Objective:ToinvestigatetheantitumoractivityandthemechanismofBRM-SJSonbreastcancercells.Methods:Flowcytometry,DNAagarosegelelectrophoresisandothertechniqueswereusedtostudytheinvitroandinvivoinhibitoryeffectonBcaP-37cellsbyBRM-SJS.Results:BRM-SJSshowedaninhibitoryrateof33.8%oninvivotransplantedtumor(P<0.05,comparedwithcontrol).TheflowcytometryanalysisofBRM-SJStreatedBcaP-37(2.5μmol/L,5μmol/L,10μmol/Lfor48hand72h)revealedtypicalsub-G1peak.ThespecificDNALadderswereexhibitedwithBRM-SJSBcaP-37cellstreated.Conclusion:BRM-SJShasmarkedantitumoractivityonBcaP-37anditsinhibitoryeffectsontumorwererealizedbybothinductionofapoptosisandnecrosisofthetumorcells.
