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  • 简介:ObjectiveTorecordtheendocochlearpotential(EP)andcalculatepotassiumconcentration[K+]inMinipigcochleae.MethodsWeusedmulti-barreledelectrodestomeasuretheEPandthepotential,[K+].EPandpotassiumelectroderecordingweremadein9cochleaefrom5minipigstogetnormalEPvalues.ResultsTheaverageEPvalueinthecochleafromtheminipigswas77.3±14mV.Theaverage[K+]fortheminipigswas147.1±13mM.ConclusionsTheEPandpotential,[K+]inminipigsarelowerthaninthehumanandrodents.ThismaybethereasonwhyporcineABRthresholdsareslightlyhigherthanhumansandrodents.

  • 标签: stria vascularis POTASSIUM SECRETION endocochlear POTENTIAL
  • 简介:Minipigmodelsarelargemammalsandtheirearsaremoresimilarwithhumanbeingsinstructureanddevelopmentthanotheranimals.However,thestudyonporcineearsisstillintheinitialstageandthereisnodescriptionofanidealoperationapproachtoendocochlearpotentialandpotassiumionconcentrationmeasurements.Inthisarticle,wedescribeapre-auricularsurgicalapproachtoaccessthemiddleandinnerearforendocochlearpotentialandpotassiumionconcentrationmeasuresinminipigmodels.Tenone-weekoldnormalminipigswereusedinthestudy.Thebullaofthetemporalbonewasaccessedviaapre-auricularapproachforendocochlearpotentialandpotassiumionconcentrationmeasurements.Theconditionoftheanimalsduringthefirstpost—experiment24hwasobserved.Oneanimaldiedduringsurgery.Thepreauricularapproachimprovedprotectionandpreservationofrelevantnervousandvascularelementsincludingthefacialnerveandcarotidartery.So,thepre-auricularapproachcanbeusedforendocochlearpotentialandpotassiumionconcentrationmeasurementswithimprovednerveandarterypreservationminipigs.

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