简介：MicroRNAs(miRNAs)aresmall,non-codingsingle-strandedRNAsthatcanmodulatetargetgeneexpressionatposttranscriptionallevelandparticipateincellproliferation,differentiation,andapoptosis.Tcellshaveimportantfunctionsinacquiredimmuneresponse;miRNAsregulatethisimmuneresponsebytargetingthemRNAsofgenesinvolvedinTcelldevelopment,proliferation,differentiation,andfunction.Forinstance,miR-181familymembersfunctioninprogressionbytargetingBcl2andCD69,amongothers.MiR-17tomiR-92clustersfunctionbybindingtoCREB1,PTEN,andBim.ConsideringthatthesuppressionofTcell-mediatedimmuneresponsesagainsttumorcellsisinvolvedincancerprogression,weshouldinvestigatethemechanismbywhichmiRNAregulatesTcellstodevelopnewapproachesforcancertreatment.

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简介：天生的免疫系统认识到通过编码germline的模式识别受体(PRR)入侵病原体，它得到天生的抗菌剂和煽动性的回答并且开始适应免疫控制或消除感染。像使用费的受体(TLR)和retinoic酸可诱导的基因(RIG-I)我是关键天生的有免疫力的PRR并且被精致的机制紧调整响应外国侵略者保证有益的结果。尽管许多在文学的焦点在发炎的蛋白质管理者的学习上，microRNAs(miRNAs)作为煽动性的过程的某些特征的重要控制器出现了。几miRNAs被TLR和RIG-I激活作为TLR并且RIG-I发信号的反馈管理者在myeloid房间和行为导致。在这评论，我们包括地讨论miRNA网络怎么对TLR并且RIG-I在煽动性的回答的开始和结束发信号和他们的角色作出回应的最近的理解。增加的证据也显示编码病毒的miRNAs和细胞的miRNAs在病毒的复制有重要功能并且招待抗病毒的豁免。

简介：Thecombinationofelectroencephalogram(EEG)andfunctionalmagneticresonanceimaging(fMRI)isaveryattractiveaiminneuroscienceinordertoachievebothhightemporalandspatialresolutionforthenon-invasivestudyofcognitivebrainfunction.Inthispaper,werecordsimultaneousEEG-fMRIofthesamesubjectinemotionalprocessingexperimentinordertoexplorethecharacteristicsofdifferentemotionalpictureprocessing,andtrytofindthedifferenceofthesubjects’brainhemispherewhileviewingdifferentvalenceemotionalpictures.Thelatepositivepotential(LPP)isareliableelectrophysiologicalindexofemotionalperceptioninhumans.Accordingtotheanalysisresults,theslow-waveLPPandvisualcorticalbloodoxygenlevel-dependent(BOLD)signalsarebothmodulatedbytheratedintensityofpicturearousal.TheamplitudeoftheLPPcorrelatesignificantlywithBOLDintensityinvisualcortex,amygdala,temporalarea,prefrontalandcentralareasacrosspicturecontents.

简介：Receptortyrosinekinases(RTKs)suchastheepidermalgrowthfactorreceptor(EGFR)regulatecellularhomeostaticprocesses.EGFRactivatesdownstreamsignalingcascadesthatpromotetumorcellsurvival,proliferationandmigration.DysregulationofEGFRsignalingasaconsequenceofoverexpression,amplificationandmutationoftheEGFRgeneoccursfrequentlyinseveraltypesofcancersandmanybecomedependentonEGFRsignalingtomaintaintheirmalignantphenotypes.Consequently,concertedeffortshavebeenmountedtodeveloptherapeuticagentsandstrategiestoeffectivelyinhibitEGFR.However,limitedtherapeuticbenefitstocancerpatientshavebeenderivedfromEGFR-targetedtherapies.Awell-documentedobstacletoimprovedpatientsurvivalisthepresenceofEGFR-inhibitorresistanttumorcellvariantswithinheterogeneoustumorcellmasses.Here,wesummarizethemechanismsbywhichtumorsresistEGFR-targetedtherapiesandhighlighttheemergingroleofmicroRNAs(miRs)asdownstreameffectormoleculesutilizedbyEGFRtopromotetumorinitiation,progressionandthatplayaroleinresistancetoEGFRinhibitors.WealsoexamineevidencesupportingtheutilityofmiRsaspredictorsofresponsetotargetedtherapiesandnoveltherapeuticagentstocircumventEGFR-inhibitorresistancemechanisms.

简介：在米饭的Phytochromes被由三个成员，PHYA，PHYB，和PHYC组成的一个基因家庭编码。通过以photomorphogenesis描绘phytochrome异种和野类型(WT)，单个phytochromes的角色preliminarily在调整米饭de青白化，flowering时间和富饶被探索了。然而，很少信息都没关于是否或怎么被报导phytochromes在米饭影响叶绿素生合成和叶绿体开发。在这研究，我们比较了野类型和phyA的叶绿素内容，在任何一个白人光(WL)下面成年或红的phyB和phyAphyB异种点亮(R)。结果建议phyB察觉R断然调整叶绿素生合成，当phyA的角色能仅仅在phyB缺乏的异种被检测时。涉及叶绿素生合成的基因的表示层次的分析表明phytochromes由调整protochlorophylloxidoreductaseA(PORA)影响了叶绿素生合成表示。在叶绿体开发的phyB的角色也被分析，并且结果建议phyB察觉R由影响叶绿体和grana的数字调整叶绿体开发，以及叶绿体膜系统。

简介：Thispaperstudiestheglobalrobustoutputregulationproblemforlowertriangularsystemssubjecttononlinearexosystems.Byemployingtheinternalmodelapproach,thisproblemcanbeboileddowntoaglobalrobuststabilizationproblemofatime-varyingnonlinearsysteminthecascade-connectedform.Then,asetofsufficientconditionsforthesolvabilityoftheproblemisderived,andthus,leadingtothesolutiontotheglobalrobustoutputregulationproblem.Anapplicationofthemainresultofthispaperisalsoproposed.

简介：由表示CD52CD4T房间的T房间规定看起来操作由二不同并且可能synergistic机制。第一由它从表示那然后绑在由损害T房间受体的phosphorylation稀释受动器T房间激活的酸绑定的像免疫球蛋白的lectins-10(Siglec-10)受体联系了的禁止的sialic的CD52的高水平的CD4T房间的房间表面的版本lck和zap-70。第二机制看起来由由被导致他们的扩大的二原子价的anti-CD52抗体模仿的迄今为止未辩别出的内长的ligand的CD52分子的crosslinkage。

简介：2013年10月12—13日中国生理学会张锡钧基金会第十二届全国青年优秀生理学学术论文交流会在湖南长沙顺利召开。由各省生理学会推荐的37名参赛选手的论文参与评选，会议展示了选手们近3年来在生理学研究方面所取得的最新研究成果。经过专家对参评者论文和现场报告的综合评判，评出一等奖、二等奖、三等奖、特别奖、最佳表达奖、最佳答辩奖和最佳图标奖共11名。从2013年第6期开始，《生理通讯》将陆续转载获奖者的参评论文各一篇，以飨读者。

简介：Effectsofshadingatthefloweringandgrainfillingstagesonosmoticregulationsubstancecontentandprotectiveenzymeactivitiesintheleavesofdifferentricegenotypes(e.g.,IIyou498,Gangyou188,Dexiang4103,Gangyou527andChuanxiang9838)wereinvestigated.TheresultsshowedthatthemalondialdehydecontentofGangyou188significantlyincreasedundershading,whereasthoseofIIyou498,Dexiang4103,Gangyou527andChuanxiang9838showednosignificantdifferencescomparedtothecontrol.ThesolublesugarcontentsignificantlydecreasedinIIyou498,Gangyou188,Dexiang4103andChuanxiang9838,whereasitdidnotsignificantlyincreaseinGangyou527undertheweaklightconditions(shading).Moreover,thesolubleproteincontentintheleavesofdifferentgenotypestendedtodecreaseundershading.Further,theprotectiveenzymeactivitiesintheleavesvariedindifferentricegenotypesundertheshadingtreatment.Basedontheosmoticregulationsubstancecontentandtheprotectiveenzymeactivitiesintheleavesofdifferentricegenotypes,itwasconcludedthatGangyou188andGangyou527hadstrongabilitiestoadapttothelowlightconditions.Inaddition,themechanismofdamagetoriceleavesindifferentgenotypesundershadingwasdiscussed.

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