简介:Methoxypolyethyleneglycolsof5000dalton(PEG)havebeenattachedcovalentlytohumanserumimmunoglobulinGusing2,4,6-trichloro-s-triazineascouplingagent.Themodi-fiedIgGshowedsubstantialchangesinpropertiesascomparedwiththeunmodifiedIgG.Themod-ifiedIgGshowedincreaseinmolecularweight,increaseoftolerancetotemperatureandPH,de-creaseofimmunogenicityandretainingmostofitsimmunoactivity.TheCDspectrashowednoap-parentchangesinitsmainstructure.IgGwith50.3%ofitsaminogroupsmodifiedbyPEGhaditsimmunogenicitycompletelyre-moved,whilemaintaining53.7%ofitsimmunoactivity.
简介:Afacileone-potsynthesisofα-cyclodextrin-basedpolyrotaxane(PR)inaqueoussolutionisreported,wherethepeptideglutathionewasusedastheend-cappingagentandthethiol-eneMichaeladditionwasusedastheend-cappingreaction.Bothpolyrotaxaneswithlowthreadingratioandhighthreadingratioweresuccessfullyobtained.Incontrasttotheconventionallyusedmultiple-stepsynthesismethodsandhydrophobicendcappers,thisone-potaqueoussynthesisaswellasthebiocompatibilityoftheend-cappingagentcouldresultinamuchmorebiocompatiblePRtobeusedasbiomaterials.
简介:基本上在在vitro和细胞外的矩阵种相关房间上面做的织物工程。织物工程的一个主要目标到preparate多孔为房间的三尺寸脚手架增殖,移居,differention并且形成理想的织物和机关的结构。在这研究,各种各样的内容的效果和到chitosan的木钉的macromolecular重量被调查并且评估。chitosan的毛孔形态学被改变集中控制,PEG.Chitosan多孔的支架的macromolecular重量有interconecting孔。毛孔形态学能与改变木钉集中和macromolecular重量被控制。毛孔尺寸在之间1050嗯,在水里胀大的度是85.70%。
简介:Injectablenanoparticlecarrier,poly(ethyleneglycol)-coatedpoly(ethylcyanoacrylate)hasbeenpreparedbyasimplemethod.AtFirst,synthesizingPEGmacromonomerofpoly(ethyleneglycol)monomethyletherwithacryloylchloride,thengraftcopolymerofpoly(ethylcyanoacrylate)andpoly(ethyleneglycol)wasyieldbyfreeradicalpolymerizationofethylcyanoacrylatewithPEGmacromonomerintoluenesolvent.CharacterizationofthecopolymerhasbeenperformedbyFTIR,1H-NMRandGPCanalysis.Nanoparticleswereeasilypreparedfromtheobtainedamphiphiliccopolymer.
简介:Asimpleapproachforthecondensationofbenzaldehydewithethyleneglycolwasadoptedwithoutemployinganycatalyst.Thestudyrevealsthatfactorsincludingtemperature,molarratioofreactants,andthewaterremovalsignificantlyinfluencetheconversionratioofbenzaldehyde.Theresultsindicatethattheuseofoptimalreactionconditionssuchastemperatureandwaterremovingexhibitsmorepronouncedeffectsontheconversionratioofbenzaldehydecomparedwiththeuseofcatalysts.Inaword,agreenandsimplemethodforthecondensationofaldehydeandmenthandiolhasbeendevisedandinvestigated.
简介:Abicentralpolymer-supportedphasetransfercatalyst,polystyrene-supportedpolyethyleneglycolandpyridiniumsalt(PS-Py-PEG-400),synthesizedwithchloromethylatedpolystyreneassupporteronwhichPEGandpyridiniumsaltwereimmobilizedsuccessively.ItscatalyticactivitywastestedforthereactionofsolidpotassiumacetateandbenzylbromidebyGCanalysis.ItwasfoundthatthebicentralcatalystperformedhigheractivitythanthemonocentralPS-PEG-400andPS-Py.
简介:AnefficientprocessfortheconversionofdimethyloxalateintoethyleneglycolwithhighselectivityandhighyieldoverCu2Owasinvestigated.InsituformedCuasatruecatalyticallyactivespeciesshowedagoodcatalyticperformanceforDMOconversiontoproduceEGin95%yield.