简介：　　【摘 要】目的：探究他克莫司与环磷酰胺治疗狼疮性肾炎的的效果和用药不良反应率。方法：纳入观察对象 40例（均确诊为狼疮性肾炎）进行实验研究，研究时间从 2015年 3月直至 2019年 5月。采用随机分组法，将观察对象分为甲乙两组，甲组 20例患儿使用他克莫司治疗，乙组 20例患儿采取环磷酰胺治疗。观察对比两组患儿治疗效果、不良反应发生情况。结果：甲组中 1例患儿疗效不明显，另外 19例均有改善，总有效率 95%;乙组中 5例疗效不明显， 1例病情恶化，另外 14例病情改善，总有效率 70%，两组间进行比较后得到 P<0.05。治疗后随访观察到，甲组患儿 1例出现尿痛的不良反应，乙组中有 6例，两组不良反应发生率的差异显著（ P<0.05）。结论：狼疮性肾炎患儿在治疗过程中可应用他克莫司与环磷酰胺进行治疗，对比发现，他克莫司可以明显提升治疗的有效率，并且控制了患儿不良反应的出现，治疗安全性得到保障，临床应用效果理想，值得推广。  　　【关键词】他克莫司 ;环磷酰胺 ;狼疮性肾炎 ;效果 ;不良反应率  　 [Abstract] Objective: To explore the effect and adverse reaction rate of tacrolimus and cyclophosphamide in the treatment of lupus nephritis. Methods: 40 patients (all diagnosed as lupus nephritis) were included in the experimental study. The study period was from March 2015 to may 2019. The observation objects were randomly divided into two groups, group A (20 cases) was treated with tacrolimus, and group B (20 cases) was treated with cyclophosphamide. The treatment effect and adverse reactions of the two groups were observed and compared. Results: in group A, the curative effect of 1 case was not obvious, the other 19 cases were improved, the total effective rate was 95%; in group B, the curative effect was not obvious in 5 cases, 1 case was deteriorated, the other 14 cases were improved, the total effective rate was 70%, the comparison between the two groups showed that P < 0.05. After treatment, 1 case of adverse reactions occurred in group A and 6 cases in group B. There was a significant difference in the incidence of adverse reactions between the two groups (P < 0.05). Conclusion: tacrolimus and cyclophosphamide can be used in the treatment of children with lupus nephritis. Compared with cyclophosphamide, tacrolimus can significantly improve the efficiency of treatment, and control the occurrence of adverse reactions in children. The safety of treatment is guaranteed and the clinical application effect is ideal, which is worthy of promotion.

简介：【摘要】目的：分析全科医学门诊老年高血压合并糖尿病患者的临床用药和治疗效果。方法：对我科收治的老年高血压合并糖尿病患者进行研究。回归性分析所有患者临床资料，掌握患者用药情况，并分析治疗前后血压、血糖变化情况。结果：在降压方案中，50例老年高血压合并糖尿病患者以CCB使用最多，占比34.00%，以利尿剂使用最少，占比12.00%；其中48.00%患者为二联用药，24.00%患者为三联用药，四联用药仅6.00%。在降糖方案中，以硫脲类药物使用最多，占比40.00%，以注射胰岛素应用最少，占比仅2.00%；其中56.00%患者为二联用药，20.00%患者三联用药。治疗后，患者DBP、SBP、FPG以及2hPG均显著低于治疗前，P＜0.05。结论：老年高血压合并糖尿病患者应根据具体病情采用合适用药进行治疗，并科学联用药物，提高降压或降糖效果。

简介：【摘要】目的：探讨冠心病合并糖尿病患者给予多样性护理方式对其生活质量和用药依从性的影响。方法：采用抽签法将我院于 2019年 5月 -2020年 5月期间收治的 94例冠心病合并糖尿病患者分为对照组和观察组，各 47例，其中对照组给予常规性护理方式，观察组记忆多样性护理方式，对比两组生活质量与用药依从性。结果：组间对比显示观察组心理职能、生理机能、物质生活、社会功能评分均较对照组高，且用药依从率更高，数据差异有统计学意义（ P＜ 0.05）。结论：冠心病合并糖尿病患者给予多样性护理方式可有效改善生活质量，确保定时、定量用药，值得推广。