Synthesis and Cytotoxicity Evaluation of Some Isoquinoline Derivatives Related to 1-Arylnaphthalene Lignans

(整期优先)网络出版时间:2005-10-20
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Twoseriesofnovelcompoundsdesignedashybridsof1-arylnaphthalenelignanswithdihydroisoquinolinesorisoquinolinesweresynthesizedandevaluatedfortheircytotoxicitiesonhumantumorcelllines,suchasA549,Hela,PC-3andKB.SomeofthesyntheticcompoundsexhibitedtheirIC50valuesonselectedcelllinesatμmol/Lscale.