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简介：Anovelmethodforpreparationofpolymer-basedmagneticmicrosphereswasproposedbyutilizingmeltreactiveblending,whichwasbasedonselectivelocationofFe_3O_4nanoparticlesinPA6domainsofpolystyrene(PS)/polyamide6(PA6)immiscibleblends.ThemorphologyofPA6/Fe_3O_4compositemagneticmicrosphereswasstudiedbyscanningelectronicmicroscopy(SEM).Thecompositemagneticmicrospheresweresphericalwithadiameterrangeof0.5-8μm;thediameterwassharplydecreasedwithaverynarrowdistributionbyaddingterminalmaleicanhydridefunctionalizedpolystyrenes(FPS)forreactiveblending.Transmissionelectronmicroscopy(TEM)andthermogravimetryanalysis(TGA)resultsshowedthatmostofFe_3O_4waslocatedinthePA6microspheres.MagnetizationdatarevealedthemagnetitecontentofPA6/Fe_3O_4microsphereswasabout32wt%andthesaturationmagnetizationcouldbeupto17.2Am~2/kg.

简介：AIM:TopreparepolylacticacidmicrospheresofErythromycinforLungtargeting.METHEDS:Theorthogonaltestdesignwasusedtooptimizethetechnology,ofpreparation.Thecharacterofthemicrospheres,drugreleaseinvitro,stabilityandtissuedistributionwereexaminedRESULTS:TheErythromycinpolylacticacidmicrosphereswasregularinitsmorphology.DrugwasenvelopedinmicrospheresbutnotphysicallymixedwithPDLLA.Theaverageparticlesizewas11.65μnwithover94%ofthemicrospheresbeingintherangeof5～20trn;Thedrugloadingandtheincorporationefciencywere18%and60%respectively.Themicrosphereswerestableforthreemonthat4℃androomtemperature.TheinvitroreleasepropertiescouldbeexpressedbytheHiguchi'sequation:y=28.067+3.8515t11/2(r=0.9834).Comparingwithinjection,thedruginmicrosphereswasmoreconcentratedinlungtissue.CONCLUSION:Erythromycinpolylacticacidmicrospheresshowedsignificantsustainedreleaseandlungtargeting.

简介：Biodegradablepolymerpoly(lactic-co-glycolicacid)(PLGA)wasusedtoencapsulatethepharmacologicalactivitymetaboliteoftolterodinebymeansofO/Wemulsionsolventevaporationmethodviahomogenizationintheemulsificationprocess.Theinfluencesofpreparationparameterswereinvestigated.TheresultsindicatethatincreasingPLGAconcentrationfrom15%to40%madetheencapsulationefficiencyof5-hydroxymethylderivativeoftolterodine(5-HMT)increasedfrom55.39%to76.32%,andtheparticlesizeincreasedfrom34.33μmto70.78μm.Inaddition,whenhomogenizationspeedincreasedfrom850r/minto2300r/min,bothparticlesizeandencapsulationefficiencyofmicrospheresdecreased.Anincreaseinthevolumeofaqueousphaseledtohigherencapsulationefficiencyandbiggerparticlesize.Increasingtemperaturemadeencapsulationefficiencyandparticlesizechangesignificantly.Whilereactiontemperatureincreasedfrom20°Cto50°C,theencapsulationefficiencydecreasedfrom70.44%to24.07%,andparticlesizeincreasedfrom38.66μmto69.38μm.Highreactiontemperature(over40°C)mayleadtoporoussurfaceofmicrospheres.Poroussurface,encapsulationefficiencyandparticlesizeinfluencedontheinvitroreleaseof5-HMTtogether.

简介：Inordertoinvestigatetheimmtmogenicityofthecontrolled-releasemicroencapsulatedhepatitisBvaccineinmice,polyethyleneglycol-poly-dl-lactide(PELA)microsphereswithentrappedHSsAgwerepreparedbydoubleemulsionW/O/Wbasedonsolventextractionmethods.BALB/cmicewereimmunizedwiththeencapsulatedvaccinebyoralfeedingorinjection.Bloodsampleswerecollectedat8^th,10^th,14^thand24^thweeks,respectively,andthelevelsofantibodyresponseweredetectedbyEI.ISA.Itwasfoundthatthescanningelectronmicroscopyshowedthepreparedmicrosphereshadsmoothandsphericalsurface,suitableforvaccinedelivery.Twogroupsofmiceorallyfedwiththeencapsulatedorconventionalrecombinantvaccines,respectively,theresereshowednoobviousdifferenceintheIgGlevels.At14^thweek,thegroupinjectedwithasingledoseofencapsulatedvaccinehadasimilarlevelofIgGresponsetothegroupinjectedwithtwodosesoftherecombinationvaccine.At24^thweek,theIgGlevelsofthegroupinjectedwithtwodosesofencapsulatedvaccinewerehigherthanthoseofthegroupinjectedwithtwodosesoftherecombinationvaccine.ItconcludesthatControlled-releasemicroencapsulatedhepatitisBvaccinepossessesthefeatureofslowlyreleasinginv/voandlongtimesimmtmogenicity.

简介：Anewpreparationmethodhasbeendevelopedforthermallystableporouspolyimidemicrospheres.Porouspolyimidemicrosphereswerepreparedusingtriblockcopolymersthatconsistedofathermallystablepolyimidederivedfrompyromelliticdianhydride/4,4’-oxydianilineasthecontinuousphaseandathermallylabilepolyetherasthedispersedphase.Spheresofcopolymersweregeneratedinanonaqueousemulsionandthengraduallyheatedtocompletetheimidizationtoformamicrophase-separatedstructure.Subsequently,thermaltreatmentataslightlyreducedpressureremovedthelabileblocksandproducedpores.Undersuitabledecompositionconditions,theporesizeoftheporouspolyimidewasintherangeof200-400nm.

简介：在这个工作，chitosan/cellulose醋酸盐microspheres(CCAM)被W/O/W乳剂的方法没有有毒的试剂准备。microspheres是球形的，免费流动，并且非聚集，它有狭窄的尺寸分布。超过90%microspheres有直径从200～280m。hemolytic分析显示CCAM是安全的并且没有hemolytic效果。植入的CCAM没在Sprague-Dawley(SD)老鼠的血液学生产任何重要变化，例如血红素的白血房间，红血房间，血小板，和体积。另外，浆液丙氨酸aminotransferase，血脲氮，和creatinine的层次没在没有任何培植，与CCAM，surger线，或正常SD老鼠植入的SD老鼠有明显的变化。因此，CCAM有好血相容性并且没有hepatotoxicity或肾的毒性到SD老鼠。而且，CCAM与或没有模型药在SD老鼠关于煽动性的反应有好织物相容性并且没从与外科线植入的SD老鼠的显示出重要差别。CCAM表演作为一个长行动的交货系统答应，它有好biocompatibility和biodegradability。

简介：在亚毫米尺寸的空幸运微范围被准备；作为药交货车辆调查了。LCB(锂钙硼酸盐)微范围，通过火焰水花过程被做，为空幸运微范围被选择为先锋的玻璃。LCB玻璃微范围与磷酸盐缓冲剂(K2HPO4)反应了在37°C的5天的答案。在反应期间，Ca-P-OH混合物在LCB玻璃的表面上猛抛微范围；形成的多孔的壳。然后，微范围转弯了是有象在LCB玻璃以后的微范围在化学反应跑出去的玻璃的一样的直径的空的。在以后在为4h的600°对待热，Ca-P-OH混合物成为了幸运，因此，空幸运微范围被生产。形成空幸运的机制通过在磷酸盐缓冲剂之间的化学反应的微范围；LCB玻璃被XRD分析证实。空、多孔的微范围的微观结构特征被SEM观察。

简介：Emulsifier-freeemulsionpolymerizationofstyreneinthepresenceofβ-hydroxypropylacrylatewasstudied.Theemulsifier-freeselfcrosslinkedpolystyrenelatexmicrosphereswasobtained.Monomerconversionishigherthan90%when[St],[β-HPA],[KPS]is2.66,0.228,and5.8×10^-3mol/Lrespectivelyunder80℃for5h.Themono-dispersedlatexparticlediameterandcolloidalparticleconcentrationweregivenasD=0.23um,N=3.13×10^13/cm^3byTEManalyse,Thefactorsofinfluencinglatexstabilitywerediscussed.ThecopolymerwascharacterizedbyIRanddissolutionexperiment.Theapparentactivationenergyofpolymerizationandpolymerizationrateconstantwereobtainedtobe78.7KJ/moland514.4/mol.srespectively.

简介：Anefficientmethodtomountacoupledsilicamicrosphereandtaperedfibersystemisproposedanddemonstratedexperimentally.Forthepurposeofoptomechanicalstudies,high-quality-factoroptical(Q_o～10~8)andmechanicalmodes(Q_m～0.87×10~4)aremaintainedafterthemountingprocess.Forthemountedmicrosphere,thecouplingsystemismorestableandcompactand,thus,isbeneficialforfuturestudiesandapplicationsbasedonoptomechanicalinteractions.Especially,thepackagedoptomechanicalsystem,whichistestedinavacuumchamber,pavesthewaytowardquantumoptomechanicsresearchincryostat.

简介：CuSpinealmicrospherescongregatedfrominterleavingnanoflakeswiththicknessof40to200nmweresynthesizedbyapyridine-solvothermalprocessviathereactionbetweencupricchloride(CuCl2·2H2O)andthioacetamide(TAA,CH3CSNH2).TheproductswerecharacterizedbyX-raydiffractionandscanningelectronmicroscopy.UV-Visabsorptionspectrum,excitationandphotoluminescencespectraofCuSpinealmicrosphereswereobtainedatroomtemperaturetoinvestigatetheiropticalproperties.ApossiblegrowthmechanismontheformationofCuSpinealmicrospheresisproposed.ThefactorsinfluencingtheevolutionofmorphologiesofCuScrystalsincludingthedosageofthereactants,surfactant,andsulphur-sourcewerealsoanalyzed.

简介：Inordertoimprovethehemostaticeffectivenessofethamsylateintreatmentofuppergastrointestinalhemorrhage,wehaddevelopedanewtypeofhemostaticdrug-oralandmagneticallycontrolledethamsylatemicrospheres(abbreviation:theetham-sylatemicrospheres)andtestedtheirparametersassociatedwithphysicalandchemi-calrespects.Itsmaincharacteristicsthatwefoundwere:1>Theethamsylatemi-

简介：Apoly(tert-butylmethacrylate)(PBMA)macromonomerwassynthesizedbyanionicpolymerizationwithbis(2,6-di-t-butylphenoxy)methylaluminum[MeAl(ODBP)2]astheinitiatorandtrimethylsilylmethacrylate(TMSMA)astheendcappingagentindryTHF.Then,apoly(methacrylicacid)(PMAA)macromonomerwasobtainedbymeansofhydrolysisreactionfromthePBMAmacromonomerinthepresenceofhydrochloricacid.ThestructuresofthePBMAmacromonomerwerecharacterizedbyusing1HNMR.ItwasfoundthattheresultedPBMAmacromonomerhashighlyisotacticpropertiesandthePMAAmacromonomerhasanendvinylgrouponperpolymerchain.Themonodispersepolymericmicrospheres,whichconsistedofpolystyrenecoresandPMAAbranchesontheirsurfaces,werepreparedbythedispersioncopolymerizationofstyrenewiththePMAAmacromonomerinanethanol/watermixedsolvent.ItwasfoundthattheconcentrationofthePMAAmacromonomerwouldaffectthemicrosphereformation,themorphologyanditssizeinthecopolymerizationsystem.

简介：一种慢版本装载药的microspheres被一个乳化/化学药品cross-linking方法作为是的crosslinking代理人和acyclovir用glutaraldehyde与明胶，chitosan和montmorillonite(MMT)准备模型药。microspheres被X光检查衍射(XRD)描绘，Fourier变换红外线(英尺红外)并且分别地扫描电子显微镜学(SEM)。形态学，药内容，封装效率和药版本行为与不同MMT内容被调查。试验性的结果显示那设置的microspheres能被准备，microspheres的形态学被MMT显著地影响。因为MMT的物理cross-linking，使不交叉连接microspheres的成球状表演被改进。当增加时，药内容和封装效率被减少MMT的内容，而是爆炸版本和药版本cantly是signifi与MMT的增加减少了。当增加的MMT，和MMT能减少有毒的化学cross-linking代理人的内容时，有效物理cross-linking能被形成。

简介：Recentresearchshowsthattheadditionofchitosanmicrospheres（CMs）topoly（L-lactide）（PLLA）canresultinacompositescaffoldmaterialwithimprovedbiocompatibilityandmechanicalpropertiesfortissueengineeringapplications.However,researchregardingtheinfluenceofCMsonscaffolddegradationisabsentintheliterature.ThispaperpresentsastudyontheinvitrodegradationofscaffoldsmadefromPLLAwithCMs.Inthisstudy,thePLLA/CMsscaffoldswitha25%ratioofCMstoPLLAwereimmersedinphosphate-bufferedsaline（PBS）solutionat37℃for8weeks.Theinvitrodegradationofthescaffoldswasinvestigatedusingmicro-computedtomography（μCT）,weightlossanalysis,Ramanspectroscopy,anddifferentialscanningcalorimetry（DSC）.MicrostructurechangesduringdegradationweremonitoredusingμCT.TheμCTresultswereconsistentwiththeresultsobtainedfromRamanspectraandDSCanalysis,whichreflectedthataddingCMsintoPLLAcandecreasethedegradationratecomparedwithpurePLLAscaffolds.TheresultssuggestthatPLLA/CMsscaffolddegradationcanberegulatedandcontrolledtomeetrequirementsimposedagiventissueengineeringapplication.

简介：Whenaproteinisencapsulatedintopoly(DL-lactide-co-glycolide)(PLGA)microspheresbymeansofthedouble-emulsionmethod,theharshmicrospheresformationprocessincludingultrasonification,exposuretoanorganicsolventandapolymermaycausethedenaturationoftheprotein.Inthisstudy,weinvestigatedtheenzymaticactivitychangeandtheeffectoftheexcipientsonthestabilityofrecombinanthumanCu,Zn-superoxidedismutase(rhCu,Zn-SOD)duringtheemulsification.ThespecificactivityrecoverywasfoundtobeconcentrationdependentandtheexcipientsinvolvedsuchasPEG600andTween20,andtrehalosewereshowntoincreasethestabilityofrhCu,Zn-SOD.TheproteinstructuralintegritywithinthemicrosphereswasanalyzedbyFTIR.ThestructureofrhCu,Zn-SODwithinPLGAmicrospherescontainingtrehalosewasfoundtobesimilartothatofthenativesolidstate,whereastheproteinencapsulatedduringthepreparationintheabsenceofanyexcipientchangedduetothepossiblehydrophobicinteractionwiththepolymer.Theresultssuggestthatarationalstabilitystrategyforproteintobeencapsulatedintomicrospheresshouldaimatdifferentprocesses.

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简介：用乳剂—溶剂挥发法制备硝苯地平的丙烯酸树脂缓释微球。微球中药物的释放速度随丙烯酸树脂ＥｕｄｒａｇｉｔＲＬ／ＲＳ比率的增加以及制备时搅拌速率的增加而增大，随内相聚合物浓度的增加及微球粒径的增加而减小，释药５０％所需时间与微球粒径呈良好线性。微球的释药速率也随药物含量的增加（从４．２％到１６．７％）而增大，并快于药物结晶的溶解速率，但药物含量达２６．６％时，微球释药速率明显下降并低于药物结晶的溶解速率。用差热分析和Ｘ射线衍射分析证明，药物含量为４．２，９．４和１６．７％的微球中药物完全是以非晶态分散的，而含药２６．６％的微球中有药物结晶存在。不同微球释药低于７０％时，释放方式均符合Ｈｉｇｕｃｈｉ时间平方根方程。

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简介：按照一定的比例，在小牛血清的水溶液中加入丙酮和乙醇，然后在加热的情况下可形成稳定的小于５００ｎｍ的微球胶体溶液。这种方法产生的微球可在较低温度（７０～７５℃）和较短时间（２０分钟）内达到稳定，比较传统的高温（１００℃以上）和长时间（３０分钟以上）的加热制备法，这种丙酮乙醇加热变性技术有许多优点。这篇文章描述了制备过程的工艺条件，如丙酮、乙醇和小牛血清比例；加热时间和加热温度对微球形成以及对四氯四碘荧光素包裹率的影响。由本方法产生的微球可包裹４０％左右的四氯四碘荧光素。在３７℃和ＰＢＳ溶液中，上述微胶囊在１５天时间里释放了起始四氯四碘荧光素包含量的２５～６０％。