简介:Notopterygiumincisum(QH)hasbeenusedforthetreatmentofrheumatoidarthritis(RA),andvolatileoilsmaybeitsmainlybioactiveconstituents.ThepresentstudywasdesignedtoanalyzethevolatilecompoundsinQHandtodeterminetheanti-arthriticcapacityofNotopterygiumvolatileoilsandthepotentialmechanismofaction.ThevolatilecompoundsanalysiswasconductedbyGC-MS.Theanti-arthriticcapacitytestofthevolatileoilswasconductedonadjuvant-inducedarthritis(AIA)rats.Theanti-inflammatorypropertywastestedinNOreleasemodelinRAW264.7cells.Endothelialcellswereusedtoevaluatetheanti-proliferativeandanti-tubeformativeeffects.70compoundswereanalyzedbyGC-MSinthevolatileoils.NotopterygiumvolatileoilsweakenedtheratAIAinadose-dependentmanner(2,4,and8gcrudedrug/kg).TheNOproductionbyRAW264.7wasdecreasedbymorethan50%inNotopterygiumvolatileoils(5,15,and45μg·mL-1)pretreatedgroups.NotopterygiumvolatileoilsalsoinhibitedEAhy926cellproliferationandfurtherdelayedEAhy926cellcapillarytubeformationinaconcentration-dependentmanner.Theanti-NOproductive,anti-proliferative,andanti-tubeformativeeffectsofNotopterygiumvolatileoilsstronglysuggestedthatthetherapeuticeffectofQHinAIAmightberelatedtothepotentanti-inflammatoryandanti-angiogeniccapacitiesofthevolatileoils.
简介:Carbon-containingrefiactoriesareeasilyoxidizedathightenperature,thusmakingserviceliferapidlydrop.Theanti-oxidationmethods,suchasimpregnationandaddinganti-oxidatonagents,can'tmeettherequire-mentsofindustry'sdevelopmentandsomespecialcases,Byanalyzingthecharcteristicsofseveraloxidesandnon-oxidesrawmaerials,theoxidationresistantmechanismoftherefractoryanti-oxidationcoatings(RAOC),whichpossessthecharacteristcofself-healingathighttemperature,isdiscussed.
简介:Canearthquakesbepredicted?Howshouldpeopleovercomethedifficultiesencounteredinthestudyofearthquakeprediction?Thisissuecantakeinspirationfromtheexperiencesofweatherforecast.Althoughweatherforecastingtookaperiodofabouthalfacenturytoadvancefromempiricaltonumericalforecast,ithasachievedsignificantsuccess.AconsensushasbeenreachedamongtheChineseseismologicalcommunitythatearthquakepredictionmustalsodevelopfromempiricalforecastingtophysicalprediction.However,itisseldommentionedthatphysicalpredictionischaracterizedbyquantitativelynumericalpredictionsbasedonphysicallaws.Thisarticlediscussesfivekeycomponentsfornumericalearthquakepredictionandtheircurrentstatus.Weconcludethatnumericalearthquakepredictionshouldnowbeputontheplanningagendaanditsroadmapdesigned,seismicstationsshouldbedeployedandobservationsmadeaccordingtotheneedsofnumericalprediction,andtheoreticalresearchshouldbecarriedout.
简介:ThedevelopmentofearthquakeengineeringinChinaisdescribedintothreestages.Theinitialstagein1950's-1960'swasmarkedwiththeinitiationofthisbranchofsciencefromitscreationinthefirstnational12-yearplanofscienceandtechnologybyspecifyingearthquakeengineeringasabranchitemandIEMwasoneparticipant.Thefirstearthquakezonationmapandthefirstseismicdesigncodeweresooncompletedandusedinengineeringdesign.Siteeffectonstructuraldesignandsiteselectionwereseriouslystudied.ThesecondstagemarkedwiththeoccurrenceofquiteafewstrongearthquakesinChina,fromwhichmanylessonswerelearnedandcorrespondingconsiderationswerespecifiedinourdesigncodesandfollowedinconstructionpractice.Thethirdstageisastageofdisastermanagement,whichismarkedbyaseriesofgovernmentdocumentations,leadingbyanationallawofthePeople'sRepublicofChinaontheprotectingagainstandmitigatingearthquakedisastersadoptedatthemeetingoftheStandingCommitteeoftheNationalPeople'sCongressofthePeople'sRepublicofChinain1997,andthenfollowedbysomeprovincialandmunicipallawstoforcetheactionsoutlinedinthenationallaw.Itmaybeexpectedthatoursocietywillbemuchmoresafertoresisttheattackoffuturestrongearthquakeswithlesslosses.Lastly,possiblefuturedevelopmentsarealsodiscussed.
简介:Thesystemofgeophysicalshells(lithosphere,atmosphere,ionosphere)isconsideredasanopencomplexnonlinearsystemwithdissipationwhereearthquakepreparationcouldberegardedasaself-organizingprocessleadingtothecriticalstateofthesystem.Theprocessesinatmosphereandionosphereareconsideredfromthepointofviewofnon-equilibriumthermodynamics.Theintensiveionizationofboundarylayerofatmosphere(probablyprovidedbyradoninoccasionofearthquakepreparation)givesstarttothesynergeticsequenceofcouplingprocesseswheretheionosphereandevenmagnetospherearethelastlinksinthechainofinteractions.Everyanomalyobservedindifferentgeophysicalfields(surfacetemperature,latentheatflux,electromagneticemissions,variationsinionosphere,particleprecipitation,etc.)isnotconsideredasanindividualprocessbutthepartoftheself-organizingprocess,thefinalgoalofwhichisthereachingofthepointofthemaximumentropy.RadonanomalybeforetheKobeearthquakeisconsideredasaperfectexampletosatisfytheformalseismologicaldeterminationoftheearthquakeprecursor.Whatisgeneticallyconnectedwithradonthroughtheionizationprocesscanalsoberegardedasaprecursor.Theproblemofco-seismicvariationsofthediscussedparametersofatmosphereandionosphereisconsideredaswell.
简介:Earthquakeengineeringresearchanddevelopmenthavereceivedmuchattentionsincethefirsthalfofthetwentiethcentury.Thisvaluableresearchpresentedahugestepforwardinunderstandingearthquakehazardmitigation,whichresultedinappreciablereductionoftheeffectsofpastearthquakes.Nevertheless,the2011Tohokuearthquakeandthesubsequenttsunamiresultedinmajordamage.Thispaperpresentsthetimelineofearthquakemitigationandrecovery,asseenbytheauthors.Possibleresearchdirectionswheretheauthorsthinkthatmanyopenquestionsstillremainareidentified.Theseareprimarilybasedontheimportantlessonslearnedfromthe2011Tohokuearthquake.
简介:ByusingthegeneralizedPoincaréindextheoremitisprovedthatifthen^2criticalpointsofann-polynomialsystemformaconfigurationoftype(2n-1)-(2n-3)+(2n-5)-…+(-1)^n-1,andthe2n-1outmostanti-saddlesformtheverticesofaconvex(2n-1)-polygon,thenamongthese2n-1anti-saddlesatleastonemustbeanode.
简介:Thepresentstudywasdesignedtoexaminetheanti-hyperuricemicandanti-inflammatoryeffectsandpossiblemechanismsofvaticaffinol,aresveratroltetramerisolatedfromethanolextractsofDipterocarpusalatus,inoxonate-inducedhyperuricemicmice.At1hafter250mg·kg~(-1)potassiumoxonatewasgiven,vaticaffinolat20,40,and60mg·kg~(-1)wasintragastricallyadministeredtohyperuricemicmiceoncedailyforsevenconsecutivedays.Vaticaffinolsignificantlydecreasedserumuricacidlevelsandimprovedkidneyfunctioninhyperuricemicmice.Itinhibitedhepaticactivityofxanthinedehydrogenase(XDH)andxanthineoxidase(XOD),regulatedrenalmRNAandproteinlevelsofuratetransporter1(URAT1),glucosetransporter9(GLUT9),organicaniontransporter1(OAT1),organiccationtransporter1(OCT1),OCT2,organiccation/carnitinetransporter1(OCTN1),andOCTN2inhyperuricemicmice.Moreover,vaticaffinolmarkedlydown-regulatedrenalproteinlevelsofNOD-likereceptor3(NLRP3),apoptosis-associatedspeck-like(ASC),andCaspase-1,resultinginthereductionofinterleukin(IL)-1β,IL-18,IL-6andtumornecrosisfactor-α(TNF-α)levelsinthisanimalmodel.Additionally,HPLCandLC-MSanalysesclearlytestifiedthepresenceofvaticaffinolinthecrudeextract.Theseresultssuggestthatvaticaffinolmaybeusefulforthepreventionandtreatmentofhyperuricemiawithkidneyinflammation.
简介:SubscriptionsEarthquakeEngineeringandEngineeringVibration(PrintISSN1671-3664,CN23-1496/Pwww.iem.net.cn/eeev)ispublishedbiannuallybytheChinaSciencePress.SubscriptionRatesVolume2,2005,2issues?80.00forinstitutionsand?60.00forindividualsformainlandofChina;andUS$80.00andUS$60.00(includingairmailpostage)forinsti-tutionsandindividuals,respectivelyforotherregions.
简介:Journalwebsite:http://www.springerlink.comAIMSANDSCOPEThisjournalisestablishedbytheInstituteofEngineeringMechanics(IEM),ChinaEarthquakeAdministration,topromotescientificexchangebetweenChineseandforeignscientistsandengineerssoastoimprovethetheoryandpracticeofearthquakehazardsmitigation,preparedness,andrecovery.Toaccomplishthispurpose,thejournalaimstoattractabalancednumberofpapersbetweenChineseand