponentsandintercepts)maybestillestablished.
简介:ThisstudyexaminedthemodelingcorrelationbetweenshareholdersdividendandcorporateperformanceinNigeria.Thestudyemployedtheexpost-factoresearchdesign.Toobtainanswersontheresearchquestionsandtotestthehypothesesformulated,datawereobtainedfromannualreportsofcompanieslistedontheflooroftheNigeriaStockExchange(NSE)thatdisclosedacomparativestatementfortheperiodof2010to2016.Thedatacollectedwereanalyzedusingdescriptivestatistics.Specifically,simpleregressionanalysisandpairedsamplet-teststatisticswereusedtoanalyzethedata.Theresultsshowedthatthereisnosignificantcorrelationbetweenshareholdersdividendpayoutandtheexplanatoryvariablesinthemodel.TheseresultstakenasawholeindicatethatbankspaydividendinNigeriawiththeintentionofreducingtheagencyconflictandmaintainingfirms'reputation.Thestudyrecommendedthatsincethepaymentofdividendindicatesthefirmhavingagoodearningscapacity,managementshouldmaintainasteadyincreaseinearnings,cashflow,anddividendpaymentandestablishadividendpolicythatcanbeacceptablebyvariousstakeholders.
简介:BasedontheresearchofChinaandabroad,thisthesiscarriedonanempiricalstudyon272EnglishmajorsusingtheinstrumentofquestionnairesandgainedsomeimportantfindingsthatEnglishmajors’BeliefsaboutTranslationandTheirUseofChineseTranslationasalearningarecloselyrelatedwitheachotherwhichprovedthefindingsofPosenLiao.
简介:有由于季风系统的复杂性在中国预言植被回答到东方亚洲季风(电动会计记帐机)可变性的简单方法的缺乏。在这研究,我们发现了变化西方的和平的副热带的高度(WPSH)是EAM的主要部件之一,在中国在植被生长上有深刻影响。当WPSH更被定位到它的气候一般水准的西方时,东方、西北的部分分别地由0.3%-2.2%,和0.2%-2.2%经历增加的每年一般水准的规范的差别植被索引(NDVI)和粗野主要生产率(GPP)。相反,当WPSH更被定位到它的气候的东方时,平均,上述区域分别地在0.4%~1.6%,和1.3%~4.5%经历减少的每年一般水准的NDVI和GPP。WPSH用作一个主要发行量索引预言植被的反应到季风。
简介:Inthisreview,weintensivelyfocusontheadvancesinresearchofnaturalproducts(NPs)discoverycarriedoutbydomesticscholarsinChinafrom2015through2017.Ingeneral,atotalof1811publications(1479inEnglishand332inChinese)wereaccumulatedregardingnewlyisolatedNPsfromplants,microorganisms,andmarinesources.Asaresult,277selectedpapersconcerningnaturallyoccurringcompoundswithextraordinaryframeworks,origins,andpromisingactivitieswerediscussedinthisreviewarticle,mainlyorganizedaccordingtotheirstructuralclassesandnovelties.
简介:TheintrinsicphysicalrelationshipofvorticitybetweenmodesAandBinthethree-dimensionalwaketransitionisinvestigated.Directnumericalsimulationsfortheflowpastasquare-sectioncylinderarecarriedoutatReynoldsnumbersof180and250,associatedwithmodesAandB,respectively.Basedontheanalysisofspacialdistributionsofvorticityinthenearwake,characteristicsoftheverticalvorticityinmodesAandBareidentified.Moreover,therelationshipofthreevorticitycomponentswithspecificsignsissummarizedintotwosignlaws,asintrinsicphysicalrelationshipsbetweentwoinstabilitymodes.Bythetheoryofvortex-inducedvortex,suchtwosignlawsconfirmthattherearetwoandonlytwokindsofvortex-sheddingpatternsinthenearwake,justcorrespondingtomodesAandB.Inbrief,alongthefreestreamdirection,modeAcanbedescribedbytheparallelsheddingverticalvorticeswiththesamesign,whilemodeBisdescribedbytheparallelsheddingstreamwisevorticeswiththesamesign.Finally,itisfoundoutthatthe-typevortexisabasickindofvortexstructureinbothmodesAandB.
简介:ThisarticleexploresthedynamicsoftheDiaspora’sdualloyaltiestowardstheirhomecountriesandhostcountriesbyusingAmericanJewryasacasestudy.Itarguesthatinliberal-democraticstates,theshiftintheDiaspora’sloyaltytowardsthehomelandvis-à-visthehostlandisaresultofthechangetothehostland’sperceptionofwheretheacceptableboundaryoftheDiaspora’spracticeofdualloyaltiesis,orinotherwords,towhatextenttheDiaspora’ssupportofthehomelandisperceivedtobeacceptablebytheirhostland.Thereconstructionofthisboundaryisdeterminedbyfourfactors:thedegreeofpoliticalcoordinationbetweenhomestatesandhoststates,theattemptofthehomestatetomobilizeitsdiasporas,themeansadvocatedandsupportedbytheDiaspora,andtheseverityofpotentialconsequencesduetotheDiaspora’saction.