Twoseriesofnovelcompoundsdesignedashybridsof1-arylnaphthalenelignanswithdihydroisoquinolinesorisoquinolinesweresynthesizedandevaluatedfortheircytotoxicitiesonhumantumorcelllines,suchasA549,Hela,PC-3andKB.SomeofthesyntheticcompoundsexhibitedtheirIC50valuesonselectedcelllinesatμmol/Lscale.