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34 个结果
  • 简介:目的评价海德堡视网膜断层扫描仪黄斑区视网膜分析系统(macularedemamodule,MEM)的三个技术参数,了解其变异性及可重复性来判断其临床应用价值。方法对78例(78只眼)正常健康志愿者应用海德堡视网膜断层扫描仪黄斑区视网膜分析系统进行检查。分析扫描深度值(Z)、视网膜信号宽度值(W)、水肿指数值(E)三参数的均值及变异系数,并分析黄斑反射图、地形图、信号宽度图、水肿指数图的图像特征。结果黄斑中心0.5mm范围内视网膜扫描深度均值(Z)为1.4430848,变异系数55.6%。W值为795.27±193.53,变异系数17.6%。E值为1.13±0.35,变异系数27.8%。不同个体三参数差异有高度显著性(P<0.01),个体变异较大。不同时间段三参数测量差异无显著性(P>0.05)。结论MEM可对黄斑区视网膜厚度进行量化分析,个体变异较大,但重复性好,HRT-Ⅱ检查适合黄斑疾病的个体随诊观察。

  • 标签: 黄斑水肿 视网膜 诊断
  • 简介:准分子激光原位角膜磨镶术(Laserinsitukeratomileusis,LASIK)是治疗近视的一种方法,因其术后有较好的稳定性、安全性和并发症少,被认为是目前最有发展前途的角膜屈光手术,但是LASIK手术后出现孔源性视网膜脱离屡有报道。因此在行LASIK术前应详细检查周边视网膜,及时处理有潜在危险的眼底并发症,从而预防或减少术后并发症的产生。我院眼科对LASIK术前所有患者常规三面镜检查眼底,对眼底检查结果做详细记录,对所有视网膜裂孔及严重变性区均予及时处理,结果报告如下。

  • 标签: 激光原位角膜磨镶术 眼底三面镜 检查结果 准分子 术前 孔源性视网膜脱离
  • 简介:·AIM:Toinvestigatethetherapeuticeffectsofnanophtha-locyaninephotosensitizersonanexperimentalratchoroidalneovescularization(CNV)model,aswellastoevaluatethecytotoxicityofwhichonhumanretinalpigmentepithelia(HRPE)andhumanretinalendothelialcells(HRECs).·METHODS:Twotypesofphotosensitizers,G1-ZnPc(COOH)8andG1-ZnPc(COOH)8/mrespectively,wereadministratedforphotodynamictherapy(PDT)afterasuccessfulestablishmentofCNVmodelonBrown-Norway(BN)ratsviafundusphotocoagulation.Thetherapeuticeffectsofthetwodrugswereassessedthroughopticalcoherencetomography(OCT),fluoresceinfundusangiography(FFA)andtransmissionelectronmicroscopy(TEM).Forcytotoxicitytests,cellcountingkit-8(CCK-8)assaysandchangesofmitochondrialtransmembranepotential(△Ψm)wereconductedonHRPEandHRECsafterinitialuptakeofthetwodrugs.·RESULTS:Bothphotosensitizersdemonstratedanimprove-mentofvascularleakageandclosureofCNV1weekafterPDTasconfirmedbyfundusimage,OCT,FFAandTEM.TwoweeksafterPDT,G1-ZnPc(COOH)8/mshowedabetterCNVclosureeffectversusG1-ZnPc(COOH)8(P<0.05).Asignificantdifference(P<0.01)wasfoundinuptakeofthetwodrugsinHRPEandHRECs,withnodifferencebetweenthedrugs(P>0.05).BothphotosensitizersshowedcytotoxicityonHRPE,butG1-ZnPc(COOH)8/minducedalowercellviability.·CONCLUSION:G1-ZnPc(COOH)8/mmediatedPDTisbetterthanG1-ZnPc(COOH)8inCNVclosureandalsohavetheadvantageoffastmetabolismleadingtolesssideeffect.·

  • 标签: PHTHALOCYANINE carrier nanoparticles photo-dynamic treatment RETINA
  • 简介:目的:分析23G玻璃体切割术后高眼压的发生率、特点及相关的危险因素,为处理及预防提供依据。方法:对于我院行23G玻璃体切割手术的患者146眼临床资料进行回顾分析,术后早期高眼压诊断标准为术后2wk内任一时间眼压测量值≥25mmHg。采用卡方检验进行统计学分析;对于术后早期高眼压患者根据眼压程度采用单一或联合降眼压药物治疗。结果:患者146眼中发生术后高眼压者42眼,占28.8%,平均出现自术后3.38d。单纯气换组、C3F8填充组及硅油填充组术后高眼压发生率分别为14.5%,33.3%和39.3%,C3F8组和硅油填充组与单纯气换组比较均有统计学意义;未行激光机冷冻处理组、部分视网膜光凝组、全视网膜光凝组及冷冻组术后早期高眼压的发生率分别为13.6%,27.4%,34.5%和35.7%,部分视网膜光凝组与未处理组相比较没有统计学意义,而其他两组与未处理组比较有统计学意义;不同原发病术后均有早期高眼压的发生,但分布不均衡。通过处理眼压均控制理想。结论:23G玻璃体切割术后早期高眼压的危险因素是多方面的,主要与眼内填充物、术中处理方式有关,不同原发病对于高眼压的影响在于其对术式的影响。术后早期高眼压多为一过性,合理药物治疗可控制。

  • 标签: 23G玻璃体切割手术 高眼压 危险因素 治疗
  • 简介:目的:探讨在基层医院行小切口非超声乳化白内障摘除联合人工晶状体植入术中玻璃体脱出的原因和预防以及处理办法。方法:对我院2008-01/2009-042000例小切口非超声乳化白内障摘除联合人工晶状体植入术中52例52眼玻璃体脱出的情况进行回顾性分析。结果:52眼玻璃体脱出发生在上浮核、劈核、圈套核和吸皮质时;49眼植入人工晶状体,3眼未植入人工晶状体;45眼获得满意圆瞳孔,7眼欠圆;18眼术后视力〉0.5,27眼视力〉0.3,3眼视力〉0.1,2眼视力〉0.05,2眼视力〈0.05。结论:小切口非超声乳化白内障摘除联合人工晶状体植入发生玻璃体脱出多在劈核、圈套核及吸取皮质时,玻璃体脱出经过及时恰当的处理仍然可以获得较满意的效果。

  • 标签: 小切口 非超声乳化 白内障 玻璃体脱出
  • 简介:目的探讨总结白内障扶贫复明术中“灌注液迷流综合征”的原因及处理方法。方法本院2011-2013年间参与防盲民生工程,共有31例患者发生“灌注液迷流综合征”,临床表现为突发性眼压升高、浅前房、虹膜脱出,通过注入黏弹剂以及升高灌注瓶高度无法维持前房深度,术中检查未发现眼内出血现象,其中7例发生在水分离和水分层后,24例发生在皮质吸出过程中。所有发生灌注液迷流综合征的患者均暂停手术,给予20%甘露醇250ml静脉滴注,若经药物降压无效,可根据手术条件行经平坦部前段玻璃体切割术或玻璃体腔穿刺术,待前房形成后继续进行手术。结果31例患者中,29例经甘露醇静滴治疗后前房形成,继续完成手术,2例经药物降压仍不能形成前房,经平坦部行前段玻璃体切割术后前房形成,继续完成手术。术后1天裸眼视力0.3~1.0者为20例(20眼),视力0.1~0.3者为8例(8眼),视力0.02~0.1者为3例(3眼),眼压高于或等于21mmHg者10例(10眼),发生角膜水肿者14例(14眼)。术后1周裸眼视力0.3~1.0者为24例(24眼),视力0.1~0.3者为7例(7眼),眼压均恢复正常,无角膜水肿发生。结论小切口白内障囊外摘除术中灌注液迷流综合征是一种少见的术中并发症,经正确处理可以缓解突发性眼压升高引起的各种体征,顺利完成手术。

  • 标签: 小切口 白内障 灌注液迷流综合征
  • 简介:随着锰在影像学和实验研究中的不断应用,其毒性损伤已经成为近期人们研究的热点。大量研究证明,锰作为机体微量元素,堆积后的损伤主要表现于神经系统。我们从锰作为影像增强剂这一角度对其给药方式、机体损伤和损伤机制的研究做一综述。

  • 标签: 影像增强 神经毒性 机制
  • 简介:为探讨迷路的老化过程,应用透射电镜观察了新生、青年、老年豚鼠的耳蜗和迷路血管系统的变化。发现老年豚鼠血浆成分有改变、听力呈下降倾向;毛细胞、迷路血管及螺旋神经和螺旋神经节细胞均可见一系列损害。作者推测在耳蜗老化过程中血管系统的变化非常重要,至少是耳蜗其他部位老年性改变的原因之一。

  • 标签: 老年聋 耳蜗 血管系统 超微结构
  • 简介:目的探讨数字化多媒体系统矫治训练对大龄儿童弱视的治疗效果。方法选取2013年1月至2016年1月我院门诊收治的大龄弱视患儿86例(128眼),作为研究对象。根据患儿治疗方案的差异将其分为观察组与对照组,对照组45例患儿接受常规综合治疗措施,观察组41例患儿接受数字化多媒体系统治疗,比较两组患儿治疗后双眼视功能变化及疗效。结果观察组患儿治疗后总有效率明显高于对照组,并且观察组患者立体视改善率明显高于对照组,P〈0.05,差异具有统计学意义。结论对大龄弱视患儿采取数字化多媒体系统治疗可有效改善患儿弱视症状,提高患儿双眼视功能,缩短患儿视功能障碍治疗时间,具有临床应用及推广价值。

  • 标签: 大龄儿童弱视 数字化多媒体系统治疗 双眼视功能
  • 简介:AIM:Anaerobicbacteriacancauseocularinfections.WetestedtheOxyPlateTMAnaerobicSystem(OXY)toisolatepertinentanaerobicbacteriathatcancauseoculardisease.METHODS:OXY,whichdoesnotrequiredirectanaerobicconditions(i.e.bags,jars),wascomparedtoconventionalisolationofincubatingculturemediainanaerobicbags.Standardcoloniescountswereperformedonanaerobicocularbacterialisolatesunderaerobicandanaerobicconditions(anaerobicbags)usingagarmedia:1)OXY(aerobiconly),2)5%sheepblood(SB),3)Chocolate,and4)Schaedler.Thebacteriatestedwerede-identifiedocularisolatesculturedfromendophthalmitisanddacryocystitisthatinclude10Propionibacteriumacnesand3Actinomycesspecies.Thecolonycountsforeachbacteriaisolate,oneachculturingcondition,wererankedfromlargesttosmallest,andnon-parametricallycomparedtodeterminethebestculturingcondition.RESULTS:Allanaerobicconditionswerepositiveforalloftheanaerobicisolates.SBandSchaedler’sagarunderaerobicconditionsdidnotsupportthegrowthofanaerobicbacteria.SparsegrowthwasnotedonchocolateagarwithPropionibacteriumacnes.Asananaerobicsystem,SBinananaerobicbagisolatedhighercolonycountsthanOXY(P=0.0028)andchocolateagar(P=0.0028).CONCLUSION:AlthoughOXYdidnottesttobemoreefficientthanotheranaerobicsystems,itappearstobeareasonablealternativeforisolatinganaerobicbacteriafromocularsites.Theuseofanagarmediuminaspeciallydesignedplate,withouttherequirementofananaerobicbag,renderedOXYasanadvantageoverotheranaerobicsystems.

  • 标签: ANAEROBIC BACTERIA BACTERIAL isolation ENDOPHTHALMITIS DACRYOCYSTITIS
  • 简介:AIM:Tomeasurecentralcornealthickness(CCT)andpre-cornealtearfilmthicknessusingtheGalileidualScheimpfluganalyzer(GSA)inNewZealandWhiterabbits.METHODS:TennormalNewZealandWhiterabbits(20eyes)wereincludedinthisstudy.Withtheassistanceof0.1%fluorescein,thepre-cornealtearfilmcanbewellvisualized.BotheyesofeachrabbitwerescannedoncewiththeGSApre-andpost-instillationof1μL0.1%fluorescein.ThedifferencebetweenthetwomeasurementsofCCT(4-mmdiameter)wasrecordedasthepachymetricvaluesofthecentraltearfilm.RESULTS:TheCCTofpre-andpost-instillationwas388.8±9.5μmand407.0±10.5μm,respectively.Afterapairedt-testanalysis,thecentralpre-cornealtearfilmthicknessof4mmdiameterwas18.2±5.31μmwitha95%confidenceintervalof(15.7,20.6)μm(P<0.001).CONCLUSION:GSAcanbeusedtomeasureCCTandanalyzecentraltearfilmthicknessofrabbitswiththehelpoffluorescein.

  • 标签: TEAR film SCHEIMPFLUG rabbits central CORNEAL
  • 简介:AIM:ToevaluatetheeffectofCollagencross-linkingonthepreventionofmeltinginrabbitcorneasafteralkaliburn.·METHODS:TwentyNewZealandwhiterabbitswererandomlydividedintomodelcontrolgroupandcollagencross-linkingtreatmentgroup.Thesecondgroupofrabbitsreceivedcollagencrosslinkedtreatment.Bothgroupswereappliedwithantibioticeyedropstopreventinfection.Thecorneaswereevaluatedformelting,opacity,pathologicalandimmunohistochemistry,recordthechangeswhen28daysaftertheanimalswerekilled.·RESULTS:Inthecontrolgroup,6outof8rabbitsshowedcornealmeltingafterinjury(14±4)days,whiletwocornealperforated.Incollagencross-linkingtreatmentgroup,onerabbitshowedcornealmeltingafterinjury23days,withoutcornealperforation;cornealdissolutionratebetweenthetwogroupswassignificantlydifferent(P<0.05).Pathologicalexaminationsuggestedthatinthetreatmentgroup,mildcornealedema,milddamagetocollagenfibers,inflammatorycellinfiltrationwassignificantlylessthanthecontrolgroup.Immunohistochemistryshowedthatcornealcollagenfibersarrangedinneatrowsinthecontrolgroup.·CONCLUSION:Collagencross-linkingtreatmentnotonlycanpreventanddelaythecornealmeltingafteralkaliburn,butalsocanreducethedestructionofcornealcollagenfibersandinfiltrationofinflammatorycellsinthecornealtissue.

  • 标签: COLLAGEN cross-linking CORNEAL ALKALI BURN CORNEAL
  • 简介:AIM:Toevaluatetheaccuracyofsphericalequivalent(SE)estimatesofadouble-passsystemandtocompareitwithretinoscopy,subjectiverefractionandatablemountedautorefractor.METHODS:Non-cycloplegicrefractionwasperformedon125eyesof65healthyadults(age23.5±3.0years)fromOctober2010toJanuary2011usingretinoscopy,subjectiverefraction,autorefraction(AutokeratorefractometerTOPCONKR-8100,Japan)andadoublepasssystem(OpticalQualityAnalysisSystem,OQAS,VisiometricsS.L.,Spain).Nineconsecutivemeasurementswiththedouble-passsystemwereperformedonasubgroupof22eyestoassessrepeatability.ToevaluatethetruenessoftheOQASinstrument,theSElaboratorybiasbetweenthedoublepasssystemandtheothertechniqueswascalculated.RESULTS:TheSEmeancoefficientofrepeatabilityobtainedwas0.22D.SignificantcorrelationscouldbeestablishedbetweentheOQASandtheSEobtainedwithretinoscopy(r=0.956,P<0.001),subjectiverefraction(r=0.955,P<0.001)andautorefraction(r=0.957,P<0.001).ThedifferencesinSEbetweenthedouble-passsystemandtheothertechniquesweresignificant(P<0.001),butlackedclinicalrelevanceexceptforretinoscopy;Retinoscopygavemorehyperopicvaluesthanthedouble-passsystem-0.51±0.50Daswellasthesubjectiverefraction-0.23±0.50D;Moremyopicvalueswereachievedbymeansofautorefraction0.24±0.49D.CONCLUSION:Thedouble-passsystemprovidesaccurateandreliableestimatesoftheSEthatcanbeusedforclinicalstudies.Thistechniquecandeterminethecorrectfocuspositiontoassesstheocularopticalquality.However,ithasarelativelysmallmeasuringrangeincomparisonwithautorefractors(-8.00to+5.00D),andrequirespriorinformationontherefractivestateofthepatient.

  • 标签: DOUBLE-PASS system optical quality RETINOSCOPY autorefraction