简介:AIM:Toinvestigatethecharacteristicsandcriterionofgraftrejectioninmicemodel.METHODS:C57BL/6orBALB/cmicecornealgraftsweregraftedontoBALB/chosts.Eachgroupwasdividedintotwosubgroupsaccordingtothecornealopacityscores12daftertransplantation.Thecharacteristicsofopacityandneovascularizationwereobserved.Miceofthe12th,50thdayaftertransplantation,thegraftsbiopsyofmiceinallogeneicgroup1,whichopacityscoreexceed3,werepreparedforhistologicalobservationandthoserestoretransparentwereendothelialstained.RESULTS:Therewasnodifferenceofcornealopacityscoreonthe7thand12thdayafteroperation;thehistologicalresultshadnodisparitybetweensyngeneicgroupandallogeneicgroup.Onthe12thdayaftersurgery,theturbiditycurvewasapparentingraftswithopacityscore<2.Mononuclearcellswereshowningraftswithopacityscorereached3inallogeneicgroup1.Differentrejectionperformancewasobservedintissuesectionsonthe50thdayaftersurgery.CONCLUSION:Grafts,opacityscoreexceeds3fromthe7thtothe12thdayafteroperationcouldnotbejudgedasarejection.Weshouldpaymoreattentiontothevariationofgraftsopacitysince12daftercornealtransplantation.
简介:摘要秦瑟是美国20世纪早期著名的细菌学及免疫学家,在斑疹伤寒的病原菌及其疫苗的研究领域颇有建树,并以其名字重新命名了流行性斑疹伤寒。他的经典著作《老鼠、虱子和历史》从具体案例入手,以斑疹伤寒和媒介生物的发展历程为线索,梳理了传染病及其涉及生物的协同演化脉络,更揭示了传染病对人类历史改变的巨大影响。书中摈弃了传统的以人类为主角的写作模式,将人类与微生物置于平等的地位进行考察。作者引经据典,分析传染病的病理学特征,以专业的视角对梅毒的起源、雅典瘟疫等历史上的传染病事件提出了独到的见解,并呼吁历史学家将传染病史纳入历史诠释的范畴之中。《老鼠、虱子和历史》问世后多次再版,后世学者在此基础上进一步将疾病史置于更宏大的人类历史的背景下考察,增强了对于生态、政治等因素的综合考量,促进了生命科学与历史学等多学科相结合的全球疾病史研究的发展。
简介:摘要目的探讨优质护理对腹腔镜子宫肌瘤剔除术患者满意度的影响。方法选择我院2017年5月-2018年5月收治子宫肌瘤患者124例,均行悬吊式无气腹腹腔镜子宫肌瘤剔除术治疗,随机分为观察组和对照组两组,每组62例,对照组予以常规护理,观察组在与对照组相同护理的基础上实施优质护理,比较两组手术情况及护理满意度。结果观察组手术时间、术中出血量及并发症发生率均显著少于对照组,差异有显著统计学意义(P<0.05);观察组护理满意度96.77%,明显高于对照组72.58%,差异有统计学意义(P<0.05)。结论优质护理可以显著改善患者手术情况,提高护理满意度,降低术后并发症发生率,值得临床大力推广及应用。
简介:·AIM:Tostudytheeffectsofdanhonghuayukoufuye(DHK)onfastingbloodglucose(FBG)anddiabeticretinopathy(DR)instreptozotocin(STZ)-inducedtype1diabeticratstofacilitatetherationalusageofthisdrug.·METHODS:DiabeticratswereinducedbyinjectionofasingledoseofSTZintraperitoneallyat50mg/kg.Flashelectroretinogram(FERG)andoscillatorypotentials(OPs)wereusedtomeasureretinalfunction.Themicrovascularperfusionofearswasperformedtostudythemicrocirculationinrats.FBG,body-weight,and24-hurinevolume,waterintakeanddietintakewerealsoassessed.·RESULTS:DHKhadnoeffectonFBGinnormalrats.However,STZ+DHKgroupweresignificantlydifferentfromthoseofModelandmovedtowardthoseofnormalcontrol.Itreversedtheincreaseindietintake(P≤0.05vsmodelcontrol)andthelossinbody-weight(P≤0.05vsmodelcontrol)indiabeticrats.DHKdecreasedtheFBGofdiabeticratsby25.6%(P≤0.05)and37.9%(P≤0.01)after14and21daysadministrationascomparedwiththemodelcontrol,respectively.Moreover,DHKsignificantlyincreasedtheFERGb-waveamplitudeby80%(P≤0.05vsmodelcontrol)anddecreasedtheFERGb-wavelatencyby15.3%(P≤0.01vsmodelcontrol)after24daysadministration.TheOP1andOP2amplitudesinDHKgroupwere2.6(P≤0.01)and2.0(P≤0.01)timesofmodelgroupafter24daysofDHKtreatment,respectively.Atthesametime,OP1andOP2latenciesinDHKgroupreducedby16.0%(P≤0.001)and14.7%(P≤0.001)ascomparedwiththemodelcontrol,respectively.Furthermore,themicrovascularperfusionofDHKgroupwas2.4timesofmodelgroup(P≤0.001)after21daysadministration.·CONCLUSION:DHKhadnoeffectonnormalFBG.Butithadantihyperglycemicactivity,andhadapreventiveandtherapeuticeffectonDRindiabeticrats.·