简介:NF-κBisatranscriptionfactorofeukaryote,fivemembersofwhosefamilyinmammalsandthreeindrosophila.TranscriptionfactorsoftheNF-κfamilyareactivatedinresponsetosignalsthatleadtocellgrowth,differentiation,apoptosisandotherevents.NF-κBtakespartinexpressionofnumerouscytokinesandadhesionmoleculeswhicharecriticalelementsinvolvedintheregulationofimmuneresponses.Inthisreview,wefocusonourcurrentunderstandingofNF-κBsignalpathwayanditsroleintheinnateandadaptiveimmuneresponsesinwhichthesetranscriptionfactorshaveakeyregulatoryfunction.Furthermorewereviewwhatiscurrentlyknownabouttheireffectsassociatedwithapoptosis.Cellular&MolecularImmunology.2004;1(5):343-350.
简介:ThemolecularmechanismsforNF-κBsignalingtransductionandtranscriptionhavebeenthemostattractivesubjectsforbothbasicresearchandpharmaceuticalindustriesduetoitsimportantrolesinbothphysiologicalandpathogenesis,particularlythecloseassociationofdysregulatedNF-κBwithtumorgenesisandinflammation.SeveralnovelintracellularmoleculareventsthatregulateNF-κBactivityhavebeendescribedrecently,includingthediscoveryofanalternativesignalingpathwaythatappearsinducingaspecificsubsetgenesinvolvedinadoptiveimmuneresponse.Multi-levelandmulti-dimensionalregulationofNF-κBactivitybyphosphorylationandacetylationmodificationshaveunveiledandbecamethehottesttargetsforpotentiallytissuespecificmolecularinterventions.AnotheremergingmechanismforNF-κB-responsivegene'sregulationwhereNF-κBparticipatesthetranscriptionalregulationindependentofitscognateregulatorybindingsitewithinthetargetgene'spromoterbutfacilitatingthetransactionactivityofotherinvolvedtranscriptionfactors,thatimplicatedannoveltranscriptionalactivitiesforNF-κB.Thus,thecurrentreviewwillfocusontheserecentprogressesthathavebeenmadeonNF-κBsignalingtransductionandtranscription.Cellular&MolecularImmunology.2004;1(6):425-435.
简介:制作合成马赛克膜的一个新奇方法被涂层根据界面的聚合(IP)学习薄选择的层到多微孔的空纤维的膜的表面上,在哪个,2,5-diaminobenzene酸性硫酸基的酸被用作IP反应的一单体,并且trimesoyl氯化物(TMCl)和4-(chloromethyl)的混合物benzoyl氯化物作为另外的单体。通过与否定地为充电的组一起的薄选择的层能是的IP反应,第一在polyethersulfone(足)上形成了支持膜。然后,trimethylamine答案被介绍通过quaternization反应修改IP层。因此,否定地两个都包含的这合成的膜的选择的层收费了并且断然为组充电了执行马赛克功能。合成马赛克膜的描述用不同的无机的盐和染料通过浸透实验被执行。试验性的结果证明膜能渗入一价、二原子价的无机的盐,但是拒绝更大的器官的分子。如此的马赛克膜为从水溶性的organics的盐的分离是潜在地有用的,特别在染料和纺织品工业。