简介：Tomakeitpossibleforthethermalwavetheoryontemperatureoscillation(TO)effectsinlivingtissuestobefoundedonthesubstantialexperimentalbasis,aseriesoftypicaldecisiveexperimentsinvivoaswellasinartificiallysimulatingcostructionswerecarredout.COnclusionsobtainedincludingsomeotherscholarsanimalexperimentalresultsallgreatlysupportthethermalwaveviewpointqualitatively,Afewexperimentalfactsusednottobeeasilyunderstoodfromtheclassicalviewpointarealsowellreinterpreted.TherevealingonthethermalwavemechanismsofTOinlivingtissuesisabrandnewdiscoveryanddeepinsightintothisimportantthermophysiologicalphenomenon,Itmaypossiblypromotenewinvestigationsonthecorrespondingtopicsinthefieldofbioheattransferscience.

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简介：Ｃｏｍｐｒｅｈｅｎｓｉｖｅｉｎｄｉｃｅｓｏｆｅａｒｌｙｊｕｄｇｅｍｅｎｔｆｏｒｅａｒｔｈｑｕａｋｅｓｅｑｕｅｎｃｅｔｙｐｅｂｙｐａｔｅｒｎｒｅｃｏｇｎｉ┐ｔｉｏｎＣＵＩ－ＹＩＮＧＺＨＯＵ１）（周翠英），ＹＵ－ＸＩＡＺＨＡＮＧ２）（张宇霞），ＨＯＮＧ...

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简介：CellResearchispublishedmonthlybyNaturePublishingGroupinpartnershipwithShanghaiInstitutesforBiologicalSciences(SIBS),ChineseAcademyofSciences(CAS).CellResearch,whichpublishesexclusivelyinEnglish,isChina'sleadingjournalinthelifescienceswithacurrentImpactFactorof3.426(Thomson-ISI,PA,USA2007).Thejournalisindexed/abstractedinIndexMedicus/Medline/PubMed,ScienceCitationlndex,CurrentContents-lifeSciences,SciSearchandISIWebofScience,ChemistryAbstracts,BIOSIS,VINITI,Cbinainfo(CD&Web),CJFD(CD&Web),CJCDandCEPS,etc.ScopeCellResearchisaninternationaljournalpublishingpeer-reviewedoriginalarticles,invitedreviews,commentaries,andshortcommunications.Thejournalhasaninternationalauthorshipandabroadscopeinbasicresearchofcellbiology,molecularcellbiology,includingcellgrowthanddifferentia-tion,signaltransduction,apoptosis,stemcells,development,immunology,neurosciences,plantcellbiology,chromatinmodulation,epigeneticsandtranscription.EditorialManuscriptsshouldbesubmittedonlineathttp://www.nature.com/crorhttp://www.cell-research.com.Howeverifyouhaveproblems,pleasecontactEditorialOfficeatcellres@sibs.ac.cn.DetailedInstructionsforAuthorsarealsoavailableattheabovewebsites.PublisherExceptforcompaniesbasedinmainlandChina,allbusinesscorrespondenceandenquiriesaboutsupplementpublication,sponsorshipopportunitiesandadvertisingshouldbeaddressedtoNaturePublishingGroup(NPG).NickCampbell,AssociatePublisher,ExecutiveEditor:NPGNatureAsia-Pacific,MacmillanPublishers,LockedBag1,PrahranVIC3181,Australia.Tel:+61(0)398251028;Fax:+61(0)398251010.E-mail:n.campbell@natureasia.com

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简介：AbstractBackground:Recent studies using mass drug administration (MDA) of antibiotics to entire communities have focused global attention on the unique ethical challenges of MDA of antibiotics in research and public health interventions. However, there is no specific guidance for Research Ethics Committees (RECs) or Institutional Review Boards (IRBs) to review such trials. We surveyed the literature to identify the unique ethical challenges and to strengthen the competencies of RECs or IRBs in low- and middle-income countries (LMICs) in their ethical reviews of these trials.Methods:We employed a desk review. We searched PubMed, Web of Science, and Google Scholar, combining terms for "mass drug administration" with terms for "research ethics committees," "institutional review boards," and "ethics." We reviewed citations of search results to retrieve additional articles. Only articles published and indexed in the above databases up to 6 January 2022 in English were included. Abstracts (without full articles), books and articles that had exclusive veterinary and environmental focus were excluded. We synthesized the literature to identify particularly challenging ethical issues relevant to antibacterial MDA trials in LMICs.Results:The most challenging ethical issues can be categorised into four broad domains: determining the social value of MDA, assessing risks and benefits, engaging all stakeholders meaningfully, and study design-related ethical challenges. These four domains interact and impact each other. Together, they reveal the need for RECs/IRBs to review MDA studies through a broader lens than that of clinical trials per se. From our findings, we propose a framework to guide the RECs and IRBs in LMICs to perform the initial and continuing review of antibiotic MDA trials. We also recommend strengthening the competencies of LMIC RECs or IRBs through ongoing training and collaboration with RECs or IRBs from high-income countries.Conclusions:REC/IRB review of research using MDA of antibiotics plays a critical role in assuring the ethical conduct of MDA studies. Local RECs/IRBs should be empowered to review MDA studies comprehensively and competently in order to advance scientific knowledge about MDA and promote improved global health.

简介：TheGroupofNuclearStructureResearchatIMPhasdevotedmuchefforttothestudyofin-beam-rayspectroscopyandγ-decayspectroscopy.Oneterminalforin-beam-rayspectroscopyhasbeennewlybuiltupin2016.Asforγ-decayspectroscopy,twopointsneedtobeemphasized.Inordertostudythein-beam-rayspectroscopy,aballwasplacedattheterminalofnewTL2beamline.Threequadrupolemagnetsfollowingthedipolemagnetarethemainbuildingblocksalongthebeamline.Theballconsistsof8cloverand16HPGedetectorswithaCsIballinsidetoselectthechargedparticlechannel.Awallisolatingtheballfromthequadrupoleswasusedtoshieldtheradiationproducedbytheacceleratoranddepositingenergyinthedetectors,whichmayresultinahighbackground.Theinstallationwasfinishedin2016andtheexperimentforin-beam-rayspectroscopyisexpectedtoperformin2017.

简介：TheGroupofNuclearStructureResearchatIMPhasdevotedmuchefforttothelifetimemeasurementsoflowlyingexcitedstatesvia??fasttimingcoincidence.Twoexperimentswereperformedin2015attheradioactivebeamlineRIBLL[1]andgas-filledrecoilseparatorSHANS[2].

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简介：烃未来的地区是在被估计生产油的一座水库的某个层。地质学家使用质的分析方法发现前景层。研究使用了三个模糊会员函数和模糊逻辑的八条规则建模的五个变量。规则在工作系统引起感觉迟钝。这研究被用36条规则为每输入变量建模进不同模型因此进行。它试图决定烃的存在通过在用有Mamdani的模糊推理系统的一座水库的质的分析的未来的地区方法。数据在水库X从井日志数据被拿。在做这研究有一些步骤，包括fuzzification，推理系统，和defuzzification。结果与97.7%精确性在水库X从3000层显示出99前景层。

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简介：Objective:ToexaminetheexpressionsofMDM2,P53andP27proteinsinchronicesophagitis,para-cancermucosaandesophagealcarcinoma.Methods:ImmunohistochemistrywasusedtodetecttheexpressionsofMDM2,P53andP27proteinsinforty-sevenpatientssufferingfromchronicesophagitisandeighty-fivecasesofesophagealcarcinomaandcorrespondingpara-cancermucosa.Flowcytometry((FCM)wasappliedtodetectthequantitiesoftheseproteinsexpressedinfreshtissuesof48casesofesophagealcancerandtheirpara-cancertissuesand24casesofrelativenormalmucosaatthesurfaceofcuttingedge.Results:Immunohistochemistryresultsshowedthattheexpressionsofthethreestudiedproteinswereverysimilarintheepitheliaofchronicesophagitisandpara-cancermucosa(P>0.05).BoththequalitativeandquantitativestudiesdisplayedthattheP53proteinhadnoexpressionanditsaccumulationswouldappearonlyintheearlystagesofesophaguscancerationwhiletheMDM2andP27proteinshaddifferentdegreesofexpressionsincasesofnormalesophagealmucosa.MDM2proteinmarkedlyincreasedintheadvancedstagesofesophagealcanceration.AquantitativestudyshowedthattheexpressionofP27proteinhadalinearityofdecreasingtendency(F=9.132,P=0.002)inthecourseofesophagealcanceration.Conclusion:Chronicesophagitismaybeaprecancerouslesion.OwingtothechangesoftheP53andP27proteins,wecanalsoconcludethattheseoccurintheearlystagesofesophagusoncogenesis,howeverthechangesofMDM2expressionmayoccurintheadvancedstageofesophagealcanceration.