AIM:Tocomparetheclinicaloutcomesofcombined25-gaugeparsplanavitrectomy（PPV）andphacoemulsification/posteriorchamberintraocularlens（PC-IOL）implantationwithvitrectomyalonesurgeryinpatientswithvariousvitreoretinaldiseases.METHODS:Atotalof306eyes（145withPPValoneand161withphaco-vitrectomy）wereenrolledinthisretrospectiveanalysis.Thesurgicalapproachwas25-gaugePPVcombinedwithphacoemulsificationandPC-IOLimplantationatthesametimeineyesinphaco-vitrectomygroupandonlyPPVineyesinvitrectomyalonesurgerygroup.Themainoutcomemeasureswerepostoperativeclinicaloutcomesincludedanteriorchamberinflammation,changesinintraocularpressure（IOP）andbestcorrectedvisualacuity（BCVA）.RESULTS:Themostcommonpostoperativecomplicationwasanteriorchamberreactionwhichhashigherincidenceinphaco-vitrectomygroup（P<0.001）.Themeanpostoperative1stdayIOPofvitrectomyalonegroupwassignificantlylowerthanthatofphaco-vitrectomygroup（16.3±5.8mmHgvs17.8±8.1mmHg,respectively,P=0.02）.Hypotony(IOP（8mmHg）wasnotdifferentbetweengroupsinthepostoperative1stday（P>0.05）.Themeanpreoperativevisualacuitywasnotdifferentbetweengroups（1.6±0.9logMARvs1.8±0.9logMAR,respectively,P>0.05）.However,themeanvisualacuitywasdecreasedinvitrectomyalonegroupatthefinalvisitcomparedtophaco-vitrectomygroup（1.2±0.8logMAR,0.9±0.7logMAR,respectivelyP<0.05）.CONCLUSION:Twenty-fivegaugePPVcombinedwithphacoemulsificationsurgeryisasafeandefficientprocedure,whichcanbepreferredinphacicpatientswithavarietyofvitreoretinaldiseasescomparedtovitrectomyalone.Despiteimprovedoutcomes,thisapproachisnotfreeoflimitationsasanteriorchambercomplicationsespeciallywithcombinedsurgery.
