简介：BackgroundAnimalmodelsofhyperlipidemiawereestablishedbyfeedingrabbitswithhigh-cholesteroldiet,andthechangesinstructureandfunctionofcellmembraneinrabbitswerealsoreducedbyhyperlipidemia.Thus,thealternationsinerythrocytemembranelipidperoxidation(EMLP)andfluidityinrabbitsinducedbyhigh-cholesteroldietwereresearchedbyus.MethodsFourteenrabbitsweresubjectedtohigh-cholesteroldiet(cholesterol2g/d)andtheother14rabbitstocommondieteverydayforconsecutivetwomonths,plasmatotalcholesterol(TC),andbloodlipidsaswellasEMLPandfluidityweremeasuredbeforeandafterthefeeding.ResultsComparedwiththefeedingbefore,levelsofTCandlowdensitylipoproteincholesterol(LDL-C)weresignificantlyraised,thoseoferythrocytemembranelowdensitylipoproteincholesterol(MLDL-C),membraneconjugateddiene(MCD),erythrocytemalonaldehyde(RMDA)weresignificantlyincreased,whilethoseoferythrocytesuperoxidedismutase(R-SOD),membranefluidity(M-Flu)andmembranehighdensitylipoprotein-cholesterol(MHDL-C)weresignificantlydecreasedinexperimentalgroup,andtherewerenochangesincontrolgroup.ConclusionsHigh-cholesteroldietinduceslipidperoxidationandlowerfluidityoferythrocytemembrane.

简介：ObjectivesToinvestigatethechangeandclinicalsignificanceofclopidogrelonplateletmembraneCD40Lincoronaryarterydiseasepatientsbeforeandafterpercutaneouscoronaryintervention(PCI).Methods30caseswhowerediagnosiscoronaryarterydiseases(CAD)bycoronaryangiography,meanage56±9yearsold.Allthepatientswhohadnoantiplateletaggregationcontraindication,weretreatedwithstandardantianginapectorisdrugs.BeforePCI,allthepatientstookclopidogrel75mgperday.ActivatedplateletmembraneCD40LexpressratewasmeasuredbyflowcytometrybeforeandafterPCI6hours.ResultsActivatedplateletmembraneCD40Lexpressratewere3.73±2.15and2.46±0.90,respectivelyin30patientsbeforeandafterPCI6hours.ActivatedplateletmembraneCD40LexpressratewassignificantlydecreaseafterPCI6hoursthanthatbeforePCI(P<0.01).ConclusionsClopidogrelhassignificanceeffectonplateletmembraneCD40LincoronaryarterydiseasepatientsundergoingPCI.Clopidogrelcansuppressionplateletactivationandpreventthromboembolismeventoccurrence.