简介：Theexperimentalstudywasperformedin78rabbits,theexposedanteriorven-tricularsurfaceoftheopen—chestrabbitswereimpactedwithapendulum—likemovementimpactorsystemwhichwascontrolledbytheCardiaccycle.Undrsomegivenconditions,theexperimentalresultswereasfollows:（1）Theimpactsat5.0m·s-1resultedinnocardiacruptureinallattemps（16/16）attheendofsystoleas

简介：无

简介：Acutewaistsprainisalocalinjuryofthemuscle,fasciaandligamentinthewaistduetosuddenoverstretchbyexternalforcebeyondthenormalphysiologicallimit.Acutewaistspraincanleadtocicatrixadhesion,lossofnormaltis-suefunctionandchronicwaistpathologicalchangeswithouttimelyandeffecthetreatment.Longtimetreatmentwithoutcurewillaffectbothworkanddailylife.

简介：丙肝在全球保健上强加重要负担。长期的感染与典型地在肝硬化，机关失败和癌症表明的肝的进步发炎被联系。由精致的避免策略的优点，丙肝病毒(HCV)作为一个坚持的人的病毒成功。它有一个非凡的能力破坏使它能建立长期的感染和联系的肝疾病的有免疫力的反应。Chemokines是低分子的重量调停的趋化性的肽进纸巾的煽动性的房间和进lymphatics和外部血的背的招募。因此，他们对受动器和规章的有免疫力的房间的时间、空间的分发中央。在chemokines和他们的血缘的受体帮助之间的相互作用塑造有免疫力的反应因此，在感染的结果上有主要影响。然而，chemokines包括HCV由病毒为调整代表一个目标。HCV被知道并且可以因此由通过改变的白血球在vivo破坏有免疫力的反应启用它的幸存趋化性导致损害病毒的清理和长期的低档发炎的建立在vitro调制chemokine表示。在这评论，在尖锐、长期的HCV感染的chemokines的角色被描述，一个特别重音作为有免疫力的颠覆的一个工具放了在chemokine调整上。我们提供一在里面部分的深度讨论在调停由chemokines玩了肝的纤维变性当在预示的药为这些chemoattractants探讨潜在的应用时。

简介：目的：评价单一穴位治疗急性腰扭伤的治疗效果。方法：根据统一的诊断标准，在多个临床中心进行随机对照研究。全部病例320例经随机数字表法分为针刺后溪穴观察纽和针刺腰痛点对照组。对患者的疼痛程度分别由医师和患者进行评分。结果：治疗2个疗程后，观察组和对照组近期有效率分别为89．4％和82．5％，远期有效率分别为95．6％和93．5％。经Ridit分析，近期疗效差异有统计意义(P<0．05)，远期疗效差异无统计意义(P>0．05)。结论：针刺单一穴位治疗急性腰扭伤疗效确切，取穴简便，后溪穴疗效好于腰痛点。

简介：ObjectiveTofurtherimprovetherateofreperfusionofinfarctionrelatedarteryinAMI,removethestricture,rescueischemicmyocardium,protectcardiacfunctionandamelioratethelong-termprognosis.MethodAmong73patientswithA-MI,50underwentdirectPICA,15immediatePICA,8rescuePTCAand20braceswereimplanted.ResultTheproportionofrecanalizationis94.5%(69/73).Thegradeofbloodflow(TIMI)improvedtograde3in20patientswithbraceimplantation,while44tograde3and5tograde2among49patientswithsimplePTCA.Residualstenosisinvesselwas1.8±5.9(-10-10)%inpatientswithbraceimplantationversus15.4±11.(0-30)%withsimplePTCA.Theincidenceofreperfusivecardiacarrythmiawas18.1%(10/62).Therewasmainlyfrequentventricularprematurebeatandshortparoxysmalventriculartachycardia,ifleftanteriordecendingbranchwasreopened,whilebradycardiaandatrialventricularblockusuallyoccurredafterrightcoronaryreperfused.ConclusionEmergencyP

简介：Background:Attentiondeficithyperactivitydisorder(ADHD)isacommonchildhooddisorderthataffectsapproximately11%ofchildrenintheUnitedStates.Researchsupportsthatasinglesessionofexercisebenefitscognitiveperformancebychildren,andalimitednumberofstudieshavedemonstratedthattheseeffectscanalsoberealizedbychildrenwithADHD.ThepurposeofthisstudywastoexaminetheeffectofacuteexerciseoncognitiveperformancebychildrenwithandwithoutADHD.Methods:ChildrenwithandwithoutADHDwereaskedtoperformcognitivetaskson2daysfollowingtreatmentconditionsthatwereassignedinarandom,counterbalancedorder.Thetreatmentconditionsconsistedofa30-mincontrolconditionon1dayandamoderateintensityexerciseconditionontheotherday.Results:ExercisesignificantlybenefitedperformanceonallthreeconditionsoftheStroopTask,butdidnotsignificantlyaffectperformanceontheTowerofLondonortheTrailMakingTest.Conclusion:childrenwithandwithoutADHDrealizebenefitsinspeedofprocessingandinhibitorycontrolinresponsetoasessionofacuteexercise,butdonotexperiencebenefitsinplanningorsetshifting.

简介：AbstractImportance:Acute respiratory infections are quite prevalent in children. Transient hyperphosphatasemia (TH) is defined as the transient elevation of serum alkaline phosphatase (ALP) level, which occurs mainly in infants and children without liver or bone disorders. Although no apparent cause has been identified, a possible association of respiratory infections with TH has been reported in the literature.Objective:In this study, we aimed to investigate the association between TH and respiratory infectious diseases.Methods:We collected the results of biochemical investigations, including ALP level, for a period of 5 years in our hospital. We then examined the patients with transiently elevated ALP levels of > 2000 U/L.Results:During the observation period, 1501 blood samples were collected from 1097 patients. Marked elevation of serum ALP level was observed in 12 patients. All patients with hyperphosphatasemia, except for one with Fanconi syndrome attributable to the underlying Wilson’s disease, were aged < 5 years and were diagnosed with TH. Ten of these 11 patients with TH had acute respiratory infections. Marked ALP elevation was not found in any patients with non-inflammatory diseases. ALP isoenzyme profiles showed a characteristic pattern in all six patients in whom the ALP isoenzyme test was conducted.Interpretation:Our results suggest an association between respiratory infections and TH. The consideration of TH in patients with acute respiratory infections may lead to earlier and accurate diagnosis of this condition, thereby avoiding unnecessary medical interventions.

简介：AbstractBackground:Intravenous thrombolysis (IVT) is an effective way for treating acute ischemic stroke (AIS). However, its effects have not been established among AIS patients with unclear stroke symptoms or with stroke onset for >4.5 h.Methods:We searched PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and Google Scholar databases for randomized controlled trials that compared IVT (IVT group) and placebo or usual care (control group [CG]) in AIS patients with disease onset for >4.5 h. The outcomes of interest included the favorable functional outcome (defined as modified Rankin Scale [mRS] scores 0-1) at 90 days, the functional independence (defined as mRS scores 0-2) at 90 days, proportion of patients with symptomatic intracerebral hemorrhage (sICH) and death at 90 days. We assessed the risk of bias using the Cochrane tool. Pre-specified subgroup analyses were performed by age (≤70 years or >70 years), National Institute of Health Stroke Scale (NIHSS, ≤10 or >10) and time window (4.5-9.0 h or >9.0 h).Results:Four trials involving 848 patients were eligible. The risk of bias of included trials was low. Patients in the IVT group were more likely to achieve favorable functional outcomes (45.8% vs. 36.7%; OR 1.48, 95% CI 1.12-1.96) and functional independence (63.8% vs. 55.7%; OR 1.43, 95% CI 1.08-1.90) at 90 days, but had higher risk of sICH (3.0% vs. 0.5%; OR 5.28, 95% CI 1.35-20.68) at 90 days than those in the CG. No significant difference in death at 90 days was found between the two groups (7.0% vs. 4.1%; OR 1.80; 95% CI 0.97-3.34).Conclusions:Use of IVT in patients with extended time window may improve their functional outcomes at 90 days, although IVT may induce increased risk of sICH. Care of these patients should well balance the potential benefits and harms of IVT.

简介：AbstractPediatric acute hyperextension spinal cord injury (SCI) named as PAHSCI by us, is a special type of thoracolumbar SCI without radiographic abnormality and highly related to back-bend in dance training, which has been increasingly reported. At present, it has become the leading cause of SCI in children, and brings a heavy social and economic burden. Both domestic and foreign academic institutions and dance education organizations lack a correct understanding of PAHSCI and relevant standards, specifications or guidelines. In order to provide standardized guidance, the expert team formulated this guideline based on the principles of science and practicability, starting from the diagnosis, differential diagnosis, etiology, admission evaluation, treatment, complications and prevention. This guideline puts forward 23 recommendations for 14 related issues.

简介：AbstractBackground:Carbon monoxide (CO) poisoning remains a major cause of accidental injuries and multiple studies have indicated that CO is also associated with significantly severe or long-term toxicity to the central nervous system. Given that CO poisoning causes serious morbidity and mortality, a better understanding of epidemiological features and clinical characteristics of acute CO poisoning in China is crucial.Methods:We collected the clinical data of acute CO poisoning in patients between November 2019 and April 2020 across Shandong province, China and analyzed its characteristics focusing on the weekly amount and the severity of the confirmed cases.Results:A total number of 21,088 acute CO poisoning cases were diagnosed. The overall incidence of acute CO poisoning was approximately 0.021%. On severity rankings, 63% of confirmed cases (n = 13,378) were mild, 27% (n = 5635) were moderate, and 10% (n = 2075) were severe. Interestingly, the coastal cities had more confirmed cases than the inland/suburban areas in Shandong. Meanwhile, the number of confirmed cases was negatively correlated with the local mean daily temperature (P = 0.0167).Conclusions:Mild acute CO poisoning cases accounted for the majority of all confirmed cases during the winter of 2019. In Shandong province, which is located in east China, residents of the coastal cities are more susceptible to CO poisoning than residents of inland cities.

简介：AbstractNearly one-fourth of the world’s population is infected with Mycobacterium tuberculosis (MTB). Female genital tuberculosis (TB) is a common cause of infertility in both developing and undeveloped countries. Furthermore, assisted reproduction treatments and pregnancy potentially increase the risk of TB infection and reactivation. In this study, we present the case of a 28-year-old infertile female without a history of TB who developed an acute miliary TB and pelvic TB after in vitro fertilization-embryo transfer (IVF-ET). Elevated serum estrogen levels during controlled ovarian hyperstimulation and T-lymphocyte function inhibition during pregnancy are the risk factors for MTB infection and reactivation. In her 7th week of gestation, the patient developed fever and spontaneously aborted. Her chest computed tomography images revealed classical miliary TB. Uterine curettage tissue and vaginal secretion samples as well as Gene X-pert MTB/rifampicin (RIF) and TB-RNA test results were positive for MTB. Histological examination of the uterine curettage tissue confirmed the diagnosis of endometrial TB. Treatment with isoniazid, RIF, pyrazinamide, amikacin, and levofloxacin was selected based on the patient’s diagnosis, complications, and test results. Currently, the patient is undergoing anti-TB treatment, and her condition is stable. It is important to rule out the presence of TB in infertile patients before performing IVF-ET to avoid TB dissemination during pregnancy.

简介：无

简介：PatientswithAcuteCoronarySyndrome(ACS)areaclinicalcontinuum-withpatientspresentingwithunstableanginaononeend,withpatientswithSTelevationmyocardialinfarction(STEMI)attheotherendofthespectrum.Inbetweenarethosewithnon-ST

简介：Thisstudysoughttoexamineneuroglobin(NGB)intheserumofacutecerebralinfarctionpatientswithdouble-antibodysandwichenzyme-linkedimmunosorbentassaytoidentifyallriskfactors,calculateinfarctsize,assessneurologicalimpairment,andanalyzetherelationbetweenNGBandeachofthesefactors.Thedouble-antibodysandwichassayindicatedthatlevelsofNGBinserumwereunalteredwithin6hoursfollowingacutecerebralinfarctioncomparedwithnormallevels.NGBlevelsthenunderwentadistinctchange,peakingat24hoursthenreturningtonormallevelsin72hours.TheresultssuggestthatthelevelofNGBmightberelatedtoinfarctsizeandlow-densitylipoproteinat24hoursafteracutecerebralinfarction.Therewerenosignificantdifferencesinneurologicalimpairmentscoresandinfarctsizeatdifferentperiodsfollowinginfarction.ThefindingsindicatedthatthelevelofNGBinserumofacutecerebralinfarctionpatientswascorrelatedwithinfarcttime.

简介：AIM:Toinvestigatethediagnosticaccuracyofthemeanplateletvolumeandplateletdistributionwidthinacuteappendicitis.METHODS:Thisretrospective,case-controlledstudycompared295patientswithacuteappendicitis(Group?Ⅰ),100patientswithotherintra-abdominalinfections(GroupⅡ),and100healthyindividuals(GroupⅢ)betweenJanuary2012andJanuary2013.Theage,gender,andwhitebloodcellcount,neutrophilpercentage,meanplateletvolume,andplateletdistributionwidthvaluesfrombloodsampleswerecomparedamongthegroups.StatisticalanalyseswereperformedusingSPSSforWindows21.0software.Inaddition,thesensitivity,specificity,positiveandnegativepredictivevaluesandlikelihoodratios,anddiagnosticaccuracywerecalculated.RESULTS:Themeanagesofpatientswere29.9±12.0yearsforGroup?Ⅰ,31.5±14.0yearsforGroupⅡ,and30.4±13.0yearsforGroupⅢ.Demographicfeaturessuchasageandgenderwerenotsignificantlydifferentamongthegroups.Whitebloodcellcount,neutrophilpercentageandplateletdistributionwidthweresignificantlyhigherinGroup?Ⅰ?comparedtogroupsⅡandⅢ(P<0.05).Diagnostically,thesensitivity,specificityanddiagnosticaccuracywere73.1%,94.0%,and78%forwhitebloodcellcount,70.0%,96.0%,and76.0%forneutrophilpercentage,29.5%,49.0%,and34.0%formeanplateletvolume,and97.1%,93.0%,and96.0%forplateletdistributionwidth,respectively.ThehighestdiagnosticaccuracydetectedwasforplateletdistributionwidthbetweenGroup?Ⅰ?andGroupⅢ(P<0.01).CONCLUSION:Plateletdistributionwidthanalysiscanbeusedfordiagnosisofacuteappendicitiswithoutrequiringadditionaltests,thusreducingthecostandlossoftime.

简介：TocomparetheclinicaleffectofneedlingtheAshipoint(4cmlateraltothelowerborderofthespinousprocessofcervicalvertebra)plusYaotongdianonthehandandpointinjectionontheAshipointwithTriamoninde.Thecurativeeffectofacupuncturewasbetterthanthatofpointinjection.

简介：目的：观察电针治疗急性腰扭伤的，临床疗效以及治疗前后腰部红外热像图的变化。方法：采用随机数字表将295例急性腰扭伤患者随机分为电针组147例和药物组148例，电针组选用后溪穴治疗，药物组用美洛昔康片治疗，各组治疗前后进行腰部红外热像图的检查。结果：电针组和药物组痊愈率分别为71．4％和42．6％；有效率分别为93．9％和87．2％（P〈0．01）；电针组与药物组红外热像图治疗前后温度差分别为为2．52℃和0．80℃（P〈0．01），二者有显著性差异。结论：电针组和药物组治疗急性腰扭伤均有显著疗效，但电针组的总体疗效优于药物组，且电针组治疗前后红外热像图的升温效应也明显高于药物组。

简介：尖锐胰腺炎是能触发全身的inammatory回答的本地织物损害描绘的inammatory疾病。胰腺炎的那么脉管的复杂并发症是病态和死亡的一个主要原因。在尖锐胰腺炎的肺的栓塞被报导了很稀罕。我们与尖锐胰腺炎报导了肺的栓塞的一个案例。一个38岁的女人爆发了没有明确的动机的上面的腹部疼痛。她没有恶心并且呕吐，发烧，呼吸困难，咳嗽和咳痰，胸疼痛。病人在本地医院里与尖锐胰腺炎被诊断了。病人与抗菌素和质子泵禁止者被对待，并且腹部疼痛稍微被减轻。但是病人向前来了有一点血的咳嗽和咳痰，进步呼吸困难。腹部的计算tomographic扫描揭示了胰腺炎。胸的随后的计算机断层摄影术angiography揭示了肺的栓塞(两个都击倒恰好肺的动脉的肺的动脉，左肺的动脉和分支)。病人的呼吸困难与thrombolytic治疗和anticoagulation治疗变好。肺的栓塞是胰腺炎的稀罕却潜在地致命的复杂并发症。对这复杂并发症的熟悉将帮助它的早诊断，治疗并且阻止肺的栓塞，稀罕却灾难的现象。

简介：