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  • 简介:摘要MARCH(membrane-associated RING-CH fingerprotein)家族是在21世纪初发现的一类E3泛素连接酶,有11个家族成员,在生物体内通过对底物蛋白进行泛素化修饰从而发挥多种调控作用。膜相关RING-CH蛋白2(membrane-associated RING-CH protein Ⅱ),简称MARCH2,常见的靶点有转铁蛋白受体(transferrin receptor,TfR)、突触融合蛋白6(syntaxin 6,STX-6)、CD86(B7-2)、人DLG1(discs large tumour suppressor)和囊性纤维跨膜传导调节因子(cystic fibrosis transmembrane conductance regulator,CFTR)以及β2肾上腺素能受体(β2-adrenergic receptors,β2-AR),在病毒免疫逃避、肿瘤发生及激动剂脱敏等方面发挥着作用。其主要通过泛素化修饰在哺乳动物的蛋白修饰及泛素化降解过程,发挥着举足轻重的作用,尤其是调控细胞内囊泡运输的蛋白及表面受体。但目前对MARCH2的功能研究仍有许多空白之处尚待填补。本文就MARCH2的起源、结构及功能进行阐述,为后续基础及临床研究提供一定的依据。

  • 标签: MARCH2 E3泛素化连接酶 核内体运输
  • 简介:风真的“疯”了吗?读读这首艾莉老师推荐的小诗,并将它翻译出来,你就知道答案了!同时别忘了把你的译作邮寄或E-mail至本刊编辑部,“最佳小诗人”等你来挑战!

  • 标签: 小学 英语 翻译方法 译文
  • 简介:MultipleChoice1.Theyshould______newwordseveryday.A.memorizeB.memorizesC.memorizingD.memorized11.Aboatisoftensmallerthana______A.goalB.shipC.yolkD.half。

  • 标签: TEST
  • 简介:Pricesofsomerareearthproductsbegantorisesincethebeginningof2017.ThethirdroundofnationalstockpilingendedonMarch28withbothquantityandpricehigherthanthesecondround.Thus,itsupportsthepricerisingofmostrareearthproducts.Especiallypriceofceriumoxideincreasedby10.10%month-on-month,leadingtherareearthmarket.

  • 标签: PRICES of some rare earth products
  • 简介:Catalogueofearthquakes(March-May,1995)Pei-ShanCHEN(陈培善)(InstituteofGeophysics,StateSeismologicalBureau,Beijing100081,China)Il...

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  • 简介:1.RareearthmarketTheNationalDevelopmentandReformCommissionandrelevantdepartmentsheldtherareearthenterprises'commercialreservesmeetingonMarch30.Themeetinghasclearlypointedoutthecommercialreserves'principles,supportingmeasures,implementationmainbody,operationpatternandconcreteplans&processes.Themeetingalsomarksthesupply-sidestructuralreformofrareearth

  • 标签: 稀土工业 国家发展和改革委员会 市场分析 商业储备 稀土企业 稀土市场
  • 简介:在现实社会生活中,交际既是人际间相互交往的主观需求,也是社会生活的重要组成部分之一。鉴于人们都生活在自己的传统和文化环境中,所以交际活动离不开一定的文化和社会背景。因此我们说,人类的交际活动都不同程度地,客观地反映了一个民族文化价值观念。正是出于这一目的,本文通过对中国自由市场店主与消费者间的商务对话,分析研究在中国文化背景下,在双方谈话中所表现出来的文化理念和会话特点。

  • 标签: 交际 自由市场 消费者 文化
  • 简介:AnearthquakewithMS5.8occurredon10March2011inYingjiangcounty,westernYunnan,China.Thisearthquakecaused25deathsandover250injuries.Inordertobetterunderstandtheseismotectonicsintheregion,wecollectedthearrivaltimedatafromtheYunnanseismicobservationalbulletinsduring1Januaryto25March2011,andpreciselyhand-pickedthearrivaltimesfromhigh-qualityseismogramsthatwererecordedbythetemporaryseismicstationsdeployedbyourInstituteofCrustalDynamics,ChinaEarthquakeAdministration.Usingthesearrivaltimes,werelocatedalltheearthquakesincludingtheYingjiangmainshockanditsaftershocksusingthedouble-differencerelocationalgorithm.OurresultsshowthattherelocatedearthquakesdominantlyoccurredalongtheENEdirectionandformedanupside-downbow-shapedstructureindepth.ItisalsoobservedthataftertheYingjiangmainshock,someaftershocksextendedtowardtheSSEoverabout10km.TheseresultsmayindicatethattheYingjiangmainshockrupturedaconjugatefaultsystemconsistingoftheENEtrendingDaYingjiangfaultandaSSEtrendingblindfault.Suchstructuralfeaturescouldcontributetoseverelyseismichazardsduringthemoderate-sizeYingjiangearthquake.

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  • 简介:ThegeomagneticeffectsofthetotalsolareclipseinMoheareaandthepartialeclipseoccurredonMarch9,1997inChinaareanalyzedinthispaper.ThegeomagneticeffectsoftheeclipsewidelydistributedinChinaareobtained,whichshowHcomponentdecreasesobviouslyandissymmetricalongthelatitudewithacenternear33(Nduringtheeclipsetime.TheseresultsofsolareclipsegeomagneticeffectsarethenewestinrecentyearsobtainedinthelargestareainChina.

  • 标签: SOLAR ECLIPSE GEOMAGNETIC effects of ECLIPSE
  • 简介:ThesynopticsituationandmesoscalestructureofanexplosiveextratropicalcycloneovertheNorthwesternPacificinMarch2007areinvestigatedthroughweatherstationobservationsanddatareanalysis.Thecycloneislocatedbeneaththepolewardsideoftheexitofa200hPajet,whichisastrongdivergentregionaloft.Atmid-level,thecycloneliesonthedownstreamsideofawell-developedtrough,whereastrongascendingmotionfrequentlyoccurs.Cross-sectionanalyseswithweatherstationdatashowthatthecyclonehasawarmandmoistcore.A'nose'ofthecoldfront,whichischaracterizedbyalow-levelprotrudingstructureintheequivalentpotentialtemperaturefield,formswhenthecyclonemovesoffshore.This'nose'structureishypothesizedtohavebeencausedbytheheatingeffectoftheKuroshioCurrent.Twolow-leveljetstreamsarealsoidentifiedonthewesternandeasternsidesofthecoldfront.Thewesternjetconveyscoldanddryairat800-900hPa.Thewindinthenorthernpartisnortheasterly,andthewindinthesouthernpartisnorthwesterly.Bycontrast,theeasternjetcarrieswarmandmoistairintothecyclonesystem,ascendingnorthwardfrom900hPato600-700hPa.Thesouthernpartisdominatedbythesoutherlywind,andthewindinthenorthernpartissouthwesterly.Theeasternandwesternjetssignificantlyincreasetheairtemperatureandmoisturecontrastinthevicinityofthecoldfront.Thisincreasecouldplayanimportantroleinimprovingtherapidcyclogenesisprocess.

  • 标签: EXPLOSIVE extratropical cyclone METEOROLOGICAL bomb rapid
  • 简介:ThedistributionalfeaturesoftemperatureandsalinityinthenorthernTaiwanStraitshavebeenanalyzedbasedontheCTDdataduringFebruary-March,1998.Thecharacteristicsoftemperatureandsalinityaresummarizedasfollows:(1)thereexistsacoastalwateralongthewesterncoastoftheTaiwanStraits,withlowtemperatureandlowsalinityattheupperlayer;(2)ahightemperatureandhighsalinitywatertongueextendsnortheastwardalongtheeasterncoastoftheTaiwanStrait.

  • 标签: temperature SALINITY northern TAIWAN STRAITS distribution