简介:·Glaucomaisoneoftheleadingcausesofvisualimpairmentandblindnessworldwide.Ofknownriskfactorsforglaucoma,anincreasedinintraocularpressureismosthighlycorrelatedwithglaucomatousdamage.Irrespectiveofthecause,apoptosisoftheretinalganglioncellsistheeventualoutcome.Itiswidelyacceptedthatglaucomaisaneurodegenerativediseasethatisstronglycorrelatedwithcentralnervoussystemdisorders,suchasAlzheimer’sdisease.Thesetwodisordersalsosharesomesimilaritiesinpathogenicmechanisms.Recentstudiessuggestthatthetransientreceptorpotentialcanonical6channelcouldworktogetherwithbrain-derivedneurotrophicfactortopromoteneuronsurvivalinbrainandretina.Inthisstudy,weproposethattransientreceptorpotentialcanonical6maycontributetothepathogenesisofhumanglaucomaandbecomeapotentialtherapeutictarget.
简介:目的分析超声乳化对闭角型青光眼并发白内障患者视力恢复的影响。方法选取我院2014年10月~2016年1月收治的57例闭角型青光眼并发白内障患者,根据治疗方法不同分为超声乳化手术组(n=34)和小梁切除组(n=23),超声乳化手术组给予超声乳化联合后房型人工晶状体植入术,小梁切除组给予小梁切除术,比较两组术前、术后7d中央前房深度、眼压、视力、并发症发生率。结果术后7d超声乳化手术组中央前房深度高于小梁切除组,降眼压效果低于小梁切除组,差异具有统计学意义(P〈0.05);术后7d超声乳化手术组视力高于小梁切除组,差异具有统计学意义(P〈0.05);超声乳化手术组并发症发生率为8.82%(3/34),小梁切除组并发症发生率为4.35%(1/23),通过χ^2检验可知,两组并发症发生率比较差异无统计学意义(χ^2=0.015,P〉0.05)。结论超声乳化可显著改善闭角型青光眼并发白内障患者中央前房深度,提高患者视力,具有较高的实用价值,值得推广应用。