Direct fabrication of a microfluidic chip for electrophoresis analysis by water-assisted femtosecond laser writing in porous glass

(整期优先)网络出版时间:2013-07-17
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Wereportthedirectfabricationofamicrofluidicchipcomposedoftwohigh-aspectratiomicrofluidicchannelswithlengthsof3.5cmand8mminaglasssubstratebyfemtosecondlasermicromachining.Thefabricationmainlyconsistsoftwosteps:1)writingmicrochannelsandmicrochambersinaporousglassbyscanningatightlyfocusedlaserbeam;2)high-temperatureannealingoftheglasssampletocollapseallthenanoporesintheglass.Migrationofderivatizedaminoacidsisobservedinthemicrofluidicchannelbyapplyingelectricvoltageacrossthelong-migrationmicrochannel.