简介:ObjectiveToobservethescopolamineonthelullationofpentobarbitalsodiumofmice.MethodsTookthreegroupsinmice,thenthegroupofchloramphenicol(25mg·kg^-1),thegroupofscopolamine(0.06mg·kg^-1),andthegroupof0.9%sodiumchloride,injectedtheequalcapacityofdrugforleaveeachother.After30minutes,theinjectionofpentobarbitalsodium(40mg·kg^-1)wasperformedonmice,toobservethetimeoflullpreserveonmice.ResultsThegroupinjectedwithchloramphenicol(25mg·kg^-1)haveextendedthetimeofthelullpreserveofmicecomparedwith0.9%sodiumchloride,ithasanabsolutedistance.Thegroupofinjectedwithscopolamine(0.06mg·kg^-1)havestrongationofincreasedthetimeoflullpreserveonmicecomparedwith0.9%sodiumchloride.Ithasabsolutedistance.ConclusionsThescopolaminehasinhibitoryeffectontheactivityofhepaticmicrosomalenzyme,ithasincreasethetimeoflullpreserve.
简介:Tostudyeffeetofscopolamineontheactivityoftheformationofthroumbusoutsideofrabbitsandmice.MethodsTheinjectionof0.025mg·0.05mg·0.15mgscopolaminewasperformedonrabbitsandmice.After30minuters,toobservetheeffectscopolamineofthrombusoutsidetheanimals.Results0.025mg·0.05mg·0.15mg·kg^-1scopolaminehaverestrainedthethrombusofrabbitsandmiceinoutside.Therestrainedrateofrabbitsandmicewere68.04%,78.35%,81.44%and68.7%,72.5%,75.53%.Comparedwith0.9%sodiumchlorideithadobsolutediscrepancy(P<0.05).Themoredosethemoreaction.ConclusionThedifferentdosescopolaminehadrestrainedformationthrombusoutsideofrabbitsandmicedisplayedthatithaddose-responserelationship.