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简介：Naturalproducts(NPs)arecompoundsthatarederivedfromnaturalsourcessuchasplants,animals,andmicroisms.Therapeuticshasbenefitedfromnumerousdrugclassesderivedfromnaturalproductsources.TheBiopharmaceuticsDrugpositionClassificationSystem(BDDCS)wasproposedtoserveasabasisforpredictingtheimportanceoftransportersandenzymesindeterminingdrugbioavailabilityanddisposition.Itcategorizesdrugsintooneoffourbiopharmaceuticalclassesaccordingtotheirwatersolubilityandextentofmetabolism.Thepresentpaperreviews109drugsfromnaturalproductsources:29%belongtoclass1(highsolubility,extensivemetabolism),22%toclass2(lowsolubility,extensivemetabolism),40%toclass3(highsolubility,poormetabolism),and9%toclass4(lowsolubility,poormetabolism).HereinweevaluatedthecharacteristicsofNPsintermsofBDDCSclassforall109drugsaswellsasforsubsetsofNPsdrugsderivedfromplantsourcesasantibiotics.Inthe109NPsdrugs,wepiled32drugsfromplants,50%(16)oftotalinclass1,22%(7)inclass2and28%(9)inclass3,nonefoundinclass4;Meantime,theantibioticswerefound5(16%)inclass2,22(71%)inclass3,and4(13%)inclass4;nodrugwasfoundinclass1.Basedonthisclassification,weanticipateBDDCStoserveasausefuladjunctinevaluatingthepotentialcharacteristicsofnewnaturalproducts.

简介：目的：观察针药并用治疗非特异性急性腰扭伤的临床疗效。方法：将69例患者按就诊川页序随机分为针药并用组、针刺组和药物组。针刺组24例，采用针刺治疗，每日1次，共治疗5次；药物组20例，采用口服双氯芬酸钠治疗，50mg每次，每日2次，连服5日；针药并用纽25例采用与针刺组、药物组相同的针刺和药物治疗。以疼痛量表和下腰痛量表评价临床疗效。结果：三组患者治疗后在疼痛，活动度方面均有一定改善，但针药并用组疗效最佳，与针刺组、药物组比较，差异有统计学意义（P〈0．01）；针刺组与药物组比较，差异无统计学意义。结论：针药并用治疗急性腰扭伤疗效优于单纯针刺治疗或常规剂量双氯芬酸钠治疗。

简介：Glioblastoma(GBM)isoneofthemostlethalhumancancers.GenomicanalysesdefinethemoleculararchitectureofGBMandhighlightacentralfunctionformechanistictargetofrapamycin(mTOR)signaling.mTORkinaseexistsintwomultiproteincomplexes,namely,mTORC1andmTORC2.Thesecomplexesdifferintermsoffunction,regulationandrapamycinsensitivity.mTORC1iswellestablishedasacancerdrugtarget,whereasthefunctionsofmTORC2incancer,includingGBM,remainspoorlyunderstood.ThisstudyreviewstherecentfindingsthatdemonstrateacentralfunctionofmTORC2inregulatingtumorgrowth,metabolicreprogramming,andtargetedtherapyresistanceinGBM,whichmakesmTORC2asacriticalGBMdrugtarget.

简介：Thepaperdescribesdrugreleaseevaluationofabiodegradablelong-actingcon-traceptiveCapsule(CaproF)containinglevonorgestrel(LNG)invivo.Poly(E-Capro-lactone)(PCL)biodegradablematerial,suitableformanymedicalapplication,wasusedinthisstudy.Itwasextrudedintotubes.ThetubeswerethencutandloadedwithLNGpowderbeforemelting-sealedonbothendstogetdrugcapsules.Thissub-dernalimplanthasbeenfoundtobehighlyeffectiveinanimalexperiments.Twoad-

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简介：CHAARTED是在荷尔蒙敏感的前列腺癌症独自除了雄激素剥夺治疗(ADT)对ADT与docetaxel的使用看早化疗的带ECOG的阶段III试用。在与ADT收到了化疗的那些在全面幸存显示出显著改进的试用的积极结果革命化了变形阉割敏感的前列腺癌症的治疗。除了全面幸存，第二等的端点象阉割抵抗的时间那样，PSA反应为收到了早化疗的病人也是重要的。

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简介：WiththeschemeofthevariationanalysisandKalmanfilter,theradardatawereadjustedbythereal-timeraingaugedata.Theaccuracyofarealrainfallcalculationwasimprovedandtheresultscanbebasicallyusedforfloodforecasting.ItisconcludedthattheschemeissuitableintheupperandmiddlereachesoftheHuaiheRiver.

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简介：Thebiogenicmonoaminesdopamine(DA),norepinephrine(NE)andserotonin(5-hydroxytryptamine,5-HT)aremajorneuromodulatorsinthemammaliancentralnervoussystem(CNS).DAcontainingneuronsarefoundini)themesolimbicsysteminwhichcellbodiesintheventraltegmentalarea(VTA)projectaxonsintotheamygdala,cortex,hippocampusandthe

简介：Moderncitiesandtownsplayasthecentralplacesofwealthaccumulationforhuman-being,notonlyinthewaysofsettlementandmaterialconsumptionastheyweretraditionallyinancienttime,butalsointhewaysofsocialproductionandenvironmentalpollutionastheyaremostlytoday.Withsuchatransition,themeaningoflanduseforurbanizationhasbroadened.Accordingtotheruleofhumanecosystem,landuseformodernurbanizationcanbedividedintothreetypes:namely,thedirect,theindirectandtheinduced.However,itsstructurefollowsitsownwayofthedirect

简介：土壤营养素的土壤侵蚀和损失是在西南中国的关键环境威胁。土壤质量上的土地使用和它的影响继续加亮。现在的学习被进行在四种陆地使用类型下面比较土壤侵蚀(即，林地，放弃的农田，耕种，和草地)并且他们土壤上的效果器官的碳(SOC)，全部的氮(TN)和在达恩奇·莱克分水岭的Shuanglong集水的全部的磷(TP)，中国。处于侵蚀率有大变化，越过四块陆地的滋养的分布使用类型。侵蚀率由137C平均2在在非栽培的地点的侵蚀率上的耕种和放弃的农田下面的133tkm−2年−1，和草地显示出网免职。为所有地点，滋养的内容基本上与土壤深度减少了。与耕种和放弃的农田相比，草地在0–40厘米土壤层以内有最高的SOC和TN内容，由林地列在后面。在137C，SOC和TN被观察。侵蚀在耕种引起的滋养的损失最高。这些结果建议因为他们由土壤侵蚀减少营养素的损失的能力，那块草地和林地将为在长期的经期上的SOC和TN隐遁是有益的。我们的学习证明在红土壤区域的滋养的损失的那减小能通过管理得好的植被恢复措施被做。

简介：一个潮模型(命名DN1.0)它在中国海和西北太平洋上包含12主要成分被从1993～2002拿的沿着轨道泛音分析withTOPEX/Poseidon测高法数据估计。CSR3.0，FES95.2和DN1.0areusedrespectively到detide为在YellowSea，华东海，华南海和西北太平洋的海水平异例(SLA)的时间系列的数据。SLA曲线和力量光谱在中国海在SLA存在的主要部件从潮的错误产生的密度表演当模特儿。

简介：陆地使用和陆地盖子变化(LULCC)强烈由联合生物化学、生物物理的过程影响地区性、全球的气候。然而，生物物理的过程经常被忽略，它可以抵消biogeochemical效果，因此到地址气候变化的措施不能到达目标。因此，LULCC的生物物理的影响为观察气候以后在过去和潜在的情形改变的理解是批评的。因此，鉴别气候上的大规模LULCC的机制和效果通过改变内在的表面变化是必要的，并且这样精力平衡。在必须被探讨包括的全球气候上理解人的活动的影响上的关键科学问题：(1)在中国和比较国家的LULCC的空间、时间的变化的基本科学事实是什么？(2)怎么理解联合在LULCC上然后到预报未来情形驾驶人的活动和气候变化的机制？(3)LULCC的科学机制是什么，在陆地表面，然后气候的生物物理的过程上影响吗？(4)怎么估计到气候的LULCC的贡献由影响土地的生物物理的过程变化出现？由国际比较，在本地、地区性、全球的规模的气候变化上的LULCC的影响被揭示并且评估。它能为全球变化提供理论基础，并且有大意义减轻并且适应全球气候变化。

简介：到控制的各种各样的方法在桥牌附近搜索墩被建议了。在现在的学习，电报或领子和领子的应用程序试验性地被检验，作为对在光滑的圆形的桥墩的本地搜索的反措施，近到一致沉积运动的开始的阀值流动条件。结果证明电报和领子的同时的使用在减少scour深度有高效率。最好的配置被作出对有利的裁决0.15的电缆线码头直径比率和15的线角度???????????????????????六?栠摹潲潬楧??????????吗？？

简介：ClimateeffectsoflandusechangeinChinaassimulatedbyaregionalclimatemodel(RegCM2)areinvestigated.Themodelisnestedinone-waymodewithinaglobalcoupledatmosphere-oceanmodel(CSIROR21L9AOGCM).Twomulti-yearsimulations,onewithcurrentlanduseandtheotherwithpotentialvegetationcover,areconducted.Statisticallysignificantchangesofprecipitation,surfaceairtemperature,anddailymaximumanddailyminimumtemperatureareanalyzedbasedonthedifferencebetweenthetwosimulations.ThesimulatedeffectsoflandusechangeoverChinaincludeadecreaseofmeanannualprecipitationoverNorthwestChina,aregionwithaprevalenceofaridandsemi-aridareas;anincreaseofmeanannualsurfaoeairtemperatureoversomeareas;andadecreaseoftemperaturealongcoastalareas.Summermeandailymaximumtemperatureincreasesinmanylocations,whilewintermeandailyminimumtemperaturedecreasesinEastChinaandincreasesinNorthwestChina.TheuppersoilmoisturedecreasessignificantlyacrossChina.Theresultsindicatethatthesamelandusechangemaycausedifferentclimateeffectsindifferentregionsdependingonthesurroundingenvironmentandclimatecharacteristics.

简介：Basedonthedataofurbanlanduseobtainedbyremotesensinginterpretationfromaeroimagesin1986and2004,thespatialstructureofJinanisstudiedinthispaperwiththemethodofGeographicInformationSystem(GIS).Accordingtotheproportionoflandforresidence,industryandcommerce,theurbandistrictcanbedistinguishedintothreerings.ComparedwiththetraditionaltheoryoftheringstructureinWesterncoun-tries,theyhavemanydistinctivecharacteristics.Themainfunc-tionsoftheinnerringincluderesidence,businessandbanking,buttheproportionofresidentialland(morethan50%)isconsiderablyhigherthanthatofthecitiesinWesterncountries.Thelandproportionforresidenceandindustryintheintermediateringisequalonthewhole.Themainlandoftheoutsideringisforindustrialuse.From1986to2004,greatchangeshavetakenplaceonthelandproportionofdifferenttypesofuse.Intheinnerring,thelandforresidentialandindustrialusehasshrunkmuchwhilethelandforcommercialusehasincreased.Intheintermediatering,thechangesofthethreetypesoflandusewerenotverymuchandthetemporalvariationwasrelativelystable.Onthecontrary,thestructureintheoutsideringvariesacutely.Thoughmostofitisalsoforindustrialuse,theproportionofresidentiallandhasin-creasedmuch.Thethreeringscanalsobedividedintoseveralsectorsrespectively,accordingtothefunctionoflanduseclusters.Newtrendsandmechanismsofthechangesoflanduseimpactingtheurbanstructurewereproposedintheendofthepaper.

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