简介:AIM:Todeterminethehistopathologicalchangesofrifampicinappliedintravitreallyonretinalganglioncellsbymeansofstereologicalandhistopathologicalmethods.METHODS:Forthisstudytwenty-fourNewZealandadultrabbitsweredividedintofourgroups(n=6foreachgroup).50μg/0.1mL(group1),100μg/0.1mL(group2),150μg/0.1mL(group3)and200μg/0.1mL(group4),rifampicinwereinjectedintothevitreousoftherighteyesofanimals,theirlefteyeswereusedascontrol(group5).Afterthe28thdayofapplication,animalswereanesthetisedwithxylazine(8mg/kg,IM)andthentheireyeswereenucleatedimmediately.Patternsweretakenawayandeyeswerepreparedforbothstereologicalandelectromicroscopicobservation.RESULTS:Dependingonthehighdoseofrifampicin,somehistopathologicalchangessuchascytoplasmicdilatationanddamagedmembranewereobservedontheelectromicroscopiclevel.Usingquantitativeexamination,whichwasdoneatthelightmicroscopiclevel,itwasshownthatthenumberofneuronsdecreasedlinearlyasrifampicindoseincreasedwhencomparedwiththecontrolgroup.CONCLUSION:Basedonthesefindings,low-doserifampicin(50μg/0.1mL)maybeusefulfortreatmentoftheoculardiseases.
简介:胡锦涛在党的十八次代表大会上指出,"全党要增强紧迫感和责任感,牢牢把握加强党的执政能力建设、先进性和纯洁性建设这条主线"。从系统论的观点看,保持党的纯洁性对于保持党的自身系统内部党员的纯洁性,加强各层党组织的战斗堡垒作用,始终保持同人民群众的血肉联系,最终提升党的执政能力,保持和充分发挥党的先进性,提升党的凝聚力、创造力和向心力,始终作为社会主义事业的领导核心具有重要意义;保持党的纯洁性也是党面对系统外部复杂多变的外部环境,充分适应社会的发展与进步,促进党的建设,推动"五位一体"的社会主义建设总体布局,带领全国人民全面建成小康社会,进行社会主义现代化建设和实现中华民族的伟大复兴具有重要作用。