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简介：本文报导了由上海三星日用品公司研究所研制的三星牌S—1型灭蝇灯,采用光诱粘捕式原理,经实验室和现场试验,证明它不仅对多种蝇类有效,也对蚊、蛾类和其它飞虫有诱捕作用;由于它不产生电击火花,就不存在噪声、电气干扰和引燃、引爆因素,也不存在电击虫骸导致周围尘埃密度增高的后果;确认了该种产品的独特优点。

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简介：AbstractTo compare efficacy and safety of nab-paclitaxel plus gemcitabine (AG) with nab-paclitaxel plus S-1 (AS) as first-line treatment for metastatic pancreatic cancer, we conducted a retrospective analysis by reviewing medical records of 53 metastatic pancreatic cancer patients in our institution. They received either AG (nab-paclitaxel 125 mg/m2 on days 1, 8 and gemcitabine 1000 mg/m2 on days 1, 8) or AS (nab-paclitaxel 125 mg/m2 on days 1, 8 and S-1 80-120 mg on days 1-14) chemotherapy. We found that AS had higher objective response rate (36% vs 21.4%), better disease control rate (84% vs 75%), prolonged time to progression (TTP, 7.1 vs 5 months), and improved overall survival (OS, 15.3 vs 12 months) when compared with AG. In Cox proportional hazards model, sex was significantly associated with TTP (P value=.031) and metastatic sites plus treatment after progression were significantly associated with OS (P value=.028 and .01, respectively). The incidence rate of chemotherapy-related adverse events was similar in both groups. Neutropenia (50% and 60%, all grade; 21.4% and 36%, grade 3 or 4, in AG and AS group) and sensory neuropathy (21.4% and 24%, all grade; 3.6% and 4%, grade 3 or 4, in AG and AS group) were the most common hematologic and non-hematologic toxicity. Thus, we believed that AS is a reasonable and convenient alternative for patients treated with AG as first-line chemotherapy for metastatic pancreatic cancer.

简介：在Diff(S1)/S之间的关系1并且磁盘上的一价的分析函数的空间被阐明并且出现为彻底的近似的卷提供上面的界限给一个无限维的空格的分析submanifold。在superdisk上的一价的superanalytic功能的系列扩大的系数的最大的大小被推断。

简介：AbstractObjective:It remains unclear whether adjuvant chemoradiotherapy (CRT) improves survival outcome of pancreatic ductal adenocarcinoma (PDAC) patients after surgery. This study aimed to investigate the efficacy and safety of tegafur/gimeracil/oteracil (S-1)-based adjuvant concurrent chemoradiotherapy in resected PDAC patients with defined high-risk pathological features.Methods:We conducted a single-arm, prospective, and interventional study at Zhongshan Hospital Fudan University from December 2012 to December 2019 and the last follow-up was conducted in December 2021. This study was approved by the Ethics Committee of Zhongshan Hospital Fudan University on December 27, 2012 (approval No. B2012-139). Resected PDAC patients with high-risk pathological features, including positive resection margin, pathological T3-4N1-2M0 disease, peripancreatic fat invasion, microvascular invasion, and perineural invasion, were recruited. Primary endpoint was overall survival and secondary endpoints were disease-free survival, treatment toxicity, and 2-, 5-year survival rates.Results:A total of 54 patients were recruited. Mean age was 63.6 years old (±7.2). The distribution of T and N stages were 24.1% for T1, 46.3% for T2, 27.8% for T3, 1.9% for T4, 33.3% for N1, and 11.1% for N2. Seven patients had R1 resection. The median overall survival and disease-free survival were 27.1 and 13.7 months, respectively, while no fatal adverse events were recorded. Subgroup analyses showed differences in survival outcomes among patients with microvascular invasion, different N stages, and preoperative CA 19-9 levels. Further, a Cox proportional hazard model demonstrated associations of lymph node metastases, CA 19-9 level, and microvascular invasion with overall survival and disease-free survival.Conclusion:S-1 -based adjuvant CRT showed promising efficacy and manageable toxicity in resected PDAC patients with highrisk pathological features.

简介：M．net出炉的榜单基本都是数量庞大的百位评选，要在这百位Star中获得前十已实属不易，更不用说是百里挑一的首位了。最近在名为“你是我男友”评选活动中拔得头筹的男星苏志燮，其高大的模特身材和雕刻般的脸庞成为了女生心中最佳男友的不二人选。最近他在热播电影《非常完美》中，也有一段上佳的表现。

简介：E伯爵主编码字爱好者美剧控队长粉新浪微博ID：E伯爵作为一个僵尸片爱好者,对人类被变异病毒感染进而世界大乱的主题已经非常熟悉了。一边看着人因为病毒变成怪物,觉得好可怕,一边觉得僵尸这个事儿涉及到的生命科学和伦理问题可真是太不好说了。

简介：在解决物理问题时，有些结论虽然不是定理、定律，但却是众所周知的，如果平时善于总结，往往会使我们的解题思路更清晰，分析解决问题能力得到提高。

简介：作者在C上给围住的双线性的表格的Fourier变换的描述*(S1)×C*(二基础半的S2)以乔丹组织S1和S2*-representations,hemimogeneous随机域，并且象一样微弱地，harmonizable随机S回答1和S2直到Hilbert空格。

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简介：重点词汇1.mattern.问题;事情What’sthematter?=What’sthetrouble?=What’swrong?怎么了?出什么事了?用于询问某人有什么病或某人遇到什么麻烦、问题。其后跟询问对象时,与介词with连用。What’sthematterwithyou?你怎么了?2.liev.(lay)躺;平躺lie是动词,意为'躺',过去式和过去分词分别为lay和lain,现在分词为lying。Ifoundhewaslyingontheground.我发现他躺在地上。lie还有'位于'的意思。Atempleliesonthetopofthemountain.一座寺庙位于山顶。

简介：重点词汇1.mattern.问题;事情What’sthematter?=What’sthetrouble?=What’swrong?怎么了?出什么事了?用于询问某人有什么病或某人遇到什么麻烦、问题。其后跟询问对象时,与介词with连用。拓展What’sthematterwithyou?你怎么了?2.liev.(lay)躺;平躺lie是动词,意为"躺",过去式和过去分词分别为lay和lain,现在分词为lying。Ifoundhewaslyingontheground.我发现他躺在地上。

简介：目的S-1是一种含5-氟尿嘧啶的复合抗癌新药,在日本已被作为治疗晚期胃癌的一线用药。本研究通过对国内外有关S-1的Ⅲ期随机对照临床研究进行荟萃分析,来评价单药及联合用药治疗晚期/进展期胃癌的疗效。方法通过MEDLINE,EMBASE,中国期刊全文数据库(CNKI)等数据库及论文集检索相关文献。依据检索策略收集资料,按纳入标准筛选文献,主要对客观缓解率,1年生存率,2年生存率以及Ⅲ/Ⅳ度毒副反应进行Meta分析。结果共纳入符合标准的4篇随机对照实验(RCT),涉及1392例患者。荟萃分析结果显示S-1单药组与联合用药组相比,S-1单药组1年生存率提高76%(95%CI为0.61~0.95);客观缓解率高出49%(95%CI为0.37~0.65),且有统计学差异(P<0.05),而在2年生存率方面比较,两组间无统计学差异(P>0.05)。Ⅲ/Ⅳ度毒副反应方面,S-1单药组较联合用药组高,S-1单药组中性粒细胞减少症增加17%(95%CI为0.12~0.24),白细胞减少症增加13%(95%CI为0.07~0.21),恶心增加43%(95%CI为0.25~0.72),均有统计学差异(P<0.05)。结论S-1单药可能有效提高晚期/进展期胃癌患者的生存率,但值得进一步的临床试验。

简介：使用方法我爱学英语不单是一本实用的英语学习纸质杂志,附送的光碟还能教你正确的英语发音,让杂志变得更有趣!

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