简介：摘要目的探讨γＧ干扰素释放试验(IGRA)在肺结核和肺外结核早期诊断中的应用.方法选取２０１４年１月至２０１４年１２月期间在我院接受治疗的结核病患者１００例,将其设为观察组;同期选取５０例健康体检者作为对照组,检测受检者血浆γＧ干扰素含量,所得检测结果与结核菌素皮肤试验(TST)结果进行比较,判定γＧ干扰素释放试验在肺结核和肺外结核早期诊断中的价值.结果在与健康体检者检验对比中,IGRA检验方法具有更高的敏感性与特异性;肺结核与肺外结核早期诊断中,IGRA检出率更高,组间比较差异具有统计学意义(P＜０．０５).结论γＧ干扰素释放试验在肺结核和肺外结核早期诊断中具有较高的应用价值,可作为结核病患者的早期诊断常规方法.关键词γＧ干扰素释放试验;肺结核;肺外结核;ApplicationofinterferongammareleasetestinearlydiagnosisoftuberculosisandpulmonarytuberculosisLiangＧshenglinYa??anPeople??sHospitalofSichuanProvince６２５０００AbstractobjectiveToinvestigatetheapplicationofinterferongammareleasetest(IGRA)intheearlydiagnosisoftuberculosisandpulmonarytuberculosis．MethodFromJanuary２０１４toDecember２０１４,１００casesoftuberculosispatientstreatedinourhospitalwereselectedastheobservationgroup,Inthesameperiod,５０healthypersonswereselectedasthecontrolgroup．Detectiontheplasmalevelsofgammainterferoninthesubjects,todeterminethevalueofinterferongammareleasetestinearlydiagnosisoftuberculosisandpulmonarytuberculosis．ResultIncomparisonwithhealthexamination,IGRAtestmethodhashighersensitivityandspecificity．Intheearlydiagnosisoftuberculosisandpulmonarytuberculosis,thedetectionrateofIGRAishigher(P＜０．０５)．ConclusionInterferongammareＧleasetestinearlydiagnosisoftuberculosisandpulmonarytuberculosishasahighapplicationvalue,canbeusedasaroutinemethodforearlydiagnosisoftubercuＧlosispKateiyenwtosr．dsInterferongammareleasetest;Tuberculosis;Pulmonarytuberculosis;中图分类号R８２５．２文献标识码B文章编号１００８－６３１５(２０１５)１２－０７９１－０１