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简介：Objective:ToanalyzemoleculartrendsoftheHIVepidemicinShenzhen.Methods:SerumcollectedfromShenzhenAIDSpatientsbetween1992-1999wasanalyzedusingmoleculartechniques.DNAfragmentsoftheHIV-1EnvgenewereamplifiedbynestedPCRfromunculturedperipheralbloodmononuclearcells(PBMCs)fromtheseserumsamples.TheC2-C3regionoftheEnvgenewassequencedandanalyzed.Specifichigh-riskbehaviorswerealsoanalyzed.Results:WefoundthatthetransmissionofHIVinthecitywasmainlythroughsexualbehaviors(46.0%).TherewerefourHIV-1subtypes:B′,B,CandEwith6.31%,7.95%,3.09%and8.92%genedivergenceinsideeachsubtypeinShenzhen.Theseresultssuggestedthatepidemictimeswere6,8,3and9respectively.ThemainepidemicsubtypeswereEandBstrains.AIDSpatient''''''''santigenicvariationwasslightlyhigherthanthatofHIVinfectedindividuals.Conclusion:SurveillancedatareflecttrendsandtheepidemictimeofHIV,whichwillbeusefulforpolicymakerstoformulateeffectivestrategiesofHIV/AIDSpreventionandcontrolinShenzhen.

简介：AbstractBackground:Chromosomal abnormalities are important causes of ventriculomegaly (VM). In mild and isolated cases of fetal VM, obstetricians rarely give clear indications for pregnancy termination. We aimed to calculate the incidence of chromosomal abnormalities and incremental yield of chromosomal microarray analysis (CMA) in VM, providing more information on genetic counseling and prognostic evaluation for fetuses with VM.Methods:The Chinese language databases Wanfang Data, China National Knowledge Infrastructure, and China Biomedical Literature Database (from January 1, 1991 to April 29, 2020) and English language databases PubMed, Embase, and Cochrane Library (from January 1, 1945 to April 29, 2020) were systematically searched for articles on fetal VM. Diagnostic criteria were based on ultrasonographic or magnetic resonance imaging (MRI) assessment of lateral ventricular atrium width: ≥10 to <15 mm for mild VM, and ≥15 mm for severe VM. Isolated VM was defined by the absence of structural abnormalities other than VM detected by ultrasonography or MRI. R software was used for the meta-analysis to determine the incidence of chromosomal abnormalities and incremental yield of CMA in VM, and the combined rate and 95% confidence interval (CI) were calculated.Results:Twenty-three articles involving 1635 patients were included. The incidence of chromosomal abnormalities in VM was 9% (95% CI: 5%-12%) and incremental yield of CMA in VM was 11% (95% CI: 7%-16%). The incidences of chromosomal abnormalities in mild, severe, isolated, and non-isolated VM were 9% (95% CI: 4%-16%), 5% (95% CI: 1%-11%), 3% (95% CI: 1%-6%), and 13% (95% CI: 4%-25%), respectively.Conclusions:Applying CMA in VM improved the detection rate of abnormalities. When VM is confirmed by ultrasound or MRI, obstetricians should recommend fetal karyotype analysis to exclude chromosomal abnormalities. Moreover, CMA should be recommended preferentially in pregnant women with fetal VM who are undergoing invasive prenatal diagnosis. CMA cannot completely replace chromosome karyotype analysis.

简介：AbstractInfectious diseases remain as an important public health threat to humans. Research into pathogens can be useful for planning an organized response to infectious diseases. Bibliometric analysis is an important method for scientific research and assessing capability. In this study, 100 pathogens of public health importance were selected, and the distributions of annual, national, institutional, and journal publications on Science Citation Index (SCI) journals were statistically analyzed. The United States of America ranked the first in terms of the number of relevant studies published. China attaches great importance to the prevention and control of infectious diseases, but still needs to improve in the following areas: for example, insufficient SCI reports on particular pathogens, institutions SCI reports on pathogens lower than world top pathogen research institutions, and lack of influential international pathogen-related journals. Scientific literature databases are important tools for science-of-science analysis. The findings of this study shed light on the hot spots and the ignored spots in pathogen researches, and thus would be useful for drawing a national and institutional research plan.

简介：基于阶段空间重建的推迟时间的嵌入方法，计算脑电图(EEG)的近似的熵(ApEn)的一个新方法被建议。计算结果证明在有嵌入尺寸的变化的近似的熵癫痫的EEG和正常EEG之间有重要差别。这个结论是有用的由熵分析不同EEG的动态行为。

简介：AbstractBackground:A surgical site infection (SSI) is a major post-operative complication from elective colorectal surgery; however, few studies have focused on evaluating the risk factors for SSI. This study aimed to analyze the relative correlation of medical and environmental factors as well as patient-related factors that contribute to the incidence of all types of SSI.Methods:A retrospective search for eligible patients was conducted using the patient database of the Gastrointestinal Surgery Center of the Third Affiliated Hospital of Sun Yat-sen University from January 2011 to August 2017. Pre-operative demographic and surgical data were extracted and recoded according to the study protocol. Univariate and multivariate analyses were performed to clarify factors affecting the incidence of SSI. Propensity analysis was conducted to minimize bias in the demographic characteristics to explore the prophylactic effect of pre-operative administration of oral antibiotics.Results:Univariate analysis of the baseline characteristics revealed that younger age (odds ratio [OR]: 0.378; 95% confidence interval [CI]: 0.218–0.657) and pre-operative oral antibiotic use (OR: 0.465; 95% CI: 0.255–0.850) were protective factors, while pre-operative anemia (OR: 4.591; 95% CI: 2.567–8.211), neoadjuvant chemotherapy history (OR: 2.398; 95% CI: 1.094–5.256), and longer surgical duration (OR: 2.393; 95% CI: 1.349–4.246; P = 0.002) were identified as risk factors for SSI. Multivariate analysis indicated that age (P = 0.003), surgical duration (P = 0.001), and pre-operative oral antibiotic use (P < 0.001) were independent factors that affect the incidence of SSI. Furthermore, a propensity-matched analysis confirmed the protective effect of oral antibiotic use, with a 1-day course of oral antibiotic producing a similar effect to a 3-day course.Conclusions:Age, surgical duration, and pre-operative oral antibiotic use were associated with the incidence of SSI. However, pre-operative oral antibiotic use was the only controllable factor. From the results of our study, pre-operative oral antibiotic use is recommended before elective colorectal surgery and a 1-day course is enough to provide the protective effect.

简介：这份报纸介绍直接体积在VTK显示的技术并且讨论ray-casting-the大多数直接体积显示的流行技术。为由raycasting的三个函数的医药容量的数据的可视化被提供。可视化效果证明VTK是容易的在短时间与好质量得到满足的结果。

简介：AbstractImportance:Staphylococcus lugdunensis (S. lugdunensis) is a coagulase-negative staphylococcus (CoNS), found commonly as skin flora in humans. While most species of CoNS are clinically benign, S. lugdunensis can exhibit a similar virulence to that of S. aureus. However, there is scant data concerning S. lugdunensis infection in the pediatric population.Objective:To ascertain local S. lugdunensis infection rates and sensitivity patterns in the pediatric population.Methods:A retrospective analysis was undertaken of all S. lugdunensis isolates across a 6-year period from 2015 to 2020. Data were collected from electronic patient notes and laboratory records. Matrix-assisted laser desorption ionization and time of flight mass spectrometry were used to identify isolates.Results:Ninety-six isolates of S. lugdunensis were identified from 86 patients. Of these, 34 isolates were treated as an infection. Twenty-three (67.6%) were found to have skin as the primary source of infection. While the observed number was small, central nervous system (CNS) sources of S. lugdunensis infection appear to be a significant source: all three isolates cultured from cerebrospinal fluid were clinically managed as infection. All three were associated with ventriculoperitoneal (VP) shunt infection. No cases of S. lugdunensis infective endocarditis were identified. About 18.6% of S. lugdunensis isolates were resistant to flucloxacillin.Interpretation:S. lugdunensis is an uncommon but significant cause of infection in the pediatric population and appears to be a rising cause of CNS infection, particularly when associated with VP shunts. Flucloxacillin is recommended locally as the first choice of antibiotic.

简介：AbstractCardiotocography measures the human fetal heart rate and uterine activity using ultrasound. While it has been a mainstay in antepartum care since the 1960s, cardiotocograms consist of complex signals that have proven difficult for clinicians to interpret accurately and as such clinical inference is often difficult and unreliable. Previous attempts at codifying approaches to analyzing the features within these signals have failed to demonstrate reliability or gain sufficient traction. Since the early 1990s, the Dawes-Redman system of automated computer analysis of cardiotocography signals has enabled robust analysis of cardiotocographic signal features, employing empirically-derived criteria for assessing fetal wellbeing in the antepartum. Over the past 30 years, the Dawes-Redman system has been iteratively updated, now incorporating analyses from over 100,000 pregnancies. In this review, we examine the history of cardiotocography, signal processing methodologies and feature identification, the development of the Dawes-Redman system, and its clinical applications.

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简介：ThemethodofproducingacompleteMRIimageisbasedontheanalysisoffreeinductiondecay.ItmainlystudieswhenandhowmagneticvectorrevestsitsinitialstateafterRFpulse,butneglectstheeffectoftheRFform.Inthispaperwemainlystudythis.WegivethemathematicexpressionofRFpulsewhichcantheoreticallyimproveimage（?）ality.InMRI,B1（t）isthealternateelectromagneticexcitationfield,itcanbeexpressedasfollows:

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简介：AnewmethodofphasespectralanalysisofEEGisproposedforthecomparativeanalysisofphasespectrabetweennormalEEGandepilepticEEGsignalsbasedonthewaveletdecompositiontechnique.Byusingmultiscalewaveletdecomposition,theoriginalEEGsaremappedtoanorthogonalwaveletspace,suchthatthevariationsofphasecanbeobservedatmultiscale.Itisfoundthatthephase(andphasedifference)spectraofnormalEEGsaredistinctfromthatofepilepticEEGs.Thatisthevariationsofphase(andphasedifference)ofnormalEEGshaveadistinctperiodicpatternwiththeelectricalactivityproceedsinthebrain,butdonottheepilepticEEGs.ForepilepticEEGs,onlyatthosetransientpoints,thephasevariationsareobvious.Inordertoverifytheseresultswiththeobservationaldata,thephasevariationsofEEGsinprincipalcomponentspaceareobservedandfoundthat,thefeaturesofphasespectraisincorrespondencewiththatthewaveletspace.TheseresultsmakeitpossibletoviewthebehaviorofEEGrhythmsasadynamicspectrum.

简介：Objective:Tosummarizethereconstructionexperienceoftheelectricalinjuriesinemergency.Methods:All309woundsin105patientswhosufferedfromelectricalinjurieswerereviewedduringa10yearperiodfromJan.1st1986toDec.31st,1996.Treatmentmethod,patientdataandresultswerecomparedandanalyzed.Acomprehensiveurgentreconstructionalternativeusedinallcasesincludedthefollowings,1)debridingthewoundinemergency,2)preservingthevitaltissuesasmuchaspossible,evendevitalizedtissuesorlocalnecrosis,3)transplantingthesevitaltissuesduringthefirstsurgeryifthefunctionalreconstructionrequired,4)nourishingthewoundbedbytissueflapscoveringwithrichbloodsupply,5)improvingflapsurvivalbycontinuousirrigationfor24-720hoursbeneaththeflapswithacompoundmedicineaftersurgery.Results:Satisfactoryresultswereobtainedwiththeextremitylossratiooflessthan7%inthisgroupcomparedwith42.5%whichwas10yearsbefore1984inthesamehospital.Conclusions:Thisurgentcomprehensivereconstructionalternativeisaneffectiveandworkablemethodforreducingextremitylossofelectricalinjuries.

简介：ThispapertoreportedSNE_bandECGseparatephenomenoninLAR,andtrytofindouttheappropriatemechanism.BecauseofSNE_b——thebirthofanewmethed,thetradition-alconceptofLARwouldneedtobefurtherdiscuss.

简介：ＩＭＡＧＩＮＧＯＦＥＥＧＢＹＳＰＨＥＲＩＣＡＬＨＡＲＭＯＮＩＣＡＮＡＬＹＳＩＳＩＭＡＧＩＮＧＯＦＥＥＧＢＹＳＰＨＥＲＩＣＡＬＨＡＲＭＯＮＩＣＡＮＡＬＹＳＩＳＹａｏＤｅｚｈｏｎｇ；ＹａｎｇＳｈａｏｇｕｏ（Ｄｅｐ．ｏｆＡｕｔｏ，ＵＥＳＴｏｆＣｈｉｎａ，Ｃ...

简介：与多重损伤在病人为错误诊断探索特征，治疗结果和原因的目的，以便减少错误诊断的发生。从1997年8月被同意进入我们的部门到2008年8月的有多重损伤的3163个病人全部的方法A，回顾地被学习比较诊断和治疗的特征。有2117男性(66.93%)，有平均数的1046女性(33.07%)36.46年变老(范围，14-80年)。象一般地位，创伤的条件，诊断和治疗状况，预后和死亡那样的参数被分析。错误诊断组和正确诊断组之间的差别以阐明的损害，复杂并发症和治疗结果的严厉被比较错误诊断的原因和预防。结果在这研究的多重损伤的错误诊断率是16.19%。误诊的主要解剖地点是手足和骨盆(299个位置，39.50%)，腹的区域和骨盆的机关(148个位置，19.55%)，并且胸的区域(109个位置，14.40%)。在错误诊断组，ISS，一些医院停留，知觉的骚乱的率，批评盒子和吃惊，盒子是33.78吗？

简介：objectivesTodemonstratethephenomenaandexplorethecausesofanemiainpatientswithchronicheartfailure(CHF).MethodsToobservethephenomenaofanemiainpatientswithCHF,atotalof276patientswithCHFwereincludedinthisretrospectivestudy.Theclinicalcharacteristicsofthepatientsare;meanage69.2±11.0years;male151,female125;NYHAⅢandⅣ115(41.7%).Results①Amongthe276patientswithCHF,81(29.4%)hadanemia(Meanhemoglobulinconcentration101.5±13.0g/L).②PatientswithAnemiaweremorelikelytobefemaleandtohavegreaterNYHA(ⅢorⅣ)(P<0.05),higherserumcreatinine,aswellaslowerserumalbuminandlow-densitylipoproteinlevels(P<0.01).③AweaknegativecorrelationwasalsonotedbetweenthelevelofNYHAandhemoglobulin.④Therewasnosignificantdifferenceinage,theprimarycardiacetiologyoftheCHF,thehistoryofdiabetes,leftventricularenddiastolicdiameter,andleftventricularejectionfractionbetweenCHFpatientwithandwithoutanemia.ConclusionsTheprevalenceofanemiaishighamongpatientswithCHF.TheanemiapatientswithCHFtendtobefemale,havegreatercardiacandrenalfunctionalimpairment,butwithlowerserumalbuminandLDLthatsuggestssomedegreeofmalnutrition.

简介：[摘要]目的：分析心内科护理风险因素及处理对策。方法：选取我院2018年11月~2020年8月期间心内科收治患者152例作为本文研究对象，将152例患者分为实验组和对照组，对照组采取常规护理干预，实验组实施风险因素针对性护理，对比两组患者护理效果、护理满意度以及不良事件发生率。结果：实验组患者护理有效率高于对照组，实施针对性护理能够提高心内科护理效果，两组对比具有差异表示统计学有意义。实验组患者采取对症护理后，护理满意度明显提升，对比对照组更高，对比两组患者护理满意度的对比具有差异表示统计学有意义（P〈0.05）。实验组患者护理后，出现1例用药错误，1例跌倒；对照组护理后，出现3例用药错误，3例坠床和4例跌倒，对比两组护理后的不良事件发生率对比就有差异，因此实施针对性护理能够提高护理质量，保证护理安全，两组对比具有统计学意义。结论：由于心内科患者的病情比较复杂，为患者实施的护理管理也存在很多的风险因素，分析心内科常见的护理风险制定针对性护理干预，能够提高护理质量，保证护理效果，改善患者对护理服务的满意度，降低不良事件发生率，改善患者预后。

简介：Objective:Population-basedcancerregistrationdatawereusedtoanalyzetheepidemiologyandtrendofmalignantmesotheliomainChina,andtheresultwouldprovidebasicdataforitspreventionandcontrol.Methods:Malignantmesotheliomadatain2013wereretrievedfromthedatabaseofNationalCancerRegistry.Malignantmesotheliomaincidenceandmortalitywereestimatedusingage-specificratebyurban/ruralandgenderaccordingtothenationalpopulationin2013.Malignantmesotheliomadatafrom22cancerregistrieswereusedfortrendanalysisduring2000–2013.Results:Itisestimatedthattherewere2,041newmalignantmesotheliomacasesand1,659malignantmesotheliomadeathsoccurredin2013.ThecrudeincidencerateinChinawere1.50/106(males1.67/106,females1.32/106),age-standardizedincidenceratesbyChinesestandardpopulation(ASIRC)andbyworldstandardpopulation(ASIRW)were1.03/106and1.02/106,respectively.ThecrudemortalityrateinChinawas1.22/106(males1.67/106,females1.32/106),age-standardizedmortalityratesbyChinesestandardpopulation(ASMRC)andbyworldstandardpopulation(ASMRW)were0.83/106and0.81/106,respectively.TherewasanincreasingtrendofincidencerateformalignantmesotheliomainregistrationareasofChinaduring2000–2013withannualpercentagechange(APC)of2.5%[95%confidenceinterval(95%CI):0.6%–4.5%].Afteragestandardization,nosignificantdifferenceswereobserved.Nomatterforcrudemortalityratesorage-standardizedmortalityrates,nosignificantdifferenceswereobservedduring2000–2013.Conclusions:Malignantmesotheliomaisthemajoroccupationalandenvironmentalneoplasmassociatedwithasbestosexposure.Theincreasingincidencetrendsuggeststhatmoreattentionshouldbepaidonthisdisease.