简介:摘要目的分析肿瘤沉积(TD)的存在对ypⅢ期直肠癌患者预后的预测作用及其对术后辅助化疗获益的影响。方法回顾分析2007—2017年间福建医科大学附属协和医院接受多学科综合治疗的338例ypⅢ期直肠癌患者资料,将其分为TD(-)组(301例)和TD(+)组(37例)。Kaplan-Meier法并log-rank检验差异和单因素预后分析,Cox模型多因素分析。结果TD(-)组5年总生存、无远处转移生存、无进展生存均高于TD(+)组(59.3%∶42.0%,P=0.001;79.1%∶55.0%,P<0.001;55.6%∶38.0%,P<0.001),但局部无复发生存相近(96.7%∶85.5%,P=0.679)。单因素预后分析显示TD(+)组中TD个数与患者预后无关(P=0.923),术后辅助化疗对两组患者预后均无影响(P=0.103)。多因素预后分析显示TD与更差的总生存相关(HR=2.343,95%CI为1.257~4.363,P=0.007)。结论对于接受多学科综合治疗的ypⅢ期直肠癌患者,TD(+)者的预后更差,TD是总生存的独立预测因子;无论患者是否存在TD,均未能从术后辅助化疗中获益。
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