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19 个结果
  • 简介:Methoxypolyethyleneglycolsof5000dalton(PEG)havebeenattachedcovalentlytohumanserumimmunoglobulinGusing2,4,6-trichloro-s-triazineascouplingagent.Themodi-fiedIgGshowedsubstantialchangesinpropertiesascomparedwiththeunmodifiedIgG.Themod-ifiedIgGshowedincreaseinmolecularweight,increaseoftolerancetotemperatureandPH,de-creaseofimmunogenicityandretainingmostofitsimmunoactivity.TheCDspectrashowednoap-parentchangesinitsmainstructure.IgGwith50.3%ofitsaminogroupsmodifiedbyPEGhaditsimmunogenicitycompletelyre-moved,whilemaintaining53.7%ofitsimmunoactivity.

  • 标签: IMMUNOGLOBULIN G(IgG) Methoxypolyethylene glycol(PEG) Chemical MODIFICATION
  • 简介:THEPROPERTIESOFLEUKOCYTEANDERYTHROCYTEADHEREDTOENDOTHELIALCELLINFLOWFIELDTHEPROPERTIESOFLEUKOCYTEANDERYTHROCYTEADHEREDTOENDOT...

  • 标签: CELL
  • 简介:DIELECTRICPROPERTIESOFHUMANBREASTCARCINOMAANDSURROUNDINGTISSUESDIELECTRICPROPERTIESOFHUMANBREASTCARCINOMAANDSURROUNDINGTISSUE...

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  • 简介:ANALYSISOFDIELECTRICRELAXATIONPROPERTIESOFCELLSANDTISSUESATRADIOFREQUENCIESANALYSISOFDIELECTRICRELAXATIONPROPERTIESOFCELLSAND...

  • 标签: 生物医学工程学 生物组织 国外医学 介电谱 测量技术 生物物质
  • 简介:THEDIELECTRICPROPERTIESOFHUMANFETALORGANTISSUESATRADIOANDMICROWAVEFREQUENCISETHEDIELECTRICPROPERTIESOFHUMANFETALORGANTISSUESA...

  • 标签: DIELECTRIC measurement Human FETAL ORGAN TISSUE
  • 简介:Withthedevelopmentofbiomedicalengineering,thethermophysicalpropertiesoftheorgansandtissuesoflivinganimalsbecomeessential.However,becausetheytendtobeofirregularshapes,limitedsizesandwithlowintensityinnerheatsource,themeasuringofthethermophysicalpropertiesoftheorgansandtissuesoflivingan-imalsismuchmoredifficult.

  • 标签: SIZES BIOMEDICAL IRREGULAR ORGANS PROBE HEATED
  • 简介:客观:在乙醇的媒介(非极),是的STMP和ADH,以由没有一个胶化阶段,得到稳定的cross-linked产品准备药交货microspheres,并且学习cross-linked产品的biocompatibility和biodegradability的crosslinkers哈。方法:是的生物医学的材料的ISO10993.1安全评估一本参考书,做溶血测试,经皮的刺激测试,vitro降级测试,和降级产品的尖锐毒性测试,和分析。结果:HA-STMPcross-linked产品没把溶血,没有激怒,没有尖锐全身的毒性,而是HA-ADH有温和皮肤激怒和不利尖锐全身的毒性。HA-STMPcross-linked产品HAse和曲线上的有的更低的敏感是flatting。随HA-STMP结果被结构分析改变的降级时间的增加,这些房间的降级产品不是毒性。结论:有到水解作用的更好的biocompatibility和更好的抵抗的HA-STMPcross-linked产品能推迟降级时间,它对可被细菌破坏的药搬运人的准备合适。

  • 标签: 生物降解性 交联剂 产品 急性毒性试验 TMP 生物相容性
  • 简介:客观:准备nanophase人工的骨头合成支架基于bionics,进满足在骨胶原和无机的部分以及黏合的代理人的不同分子的重量之间的比率怎么不同的理论,和探查影响支架的微观结构和性质。方法:在象内容比率和环境,然后nanophasecollagen/calcic的pH价值那样的某些反应条件下面在一起沉淀期间带钙的无机的分子到deposite到自我装配的骨胶原模板上盐被获得。以便改进机械性质,有性质和可控制的可被细菌破坏的活动被选择为黏合的代理人的稳定的平等者的poly乳的酸(PLLA),然后瞄准人工的骨头支架(nanophasecollagen/calcicsalt/PLLA合成)被完成。在有isoproanol酒精的准备液体排水量方法以后,扫描电子显微镜(SEM),传播电子显微镜(TEM),fourier变换红外线的spectrometry(FTIR),机械测试系统被执行到测试孔和密度,形态学,符合构造,作文和机械性质,respectively.Results:合成支架主要是的人工的综合骨头部分与B类型碳酸盐代替的骨胶原和钙磷酸盐创作了。crystallinity是低的,并且水晶尺寸到达类似于自然骨头的纳米。有效地使用的PLLA改进能在cancellous标准的地板水平到达的机械性质,并且与80%的高孔开发three-dimensional-porous结构。根据比较,在象黏合的PLLA的增加一样的骨胶原和钙的无机的盐之间的内容比率都在综合支架的微观结构上有效果,这能被看见,PLLA的另外分子的重量在机械properties.Conclusion上有效果:nanophase人工的骨头合成支架由biomimetic综合了进程是最答应为临床的申请的最佳的材料不管怎么从结构,作文和pr判定了之一

  • 标签: BIOMINERALIZATION 自我装配 NANOPHASE 骨胶原 钙磷酸盐 PLLA
  • 简介:开发shear变瘦代替血的非牛顿的液体在自从血是展出的shear变瘦nonNewtonian液体,设计的biomedicine的研究是合乎需要的粘滞、有弹性性质,并且通常在大体积不可得到。有不同集中和温度的水的Xanthan口香糖的rheological性质在现在的纸被学习。结果证明水的Xanthan口香糖是显示的非牛顿的液体显著砍变瘦行为并且是合适的血类似物液体。在之间有一种幂定律分发关系砍强调并且砍率,并且答案集中越高,它显示越多强烈砍变瘦行为。有解决方案温度减少或与解决方案集中的水的Xanthan口香糖增加的粘性值在线性增加。而且在37的温度,有0.4和0.6的集中的水的Xanthan口香糖在rheological性质最好匹配人的血。根据重新适合,与温度和concentrition改变的粘性表示被获得,并且Xanthan口香糖答案的稳定性被讨论。

  • 标签: 实验研究 流变学 血液 治疗
  • 简介:Inmodernwarsbulletwoundscausedbysteelballsrepresentoneofthemajorkindsofcombatwounds,anddevelopingthecriteriafornecrosisoftissuesinsteel-ball-woundedorganismsisthereforeofgreatsignificanceforbothmilitaryandclini-calapplications.Severeinjuriescanbereadilyrecognizedbynakedeyes,butslighteronesareoftendifficulttobeidentifiedbyvisualexaminationorexperience.Moreoveritseemstobeunlikelytoestablishconsiatentcriteriaforvisualexaminationbecause

  • 标签: MILITARY INJURIES naked readily COMBAT CANINE
  • 简介:Theroomtemperaturecuringdenturebaseresinhaslowmechanicalproperties,soitwaslimitedinclinicalapplication.Ithadpreviouslydisscusedthatreinforedmaehinicalpropertieswithmetalfiber,glassfiber,plasticfiberandbyaddingthefractureresistancesubstancesinpowderTheaimofthisstudywastodeterminedthemechanicalproperitiesoffourroomtemperaturecuringdenturebaseresinwhichhadbeenmodifiedperformancewithhighboilpointmethacrylate.

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  • 简介:Theobjectiveofthispaperistodesignaporouspolyvinylalcohol(PVA)basedoncompositemembranewithcertainmechanicalstrengthandbiocompatibilitiesservingastissueregenerativescaffolds.PVA-glycosaminoglycan(GAG)-typeIcollagen(COL)compositemembranewasfabricatedbyPVAwithdifferentmolecularweight(Mw)andalcoholysisdegree(AD)beingblendedwithcertainamountsofGAGandCOLanddriedat38℃for24h.Thewatercontentofthecompositemembraneswerefrom61.9%to95.1%andswellingratiorangedfrom123.6%to621.7%.Scanningelectronmicroscope(SEM)analysisprovedthatPVA-GAG-COLcompositemembranehasporousandhomogenousstructure.Biocompatibilitytestresultsshowedthatthecompositemembranewasnontoxic,whichcouldpromoteadhesionandproliferationoffibroblastsonthecompositemembrane.Inconclusion,PVA-GAG-COLcompositemembranewithhighwatercontentandswellingratio,suitablemechanicalstrengthandgoodbiocompatibility,haspotentialintissueengineeringandregenerativemedicine.更多还原

  • 标签: 聚乙烯醇 复合膜 组织再生 胶原 制备 支架
  • 简介:客观:在水下吃惊能生产极其高的加速,在腰部的脊骨是的舷侧,和人的thoraco上导致严重人的损害容易打手势由轮船吃惊受不了损害。观察年轻新鲜死尸的thoracolumbar的粘弹性,并且为研究和临床的实践提供biomechanical参数。材料和Methods:5新鲜年轻男死尸(22~31年)被提供,并且15thoracolumbar5件样品的针的解剖在1小时死亡以内被收获。WE-10A通用严峻的机器被用于爬并且松驰tests.Results:强调松驰并且爬变丑方程从biomechanics模型被导出,测量并且模仿的曲线被比较。在显著地展出的脊椎的身体和intervertebral磁盘的creep分别地在开始的5min和10min变化。压力很快在开始的2min减少了,然后逐渐地去了平衡在松驰过程期间。结论:变化在爬率在早舞台是重要的,并且逐渐地减缓down.This显示内部压力和本地压力之间的差别被减少直到平衡。从方程导出的模仿的曲线与试验性的数据与一致到大度,它声明方程合理、可靠。

  • 标签: 蠕变性能 应力松弛 实验数据 椎间盘 生物力学模型 模拟曲线
  • 简介:Thecruxoftissueengineeringistoconstructhighlyporousthree-dimensionalscaffoldwithdesiredcellsonit.Becausethescaffoldservesasbothaphysicalsupportandanadhesivesubstrateforisolatedcellsduringinvitrocultureandsubsequentimplantation,thematerialsforscaffoldshouldbenon-toxicandbiocompatible,highlyporousandprocessableintodevicesofvariousshapes.

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  • 简介:Thedataofdielectricpropertiesofhumantissuesmainlycomefromanimaltissuesorhumancorpseatpresent.Uptonow,therehasnotbeenareportofdielectricpropertiesofhumanlivingliver.Ourobjectiveistostudythedielectricpropertiesofhumanlivingliverandcomparetheresultswiththoseofanimallivingliveraswellasthehumannon-livingliver.Invitromeasurementsoflivingandnon-livingliversfromhumanandrabbitsareshowninthe10Hzto100MHzrange.Analysisoftheconductivity,permittivityandcharacteristicparametersfromthedataweremade.Theconductivityofthreekindsofliverweremarkedlydifferentatlowfrequencyof0.06s/m(livingrabbitliver),0.13s/m(livinghumanliver)and0.24s/m(non-livinghumanliver).TheColeparametersthatbestcharacterizetheliverofhumanandrabbitareR0,fc1,R1,andR∞TheColeparametersthatbestcharacterizethelivingandnonlivingliverofhumanareR0,fc1,ΔR1,ΔR2andR∞.Inconclusion,wecan’tsubstitutethedielectricpropertiesofanimalorhumancorpseliverforthelivinghumanliver.Theresultssuggestthatthedielectricpropertiesoflivinghumantissueshasgreatsignificanceonstudying.

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  • 简介:在这篇论文,一种合成microtube,由特级的丝绸粉末和聚氨酯制造,由polyster和斯潘德克斯弹性纤维增强了管状的织物,被检验。合成microtubes的剖面图是多微孔的,并且micropores是散布的制服,内部表面是相对光滑的。结果证明合成microtubes的墙厚度增加了,它导致了力量,碎工作和起始的模量incresead;增加的斯潘德克斯弹性纤维内容引起了起始的模量和碎工作,这减少了,但是碎延期和碎负担第一被增加然后减少;并且当SFSP内容增加了,所有机械性质减少了。

  • 标签: 管状织物 聚氨酯 针织面料 力学性能 蚕丝 超细
  • 简介:OBJECTIVEPoly-L-lactide(PLLA)isthemainmaterialmakingforbiodegradableosteosynthesis.ButthecommonlyusedprocessesmakethePLLA'sinitialmechanicalpropertiestoolowtosufficientfortheneedforclinicalosteosynthesis.Thenitmustbetodevelopsomespecialprocesstoenhancethemechanicalproperties.

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