简介：摘要MARCH（membrane-associated RING-CH fingerprotein）家族是在21世纪初发现的一类E3泛素连接酶，有11个家族成员，在生物体内通过对底物蛋白进行泛素化修饰从而发挥多种调控作用。膜相关RING-CH蛋白2（membrane-associated RING-CH protein Ⅱ），简称MARCH2，常见的靶点有转铁蛋白受体（transferrin receptor，TfR）、突触融合蛋白6（syntaxin 6，STX-6）、CD86（B7-2）、人DLG1（discs large tumour suppressor）和囊性纤维跨膜传导调节因子（cystic fibrosis transmembrane conductance regulator，CFTR）以及β2肾上腺素能受体（β2-adrenergic receptors，β2-AR），在病毒免疫逃避、肿瘤发生及激动剂脱敏等方面发挥着作用。其主要通过泛素化修饰在哺乳动物的蛋白修饰及泛素化降解过程，发挥着举足轻重的作用，尤其是调控细胞内囊泡运输的蛋白及表面受体。但目前对MARCH2的功能研究仍有许多空白之处尚待填补。本文就MARCH2的起源、结构及功能进行阐述，为后续基础及临床研究提供一定的依据。

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简介：MultipleChoice1.Theyshould______newwordseveryday.A.memorizeB.memorizesC.memorizingD.memorized11.Aboatisoftensmallerthana______A.goalB.shipC.yolkD.half。

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简介：Pricesofsomerareearthproductsbegantorisesincethebeginningof2017.ThethirdroundofnationalstockpilingendedonMarch28withbothquantityandpricehigherthanthesecondround.Thus,itsupportsthepricerisingofmostrareearthproducts.Especiallypriceofceriumoxideincreasedby10.10%month-on-month,leadingtherareearthmarket.

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简介：1.RareearthmarketTheNationalDevelopmentandReformCommissionandrelevantdepartmentsheldtherareearthenterprises'commercialreservesmeetingonMarch30.Themeetinghasclearlypointedoutthecommercialreserves'principles,supportingmeasures,implementationmainbody,operationpatternandconcreteplans&processes.Themeetingalsomarksthesupply-sidestructuralreformofrareearth

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简介：在现实社会生活中，交际既是人际间相互交往的主观需求，也是社会生活的重要组成部分之一。鉴于人们都生活在自己的传统和文化环境中，所以交际活动离不开一定的文化和社会背景。因此我们说，人类的交际活动都不同程度地，客观地反映了一个民族文化价值观念。正是出于这一目的，本文通过对中国自由市场店主与消费者间的商务对话，分析研究在中国文化背景下，在双方谈话中所表现出来的文化理念和会话特点。

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简介：AnearthquakewithMS5.8occurredon10March2011inYingjiangcounty,westernYunnan,China.Thisearthquakecaused25deathsandover250injuries.Inordertobetterunderstandtheseismotectonicsintheregion,wecollectedthearrivaltimedatafromtheYunnanseismicobservationalbulletinsduring1Januaryto25March2011,andpreciselyhand-pickedthearrivaltimesfromhigh-qualityseismogramsthatwererecordedbythetemporaryseismicstationsdeployedbyourInstituteofCrustalDynamics,ChinaEarthquakeAdministration.Usingthesearrivaltimes,werelocatedalltheearthquakesincludingtheYingjiangmainshockanditsaftershocksusingthedouble-differencerelocationalgorithm.OurresultsshowthattherelocatedearthquakesdominantlyoccurredalongtheENEdirectionandformedanupside-downbow-shapedstructureindepth.ItisalsoobservedthataftertheYingjiangmainshock,someaftershocksextendedtowardtheSSEoverabout10km.TheseresultsmayindicatethattheYingjiangmainshockrupturedaconjugatefaultsystemconsistingoftheENEtrendingDaYingjiangfaultandaSSEtrendingblindfault.Suchstructuralfeaturescouldcontributetoseverelyseismichazardsduringthemoderate-sizeYingjiangearthquake.

简介：ThegeomagneticeffectsofthetotalsolareclipseinMoheareaandthepartialeclipseoccurredonMarch9,1997inChinaareanalyzedinthispaper.ThegeomagneticeffectsoftheeclipsewidelydistributedinChinaareobtained,whichshowHcomponentdecreasesobviouslyandissymmetricalongthelatitudewithacenternear33(Nduringtheeclipsetime.TheseresultsofsolareclipsegeomagneticeffectsarethenewestinrecentyearsobtainedinthelargestareainChina.

简介：ThesynopticsituationandmesoscalestructureofanexplosiveextratropicalcycloneovertheNorthwesternPacificinMarch2007areinvestigatedthroughweatherstationobservationsanddatareanalysis.Thecycloneislocatedbeneaththepolewardsideoftheexitofa200hPajet,whichisastrongdivergentregionaloft.Atmid-level,thecycloneliesonthedownstreamsideofawell-developedtrough,whereastrongascendingmotionfrequentlyoccurs.Cross-sectionanalyseswithweatherstationdatashowthatthecyclonehasawarmandmoistcore.A'nose'ofthecoldfront,whichischaracterizedbyalow-levelprotrudingstructureintheequivalentpotentialtemperaturefield,formswhenthecyclonemovesoffshore.This'nose'structureishypothesizedtohavebeencausedbytheheatingeffectoftheKuroshioCurrent.Twolow-leveljetstreamsarealsoidentifiedonthewesternandeasternsidesofthecoldfront.Thewesternjetconveyscoldanddryairat800-900hPa.Thewindinthenorthernpartisnortheasterly,andthewindinthesouthernpartisnorthwesterly.Bycontrast,theeasternjetcarrieswarmandmoistairintothecyclonesystem,ascendingnorthwardfrom900hPato600-700hPa.Thesouthernpartisdominatedbythesoutherlywind,andthewindinthenorthernpartissouthwesterly.Theeasternandwesternjetssignificantlyincreasetheairtemperatureandmoisturecontrastinthevicinityofthecoldfront.Thisincreasecouldplayanimportantroleinimprovingtherapidcyclogenesisprocess.

简介：ThedistributionalfeaturesoftemperatureandsalinityinthenorthernTaiwanStraitshavebeenanalyzedbasedontheCTDdataduringFebruary-March,1998.Thecharacteristicsoftemperatureandsalinityaresummarizedasfollows:(1)thereexistsacoastalwateralongthewesterncoastoftheTaiwanStraits,withlowtemperatureandlowsalinityattheupperlayer;(2)ahightemperatureandhighsalinitywatertongueextendsnortheastwardalongtheeasterncoastoftheTaiwanStrait.