简介：the use of body language in English teaching is necessary and practical. In the English teaching in middle schools,and the teachers should make full use of body language to develop the students' ability of reading aloud.When reading the sentences,the students' interest is motivated and the effect of teaching is greatly improved.II. The necessity and importance of using body language in English teaching English teaching is a key part of the school education. With the English teaching methods reform

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简介：Specificchangesinlandusecan,andoftendo,occurwhenanysocialeconomicsystemmovesfromoneformtoanother.Whentraditionalsocietiestransitfromtraditionallandusestophilosophicallydeterminedlanduses,asinthecaseoftheintroductionofsooialismorthetransitionfromsystemofplannedeconomytoamarketsystem,suchchangesseemconcentratedandperhapsexacerbated.Certainly,suchcircumstancesprovidetheopportunitytoseetheprocessofsocialphilosophyanditsimpactuponlanduseinatelescopedfashion.Thediscoveryandexplanationoftheseelementsmightprovidesomeinsightintobasichumanbehavior,anditsrelationshiptosocialcontrotandhowpeopleorganizespacebothwithandwithoutcontrol.ThispaperpresentstheresultsofobservationsofchangesinlanduseastheyhaveoccurredduringthecourseoftransitionaleconomicdevelopmentinBeijing,Chinaforthepastdecade,itsuggeststhreenewgenericcategoriesthatcanbeappliedtoanycultureorsociety.

简介：and the teachers should make full use of body language to develop the students' ability of reading aloud.When reading the sentences,3. Body language helps to improve reading The purpose of Senior English teaching is to train the students' preliminary ability of using spoken and written English. In the senior school,first rising tones and then falling tones in the choosing interrogative sentence. The students in the middle school are not often accustomed to and always confuse them

简介：1Background1.1BasicsituationofstudysiteYao’ancountyislocatedinthenorthwesternpartofcentralYunnanplateau.ItisoneoftheimportantgrainProductionbasecountiesofYunnanProvince.HanandYiarethemainethnicgroupsinthisprovince.BanliuAdministrativeVillagebelongsto...

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简介：AbstractThe field of drug-induced sleep endoscopy (DISE) has grown considerably over the last 10~15 years, to now include its use in pediatric patients. In this review article, we outline our approach to the use of this technology in Children with Airway Obstruction, most specifically in the management of children with airway obstruction and known or suspected adenotonsillar enlargement.

简介：AbstractBackground:Despite free diagnosis and treatment for tuberculosis (TB), the costs during treatment impose a significant financial burden on patients and their households. The study sought to identify the determinants for cata-strophic costs among patients with drug-sensitive TB (DSTB) and their households in Kenya.Methods:The data was collected during the 2017 Kenya national patient cost survey from a nationally representative sample (n= 1071). Treatment related costs and productivity losses were estimated. Total costs exceeding 20% of household income were defined as catastrophic and used as the outcome. Multivariable Poisson regression analysis was performed to measure the association between selected individual, household and disease characteristics and occurrence of catastrophic costs. A deterministic sensitivity analysis was carried using different thresholds and the significant predictors were explored.Results:The proportion of catastrophic costs among DSTB patients was 27% (n = 294). Patients with catastrophic costs had higher median productivity losses, 39 h [interquartile range (IQR): 20-104], and total median costs of USD 567 (IQR: 299-1144). The incidence of catastrophic costs had a dose response with household expenditure. The poorest quintile was 6.2 times [95% confidence intervals (CI): 4.0-9.7] more likely to incur catastrophic costs compared to the richest. The prevalence of catastrophic costs decreased with increasing household expenditure quintiles (proportion of catastrophic costs: 59.7%, 32.9%, 23.6%, 15.9%, and 9.5%) from the lowest quintile (Q1) to the highest quintile (Q5). Other determinants included hospitalization: prevalence ratio (PR)= 2.8 (95% CI: 1.8-4.5) and delayed treatment: PR = 1.5 (95% CI: 1.3-1.7). Protective factors included receiving care at a public health facility: PR = 0.8 (95% CI: 0.6-1.0), and a higher body mass index (BMI): PR= 0.97 (95% CI: 0.96-0.98). Pre TB expenditure, hospitalization and BMI were significant predictors in all sensitivity analysis scenarios.Conclusions:There are significant inequities in the occurrence of catastrophic costs. Social protection interventions in addition to existing medical and public health interventions are important to implement for patients most at risk of incurring catastrophic costs.

简介：AbstractMost of the medical and nonmedical research labs, all around the world, are racing against time to produce an effective vaccine or an antiviral medicine for coronavirus disease 2019 (COVID-19). Conventional medicines and novel nano-materials including chemical and herbal-based compounds are all into positive trials toward coronaviruses and other pandemic infections. Among them, natural immune boosters have attracted physicians because of their longevity and reliability for fewer side effects. This is a review article with a detailed picture of an unexplored antiviral source with maximum potency in curing viral infections. Cyanobacteriae have been known for centuries and are rich in secondary metabolites of proteins, biopeptides, and polysaccharides for prominent antiviral action against chest infections. But detailed exploratory research is required to purify, scale-up, and commercialize the pharmacologically active agents from these drug reserves.

简介：Inrecentyears,therearemanycrimesrelateddrugfraudoccuringinChinaandmanyexpertsthinkthatthemaincauseisthatChinaFoodandDrugAdministration(CFDA)adoptsannouncedinspection(AI).Inordertocircumventthisdifficulty,CFDAhasexploitedunannouncedinspection(UI)since2014.Inthispaper,theauthorsstudytheproblemofwhichoneperformsbetter,AIorUI.Specifically,theauthorsconsiderasupervisor,whichdecidestheinspectionapproach,inspectionstrengthandpunishmenttoforcethefirmtoputself-inspectionefforttomeettherequirementsofGoodManufacturingPractice,andafirm,whichproducesadruganddecidesitsself-inspectioneffort.Theauthorsusegametheorytomodelthisproblem,characterizetheequilibriumpoliciesunderAI,andcomparetheeffectsofthetwoapproachesonpreventingdrugfraudundercompleteandincompleteinformation.Theresultsshowthatunderthecompleteinformation,UIperformsbetterifthefirm'stechnicallevelandtheinspectioncostarelowandAIperformsbetterotherwise.Whenthesupervisordoesn'tknowthefirm'stechnicallevel,ifthelowtechnicallevelishigh,AIperformsbetter.Otherwise,UIperformsbetteriftheinspectioncostislowandAIperformsbetteriftheinspectioncostishigh.

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简介：Thelymphaticsystemhasanimportantdefensiveroleinthehumanbody.Themetastasisofmosttumorsinitiallyspreadsthroughthesurroundinglymphatictissueandeventuallyformslymphaticmetastatictumors;thetumorcellsmayeventransfertootherorganstoformothertypesoftumors.Clinically,lymphaticmetastatictumorsdeveloprapidly.Giventhelimitationsofsurgicalresectionandtheloweffectivenessofradiotherapyandchemotherapy,thetreatmentoflymphaticmetastatictumorsremainsagreatchallenge.Lymphnodemetastasismayleadtothefurtherspreadoftumorsandmaybepredictiveoftheendpointevent.Underthesecircumstances,novelandeffectivelymphatictargeteddrugdeliverysystemshavebeenexploredtoimprovethespecificityofanticancerdrugstotumorcellsinlymphnodes.Inthisreview,wesummarizetheprinciplesoflymphatictargeteddrugdeliveryanddiscussrecentadvancesinthedevelopmentoflymphatictargetedcarriers.

简介：Objective:Toclonemultidrugresistance(MDR)relatedgenesinlungadenocarcinomacelllines.Methods:ThedifferentiallyexpressedcDNAfragmentsbetweenA549andA549DDPcellswereanalyzedbymRNAdifferentialdisplayPCR(DDRT-PCR).ThefragmentsthusobtainedwerefurtheranalyzedbyDNAsequencingandNorthernblotting.Results:ThreedifferentiallyexpressedcDNAfragmentswereobtainedandconfirmedbyNorthernblot.Sequenceanalysisrevealedthattwoofthemwerenovelandonewas100%identicalwithICEgene.Conclusion:AnalyzingdifferentiallyexpressedfragmentbetweenA549andA549DDPcellsmaybehelpfulforfindingnewMDRrelatedgenes.ThedrugresistanceofA549DDPcellsmayberelatedtotheinhibitionordown-regulationofICEgene.

简介：Thereareseveralchallengestoinnereardrugdeliveryandimagingduetotheexistenceoftightbiologicalbarrierstothetargetstructureandthedensebonesurroundingit.Advancesinimagingandnanomedicinemayprovideknowledgeforovercomingtheexistinglimitationstoboththediagnosisandtreatmentofinnereardiseases.Noveltechniqueshaveimprovedtheefficacyofdrugdeliveryandtargetingtotheinnerear,aswellasthequalityandaccuracyofimagingthisstructure.Inthisreview,wewilldescribethepathwaysandbiologicalbarriersoftheinnerearregardingdrugdelivery,thebeneficialapplicationsandlimitationsoftheimagingtechniquesavailableforinnerearresearch,thebehaviorofengineerednanomaterialsininnerearapplications,andfutureperspectivesfornanomedicine-basedinnerearimaging.

简介：Platinum-basedanticanceragentsarewidelyusedasfirst-linedrugsincancerchemotherapyforvarioussolidtumors.However,greatsideeffectsandoccurrenceofresistanceremainasthemajordrawbacksforalmostalltheplatinumdrugsdeveloped.Toconquertheseproblems,newstrategiesshouldbeadoptedforplatinumdrugbasedchemotherapy.Modernnanotechnologyhasbeenwidelyemployedinthedeliveryofvarioustherapeuticsanddiagnostic.Itprovidesthepossibilityoftargeteddeliveryofacertainanticancerdrugtothetumorsite,whichcouldminimizetoxicityandoptimizethedrugefficacy.Here,inthisreview,wefocusedontherecentprogressinpolymerbaseddrugdeliverysystemsforplatinum-basedcombinationtherapy.

简介：Mitoxantrone,aclinicallyusefulantitumourantibioticforleukaemiaandbreastcancer,hasreceivedmoreattentions.Inthispaper,theinteractionbetweenmitoxantroneandcalfthymusDNAisinvestigatedbyRamanandfluorescencespectroscopies,andthebindingsiteofmitoxantronetocalfthymusDNAisexplored.TheresultsshowedthatmitoxantroneinteractswithcalfthymusDNAbasesbytheintercalationofanthracyclineintothebasepairplaneofadenine(A)andthymine(T),anditresultsinthedisruptionofthehydrogenbondsbetweencalfthymusDNAbases,andthusthecalfthymusDNAdouble-strandcanbedisruptedintotheB-formDNAdouble-strandsegments.

简介：TanshinoneIIAisapharmacologicallyactivecompoundisolatedfromDanshen(Salviamiltiorrhiza),atraditionalChineseherbalmedicineforthemanagementofcardiacdiseasesandotherdisorders.Butitsunderlyingmolecularmechanismsofactionarestillunclear.ThepresentinvestigationutilizedadataminingapproachbasedonnetworkpharmacologytouncoverthepotentialproteintargetsofTanshinoneIIA.Networkpharmacology,anintegratedmultidisciplinarystudy,incorporatessystemsbiology,networkanalysis,connectivity,redundancy,andpleiotropy,providingpowerfulnewtoolsandinsightsintoelucidatingthefinedetailsofdrug-targetinteractions.Inthepresentstudy,twoseparatedrug-targetnetworksforTanshinoneIIAwereconstructedusingtheAgilentLiteratureSearch(ALS)andSTITCH(searchtoolforinteractionsofchemicals)methods.AnalysisoftheALS-constructednetworkrevealedatargetnetworkwithascale-freetopologyandfivetopnodes(proteintargets)correspondingtoFos,Jun,Src,phosphatidylinositol-4,5-bisphosphate3-kinase,catalyticsubunitalpha(PIK3CA),andmitogen-activatedproteinkinasekinase1(MAP2K1),whereasanalysisoftheSTITCH-constructednetworkrevealedthreetopnodescorrespondingtocytochromeP4503A4(CYP3A4),cytochromeP450A1(CYP1A1),andnuclearfactorkappaB1(NFκB1).Thediscrepancieswereprobablyduetothedifferencesinthedivergentcomputerminingtoolsanddatabasesemployedbythetwomethods.However,itisconceivablethatalleightproteinsmediateimportantbiologicalfunctionsofTanshinoneIIA,contributingtoitsoveralldrug-targetnetwork.Inconclusion,thecurrentresultsmayassistindevelopingacomprehensiveunderstandingofthemolecularmechanismsandsignalingpathwaysofinasimple,compact,andvisualmanner.