简介：目的:针对较大翼状胬肉，采用胬肉切除、角膜缘干细胞移植联合全角膜羊膜覆盖术，或胬肉切除和角膜缘干细胞移植术后配戴绷带型角膜接触镜进行治疗，观察两种方法的临床效果。方法:将侵及瞳孔区的较大翼状胬肉40眼随机分成两组，一组行翼状胬肉切除、角膜缘干细胞移植术联合全角膜羊膜覆盖术（羊膜组），另一组行胬肉切除和角膜缘干细胞移植术后配戴绷带型角膜接触镜（绷带镜组），每组各20眼。比较两组患者手术时间，以及术后第l、3d，1、3wk眼部舒适程度和角膜愈合情况与随访复发情况等。结果:平均手术时间：羊膜组为61.4±5.2min，绷带镜组为34.5±2.7min，绷带镜组手术时间明显缩短，两组差异有统计学意义（P<0.05)。两组患者的眼部舒适度在术后第Id无明显差异，但在术后第3d和术后lwk，绷带镜组患者的眼部舒适度明显优于羊膜组（P<0.01)，至术后3wk时两组间差异无统计学意义（P>0.05)。术后3wk时两组患者的角膜愈合率评分分别为0.85±0.18分和1.15±0.18分，两组差异无统计学意义（P=0.25)。羊膜组有1眼胬肉复发。结论:在侵及角膜的较大翼状胬肉治疗中，胬肉切除和角膜缘干细胞移植术后联合全角膜羊膜覆盖或术后配戴绷带型角膜接触镜均有助于缓解眼部不适症状和促进角膜创面修复，使用绷带型角膜接触镜患者更舒适，治疗更便捷。

简介：目的：比较白内障超声乳化吸除人工晶状体植入术后和小切口囊外门内障摘除人工品状体植入术后患者生存质量的变化。方法：分别于术前和术后1／4，1，3mo，观察I组108例单眼行白内障超声乳化吸除人工晶状体植入术后患者和II组94例单眼行小切口白内障囊外摘除人工晶状体植入的眼部情况，使用生存质量调杏量表记录分数。结果：术前生存质量总分数和各指标分数，术后1mo和3mo的生存质量总分数，I组和Ⅱ组比较差异均无显著意义（P〉0．05）。术后1／4mo生存质量总分数和各指标分数，I组高于Ⅱ组，两组比较差异有显著意义（P〈0．05）。结论：白内障超声乳化吸除人工品状体植入术患者的生存质量在短期内就得到明显提高。手术效果优于小切口囊外白内障摘除术。中期效果I组和Ⅱ组无明显差异，远期结果尚待进步深入探讨。

简介：目的：分析玻璃体腔注射曲安奈德术后继发性青光眼的发生率和危险因素。方法：对连续收治的256例有玻璃体腔注射曲安奈德适应证的各类眼底病患者实施单次玻璃腔注射4mg/0.1mL曲安奈德手术,观察其术后眼压变化情况。主要适应证包括湿性年龄相关性黄斑变性,其它原因如糖尿病性视网膜病变、视网膜中央静脉阻塞、视网膜分支静脉阻塞,视网膜静脉周围炎等引起的黄斑水肿性疾病。结果：256例256眼经至少3mo的追踪观察随访中,56眼发生继发性青光眼,发病率为21.9%。结论：继发性青光眼与年龄、性别、血压、糖尿病、玻璃体腔注药术的不同适应证、术前是否行白内障手术、是否行光动力治疗、是否行玻璃体切除手术等因素没有相关性。注药前青光眼病史的存在和基础眼压高于19mmHg等情况为术后继发性青光眼的显著危险因素。

简介：三、盲和低视力的原因阜阳市颖州区盲和低视力的原因中，白内障仍高居首位，占59．06％，其次为弱视，7．09％，第三位为青光眼，5．12％。（见表5）

简介：AIM:TodiscusstheimpactofLyciumBarbarumPolysaccharide(LBP)andDanshensupurifiedfromTraditionalChineseMedicine(TCM)onvascularendothelialgrowthfactor(VEGF)ofrabbitswithretinalneovascularization.METHODS:Fortyrabbitsweredividedintonormalcontrolgroup,modelcontrolgroup,LBPgroupandDanshensugroup.Animalsinthenormalcontrolgroupwerefedinthenormaloxygenenvironment.Animalsintheotherthreegroupswereputintotheenvironmentwith70%oxygenfor5daysinordertobuildthemodelofoxygen-inducedvascularproliferationretinopathy.AndthendifferentTCMextractwasinjectedintotheabdominalcavitiesoftheseannimals.After7days,theVEGFcontentofintheserumofrabbitwasmeasuredbydoubleantibodysandwichmethod.RESULTS:DataanalysisindicatedthatVEGFcontentwasasfollows:Danshensugroupwaslowerthanmodelcontrolgroup(12.92±3.84ng/Lvs19.32±4.15ng/L,P<0.05);LBPgroupandnormalcontrolgroupwerelowerthanmodelcontrolgroup(12.92±3.84ng/L,9.26±1.61ng/Lvs19.32±4.15ng/L,P<0.01);totalbloodviscosity,plasmaviscosity,cholesterolcontent,fibrinogencontentandtriacylglycerolcontentafterperitonealinjectionofLBPandDanshensuwereobviouslylowerthanbeforeinjection.CONCLUSION:TCMextract-LBPandDanshensucanprominentlyreducethecontentofVEGFintheprocessofvascularproliferativeretinopathyofrabbit;canpreventtheoccurrenceofretinalmicrovasculardiseasebyimprovingpartialoxygen-deficientenvironmentoraffectingallkindsofnewgrowthfactor.

简介：目的方法结果结论对安徽省两地人群盲和低视力及眼病的流行病学情况进行抽样调查。选择阜阳市颍州区和宣城市绩溪县,采用随机整体抽样方法,对所属居民进行眼部及其他情况的调查。两地的受检人数和受检率分别为3336人（91.40%）和3602人（92.10%）,达到抽样调查要求;两地双眼盲、单眼盲、双眼低视力和单眼低视力的患病率分别为1.05%和0.69%、1.71%和1.25%、1.02%和0.97%、0.87%和0.89%;两地盲和低视力的主要原因分别为：白内障、弱视、青光眼和白内障、眼球萎缩/缺如、青光眼;两地主要眼病都为：屈光不正、白内障、翼状胬肉和沙眼;两地的白内障手术率分别为600和278。据不完全资料估计我省盲和低视力的患病率远高于全国平均水平,盲和低视力的高发人群为50岁以上老年人,女性,孤寡,文盲,低收入者,白内障仍是最主要致盲原因,屈光不正/弱视已日益成为影响人民特别是青少年视力的最主要因素,广泛宣传正确用眼方式,推广青少年正确验光配镜方法,提高相关人员验光配镜水平对于有效降低弱视致残率至关重要。

简介：目的：评价并比较180°和360°选择性激光小梁成形术（selectivelasertrabeculoplasty,SLT）治疗原发性开角型青光眼（primaryopenangleglaucoma,POAG）的临床效果。方法：POAG患者60例60眼,分别采用532nm倍频Q-开关Nd：YAG激光治疗仪,以光斑400μm,脉冲时间3ns,能量0.3～1.2mJ行180°和360°SLT。观察患者术后6mo的眼压变化。结果：两组患者眼压在激光治疗后均有显著下降,180°组患者术前平均眼压为25.6±2.0mmHg（1kPa=7.5mmHg）,术后1h;1d;1wk;1,3,6mo眼压分别为27.1±2.1,16.5±1.9,19.6±1.9,18.5±1.8,19.9±1.9,20.3±1.8mmHg。360°组患者术前平均眼压为25.4±2.1mmHg,术后对应时间点眼压分别为26.6±1.9,15.9±2.0,19.0±2.0,17.8±1.9,18.7±2.0,19.2±1.9mmHg。两组术后1d;1wk;1,3,6mo的眼压与术前相比明显下降,差异均有统计学意义（P〈0.01）。术后两组各时间点眼压的平均下降幅度比较,360°组较180°组术后眼压的平均下降幅度更大,其中术后3mo和6mo差异具有统计学意义（P〈0.05）。结论：360°SLT治疗POAG的疗效可能优于180°SLT。

简介：目的：观察超声乳化白内障吸出术联合人工晶状体（IOL）植入治疗激光周边虹膜切除术后闭角型青光眼的治疗效果。方法：激光周边虹膜切除术后闭角型青光眼并白内障患者39例（39眼），被分为两组，Ⅰ组须用抗青光眼药控制眼压，Ⅱ组不须用抗青光眼药控制眼压，患者均行超声乳化白内障吸出和折叠式人工晶状体植入术，术后随访3mo。结果：两组术后最佳矫正视力均较术前显著提高（P〈0．05）。术后3moⅠ组眼压为15．72±3．02mmHg，1／组为16．30±3．81mmHg，两组眼压均比术前明显下降，有显著性差别（P〈0．05）。Ⅰ组中央前房深度由术前1．64±0．45mm加深至术后3mo的3．21±0．41mm，Ⅱ组中央前房深度由术前1．92±0．52mm加深至术后3mo的3．18±0．39mm．两组术后中央前房深度均比术前明显加深，有显著性差异（P〈0．05），前房角明显增宽。结论：超声乳化白内障吸出和人工晶状体（IOL）植入术不仅能提高激光周边虹膜切除术后青光眼视力，而且可彻底解除闭角型青光眼的瞳孔阻滞。

简介：AIM:Todescribethecharacteristicsofmodulationtransferfunction(MTF)ofanteriorcornealsurface,andobtainthethenormalreferencerangeofMTFatdifferentspatialfrequenciesandopticalzonesoftheanteriorcornealsurfaceinmyopes.·METHODS:Fourhundredeyesfrom200patientswereexaminedunderSIRIUScornealtopographysystem.PhoenisanalysissoftwarewasappliedtosimulatetheMTFcurvesofanteriorcornealsurfaceatverticalandhorizontalmeridiansatthe3,4,5,6,7mmopticalzonesofcornea.TheMTFvaluesatspatialfrequenciesof5,10,15,20,25,30,35,40,45,50,55and60cycles/degree(c/d)wereselected.·RESULTS:TheMTFcurveofanteriorcornealsurfacedecreasedrapidlyfromlowtointermediatefrequency(0-15cpd)atvariousopticalzonesofcornea,thevaluedecreasedto0slowlyathigherfrequency(>15cpd).Withtheincreaseoftheopticalzonesofcornea,MTFcurvedecreasedgradually.3)Intherangeof3mm-6mmopticalzonesofthecornea,theMTFvaluesmeasuredathorizontalmeridianweregreaterthanthecorrespondingvaluesathorizontalmeridianofeachspatialfrequency,thedifferencewasstatisticallysignificant(P<0.05).At7mmopticalzonesofcornea,theMTFvaluesmeasuredathorizontalmeridianwerelessthanthecorrespondingvaluesatverticalmeridianat10-60spatialfrequencies(cpd),andthedifferencewasstatisticallysignificantin25,30,35,40,45,50cpd(P<0.05).·CONCLUSION:MTFcanbeusedtodescribetheimagingqualityofopticalsystemsatanteriorcornealsurfaceobjectivelyindetail.

简介：目的比较双眼行超声乳化白内障吸除联合植入AcrySofReSTOR与ATLISAtri839MP多焦点人工晶状体（M10L）术后的视觉质量。方法前瞻性非随机对照研究。收集双眼年龄相关性白内障24例（48跟），行超声乳化术，12例（24眼）植入AcrysofReSTOR为对照组，12例（24眼）植入ATLISAtri839MP为实验组，术后3月测量其裸眼远、中及近视力，最佳矫正远、中及近视力，离焦曲线，并通过问卷调查的方式评价患者术后脱镜情况及患者对全程视力的满意度。结果植入ATLISAtri839MP患者的中距离视力高于植入AcrySofReSTOR（P〈0．05），而远、近视力差异无统计学意义（P〉0．05）。离焦曲线显示两组第一峰位均在附加OD处；第二峰位对照组位于附加-3．0D，实验组位于-1．5D至-3．0D之间，此段呈现平台期。两组患者在各空间频率的对比敏感度比较差异均无统计学意义（P〉0．05）。在调查问卷中，实验组的脱镜率及中距离视力满意度高于对照组（P〈0．05）。结论两种人工晶状体植入术后均可获得良好的远近视力，ATLISAtri839MP人工晶状体能够获得更好的中距离视力及较高的患者满意度，具有更为理想的全程视力。

简介：目的：比较原发性开角型青光眼和高眼压患者及拥有健康眼球表面的正常人群的泪膜功能和印象细胞学检查的数值。方法：此前瞻性研究中纳入了原发性开角型青光眼患者11例11眼（平均年龄：62.7±6.1岁）,高眼压患者12例12眼（平均年龄：62.8±6.4岁）及健康人12例12眼（平均年龄：62.9±6.03岁）。这些患者均是最近被诊断出患有原发性开角型青光眼及高眼压,且之前未接受过抗青光眼方面的治疗。均行结膜印迹细胞学检查、泪膜破裂时间和基础泪液分泌试验。每组印迹细胞学检查的样本根据Nelson分级法分为0-3级。应用Kruskal-Wallis检验和Dunn多重比较检验进行统计分析。结果：原发性开角型青光眼患者,高眼压患者及正常人群平均基础泪液分泌值分别为10.4±1.3,10.9±1.2和11.1±1.1mm/5min,其差距没有统计学意义（P=0.33）；三组的泪膜破裂时间分别为11.2±1.1,11.3±1.1和11.8±1.2s,其差距没有统计学意义（P=0.35）。原发性开角型青光眼患者中6眼（54.5%）为0级,5眼（45.5%）为1级。高眼压患者中6眼（50%）为0级,6眼（50%）为1级,健康人中6眼（50%）为0级,6只眼（50%）为1级（P=0.97）。结论：氧化应激可能会导致青光眼,眼表疾病,泪腺功能障碍及机体杯状细胞所分泌的黏液减少。原发性开角型青光眼患者,高眼压症患者及健康人群间的印象细胞学检查数值并无显著差异。

简介：AIM:Toinvestigatethediffusioncharacteristicsofwaterofopticnerveandopticradiationinhealthyadultsanditsrelatedfactorsbydiffusiontensorimaging（DTI）at3T.METHODS:Atotalof107healthyvolunteersperformedheadconventionalMRIandbilateralopticnerveandopticradiationDTI.TheprimarydataofDTIwasprocessedbypost-processingsoftwareofDTIstudio2.3,obtainingfractionalanisotropyvalue,meandiffusivityvalue,principalenginevalue,orthogonalenginevaluebymeasuring,andanalyzedbytheSPSS13.0statisticalsoftware.RESULTS:Thebilateralopticnerveandopticradiationfiberspresentedgreencolorindirectionalencodedcolor（DEC）mapsandpresentedhighsignalinfractionalanisotropy（FA）maps.TheFAvalueoftheleftopticnervewas0.598±0.069andtherightwas0.593±0.065;themeandiffusivity（MD）valueoftheleftopticnervewas（1.324±0.349）×10-3mm2/sandtherightwas（1.312±0.350）x10-3mm2/s;theprincipalenginevalue(λ?)oftheleftopticnervewas（2.297±0.522）×10-4mm2/sandtherightwas（2.277±0.526）×10-3mm2/s;theorthogonalenginevalue（λ⊥）oftheleftopticnervewas（0.838±0.285）×10-3mm2/sandtherightwas（0.830±0.280）×10-3mm2/s;theFAvalueoftheleftopticradiationwas0.636±0.057andtherightwas0.628±0.056;themeandiffusivity（MD）valueoftheleftopticradiationwas（0.907±0.103）×10-3mm2/sandtherightwas（0.889±0.125）×10-3mm2/s;theprincipaleigenvalue(λⅡ)oftheleftopticradiationwas（1.655±0.210）×10-3mm2/sandtherightwas（1.614±0.171）×10-3mn2/s;theorthogonalenginvalue（λ⊥）oftheleftopticradiationwas（0.531±0.103）×10-3mm2/sandtherightwas（0.524±0.152）×10-3m

简介：Choroidalneovascularization(CNV)isanuncommoncomplicationassociatedwithamacularhole.Inthiscasereportofararecondition,wepresentapathologicmyopiapatientwithaco-existentmacularholeandchoroidalneovascularmembrane.ThepatientwastreatedwithphotodynamictherapyforCNV,andthenvitreoussurgeryfortheretinaldetachmentandmacularhole.Attheendof4yearsfollow-up,hervisualacuitywasimprovedto0.1whilethemacularholeremainedopen.OpticalcoherencetomographyisausefulinspectionmethodofthediagnosisofCNVandmacularhole.

简介：AIM:Toinvestigatetheaccuracyofintraocularpressure(IOP)asmeasuredbyaReichertOcularResponseAnalyzer(ORA),aswellastherelationshipbetweencentralcornealthickness(CCT)andIOPasmeasuredbyORA,Goldmannapplanationtonometry(GAT),anddynamiccontourtonometry(DCT).·METHODS:Atotalof158healthyindividuals(296eyes)werechosenrandomlyformeasurementofIOP.AfterCCTwasmeasuredusingA-ultrasound(A-US),IOPwasmeasuredbyORA,GAT,andDCTdevicesinarandomizedorder.TheIOPvaluesacquiredusingeachofthethreetonometrieswerecompared,andtherelationshipbetweenCCTandIOPvalueswereanalyzedseparately.TwoIOPvalues,Goldmann-correlatedIOPvalue(IOPg)andcorneal-compensatedintraocularpressure(IOPcc),weregotusingORA.ThreegroupsweredefinedaccordingtoCCT:1)thincornea(CCT<520μm);2)normal-thicknesscornea(CCT:520-580μm);and3)thickcornea(CCT>580μm)groups.·RESULTS:Innormalsubjects,IOPmeasurementswere14.95±2.99mmHgwithORA(IOPg),15.21±2.77mmHgwithORA(IOPcc),15.22±2.77mmHgwithGAT,and15.49±2.56mmHgwithDCT.Meandifferenceswere0.01±2.29mmHgbetweenIOPccandGAT(P>0.05)and0.28±2.20mmHgbetweenIOPccandDC(P>0.05).TherewasagreatercorrelationbetweenIOPccandDCT(r=0.946,P=0.000)thanthatbetweenIOPccandGAT(r=0.845,P=0.000).DCThadasignificantcorrelationwithGAT(r=0.854,P=0.000).GATwasmoderatelycorrelatedwithCCT(r=0.296,P<0.001),whileIOPccshowedaweakbutsignificantcorrelationwithCCT(r=0.155,P=0.007).TherewasastrongnegativecorrelationbetweenCCTandthedifferencebetweenIOPccandGAT(r=-0.803,P=0.000),withevery10increaseinCCTresultinginanincreaseinthisdifferenceof0.35mmHg.Thethickcorneagroup(CCT>580μm)showedtheleastsignificantcorrelationbetweenIOPccandGAT(r=0.859,P=0.000);whilethethincorneagroup(CCT<520μm)hadthemostsignificantcorrelationbetweenIOPccandGAT(r=0.926,P=0.000).ThecorrelateddifferencesbetweenIOPccan

简介：目的:研究巩膜扣带术(scleralbuckling,SB)联合玻璃体注气术治疗孔源性视网膜脱离(rhegmatogenousretinaldetachment,RRD)的临床疗效及对患者血清中氨基酸、血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)的影响。方法:回顾性分析我院收治的RRD患者150例150眼临床资料,将仅接受SB的患者81例81眼纳入未注气组,接受SB+玻璃体注气术的患者69例69眼纳入注气组,比较两组患者手术疗效和术前、术后血清中氨基酸、VEGF水平等情况。结果:两组患者术后各时间点视网膜复位率比较,差异均无统计学意义(P>0.05);注气组术后1d眼压明显高于未注气组,差异有统计学意义(P<0.05),两组患者术后5d眼压比较差异无统计学意义(P>0.05);两组患者术后术眼裸眼视力较术前均明显改善,差异有统计学意义(P<0.05);术后5d,两组患者血清中组氨酸、谷氨酸、苯丙氨酸、VEGF水平较术前均显著降低,差异有统计学意义(P<0.05),但组间比较差异无统计学意义(P>0.05);两组患者血清中精氨酸、亮氨酸、异亮氨酸、甘氨酸水平与术前比较,差异无统计学意义(P>0.05);术后1mo,两组患者视功能相关生活质量总分和各维目评分均较术前明显升高,差异有统计学意义(P<0.05),但两组间各评分比较差异无统计学意义(P>0.05);注气组术后并发症总发生率为7.2%(5/69)与未注气组的9.9%(8/81)比较,差异无统计学意义(P>0.05)。结论:SB联合玻璃体注气术有助于RRD患者视功能和眼压的早期恢复,降低血清中组氨酸、谷氨酸、苯丙氨酸、VEGF水平,且安全性较高。

简介：AIM:Todeterminewhethersinglenucleotidepolymorphism(SNP)rs641153isassociatedwiththeriskofage-relatedmaculardegeneration(AMD),weperformedasystematicmeta-analysisof15eligiblestudies.SNPinthecomplementfactorB(CFB)geneisconsideredtohavesignificantassociationwithAMDsusceptibility,butthereisgreatdiscrepancyintheseresults.METHODS:TheeligiblestudieswereidentifiedbysearchingthedatabasesofPubMed,EMBASE,andWebofScience.Oddsratios(ORs)with95%confidenceintervals(CIs)wereusedtoassesstheassociation.AlldatawereanalyzedusingStatasoftware.RESULTS:Theassociationbetweenrs641153andAMDriskwasstatisticallysignificantunderthehomozygousmodel(AAvsGG:OR=0.26,95%CI=0.15-0.45,P_h=0.973,/~2=0.0%,fixedeffects),dominantmodel(AA+GAvsGG:OR=0.49,95%CI=0.40-0.59,P_h=0.004,/~2=56.4%,randomeffects)andrecessivemodel(AAvsGA+GG:OR=0.30,95%CI=0.17-0.51,R_n=0.983,I~2=0.0%,fixedeffects).Thesameresultswerealsoobservedinthestratifiedanalysesbyethnicity,sourceofcontrolandsamplesize.CONCLUSION:Ourmeta-analysissuggeststhatrs641153intheCFBgenemayplayaprotectiveroleinAMDsusceptibility,thelateAMDinparticular,bothinCaucasiansandinAsians.

简介：目的：系统评价拉坦前列素（Latanoprost）滴眼液与噻吗心安（Timolol）滴眼液降眼压的有效性和安全性。方法：计算机检索PubMed，Medline，CNKI及中国生物医学文献数据库收录的，并辅以手工检索、因特网搜索的有关拉坦前列素与噻吗心安治疗原发性开角型青光眼和高眼压症的随机对照试验（RCT）。按照纳入和排除标准限定研究对象，通过Jadad评分量表进行文献质量评估后，针对眼压下降比例、药物不良反应2项内容，使用Cochrane协作网提供的RevMan5．0软件进行Meta分析。结果：共纳入9项RCT，合计555例患者。Meta分析结果显示：（1）拉坦前列素滴眼液与噻吗心安滴眼液降眼压效果，在2，6，12wk时差异均有统计学意义（P＜0．01），加权平均差（WMD）分别为：在2wk[WMD＝-0．76，95％CI（-1．32，-0．20）]，在6wk[WMD＝-1．15，95％CI（-1．68，0．63）]和12wk[WMD＝-1．01，95％CI（-1．42，-0．61）]。（2）随访结束时，结膜充血、异物感为拉坦前列素的两种较为常见的不良反应，但其发生率拉坦前列素组与噻吗心安组比较，结膜充血的发生率[OR＝2．25，95％CI（0．99，5．08）]，异物感的发生率[OR＝2．48，95％CI（1．02，6．03）]，显示二者差异均无统计学意义。结论：治疗原发性开角型青光眼和高眼压症，拉坦前列素降眼压效果在用药12wk内较噻吗心安好；两者在12wk内引起结膜充血、异物感、虹膜色素加深、视野损害等的不良反应方面，差异不明显。由于纳入研究的样本量偏小，且方法学质量中等，致使本系统评价结果论证强度不高，因此还需要开展更多的高质量的临床随机对照研究，以便更客观、准确、全面地评价其疗效和安全性。

简介：AIM:Toinvestigatethespecialtyoftranscranialsurgerythroughpterionalapproachforremovalofcranio-orbitaltumors,introducetheophthalmologicalexperiencesofenteringtheorbittoreducetheincidencerateofassociatedcomplicationsofthisoperation.·METHODS:Weperformedaretrospectiveanalysisofaseriesof37casesinvolvingpatientswhounderwenttranscranialsurgerythroughpterionalapproachfortreatmentofcranio-orbitaltumorsinourdepartmentinthepast8years.Pterionapproachcraniotomywasperformedtoallpatients.Afterremovingtumorsintheskullbytheneurosurgeon,ophthalmologistremovedtumorsinorbit.Wetookmeasuresbelowtodecreasecomplications,includinggroundingopticcanalthroughanabrasivedrillingwhennecessary,hangingvariousextraocularmusclestobeexposedforprotection,refrigeratingbyrefrigerationheadstoremovetumors,atlastsewinguporbitseptumaftersurgery.·RESULTS:Tumorswereremovedcompletelyin32cases,andincompletein5casesduetoextensiveinvasionintothecavernoussinusorsphenoidsinus.Ofallthecases,benigntumorsweredemonstratedin28cases(75.6%,28/37)andmalignantin9(24.3%,9/37).Themostcommonlesiontypewasmeningiomain11cases(29.7%,11/37).Extraocularmuscles(EOM)impairment,occurringin21cases(56.7%,21/37),wasthemostfrequentpostoperativecomplication.Themostseriousconsequencewasvisionlossoccurredin4cases(10.8%,4/37).Othercomplications,suchas11casesoftransientblepharoptosis29.7%(11/37),5casesofmydriasisin13.5%(5/7);2casesofcerebrospinalrhinorrheain5.4%(2/37).·CONCLUSION:Cranio-orbitaltumorscanberemovedcompletelyusingtranscranialapproach,andthepterionalapproachoffersexcellentexposure.Cooperationofinterdisciplinaryteamofneurosurgeonsandophthalmologistsconducestofulluseofrespectiveprofessionaladvantages.Theexperienceofophthalmicoperationtechnologycandecreaseoccurrenceofocularcomplicationsaftersurger

简介：AIM:Tocomparetheregularityandaccuracyoflaserinsitukeratomileusis(LASIK)flapscreatedbytheZiemerFEMTOLDV'Classic'(Ziemer'Classic')andZiemerFEMTOLDVCrystalLinefemtosecondlaser(ZiemerCrystalLine).METHODS:Fourier-domainopticalcoherencetomography(RTVueOCT)wasusedtomeasurethemorphologyof200LASIKflapsof100consecutivepatientscreatedwiththeZiemerClassic(100flaps)ortheZiemerCrystalLine(100flaps)atoneweekpostoperatively.Flapthicknesswasevaluatedat36specifiedmeasurementpointsoneachflap.Forallprocedureswithbothlasers,thenominalflapthicknesswas110μm.RESULTS:ThemeanflapthicknessoftheZiemerCrystalLinegroup(102.49±2.68μm)wasthinnerthanthatoftheZiemerClassicgroup(107.65±5.09μm)(P<0.01).Averagethicknessofallflapswasuniformwithin4μmatallmeasurementpoints.TheflapsintheZiemerCrystalLinegroupweremoreregularthanthoseintheZiemerClassicgroupwhenmeasuredfromthecentertotheperiphery.Themaximumdeviationfromthenominal110μmof36measurementswas8μmintheZiemerClassicgroup,whileintheZiemerCrystalLinegroupitwas9μm.Withinthe3600measurementsonthe100eyes,differencesgreaterthan20μmwereobserved0.14%intheZiemerClassicgroup,and0.04%intheZiemerCrystalLinegroup.CONCLUSION:TheflapscreatedwiththeZiemerFEMTOLDVCrystalLinefemtosecondlaseraremoreuniformandthinnerthanthosecreatedbytheZiemerFEMTOLDVClassicfemtosecondlaser.

简介：AIM:Toinvestigatethelevelsofserumsolubleintercellularadhesionmolecules-1(sICAM-1)andneutrophilicexpressionofCD18inpatientswithvariousstagesofdiabeticretinopathyandtodeterminetheirdifferentexpressionpatterninthedevelopmentofdiabeticretinopathy(DR).·METHODS:LevelsofserumsICAM-1andCD18onthesurfaceofneutrophileweremeasuredin41DRpatients,theywereclassifiedinthreesubgroupsaccordingtothestageofretinopathyasdeterminedbyfund’sophthalmoscopy;10controlsubjectswerealsostudied.sICAM-1weremeasuredbyenzyme-linkedimmunosorbentassayandCD18byflowcytometry.·RESULTS:TheneutrophilicCD18expressionandserumsICAM-1levelwereallsignificantlyelevatedinalldiabeticsubgroupscomparedtocontrolsubjects(P<0.01).ThedifferencesofCD18andsICAM-1amongthediabeticsubgroupsweresignificantinCD18butnotinsICAM-1.TheprogressionofretinopathywasassociatedwithanincreasebothinCD18andinsICAM-1levelsbysimplecorrelationanalysis(β=0.74,P<0.001;β=0.38,P<0.01,respectively).ButstepwisemultipleregressionanalysisrevealedthatonlyCD18wasindependentdeterminantofretinopathy(β=1.04,P<0.01).·CONCLUSION:OurresultsconfirmthecontributionofendothelialandneutrophilicactivationinthedevelopmentofDRasindicatedbyincreasedlevelsofCD18andsICAM-1.However,adirectimplicationofCD18andICAM-1intheprogressionofDRcanbesupportedonlyintheCD18butnotICAM-1.CD18andICAM-1mayplaydifferentroleinthedevelopmentofdiabeticretinopathy.