简介：反应粉末水泥(RPC)的三种类型的影响行为用测试方法的裂口Hopkinson出版社酒吧(SHPB)被学习。这些RPC分别地与0%，3%，和4%的钢纤维体积部分被准备。压力紧张关系，紧张率敏感阀值价值，动态力量增加因素，弹性的模量和使遭到影响负担的这些RPC标本的失败模式被调查。从测试，50s1的紧张率敏感阀值价值被获得。试验性的结果看了那紧张率什么时候从阀值价值增加了到RPC的最大的压力增加了大约20%的95s1,，RPC的弹性的模量增加了大约30%。当使遭到了影响时，有钢纤维加强的RPC标本的失败模式与RPC矩阵标本的很不同装载。在装载率的类似的影响下面，在钢纤维开发的裂缝增强了RPC标本，虽然RPC矩阵标本被分解为小片。

简介：

简介：benzothiazole衍生物的新系列被设计并且综合。最新综合的混合物对Escherichiacoli，葡萄球菌aureus和杆菌仙影拳为他们的抗菌剂活动被屏蔽。混合物6j和6o对E显示出最高的活动。coli和S。aureus。这些混合物的抗真菌的活动也对Candidaalbicans和曲霉属菌fumigatus被测试293。混合物4c，4g和6j对C展出了最高的活动。albicans。另外，混合物4a和6j对A显示了有希望的活动。fumigatus293。而混合物4a，6j和6p显示出中等活动，一样的混合物对ChromobacteriumviolaceumATCC12472为他们的察觉到antiquorum活动被检验。在里面综合混合物测试的vitrocytotoxicity对颈的癌症(Hela)和肾成纤维细胞癌症(COS-7)房间被执行线。结果显示所有测试混合物有IC50价值>50 ；对两根房间线的mol/L。分子的性质，毒性，药相似，和药获得混合物4a-c，5a，6g，h，6j，6l，6o和7c的侧面，d也被估计。

简介：Coloncancersdevelopadaptivemechanismstosurviveunderextremeconditionsanddisplayhallmarksofunlimitedproliferationandresistancetocelldeath.Thederegulationofcelldeathisakeyfactorthatcontri-butestochemoresistanceintumors.Inaphysiologicalcontext,balancebetweencellproliferationanddeath,andprotectionagainstcelldamagearefundamentalprocessesformaintaininggutepithelialhomeostasis.Themechanismsunderlyinganti-deathcytoprotectionandtumorresistanceoftenbearcommonpathways,andalthoughdistinguishingthemwouldbeachallenge,itwouldalsoprovideanopportunitytodevelopadvancedanti-cancertherapeutics.Thisreviewwilloutlinecelldeathpathways(i.e.,apoptosis,necrosis,andnecroptosis),anddiscusscytoprotectivestrategiesinnormalintestinalepitheliumanddeathresistancemechanismsofcolontumor.Incolorectalcancers,theintracellularmechanismsofdeathresistanceincludethedirectalterationofapoptoticandnecroptoticmachineryandtheupstreameventsmodulatingdeatheffectorssuchastumorsuppressorgeneinactivationandpro-survivalsignalingpathways.Theautocrine,paracrineandexogenousfactorswithinatumormicroenvironmentcanalsoinstigateresistanceagainstapoptoticandnecroptoticcelldeathincoloncancersthroughchangesinreceptorsignalingortransporteruptake.Therolesofcyclooxygenase-2/prostaglandinE2,growthfactors,glucose,andbacteriallipopolysaccharidesincolorectalcancerwillbehighlighted.Targetinganti-deathpathwaysinthecoloncancertissuemightbeapromisingapproachoutsideofanti-proliferationandanti-angiogenesisstrategiesfordevelopingnoveldrugstotreatrefractorytumors.

简介：

简介：

简介：Theshiphullsurfaceoptimizationbasedonthewaveresistanceisanimportantissueintheshipengineeringindustry.Thewaveletmethodmayprovideaconvenienttoolforthesurfacehulloptimization.Asapreliminarystudy,weusethewaveletmethodtooptimizethehullsurfacebasedontheMichelwaveresistanceforaWigleymodelinthispaper.Firstly,weexpressthemodel’ssurfacebythewaveletdecompositionexpressionsandobtainareconstructedsurfaceandthenvalidateitsaccuracy.Secondly,werewritetheMichelwaveresistanceformulainthewaveletbases,resultinginasimpleformulacontainingonlytheshiphullsurface’swaveletcoefficients.Thirdly,wetakethesewaveletcoefficientsasoptimizationvariables,andanalyzethemainwaveresistancedistributionintermsofscalesandlocations,toreducethenumberofoptimizationvariables.Finally,weobtaintheoptimalhullsurfaceoftheWigleymodelthroughgeneticalgorithms,reducingthewaveresistancealmostbyahalf.Itisshownthatthewaveletmethodmayprovideanewapproachforthehulloptimization.

简介：Ballisticthermalresistanceofgraphenenano-junctionsisinvestigatedusingnon-equilibriummoleculardynamicssimulation.Thesimulationsystemisconsistedoftwosymmetricaltrapezoidalorrectangulargraphenenanoribbons(GNRs)andaconnectingnanoscaleconstrictioninbetween.Fromthesimulatedtemperatureprofile,abigtemperaturejumpresultedfromtheconstrictionisfound,whichisproportionaltotheheatcurrentandcorrespondstoalocalballisticthermalresistance.FixingtheconstrictionwidthandthelengthofGNRs,thisballisticthermalresistanceisindependentofthewidthoftheGNRsbottomlayer,i.e.,theconvexangle.Butinterestingly,thisthermalresistancehasobvioussizeeffect.Itisinverselyproportionaltotheconstrictionwidthandwilldisappearwiththeconstrictionbeingwider.Moreover,basedonthephonondynamicstheory,atheoreticalmodeloftheballisticthermalresistanceintwo-dimensionalnano-systemsisdeveloped,whichgivesagoodexplanationonmicrocosmiclevelandagreeswellwiththesimulationresultquantitativelyandqualitatively.

简介：

简介：Thecombinationofdeepwetetchingandamagneto-rheologicalfinishing(MRF)processisinvestigatedtosimultaneouslyimprovelaserdamageresistanceofafused-silicasurfaceat355nm.ThesubsequentlydepositedSiO2coatingsareresearchedtoclarifytheimpactofsubstratefinishingtechnologyonthecoatings.Itisrevealedthatadeepremovalproceedingfromthesinglesideordoublesidehadasignificantimpactonthelaser-induceddamagethreshold(LIDT)ofthefusedsilica,especiallyfortherearsurface.Afterthedeepetching,theMRFprocessthatfolloweddoesnotactuallyincreasetheLIDT,butitdoesamelioratethesurfacequalitieswithoutadditionalLIDTdegradation.Thecombinationguaranteeboththeintegrityofthesurface’sfinishandthelaserdamageresistanceofthefusedsilicaandsubsequentSiO2coatings.

简介：TheChineseAnti-JapaneseWarwasabattlebetweenhumanrightsprotectionsandabuses,betweencivilizationandbrutality,andbetweenjusticeandevil.Duringthewar,thehumanrightsofChinesepeoplewerecompletelyviolatedbytheJapaneseaggressors,causinganunprecedentedhumanrightscatastrophe.Atthesametime,Chinesepeoplevigorouslyresistedtheaggressioninordertodefendthenationalsurvivalrightandsafeguardthehumanpeaceagainstwar.Thehistoryofhumanrights’victoryoverhumanrightsabusestellsus:aggressivewarsarethemostseriousviolationsofhumanrights.Wemustprotectpeople’srighttopeaceforeverycountryintheworld.Inordertoavoidviolationsofhumanrightsbywaronceagain,wemustsafeguardtheinternationalpostwarorderandpreventtherevivaloffascism,whoseessencesarecontemptforandtrampleonhumanrights.Thereforewehavetorespectandprotecthumanrightsanddefendboththecollectiverightsofeverynationandtheindividualrightsofeverypersonintheworld.

简介：

简介：