简介:Twonewsteroidalalkaloids,isoconkuressineandN-formylconessimine,togetherwith6knownsteroidalalkaloidsincludingconkuressine,conessine,isoconessimine,conimine,conarrhimine,andfuntudienine,wereisolatedfromtheseedsofHolarrhenaantidysenteriacaWall.exA.DC.Theirintrinsicantibacterialactivitiesandsynergisticeffectswithpenicillinandvancomycinwereanalyzedinmethicillinsensitivestaphylococcusaureus(MSSA)andmethicillinresistantstaphylococcusaureus(MRSA).Twoofthesteroidalalkaloidsincludingonenewcompound(N-formylconessimine)showedpotentialantibacterialactivityandpossessedsynergisticeffectswithpenicillinandvancomycin,respectively.
简介:二新C-21steroidalglycosides,mucronatosidesM(1)和N(2),从白前科植物mucronata的茎被孤立,和一已知的复合stephanosideM(3)。根据化学证据和广泛的分光镜的方法,包括一个维、二维的NMR,二新混合物的结构作为12-O-tigloyl-20-O-N-methylanthraniloylsarcostin3-O--D-glucopyranosyl-(14)被识别-6-deoxy-3-O-methyl--D-allopyranosyl-(14)-(-D-cymaropyranosyl-(14)--D-cymaropyranoside(1),和12-O-cinnamoyl-20-O-nicotinoyl(20S)-pregn-6-ene-3(,5(,8,12,14(,17,20-heptanol3-O--D-glucopyranosyl-(14)-6-deoxy-3-O-methyl--D-allopyranosyl-(14)--D-cymaropy
简介:Themostimportantriskfactorforstrokeandneurodegenerationisaging.Infact,survivalafterstrokediminisheslargelywithaging.Infact,recoveryafterbrainarteryocclusionisdramaticallyworsenedbyaging,evennormalagingisassociatedwithneurondamageandcognitivedecline.Mechanismsinvolvedinaging-related,cognitivedeclineandsusceptibilitytoneurondamageinstrokeandneurodegenerationarelargelyunknown.Oneofthemostimportant
简介:Thedifferentregioselectiveandstereoselectiveproductswereobtainedbythereductionofstigmast-4,22-dien-3,6-dionewithNaBH4-CH3OHwhendifferentkindsofmetalionswasaddedtothereaction.