简介：nano-TiO2粒子被液体水解作用方法准备并且描绘了使用XRD。它对二个代表的抗菌剂活动细菌，Escherichiacoli和葡萄球菌aureus，也被学习。试验性的结果出现了在600700瑵椠?楶牴?整瑳?湡?敲慰物?的nano-TiO2calcinated???業散挠污慶楲污搠晥'太B.吗？？

简介：从一只使免疫的dipteran昆虫的一抗菌剂活动部分，Bactrocera背面由prepurification，离子交换层析，胶化过滤层析和反向阶段的高效液体层析(HPLC)是，被孤立并且净化。最后的净化的部分在聪明的系统HPLC上被检查并且被认为是纯部分。Theresults物理并且生物检验表明这部分是热对克积极的细菌的生长的稳定、显示出的强壮的活动。它拥有antibicrobial肽性质并且值得进一步的调查。

简介：新不对称的Schiff基础配合体(H_2LLi)是综合usingL离氨酸，水杨酸基醛和2-hydroxy-1-naphthaldehyde。这配合体的三稳固的金属建筑群[行(H_2L)(NO_3)]NO_3·2H_2O(行=La，Sm，惊讶)被元素的分析，红外系列，紫外系列，TG-DTG和臼齿的传导力准备了并且描绘。theligand和它的建筑群的抗菌剂活动也被学习。抗菌剂实验显示它的建筑群拥有的ligandand对Escherichia关口i，葡萄球菌aureus和杆菌的抗菌剂活动敏锐并且建筑群配合体比那些举办更高的活动。

简介：因为他们联合了木头和无机的混合物的优点，混合木头材料吸引了可观的注意。这个工作调查了微结构形态学，热稳定性，紫外(紫外)用wood/ZnO混血儿材料做通过的composites的稳定性，和抗菌剂性质一灵巧在原处化学合成方法。X光检查衍射(XRD)和thermogravimetric分析(TGA)结果显示综合ZnO粒子有大约10.8nm的一种平均谷物尺寸。扫描电子显微镜学(SEM)观察证明与nanosheets自我装配的ZnOnanoflowers在木头房间腔被介绍并且与增加Zn2+集中增加了。ZnOnanoparticles也在木头房间墙中被产生，它被精力散的光谱学(版本)的结果证实。TGA测试也显示wood/ZnO混血儿材料的热稳定性在ZnO无机的粒子的形成以后被改进。最后，抗菌剂功效测试的结果和紫外抵抗测试表明ZnOnanoparticles对Escherichiacoli作为抗菌剂代理人显示出有希望的未来(E。coli)并且为木头保护的紫外抵抗代理人。

简介：我们为把坚持、有效的抗菌剂性质合并到广泛地使用的聚合物报导灵巧的策略，poly(甲基methacrylate)(PMMA)，由异分子聚合有2-(tert-butylamino)的甲基methacrylate(MMA)在经由原子转移基聚合(ATRP)的一个壶的乙醇methacrylate(TA)。随后自己组装结果poly(甲基methacrylate)-block-poly[(2-tert-butylamino)ethylmethacrylate](PMMA20-b-PTA15)diblock共聚物负担得起明确的水可分散的泡，它能轻易地为有效抑制在医院里在墙上被喷洒并且细菌杀死。1H-NMR和胶化浸透层析(GPC)研究证实了良好共聚物的成功的合成。传播电子显微镜学(TEM)，原子力量显微镜学(AFM)和散布的动态光(DLS)学习与狭窄的尺寸分发证明了泡的形成。DLS研究在各种各样的温度揭示了泡的优秀稳定性。抗菌剂测试对克积极、克否定的细菌显示出聚合物泡的有效抗菌剂活动。而且，这策略可以为在许多领域里为灵巧的抗菌剂应用准备大量聚合材料被扩大。

简介：

简介：Magnesium(Mg)alloyshaveattractedconsiderableresearchattentionaspotentialbiocompatibleimplantmaterials.However,themajorbarrierstotheextendeduseofsuchmedicaldevicesarethepossibilityofhighcorrosionrateandimplantassociatedinfections.Tosolvethem,anovelpolyacrylicacid(PAA)/gentamicinsulfate(GS)-hydroxyapatite(HAp)coatingwassynthesizedbyaone-stephydrothermaldepositionmethod.CharacteristicsoffunctionalcoatingswereinvestigatedbySEM,FTIRandXRD.Corrosionpropertiesofsampleswereevaluatedbyelectrochemicalandhydrogenevolutiontests.AntibacterialactivitiesofthecoatingsagainstStaphylococcusaureus(S.aureus)weremeasuredbytheplate-countingmethod.Resultsshowedthattheas-preparedHApcoatingwithdenseandflawlessmorphologiescouldnotonlyenhancethecorrosionresistanceofMgalloys,butalsoimprovetheadhesionstrengthbetweentheHApcoatingandthesubstrate.Inaddition,theinductionoftheapatitecoatingduringimmersionconfirmedtheexcellentmineralizationabilityoftheHApcoating.Moreover,theobtainedHApcoatingpossessedantibacterialpropertiesandcouldprolongthereleaseofGS.Thus,thePAA/GS-HApcoatedMgalloycouldserveasabettercandidateforbiomedicalapplicationswithgoodanti-corrosionandantibacterialproperties.

简介：AninorganicnanomaterialscombinationofSm,Ag,andTiO2wassynthesizedusingsupercriticalfluiddrying(SCFD)combinedwithsol-geltechniques.Thestructure,photocatalysisandbacteriostaticactivityofthematerialswerecharacterizedbyX-raydiffraction(XRD),transmissionelectronmicroscopy(TEM),X-rayphotoelectronspectroscopy(XRPS),photocatalyticperformance,andantibacterialactivityexperiments.TheXRDresultsshowedthattheaverageparticlediameterofSm/Ag/TiO2was14.62nmandAgandSmionsweredispersedonthesurfaceofTiO2inahighlydispersed,amorphousform.TheTEMimageshowedthatthesizeoftheparticlewas12nmusingtheschererformula.TheXPSresultshowedthattheelementSmwasdopedandAgwasloadedinorganicnanomaterialssuccessfully.Sm/Ag/TiO2exhibitedoptimalphotocatalyticpropertiesat600oC,thephotocatalyticoptimalproportionofSm/Ag/TiO2was2:2:100.Whenthemolarratiowas2:2:100,thebacteriostaticcirclediameterwas16mmforStaphylococcusaureus,theminimumbacteriostaticconcentrationwas200μg/mLforwhitebeadscoccus,andtheminimumbactericidalconcentrationwas2×104μg/mLforwhitebeadscoccus.TheSEMresultsshowedthattheantibacterialmaterialattachedtothecandidaalbicanscellsurface,cellsappearedfolddeformation.ThereforetheinorganicnanomaterialsSm/Ag/TiO2hadhightemperatureresistance,goodphotocatalyticandantibacterialcharacteristicsinvisiblelight.

简介：NocathiacinI,aglycosylatedthiopeptideantibiotic,displaysexcellentantibacterialactivitiesagainstmultidrugresistantbacterialpathogens.Previously,anovelnocathiacinIformulationforintravenousadministrationhasbeensuccessfullydevelopedanditsaqueoussolubilityisgreatlyenhancedforclinicalapplication.ThepurposeofthepresentstudywastoincreasethefermentationtiterofnocathiacinIandreduceoreliminateanalogousimpuritiesbyscreeningthemediumingredientsusingresponsesurfacemethodology.Afterasysmaticoptimization,awater-solublemediumcontainingquality-controllablecomponentswasdevelopedandvalidated,resultinginanincreaseintheproductionofnocathiacinIfrom150to405.8mg·L-1at150-Lscale.Meanwhile,theanalogousimpuritiesexistedinreportedprocessesweregreatlyreducedoreliminated.Usingoptimizedmediumforfermentation,nocathiacinIwithpharmaceuticallyacceptablequalitywaseasilyobtainedwitharecoveryof67%.Inconclusion,theresultsfromthepresentstudyofferapracticalandefficientfermentationprocessfortheproductionofnocathiacinIasatherapeuticagent.

简介：Antibacterialpoly(D,L-lactide)(PDLLA)fibrousmembranesweredevelopedviaelectrospinning,followedbysurfacemodificationwhichinvolvedplasmapretreatment,UV-inducedgraftcopolymerizationof4-vinylpyridine(4VP)andquaternizationofthegraftedpyridinegroupswithhexylbromide.ThesuccessofmodificationwithquatemizedpyridiniumgroupsonthePDLLAfibrousmembraneswasascertainedbyX-rayphotoelectronspectroscopy(XPS).TheantibacterialactivitiesofthesemembraneswereassessedagainstGram-positiveStaphylococcusaureus(S.aureus)andGram-negativeEscherichiacoli(E.coli).ThePDLLAfibrousmembranesmodifiedwithquaternizedpyridiniumgroupsshowedantibacterialefficiencyagainstbothbacteriaashighas99.999%.Theresultsdemonstratedthattheantibacterialactivitywasbasedontheinteractionofthepositivechargeofpyridiniumgroupandnegativelychargedcellmembraneofbacteria,resultinginlossofmembranepermeabilityandcellleakage.

简介：Asystematicstudyonthesynthesisandantibacterialactivityofthequaternary"onium"saltsgraftedonaninsoluble"gel-type"stryene-7%divinylbenzenecopolymerbypolymer-analogousreactionsisshowed.Antibacterialactivityofquaternaryammoniumand/orphosphoniumsaltsgraftedonpolymer-supportshasbeenstudiedagainststaphylococcusaureusandEscherichiacoli.Awidevarietyof"onium"saltsboundtomacromolecularsupportswithdifferentquaternarygroupsanddifferentquaternarychainlengthsubstituentswereexamined.Theantibacterialactivityofmixed"onium"saltsincreasesasaconsequenceoftheassociationofammoniumandphosphoniumsaltsgraftedonthesamepolymericsupport.

简介：

简介：Thepurposeofthisstudywastoevaluatethelongtimeantibacterialpropertiesandshearbondstrengthofexperimentalnanosilver-containingcements(NSC).Nanosilverbaseinorganicantibacterialpowderwasaddedtothereinforcedglassionomercementatfivedifferentweightratiostoobtainaseriesofnanosilver-containingcements,thentheantibacterialpropertiesofthreeorthodonticcementproductsandfiveNSCsampleswereevaluatedbythedirectcontacttest(DCT)andtheagardiffusiontest(ADT).TheDCT,whichwasbasedonturbidnessdeterminationofbacterialgrowthin96-wellmicrotiterplates,wasperformedinbothfreshandagedfor1day,1week,2weeks,3weeks,4weeks,6weeks,and8weekstestedmaterials.TheshearbondstrengthesofthreeorthodonticcementproductsandfiveNSCsampleswereexaminedusingauniversaltestingmachine.TheADTresultsindicatedthattherewerenosignificantdifferencesbetweenNSCsandORTHOLCfreshspecimens.IntheDCTexperiment,allfreshsilvernanoparticles-containingtestedsamplespresentedpowerfulantibacterialproperties,buttheygraduallylosttheeffectiveantimicrobialagentswiththeextensionofagingtime.Finally,noneofthetestedmaterialsmaintaineditsantibacterialpropertyafteragingfor8weeks.Agraduallydecreasingtrendofbondstrengthpresentedwiththeincreasingincorporationofnanosilverbaseinorganicantibacterialpowderintotheglassionomercement,eventhoughallthetestedmaterialspecimensreachedtheidealbondstrengthrange.WemayconcludethatNSCscancontributetodecreasethedemineralizationratearoundbracketswithoutcompromisingbondstrength.

简介：

简介：TheantibacterialeffectofcarryingsilverB2O3-SiO2-Na2Oglassmaterialwasstudiedbymeansofantibacterialring,nephelometery,MICvalue,thinfilmattachmentandmicrocalorimetry,respectively.TheexperimentalresultsoffivekindsofantibacterialtestmethodsarealmostidenticalandcanverifythatcarryingsilverB2O3-SiO2-Na2Oglassmaterialexertsanexcellentantibacterialperformance.Antibacterialringandnephelometeryaresimple,quick,buttheprecisionisrestrictive.MICvalue,thinfilmattachmentmethodandmicrocalorimetrycanquantitativelycomparetheantibacterialeffectsoftheantibacterialglassmaterial.Comparedwiththetraditionalmicrobetestmethods,themicrocalorimetrycananalyzetheinhibitingeffectofthecell'sgrowthandmetabolismontheantibacterialglassmaterialbymonitoringthethermaleffectcontinuouslyandautomatically.

简介：Lactivicin,anovelinhibitorofbacterialcellwallsynthesis,wasisolatedfromtheculturefil-tratesofmicroorganismYK-258andYK-422.Itexhibitsbiologicalactivitiessimilartothoseoftheβ-lactamantibiotics,althoughitdoesnothaveaβ-lactamringinitsmolecule.Sincethediscoveryoflactivicin,hundredsofitsderivativeshavebeensynthesized.Most

简介：6/3-(4-Chlorophenyl)-s-triazolo[3,4-b][1,3,4]thiadiazoles(2a-e)and(5a-e)weresynthesizedrespectivelybyintermolecularcyclizationof5-aryl/4-chlorophenyl-4-amino-3-mercapto-1,2,4-triazoles(1a-e)and(4)with4-chlorobenzoicacid/arylacids,whichwerecondensedwithpiperazineunderphasetransfercatalystTBABtoyieldthecorrespondingfreebasesofmonopiperazinederivativesandfollowedtoformwater-solublesalts(3a-e)and(6a-e)withhydrochloricacidingoodyields.Theinvitrobiologicalresultsshowedthatpiperazinegroupconjugatedwiththeabovefusedheterocyclesplayedanimportantroleinantibacterialactivity.ThestructuresofnovelcompoundswereconfirmedbyIR,1HNMR,MSandelementalanalysis.

简介：Treatmentof4-amino-3-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-5-mercapto-1,2,4-triazoles/2-amino-5-(1-aryl-5-methyl-1,2,3-triazole-4-yl)-1,3,4-thiadiazoleswithbenzaldehyde,acetoneandω-bromoacetophenonewastestedandcompared.ThetitlecompoundsSchiffbases,amides,imidazolo[2,1-b]-1,3,4-thiadiazolesand7H-s-triazolo[3,4-b]-1,3,4-thiadiazineshavebeenconfirmedbyelementalanalyses,^1HNMR,IRandMSspectra.AllthecompoundshavealsobeenscreenedfortheirantibacterialactivitiesagainstB.subtilis,S.aureusandE.coli.